Impaired endothelial function in preadolescent children with type 1 diabetes.

Abstract:

OBJECTIVE:We evaluated the prevalence of endothelial dysfunction as measured by flow-mediated dilatation (FMD) of the brachial artery and carotid intima-media thickness (c-IMT) in relationship to vascular inflammatory biomarkers in preadolescent children with type 1 diabetes. RESEARCH DESIGN AND METHODS:We studied 21 type 1 diabetic children (aged 8.3 ± 0.3 years with diabetes duration of 4.3 ± 0.4 years) and 15 group-matched healthy siblings (aged 7.6 ± 0.3 years). Fasting plasma glucose (FPG), lipid profile, HbA(1c), high-sensitivity C-reactive protein (hs-CRP), fibrinogen, homocysteine, and erythrocyte (red blood cell [RBC]) folate were evaluated in all subjects. Each subject underwent c-IMT and brachial artery FMD percentage (FMD%) measurements using high-resolution vascular ultrasound. RESULTS:Type 1 diabetic children had higher FPG (173.4 ± 7.9 mg/dL vs. 81.40 ± 1.7 mg/dL; P < 0.0001), HbA(1c) (8.0 ± 0.2% vs. 5.0 ± 0.1%; P < 0.0001), and hs-CRP (1.8 ± 0.3 vs. 0.70 ± 0.2; P = 0.017) than control children without significant differences in BMI, homocysteine, and fibrinogen levels; RBC folate content; and c-IMT between the groups. Children with type 1 diabetes had lower FMD% than control children (7.1 ± 0.8% vs. 9.8 ± 1.1%; P = 0.04), whereas c-IMT did not differ between groups. CONCLUSIONS:Preadolescent children with type 1 diabetes and mean diabetes duration of 4 years displayed evidence of low-intensity vascular inflammation and attenuated FMD measurements. These data suggest that endothelial dysfunction and systemic inflammation, known harbingers of future cardiovascular risk, are present even in preadolescent children.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Babar GS,Zidan H,Widlansky ME,Das E,Hoffmann RG,Daoud M,Alemzadeh R

doi

10.2337/dc10-2134

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

681-5

issue

3

eissn

0149-5992

issn

1935-5548

pii

dc10-2134

journal_volume

34

pub_type

杂志文章
  • Back to basics in diagnosing diabetic polyneuropathy with the tuning fork!

    abstract:OBJECTIVE:Several national and international scoring systems are used to diagnose diabetic polyneuropathy (PNP). The variety in these scores and the lack of data on validity and predictive value has led to a comparison and validation of the scores with clinical standards for PNP to determine the most powerful measureme...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.28.9.2201

    authors: Meijer JW,Smit AJ,Lefrandt JD,van der Hoeven JH,Hoogenberg K,Links TP

    更新日期:2005-09-01 00:00:00

  • Increased Liver Fatty Acid Uptake Is Partly Reversed and Liver Fat Content Normalized After Bariatric Surgery.

    abstract:OBJECTIVE:Changes in liver fatty acid metabolism are important in understanding the mechanisms of diabetes remission and metabolic changes after bariatric surgery. RESEARCH DESIGN AND METHODS:Liver fatty acid uptake (LFU), blood flow, and fat content (LFC) were measured in 25 obese subjects before bariatric surgery an...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/dc17-0738

    authors: Immonen H,Hannukainen JC,Kudomi N,Pihlajamäki J,Saunavaara V,Laine J,Salminen P,Lehtimäki T,Pham T,Iozzo P,Nuutila P

    更新日期:2018-02-01 00:00:00

  • Lifestyle Counseling and Long-term Clinical Outcomes in Patients With Diabetes.

    abstract:OBJECTIVE:To investigate the relationship between lifestyle counseling in primary care settings and clinical outcomes in patients with diabetes. RESEARCH DESIGN AND METHODS:We retrospectively studied hyperglycemic adults with diabetes treated at primary care practices between 2000 and 2014. We analyzed the relationshi...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc19-0629

    authors: Zhang H,Goldberg SI,Hosomura N,Shubina M,Simonson DC,Testa MA,Turchin A

    更新日期:2019-09-01 00:00:00

  • Implementation of treatment protocols in the Diabetes Control and Complications Trial.

    abstract:OBJECTIVE:To describe the methods used to implement intensive and conventional therapies in the Diabetes Control and Complications Trial (DCCT) and the metabolic results that occurred with the different treatment regimens. RESEARCH DESIGN AND METHODS:The DCCT was a controlled clinical trial that demonstrated the benef...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.2337/diacare.18.3.361

    authors:

    更新日期:1995-03-01 00:00:00

  • Prevalence and predictors of breast and cervical cancer screening among Spanish women with diabetes.

    abstract::OBJECTIVE To examine the use of mammography and Papanicolaou (Pap) smear among women with diabetes and to identify predictors of adherence to these tests. RESEARCH DESIGN AND METHODS We analyzed data of a nationally representative sample of Spanish women. Diabetes status was self-reported. Screenings were assessed ask...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-0479

    authors: Jiménez-Garcia R,Hernandez-Barrera V,Carrasco-Garrido P,Gil A

    更新日期:2009-08-01 00:00:00

  • Effects of BAYm 1099, new alpha-glucosidase inhibitor, on acute metabolic responses and metabolic control in NIDDM over 1 mo.

    abstract::To examine the clinical role of BAYm 1099, 15 diet-treated non-insulin-dependent diabetic (NIDDM) subjects were randomized to start drug (50 mg 3 times/day) or placebo after a 4-wk run-in period in a double-blind crossover study. Treatment periods (4 wk) were separated by a 2-wk washout period. During the last week of...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.11.4.337

    authors: Samad AH,Ty Willing TS,Alberti KG,Taylor R

    更新日期:1988-04-01 00:00:00

  • Contribution of nerve-axon reflex-related vasodilation to the total skin vasodilation in diabetic patients with and without neuropathy.

    abstract:OBJECTIVE:To examine the contribution of nerve-axon reflex-related vasodilation to total acetylcholine-induced vasodilation in the skin of normal and diabetic subjects. RESEARCH DESIGN AND METHODS:The skin microcirculation was evaluated at the forearm level in 69 healthy subjects and 42 nonneuropathic diabetic patient...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.24.2.344

    authors: Hamdy O,Abou-Elenin K,LoGerfo FW,Horton ES,Veves A

    更新日期:2001-02-01 00:00:00

  • Neuronal Food Reward Activity in Patients With Type 2 Diabetes With Improved Glycemic Control After Bariatric Surgery.

    abstract:OBJECTIVE:Obesity and type 2 diabetes mellitus (T2DM) are associated with altered food-related neuronal functions. Besides weight loss, substantial improvement of glucose metabolism in patients with T2DM can be achieved by bariatric surgery. We aimed to target the neuronal and behavioral correlates of improved glycemic...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc16-0094

    authors: Frank S,Heinze JM,Fritsche A,Linder K,von Feilitzsch M,Königsrainer A,Häring HU,Veit R,Preissl H

    更新日期:2016-08-01 00:00:00

  • Is type 2 diabetes a different disease in obese and nonobese patients?

    abstract:OBJECTIVE:The main purpose of this work was to study the possible differences in insulin secretion in a large group of type 2 diabetic patients in relation to diabetes duration, obesity, and the presence of secondary failure after treatment with oral hypoglycemic agents. RESEARCH DESIGN AND METHODS:There were 147 nono...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.21.10.1680

    authors: Prando R,Cheli V,Melga P,Giusti R,Ciuchi E,Odetti P

    更新日期:1998-10-01 00:00:00

  • Prevalence of Candida glabrata and its response to boric acid vaginal suppositories in comparison with oral fluconazole in patients with diabetes and vulvovaginal candidiasis.

    abstract:OBJECTIVE:A large proportion of vulvovaginal candidiasis (VVC) in diabetes is due to non-albicans Candida species such as C. glabrata and C. tropicalis. Observational studies indicate that diabetic patients with C. glabrata VVC respond poorly to azole drugs. We evaluated the response to oral fluconazole and boric acid ...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc06-1469

    authors: Ray D,Goswami R,Banerjee U,Dadhwal V,Goswami D,Mandal P,Sreenivas V,Kochupillai N

    更新日期:2007-02-01 00:00:00

  • Diabetes, Associated Clinical Spectrum, Long-term Prognosis, and Genotype/Phenotype Correlations in 201 Adult Patients With Hepatocyte Nuclear Factor 1B (HNF1B) Molecular Defects.

    abstract:OBJECTIVE:Molecular defects of hepatocyte nuclear factor 1B (HNF1B) are associated with a multiorgan disease, including diabetes (maturity-onset diabetes of the young 5) and kidney abnormalities. The HNF1B syndrome is related to HNF1B mutations or to a 17q12 deletion spanning 15 genes, including HNF1B. Here, we describ...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/dc16-2462

    authors: Dubois-Laforgue D,Cornu E,Saint-Martin C,Coste J,Bellanné-Chantelot C,Timsit J,Monogenic Diabetes Study Group of the Société Francophone du Diabète.

    更新日期:2017-11-01 00:00:00

  • Advancing insulin therapy in type 2 diabetes previously treated with glargine plus oral agents: prandial premixed (insulin lispro protamine suspension/lispro) versus basal/bolus (glargine/lispro) therapy.

    abstract:OBJECTIVE:The purpose of this study was to compare two analog insulin therapies (prandial premixed therapy [PPT] versus basal/bolus therapy [BBT]) in type 2 diabetic patients previously treated with insulin glargine (>or=30 units/day) plus oral agents, with the aim of demonstrating noninferiority of PPT to BBT. RESEAR...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc07-1122

    authors: Rosenstock J,Ahmann AJ,Colon G,Scism-Bacon J,Jiang H,Martin S

    更新日期:2008-01-01 00:00:00

  • Translating the chronic care model into the community: results from a randomized controlled trial of a multifaceted diabetes care intervention.

    abstract:OBJECTIVE:To determine whether using the chronic care model (CCM) in an underserved community leads to improved clinical and behavioral outcomes for people with diabetes. RESEARCH DESIGN AND METHODS:This multilevel, cluster-design, randomized controlled trial examined the effectiveness of a CCM-based intervention in a...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/diacare.29.04.06.dc05-1785

    authors: Piatt GA,Orchard TJ,Emerson S,Simmons D,Songer TJ,Brooks MM,Korytkowski M,Siminerio LM,Ahmad U,Zgibor JC

    更新日期:2006-04-01 00:00:00

  • Fulminant type 1 diabetes: a nationwide survey in Japan.

    abstract:OBJECTIVE:To describe the clinical and immunologic characteristics of fulminant type 1 diabetes, a novel subtype of type 1 diabetes, we conducted a nationwide survey. RESEARCH DESIGN AND METHODS:History and laboratory data, including islet-related autoantibodies, were examined in 222 patients with fulminant and nonful...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/diacare.26.8.2345

    authors: Imagawa A,Hanafusa T,Uchigata Y,Kanatsuka A,Kawasaki E,Kobayashi T,Shimada A,Shimizu I,Toyoda T,Maruyama T,Makino H

    更新日期:2003-08-01 00:00:00

  • Risk and recurrence of serious adverse outcomes in the first and second pregnancies of women with preexisting diabetes.

    abstract:OBJECTIVE:Women with preexisting (type 1 or type 2) diabetes experience an increased risk of serious adverse pregnancy outcomes. It is not known, however, how these risks change between the first and second pregnancy and whether there is an increased risk of recurrence. This study describes the absolute risks and recur...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc14-1888

    authors: Tennant PW,Bilous RW,Prathapan S,Bell R

    更新日期:2015-04-01 00:00:00

  • Effect of protein ingestion on the glucose and insulin response to a standardized oral glucose load.

    abstract::Type II diabetic subjects were given 50 g protein, 50 g glucose, or 50 g glucose with 50 g protein as a single meal in random sequence. The plasma glucose and insulin response was determined over the subsequent 5 h. The plasma glucose area above the baseline following a glucose meal was reduced 34% when protein was gi...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.7.5.465

    authors: Nuttall FQ,Mooradian AD,Gannon MC,Billington C,Krezowski P

    更新日期:1984-09-01 00:00:00

  • Glucose indices, health behaviors, and incidence of diabetes in Australia: the Australian Diabetes, Obesity and Lifestyle Study.

    abstract:OBJECTIVE:This national, population-based study reports diabetes incidence based on oral glucose tolerance tests (OGTTs) and identifies risk factors for diabetes in Australians. RESEARCH DESIGN AND METHODS:The Australian Diabetes, Obesity and Lifestyle Study followed-up 5,842 participants over 5 years. Normal glycemia...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/dc07-0912

    authors: Magliano DJ,Barr EL,Zimmet PZ,Cameron AJ,Dunstan DW,Colagiuri S,Jolley D,Owen N,Phillips P,Tapp RJ,Welborn TA,Shaw JE

    更新日期:2008-02-01 00:00:00

  • Nutrition of the fetus and the premature infant.

    abstract::Developments in fetal and placental nutrition have highlighted the interaction of the placenta and fetal liver for the exchange and metabolism of nutrients. Of particular importance is the exchange of serine and glycine and their interconversion within these two organs and the exchange of glutamine and glutamate. Plac...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:

    authors: Battaglia FC,Thureen PJ

    更新日期:1998-08-01 00:00:00

  • Hemoglobin A1c versus oral glucose tolerance test in postpartum diabetes screening.

    abstract:OBJECTIVE:To determine the usefulness of measuring hemoglobin A(1c) (A1C), alone or combined with the fasting glucose test, compared with the oral glucose tolerance test (OGTT) for the reassessment of the carbohydrate metabolism status in postpartum women with a history of gestational diabetes mellitus (GDM). RESEARCH...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-2111

    authors: Picón MJ,Murri M,Muñoz A,Fernández-García JC,Gomez-Huelgas R,Tinahones FJ

    更新日期:2012-08-01 00:00:00

  • Food Insecurity, Food "Deserts," and Glycemic Control in Patients With Diabetes: A Longitudinal Analysis.

    abstract:OBJECTIVE:Both food insecurity (limited food access owing to cost) and living in areas with low physical access to nutritious foods are public health concerns, but their relative contribution to diabetes management is poorly understood. RESEARCH DESIGN AND METHODS:This was a prospective cohort study. A random sample o...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc17-1981

    authors: Berkowitz SA,Karter AJ,Corbie-Smith G,Seligman HK,Ackroyd SA,Barnard LS,Atlas SJ,Wexler DJ

    更新日期:2018-06-01 00:00:00

  • Glyburide Versus Metformin and Their Combination for the Treatment of Gestational Diabetes Mellitus: A Randomized Controlled Study.

    abstract:OBJECTIVE:To compare the efficacy and safety of glyburide versus metformin and their combination for the treatment of gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS:In this prospective randomized controlled study, we randomly assigned patients with GDM at 13-33 weeks gestation and whose blood glucose...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc16-2307

    authors: Nachum Z,Zafran N,Salim R,Hissin N,Hasanein J,Gam Ze Letova Y,Suleiman A,Yefet E

    更新日期:2017-03-01 00:00:00

  • Glycemic control and prevention of retinopathy in Japanese NIDDM patients. A 10-year follow-up study.

    abstract:OBJECTIVE:To examine glycemic control for the prevention of retinopathy in early diagnosed Japanese NIDDM patients. RESEARCH DESIGN AND METHODS:There were 137 patients with NIDDM but without retinopathy who first visited our facility from 1983-1985. Their age at diagnosis ranged from 30-65 years, with a disease durati...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.20.4.621

    authors: Nakagami T,Kawahara R,Hori S,Omori Y

    更新日期:1997-04-01 00:00:00

  • Impact of oral antihyperglycemic therapy on all-cause mortality among patients with diabetes in the Veterans Health Administration.

    abstract:OBJECTIVE:The objective of this analysis was to evaluate the impact of several classes of oral antihyperglycemic therapy relative to sulfonylurea monotherapy on all-cause mortality among a cohort of patients with diabetes from the Veterans Health Administration (VHA). RESEARCH DESIGN AND METHODS:A retrospective cohort...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc06-2272

    authors: Kahler KH,Rajan M,Rhoads GG,Safford MM,Demissie K,Lu SE,Pogach LM

    更新日期:2007-07-01 00:00:00

  • Absence of Islet Autoantibodies and Modestly Raised Glucose Values at Diabetes Diagnosis Should Lead to Testing for MODY: Lessons From a 5-Year Pediatric Swedish National Cohort Study.

    abstract:OBJECTIVE:Identifying maturity-onset diabetes of the young (MODY) in pediatric populations close to diabetes diagnosis is difficult. Misdiagnosis and unnecessary insulin treatment are common. We aimed to identify the discriminatory clinical features at diabetes diagnosis of patients with glucokinase (GCK), hepatocyte n...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc19-0747

    authors: Carlsson A,Shepherd M,Ellard S,Weedon M,Lernmark Å,Forsander G,Colclough K,Brahimi Q,Valtonen-Andre C,Ivarsson SA,Elding Larsson H,Samuelsson U,Örtqvist E,Groop L,Ludvigsson J,Marcus C,Hattersley AT

    更新日期:2020-01-01 00:00:00

  • Association of Cardiometabolic Multimorbidity and Depression With Cardiovascular Events in Early-Onset Adult Type 2 Diabetes: A Multiethnic Study in the U.S.

    abstract:OBJECTIVE:To evaluate the temporal patterns of cardiometabolic multimorbidity (CM) and depression in White Caucasians (WCs) and African Americans (AAs) with early-onset type 2 diabetes and their impact on long-term atherosclerotic cardiovascular disease (ASCVD). RESEARCH DESIGN AND METHODS:From U.S. electronic medical...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc20-2045

    authors: Dibato JE,Montvida O,Zaccardi F,Sargeant JA,Davies MJ,Khunti K,Paul SK

    更新日期:2021-01-01 00:00:00

  • Diabetic complications among American Indians of Washington, Oregon, and Idaho. Prevalence of retinopathy, end-stage renal disease, and amputations.

    abstract:OBJECTIVE:To estimate the prevalence of severe diabetic complications. RESEARCH DESIGN AND METHODS:We surveyed the data systems of the IHS and local care providers to identify all AI/AN people with any of three diabetic complications: retinopathy needing one or more laser treatments, ESRD needing dialysis, and one or ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.16.1.357

    authors: Freeman WL,Hosey GM

    更新日期:1993-01-01 00:00:00

  • Delayed vascular reactivity to ischemia in diabetic microangiopathy.

    abstract::To investigate vascular responses in insulin-dependent diabetic patients both with and without retinopathy, we have assessed vasodilation by forearm transcutaneous pO2 measurement after 10 min of ischemia produced by a sphygmomanometer cuff. Diabetic patients with proliferative retinopathy had a delayed vasodilatory r...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.7.1.47

    authors: Haitas B,Barnes A,Shogry ME,Weindling M,Rolfe P,Turner RC

    更新日期:1984-01-01 00:00:00

  • Sodium-Glucose Cotransporter 2 Inhibitors and the Risk of Below-Knee Amputation: A Multicenter Observational Study.

    abstract:OBJECTIVE:Reports of amputations associated with sodium-glucose cotransporter 2 (SGLT2) inhibitors have been inconsistent. We aimed to compare the risk of below-knee amputation with SGLT2 inhibitors versus dipeptidyl peptidase 4 (DPP-4) inhibitors among patients with type 2 diabetes. RESEARCH DESIGN AND METHODS:This m...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc20-0267

    authors: Yu OHY,Dell'Aniello S,Shah BR,Brunetti VC,Daigle JM,Fralick M,Douros A,Hu N,Alessi-Severini S,Fisher A,Bugden SC,Ronksley PE,Filion KB,Ernst P,Lix LM,Canadian Network for Observational Drug Effect Studies (CNODES) Investiga

    更新日期:2020-10-01 00:00:00

  • Utility of casual postprandial glucose levels in type 2 diabetes management.

    abstract:OBJECTIVE:Because readily available glycemic indicators are needed to guide clinical decision-making for intensification of diabetes therapy, our goals were to define the relationship between casual postprandial plasma glucose (cPPG) levels and HbA(1c) in patients with type 2 diabetes and to determine the predictive ch...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.27.2.335

    authors: El-Kebbi IM,Ziemer DC,Cook CB,Gallina DL,Barnes CS,Phillips LS

    更新日期:2004-02-01 00:00:00

  • Effect of case-based training for medical residents on inpatient glycemia.

    abstract:OBJECTIVE:To determine whether an educational intervention for medical house staff improves blood glucose (BG) in hospitalized patients. RESEARCH DESIGN AND METHODS:All 116 medicine residents at an academic medical center were assigned to online or classroom training on inpatient dysglycemia in fall 2008. Both groups ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-0517

    authors: Tamler R,Green DE,Skamagas M,Breen TL,Looker HC,Babyatsky M,Leroith D

    更新日期:2011-08-01 00:00:00