Non-insulin-dependent diabetes: 10-year outcome in relation to initial response to diet and subsequent sulfonylurea therapy.

Abstract:

:Thirty-eight non-insulin-dependent diabetic patients within 130% of desirable body weight were given a 100-g oral glucose tolerance test (OGTT) at diagnosis and after at least 1 mo of dietary treatment with energy and carbohydrate restriction. Thirteen "responders" showed an improvement in fasting blood glucose, glucose tolerance, and insulin secretion, with near-normalization of plasma, lactate, pyruvate, free fatty acids, glycerol, and ketone bodies. There were no significant changes in the 25 "non-responders." The responders were, at diagnosis, heavier than the non-responders (75.5 versus 64.3 kg, P less than 0.01). Twenty non-responders subsequently completed a prospective controlled study of glibenclamide, chlorpropamide, and placebo lasting for 16 mo with OGTTs at the end of each 4-mo treatment phase. The results showed that there were no significant differences between the metabolic effects of glibenclamide and chlorpropamide. On active treatment, insulin levels rose coincident with a fall in fasting blood glucose and an improvement in glucose tolerance and near-normalization of plasma lactate, pyruvate, free fatty acids, glycerol, and ketone bodies, all of which relapsed to initial values after placebo. Ten years after the initial study, 29 of the original patients were traced and reviewed and the outcome related to their earlier tests. Twenty-two percent of the responders and 70% of the non-responders were now on insulin (P less than 0.02); the initial insulin response to OGTT at the end of the diet treatment was significantly lower in those subsequently treated with insulin (P less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Sönksen PH,Lowy C,Perkins JR,Lim HS

subject

Has Abstract

pub_date

1984-05-01 00:00:00

pages

59-66

eissn

0149-5992

issn

1935-5548

journal_volume

7 Suppl 1

pub_type

临床试验,杂志文章
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    pub_type: 杂志文章

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    更新日期:1999-08-01 00:00:00

  • HLA-DQ beta typing and non-Asp57 alleles in IDDM and nondiabetic subjects in New Zealand.

    abstract:OBJECTIVE:To determine the frequency of IDDM risk-associated HLA-DQ beta alleles in New Zealanders with IDDM and nondiabetic control subjects, and to examine these as susceptibility markers in relation to IDDM incidence. RESEARCH DESIGN AND METHODS:HLA-DQ beta typing was conducted in 55 juvenile-onset IDDM subjects di...

    journal_title:Diabetes care

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    doi:10.2337/diacare.16.8.1179

    authors: Forbes LV,Brown LJ,Scott RS

    更新日期:1993-08-01 00:00:00

  • Lifestyle Counseling and Long-term Clinical Outcomes in Patients With Diabetes.

    abstract:OBJECTIVE:To investigate the relationship between lifestyle counseling in primary care settings and clinical outcomes in patients with diabetes. RESEARCH DESIGN AND METHODS:We retrospectively studied hyperglycemic adults with diabetes treated at primary care practices between 2000 and 2014. We analyzed the relationshi...

    journal_title:Diabetes care

    pub_type: 杂志文章

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    authors: Zhang H,Goldberg SI,Hosomura N,Shubina M,Simonson DC,Testa MA,Turchin A

    更新日期:2019-09-01 00:00:00

  • Malfunction of continuous subcutaneous insulin infusion systems: a one-year prospective study of 127 patients.

    abstract::Malfunction of portable continuous subcutaneous insulin infusion (CSII) systems may result in either ketoacidosis or serious hypoglycemia. To determine the types and frequencies of infusion system failure and the resulting clinical consequences, we recorded their occurrences in a 1-yr prospective study of 127 patients...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.9.4.351

    authors: Mecklenburg RS,Guinn TS,Sannar CA,Blumenstein BA

    更新日期:1986-07-01 00:00:00

  • Role of height and glycosylated hemoglobin in abnormal nerve conduction in pediatric patients with type I diabetes mellitus after 4-9 yr of disease.

    abstract:OBJECTIVE:To determine the role of height and glycosylated hemoglobin in abnormal nerve conduction in pediatric patients with insulin-dependent (type I) diabetes mellitus. RESEARCH DESIGN AND METHODS:Sixty-six pediatric patients (aged 6.3-18.2 yr) with a duration of diabetes from 4 to 8.5 yr but free of clinical neuro...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.14.5.386

    authors: Duck SC,Wei FF,Parke J,Swick HM

    更新日期:1991-05-01 00:00:00

  • Risk factors for myocardial infarction case fatality and stroke case fatality in type 2 diabetes: UKPDS 66.

    abstract:OBJECTIVE:Patients with diabetes have a higher case fatality rate in myocardial infarction (MI) or stroke than those without diabetes: that is, MI and stroke are more often fatal if diabetes is present. We investigated whether the risk of MI or stroke being fatal in type 2 diabetes can be estimated using information av...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/diacare.27.1.201

    authors: Stevens RJ,Coleman RL,Adler AI,Stratton IM,Matthews DR,Holman RR

    更新日期:2004-01-01 00:00:00

  • Effect of training status on regional disposal of circulating free fatty acids in the liver and skeletal muscle during physiological hyperinsulinemia.

    abstract:OBJECTIVE:Fat metabolism is increasingly implicated in the pathogenesis of type 2 diabetes. Endurance training has been shown to prevent hepatic steatosis and to alter skeletal muscle fat metabolism, and regional free fatty acid (FFA) uptake adaptations were suggested as a mechanism. Thus, we tested whether endurance t...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.27.9.2172

    authors: Iozzo P,Takala T,Oikonen V,Bergman J,Grönroos T,Ferrannini E,Nuutila P,Knuuti J

    更新日期:2004-09-01 00:00:00

  • American Diabetes Association's Fourth International Workshop-Conference on Gestational Diabetes Mellitus: summary and discussion. Therapeutic interventions.

    abstract::This review summarizes Session IV: Therapeutic Interventions of the Fourth International Gestational Diabetes Workshop and suggests intervention protocols based on the presentations at this meeting and the literature. The opinions of the six presenters and their interpretation of the review of the literature in their ...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:

    authors: Jovanovic L

    更新日期:1998-08-01 00:00:00

  • Reconciliation of Type 2 Diabetes Remission Rates in Studies of Roux-en-Y Gastric Bypass.

    abstract:OBJECTIVE:Bariatric surgery may induce remission of type 2 diabetes in obese patients. However, estimates of remission rates reported in the literature range from 25 to 81%, contributing to the uncertainty patients and physicians both face as they assess treatment options. This analysis attempts to reconcile the seemin...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc16-0954

    authors: Isaman DJ,Rothberg AE,Herman WH

    更新日期:2016-12-01 00:00:00

  • Metformin and exercise in type 2 diabetes: examining treatment modality interactions.

    abstract:OBJECTIVE:To determine the effect of metformin on the acute metabolic response to submaximal exercise, the effect of exercise on plasma metformin concentrations, and the interaction between metformin and exercise on the subsequent response to a standardized meal. RESEARCH DESIGN AND METHODS:Ten participants with type ...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc10-2207

    authors: Boulé NG,Robert C,Bell GJ,Johnson ST,Bell RC,Lewanczuk RZ,Gabr RQ,Brocks DR

    更新日期:2011-07-01 00:00:00

  • White matter structural differences in young children with type 1 diabetes: a diffusion tensor imaging study.

    abstract:OBJECTIVE:To detect clinical correlates of cognitive abilities and white matter (WM) microstructural changes using diffusion tensor imaging (DTI) in young children with type 1 diabetes. RESEARCH DESIGN AND METHODS:Children, ages 3 to <10 years, with type 1 diabetes (n = 22) and age- and sex-matched healthy control sub...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc12-0017

    authors: Aye T,Barnea-Goraly N,Ambler C,Hoang S,Schleifer K,Park Y,Drobny J,Wilson DM,Reiss AL,Buckingham BA

    更新日期:2012-11-01 00:00:00

  • Outcomes of screening for diabetes in high-risk Hong Kong Chinese subjects.

    abstract:OBJECTIVE:To examine the significance of individual risk factors on the development of diabetes in subjects who underwent screening for diabetes. RESEARCH DESIGN AND METHODS:A total of 1,649 Chinese subjects underwent screening for diabetes. They were asymptomatic but had known risk factors for diabetes, including a p...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.23.9.1290

    authors: Ko GT,Chan JC,Tsang LW,Yeung VT,Chow CC,Cockram CS

    更新日期:2000-09-01 00:00:00

  • Evaluation of the effect of performance monitoring and feedback on care process, utilization, and outcome.

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    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.23.2.192

    authors: Petitti DB,Contreras R,Ziel FH,Dudl J,Domurat ES,Hyatt JA

    更新日期:2000-02-01 00:00:00

  • Inflammation markers and metabolic characteristics of subjects with 1-h plasma glucose levels.

    abstract:OBJECTIVE:To assess the association of 1-h plasma glucose (1hPG) and inflammation with normal glucose tolerance (NGT) and pre-diabetes. RESEARCH DESIGN AND METHODS:A cohort of 1,062 subjects was enrolled. After oral glucose load (oral glucose tolerance test), we compared subjects with NGT and pre-diabetes above and be...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-1342

    authors: Bardini G,Dicembrini I,Cresci B,Rotella CM

    更新日期:2010-02-01 00:00:00

  • High concentrations of AGE-LDL and oxidized LDL in circulating immune complexes are associated with progression of retinopathy in type 1 diabetes.

    abstract:OBJECTIVE:To determine whether immunocomplexes (ICs) containing advanced glycation end product (AGE)-LDL (AGE-LDL) and oxidized LDL (oxLDL) contribute to the development of retinopathy over a 16-year period in subjects with type 1 diabetes. RESEARCH DESIGN AND METHODS:Levels of AGE-LDL and oxLDL in ICs were measured i...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc11-2040

    authors: Lopes-Virella MF,Baker NL,Hunt KJ,Lyons TJ,Jenkins AJ,Virella G,DCCT\/EDIC Study Group.

    更新日期:2012-06-01 00:00:00

  • Stroke in the diabetic patient.

    abstract::A higher prevalence of stroke is found in the patient with both diagnosed and undiagnosed diabetes and glucose intolerance. Because of local cerebral acidosis caused by ischemia and hyperglycemia, morbidity and mortality from a stroke are increased. Most studies show that individuals with admission serum glucose > 120...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/diacare.17.3.213

    authors: Bell DS

    更新日期:1994-03-01 00:00:00

  • Lixisenatide Therapy in Older Patients With Type 2 Diabetes Inadequately Controlled on Their Current Antidiabetic Treatment: The GetGoal-O Randomized Trial.

    abstract:OBJECTIVE:To evaluate the efficacy and safety of lixisenatide versus placebo on glycemic control in older patients with type 2 diabetes uncontrolled on their current antidiabetic treatment. RESEARCH DESIGN AND METHODS:In this phase III, double-blind, randomized, placebo-controlled, two-arm, parallel-group, multicenter...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2337/dc16-2143

    authors: Meneilly GS,Roy-Duval C,Alawi H,Dailey G,Bellido D,Trescoli C,Manrique Hurtado H,Guo H,Pilorget V,Perfetti R,Simpson H,GetGoal-O Trial Investigators.

    更新日期:2017-04-01 00:00:00

  • Smoking and mortality among women with type 2 diabetes: The Nurses' Health Study cohort.

    abstract:OBJECTIVE:To assess the relationship between cigarette smoking and mortality among women with type 2 diabetes in the Nurses' Health Study cohort. RESEARCH DESIGN AND METHODS:The Nurses' Health Study, a prospective cohort of U.S. female registered nurses, included 7,401 women with type 2 diabetes diagnosed at baseline ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.24.12.2043

    authors: Al-Delaimy WK,Willett WC,Manson JE,Speizer FE,Hu FB

    更新日期:2001-12-01 00:00:00

  • Role of adiposity and lifestyle in the relationship between family history of diabetes and 20-year incidence of type 2 diabetes in U.S. women.

    abstract:OBJECTIVE:To evaluate to what extent the association between family history of diabetes and risk of type 2 diabetes can be explained by excess adiposity and lifestyle risk factors. RESEARCH DESIGN AND METHODS:We analyzed data from 73,227 women who participated in the Nurses' Health Study cohort. A family history of di...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-1586

    authors: van 't Riet E,Dekker JM,Sun Q,Nijpels G,Hu FB,van Dam RM

    更新日期:2010-04-01 00:00:00

  • Serum interleukin-18 levels are associated with nephropathy and atherosclerosis in Japanese patients with type 2 diabetes.

    abstract:OBJECTIVE:Interleukin (IL)-18 is a proinflammatory cytokine secreted from mononuclear cells. Serum concentration of IL-18 is a strong predictor of death in patients with cardiovascular diseases. Recent studies have shown that microinflammation is involved in the pathogenesis of diabetic nephropathy as well as of cardio...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.28.12.2890

    authors: Nakamura A,Shikata K,Hiramatsu M,Nakatou T,Kitamura T,Wada J,Itoshima T,Makino H

    更新日期:2005-12-01 00:00:00

  • Additional lunchtime basal insulin during insulin lispro intensive therapy in a randomized, multicenter, crossover study in adults : a real-life design.

    abstract:OBJECTIVE:This study was performed to evaluate whether an additional dose of NPH insulin at lunchtime might overcome the deleterious effects of waning basal insulinemia on pre-dinner and evening glucose values during insulin lispro intensive therapy with once daily basal insulin at night. RESEARCH DESIGN AND METHODS:T...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.2337/diacare.25.4.712

    authors: Stades AM,Hoekstra JB,van den Tweel I,Erkelens DW,Holleman F,STABILITY Study Group.

    更新日期:2002-04-01 00:00:00

  • High systolic blood pressure increases prevalence and severity of retinopathy in NIDDM patients.

    abstract:OBJECTIVE:To determine whether the severity of retinopathy is higher in a group of NIDDM patients with sBP greater than or equal to 140 mmHg compared with NIDDM patients with sBP less than 140 mmHg. RESEARCH DESIGN AND METHODS:Ophthalmoscopy and FAG were conducted among a group of NIDDM patients with either a sBP abov...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.15.8.1002

    authors: Cignarelli M,De Cicco ML,Damato A,Paternostro A,Pagliarini S,Santoro S,Cardia L,De Pergola G,Giorgino R

    更新日期:1992-08-01 00:00:00

  • Improvement of the plasma lipoprotein pattern after institution of insulin treatment in diabetes mellitus.

    abstract::Plasma lipids and lipoproteins were studied in 26 nonobese diabetic patients, either newly diagnosed or unsatisfactorily controlled by oral antidiabetic treatment. Measurements were performed before and 3-4 mo after the institution of insulin treatment. In a subgroup of seven patients, the activities of lipoprotein li...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.5.3.322

    authors: Agardh CD,Nilsson-Ehle P,Scherstén B

    更新日期:1982-05-01 00:00:00

  • Intensity of resistance exercise determines adipokine and resting energy expenditure responses in overweight elderly individuals.

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    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc08-1994

    authors: Fatouros IG,Chatzinikolaou A,Tournis S,Nikolaidis MG,Jamurtas AZ,Douroudos II,Papassotiriou I,Thomakos PM,Taxildaris K,Mastorakos G,Mitrakou A

    更新日期:2009-12-01 00:00:00

  • A 16-week comparison of the novel insulin analog insulin glargine (HOE 901) and NPH human insulin used with insulin lispro in patients with type 1 diabetes.

    abstract:OBJECTIVE:To determine the safety and efficacy of the long-acting insulin analog, insulin glargine, as a component of basal bolus therapy in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS:Patients with type 1 diabetes receiving basal-bolus insulin treatment with NPH human insulin and insulin lispro were ra...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.2337/diacare.23.11.1666

    authors: Raskin P,Klaff L,Bergenstal R,Hallé JP,Donley D,Mecca T

    更新日期:2000-11-01 00:00:00

  • Influence of time of day of blood pressure-lowering treatment on cardiovascular risk in hypertensive patients with type 2 diabetes.

    abstract:OBJECTIVE:We prospectively investigated in hypertensive patients with type 2 diabetes if bedtime treatment with ≥1 hypertension medications exerts better blood pressure control and cardiovascular risk reduction than conventional therapy, in which all medications are ingested in the morning. RESEARCH DESIGN AND METHODS...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc11-0297

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    更新日期:2011-06-01 00:00:00

  • Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes.

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    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/diacare.27.3.813

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    更新日期:2004-03-01 00:00:00

  • Comparative Effectiveness of the Sodium-Glucose Cotransporter 2 Inhibitor Empagliflozin Versus Other Antihyperglycemics on Risk of Major Adverse Kidney Events.

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    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc20-1231

    authors: Xie Y,Bowe B,Gibson AK,McGill JB,Yan Y,Maddukuri G,Al-Aly Z

    更新日期:2020-11-01 00:00:00

  • Risk of Anemia With Metformin Use in Type 2 Diabetes: A MASTERMIND Study.

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    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc20-1104

    authors: Donnelly LA,Dennis JM,Coleman RL,Sattar N,Hattersley AT,Holman RR,Pearson ER

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  • Detection of GAD65-reactive T-Cells in type 1 diabetes by immunoglobulin-free ELISPOT assays.

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    更新日期:2002-08-01 00:00:00