Abstract:
OBJECTIVE:Women exhibit exaggerated renal hemodynamic responses to hyperglycemia, which may promote kidney disease progression. Our aim was to determine if increased nitric oxide generation by l-arginine infusion would reverse this deleterious response to clamped hyperglycemia in women with type 1 diabetes mellitus. RESEARCH DESIGN AND METHODS:Renal function, blood pressure, and plasma cyclic guanosine monophosphate (cGMP) were measured in 20 men and 15 women with type 1 diabetes mellitus during clamped euglycemia and clamped hyperglycemia. Renal function, blood pressure, and plasma cGMP responses to graded infusions of intravenous l-arginine and N(G)-monomethyl-l-arginine (l-NMMA) were measured during clamped hyperglycemia. RESULTS:Subjects were young, normotensive, normoalbuminuric men and women who adhered to a high-sodium, moderate-protein diet. Plasma cGMP levels during euglycemia were generally lower in men compared with women, and systolic blood pressure (SBP) was higher in men. In response to hyperglycemia, cGMP levels did not change in men but did decline in women (Δ-1.10 ± 0.20 vs. Δ+0.05 ± 0.20 pmol/L, between-group effect of hyperglycemia on cGMP; P = 0.012). Hyperglycemia also was associated with an increase in SBP, glomerular filtration rate (GFR) (124 ± 6 to 143 ± 7 mL/min/1.73 m(2); P = 0.003) and filtration fraction (FF) in women, but these parameters did not change in men. In response to l-arginine during hyperglycemia, the increase in cGMP was exaggerated in women versus men and GFR and FF decreased in women only, back toward baseline values observed during clamped euglycemia. l-NMMA infusion did not exaggerate changes in hemodynamic function in response to hyperglycemia. CONCLUSIONS: l-Arginine reversed the renal hemodynamic effects of hyperglycemia in women, suggesting that nitric oxide is an important regulator of sex-dependent vascular responses to hyperglycemia in humans.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Cherney DZ,Scholey JW,Sochett EBdoi
10.2337/dc12-1305subject
Has Abstractpub_date
2013-05-01 00:00:00pages
1290-6issue
5eissn
0149-5992issn
1935-5548pii
dc12-1305journal_volume
36pub_type
杂志文章相关文献
DIABETES CARE文献大全abstract:OBJECTIVE:Dyslipidemia contributes to the progression of microvascular disease in diabetes. However, different lipid variables may be important at different stages of nephropathy. This study examines the pattern of dyslipidemia associated with the progression of nephropathy in patients with type 1 diabetes. RESEARCH D...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.29.02.06.dc05-0809
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVE:Hypoglycemic symptoms have been reported by more than half of pancreas transplantation (PTX) recipients. To better understand the mechanism for the hypoglycemia documented in some of these patients, we studied the glucose and pancreatic hormone response to Sustacal in patients with and without hypoglycemia fo...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/diacare.17.9.988
更新日期:1994-09-01 00:00:00
abstract:OBJECTIVE:To determine whether, after adjustment for glycemia and other selected covariates, hemoglobin A1c (HbA1c) differed among adults from six Hispanic/Latino heritage groups (Central American, Cuban, Dominican, Mexican, Puerto Rican, and South American) and between Hispanic/Latino and non-Hispanic white adults wit...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc15-2579
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVE:Bimodality in the distribution of glucose has been used to define the cut point for the diagnosis of diabetes. Previous studies on bimodality have primarily been in populations with a high prevalence of type 2 diabetes, including one study in a white Caucasian population. All studies included participants wit...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc08-0867
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVE:To establish differences in blood glucose between different regimens of optimized basal insulin substitution in type 1 diabetic patients given lispro insulin at meals, i.e., NPH injected four times a day versus glargine insulin once daily at dinner or at bedtime. RESEARCH DESIGN AND METHODS:A total of 51 pat...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.26.5.1490
更新日期:2003-05-01 00:00:00
abstract:OBJECTIVE:Hypertriglyceridemia is associated with cardiovascular disease in diabetes. Fibrates effectively lower, but do not always normalize, serum triglyceride levels. Fish oil supplements may then be added to lower serum triglyceride levels. Doubt remains whether the net effect of fish oil intake on glycemic control...
journal_title:Diabetes care
pub_type: 杂志文章,meta分析
doi:10.2337/diacare.21.4.494
更新日期:1998-04-01 00:00:00
abstract:OBJECTIVE:Reports of amputations associated with sodium-glucose cotransporter 2 (SGLT2) inhibitors have been inconsistent. We aimed to compare the risk of below-knee amputation with SGLT2 inhibitors versus dipeptidyl peptidase 4 (DPP-4) inhibitors among patients with type 2 diabetes. RESEARCH DESIGN AND METHODS:This m...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc20-0267
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:To determine the best autoantibody-based testing strategy for recruiting relatives for future intervention trials and to establish the role of islet cell antibodies (ICAs) within this strategy. RESEARCH DESIGN AND METHODS:ICAs, insulin autoantibodies (IAAs), GAD antibodies, and IA-2 antibodies were determine...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.22.11.1796
更新日期:1999-11-01 00:00:00
abstract:OBJECTIVE:Recent studies show the importance of controlling blood glucose variability in relationship to both reducing hypoglycemia and attenuating the risk for cardiovascular and behavioral complications due to hyperglycemia. It is therefore important to design variability measures that are equally predictive of low a...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc06-1085
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVE:Under the auspices of the National Institutes of Health, American Diabetes Association, and World Health Organization, expert committees lowered the fasting plasma glucose (FPG) concentration diagnostic for diabetes from 7.8 to 7.0 mmol/l and defined 6.1-6.9 mmol/l as impaired fasting glucose (IFG) and <6.1 m...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.28.11.2626
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVE:Ruboxistaurin selectively inhibits protein kinase C-beta and ameliorates kidney disease in animal models of diabetes. The purpose of this study was to evaluate the effects of ruboxistaurin on diabetic nephropathy in humans. RESEARCH DESIGN AND METHODS:A randomized, double-blind, placebo-controlled, multicent...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.2337/diacare.28.11.2686
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of clinically obtainable improvements in metabolic control in patients with type 1 diabetes on biochemical cardiovascular risk factors. RESEARCH DESIGN AND METHODS:Blood and 24-h urinary samples were obtained from 49 patients with type 1 diabetes before and after a run-in period and af...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/diacare.22.4.546
更新日期:1999-04-01 00:00:00
abstract:OBJECTIVE:The goal of the study was to examine risk factors in the prediction of coronary heart disease (CHD) and differences in men and women in the EURODIAB Prospective Complications Study. RESEARCH DESIGN AND METHODS:Baseline risk factors and CHD at follow-up were assessed in 2,329 type 1 diabetic patients without ...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.27.2.530
更新日期:2004-02-01 00:00:00
abstract:OBJECTIVE:To examine the association of renal function in diabetic patients with apolipoprotein (apo) E polymorphism. RESEARCH DESIGN AND METHODS:Apo E genotypes, lipid and lipoprotein serum levels, creatinine clearance (CCr), and excretion of marker proteins were determined in German type 1 (IDDM; n = 162) and type 2...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.21.6.994
更新日期:1998-06-01 00:00:00
abstract:OBJECTIVE:There is considerable interest in identifying biomarkers that predict high risk for the development of macrovascular complications in patients with diabetes. Therefore, the longitudinal association between subclinical atherosclerosis as measured by internal carotid artery intima-media thickness (IMT) and acut...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc14-2877
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:Uncertainty remains regarding the predictive value of various glycemic measures as they relate to the risk of diabetes and its complications. Using the cutoffs recommended by the American Diabetes Association's 2010 criteria, we determined the associations of fasting plasma glucose (FPG), 2-h postload glucose...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/dc18-1390
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to investigate alcohol consumption in relation to the incidence of type 2 diabetes. RESEARCH DESIGN AND METHODS:The study population consisted of 22778 twins of the Finnish Twin Cohort. This cohort was compiled in 1975 and includes all same-sexed twins born in Finland before 1958. I...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.26.10.2785
更新日期:2003-10-01 00:00:00
abstract::Increasingly more tests are being used to detect and characterize diabetic polyneuropathy, but their value in setting minimal criteria for the diagnosis of neuropathy and for staging severity remains inadequately studied. In 180 diabetics, we compared the percentage of patients with test abnormalities and associations...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.10.4.432
更新日期:1987-07-01 00:00:00
abstract:OBJECTIVE:In observational studies, low vitamin D levels are associated with type 2 diabetes (T2D), impaired glucose metabolism, insulin sensitivity, and insulin secretion. We evaluated the efficacy of vitamin D supplementation on insulin sensitivity and insulin secretion in subjects with T2D and low vitamin D (25-hydr...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc16-2302
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:To examine urinary levels of enterolactone and enterodiol, intestinal microbial metabolites of dietary lignans, in relation to type 2 diabetes (T2D) risk. RESEARCH DESIGN AND METHODS:Urinary concentrations of the lignan metabolites were assayed by liquid chromatography-mass spectrometry among 1,107 T2D and 1...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/dc13-2513
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:Insulin resistance (IR) and the metabolic syndrome (MS) are associated with type 2 diabetes and adverse cardiovascular disease (CVD) risk factor profiles. Whether IR and MS predict CVD independently of diabetes and other CVD risk factors is not known. This study examines whether IR and/or presence of MS are i...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.26.3.861
更新日期:2003-03-01 00:00:00
abstract:OBJECTIVE:The International Diabetes Federation (IDF) has proposed a new definition of the metabolic syndrome that emphasizes central adiposity as determined by ethnic group-specific thresholds of waist circumference. The objective of this study was to estimate the prevalence of this syndrome using the IDF definition a...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.28.11.2745
更新日期:2005-11-01 00:00:00
abstract::Cardiovascular outcome trials have provided evidence that sodium-glucose cotransporter 2 inhibitor (SGLT2i) treatment is associated with remarkably favorable cardiovascular outcomes. Here, we offer a novel hypothesis that may encompass many of these hypothetical mechanisms, i.e., the ability of SGLT2i to modify the tr...
journal_title:Diabetes care
pub_type: 评论,杂志文章
doi:10.2337/dc19-1410
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVE:To investigate the basis of central nervous system dysfunction in diabetes associated with the 3243 mitochondrial tRNA mutation, we studied neuroimaging findings in patients with this disease. RESEARCH DESIGN AND METHODS:We screened 205 diabetic patients. Those patients who had the 3243 mutation in leukocyte...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.19.7.739
更新日期:1996-07-01 00:00:00
abstract:OBJECTIVE:Growth deferentiation factor-15 (GDF-15) is involved in inflammation and apoptosis. Expression is induced in the heart in response to ischemia and in atherosclerotic plaques. The aim of this study was to investigate GDF-15 levels in relation to all-cause mortality, cardiovascular mortality and morbidity, decl...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-2174
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVE:Type 2 diabetes is frequently complicated with atherogenic dyslipidemia. This study aimed to evaluate the efficacy and safety of pemafibrate (K-877) in patients with type 2 diabetes comorbid with hypertriglyceridemia. RESEARCH DESIGN AND METHODS:Patients were randomly assigned to three groups and received pl...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2337/dc17-1589
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:Little is known about the psychosocial challenges of adults living with type 1 diabetes or its impact on partner relationships. This qualitative study was undertaken to gain better understanding of these issues. RESEARCH DESIGN AND METHODS:Four focus groups were held, two with adult type 1 diabetic patients ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-1718
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:To evaluate glycemia and metrics of glucose variability in youth with type 1 diabetes, and to assess patterns of 24-h glucose variability according to pubertal status. RESEARCH DESIGN AND METHODS:Metrics of glycemia, glucose variability, and glucose patterns were assessed by using 4 weeks of continuous gluco...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc19-0083
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:We sought to study the prevalence of autoantibodies to various islet cell antigens in the background population of two neighboring countries with a sixfold difference in the incidence of type 1 diabetes. RESEARCH DESIGN AND METHODS:Serum samples were obtained from 3,652 nondiabetic schoolchildren in Finland ...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/dc06-0711
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:To assess the long-term cost-effectiveness of aspirin use among adults aged >or=40 years with newly diagnosed type 2 diabetes. RESEARCH DESIGN AND METHODS:We used a validated cost-effectiveness model of type 2 diabetes to assess the lifetime health and cost consequences of use or nonuse of aspirin. The model...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-1888
更新日期:2010-06-01 00:00:00