Advancing insulin therapy in type 2 diabetes previously treated with glargine plus oral agents: prandial premixed (insulin lispro protamine suspension/lispro) versus basal/bolus (glargine/lispro) therapy.

abstract：OBJECTIVE:A common variant rs236918 in the PCSK7 gene has the strongest association with iron homeostasis and is related to insulin resistance. Dietary carbohydrate (CHO) modulates the genetic effect on insulin resistance. We examined whether 2-year weight-loss diets modify the effect of PCSK7 genetic variants on chang...

journal_title：Diabetes care

authors： Huang T,Huang J,Qi Q,Li Y,Bray GA,Rood J,Sacks FM,Qi L

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:To compare clinical outcomes obtained using treatment algorithms versus standard "usual care" to treat patients with type 2 diabetes in a community setting. RESEARCH DESIGN AND METHODS:An observational group comparison was implemented in three community-based clinics in San Antonio, Texas: 1). a community cl...

journal_title：Diabetes care

authors： Fanning EL,Selwyn BJ,Larme AC,DeFronzo RA

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVE:Early use of insulin after diagnosis of type 2 diabetes is met with resistance because of associated weight gain, hypoglycemia, and fear of decreased compliance and quality of life (QoL). RESEARCH DESIGN AND METHODS:In treatment-naive patients with newly diagnosed type 2 diabetes, insulin and metformin were ...

journal_title：Diabetes care

authors： Lingvay I,Legendre JL,Kaloyanova PF,Zhang S,Adams-Huet B,Raskin P

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVE:Poorer glycemic control in type 1 diabetes may alter N-glycosylation patterns on circulating glycoproteins, and these alterations may be linked with diabetic kidney disease (DKD). We investigated associations between N-glycans and glycemic control and renal function in type 1 diabetes. RESEARCH DESIGN AND ME...

journal_title：Diabetes care

authors： Bermingham ML,Colombo M,McGurnaghan SJ,Blackbourn LAK,Vučković F,Pučić Baković M,Trbojević-Akmačić I,Lauc G,Agakov F,Agakova AS,Hayward C,Klarić L,Palmer CNA,Petrie JR,Chalmers J,Collier A,Green F,Lindsay RS,Macrury S

更新日期：2018-01-01 00:00:00

abstract：:Nine healthy volunteers with normal body weights were injected subcutaneously with 125I-labeled soluble human insulin (10 U) in one thigh and 133Xe in the contralateral thigh for the measurement of subcutaneous blood flow on 2 consecutive mornings. On one of the days, standardized massage of both injection sites was p...

journal_title：Diabetes care

authors： Linde B

更新日期：1986-11-01 00:00:00

abstract：OBJECTIVE:Roux-en-Y gastric bypass (RYGB) ameliorates type 2 diabetes in severely obese patients through mechanisms beyond just weight loss, and it may benefit less obese diabetic patients. We determined the long-term impact of RYGB on patients with diabetes and only class I obesity. RESEARCH DESIGN AND METHODS:Sixty-...

journal_title：Diabetes care

authors： Cohen RV,Pinheiro JC,Schiavon CA,Salles JE,Wajchenberg BL,Cummings DE

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVE:Molecular defects of hepatocyte nuclear factor 1B (HNF1B) are associated with a multiorgan disease, including diabetes (maturity-onset diabetes of the young 5) and kidney abnormalities. The HNF1B syndrome is related to HNF1B mutations or to a 17q12 deletion spanning 15 genes, including HNF1B. Here, we describ...

journal_title：Diabetes care

authors： Dubois-Laforgue D,Cornu E,Saint-Martin C,Coste J,Bellanné-Chantelot C,Timsit J,Monogenic Diabetes Study Group of the Société Francophone du Diabète.

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE:The effects of longitudinal changes in the visceral fat area (VFA), and other anthropometric indices, on the risk factors of metabolic syndrome were not studied. We calculated the changes in metabolic risk factors in relation to changes in certain anthropometric indices in a large-scale study of Japanese men....

journal_title：Diabetes care

authors： Matsushita Y,Nakagawa T,Yamamoto S,Takahashi Y,Yokoyama T,Mizoue T,Noda M

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVE:Arterial stiffness occurs early in the atherosclerotic process; however, few data are available concerning risk factors for arterial stiffness in youth with diabetes. We identified factors associated with arterial stiffness in youth with diabetes and assessed the effects of these factors on the relationship b...

journal_title：Diabetes care

authors： Wadwa RP,Urbina EM,Anderson AM,Hamman RF,Dolan LM,Rodriguez BL,Daniels SR,Dabelea D,SEARCH Study Group.

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVE:To evaluate temporal trends in rates of initial lower extremity amputation (ILEA) among patients with diabetes in the Veterans Health Administration (VHA). RESEARCH DESIGN AND METHODS:Retrospective administrative data analysis of VHA clinic users with diabetes in fiscal years (FY) 2000 to 2004 (1 October 199...

journal_title：Diabetes care

authors： Tseng CL,Rajan M,Miller DR,Lafrance JP,Pogach L

更新日期：2011-05-01 00:00:00

abstract：OBJECTIVE:Available basal insulin formulations do not provide a constant and reliable 24-h insulin supply. We compared the efficacy and safety of glargine (a long-acting insulin analog) and NPH insulins in insulin-naive type 2 diabetic patients treated with oral antidiabetic agents. RESEARCH DESIGN AND METHODS:There w...

journal_title：Diabetes care

authors： Yki-Järvinen H,Dressler A,Ziemen M,HOE 901\/300s Study Group.

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVE:To determine the association between nonalcoholic fatty liver disease and the risk for development of diabetes. RESEARCH DESIGN AND METHODS:We conducted an observational cohort study in male workers > or = 40 years old in a Japanese company from 1997 to 2005. We excluded workers with alcohol intake > or = 20...

journal_title：Diabetes care

authors： Shibata M,Kihara Y,Taguchi M,Tashiro M,Otsuki M

更新日期：2007-11-01 00:00:00

abstract：:OBJECTIVE We examine barriers to receiving recommended eye care among people aged ≥40 years with diagnosed diabetes. RESEARCH DESIGN AND METHODS We analyzed 2006-2010 Behavioral Risk Factor Surveillance System data from 22 states (n = 27,699). Respondents who had not sought eye care in the preceding 12 months were ask...

journal_title：Diabetes care

authors： Chou CF,Sherrod CE,Zhang X,Barker LE,Bullard KM,Crews JE,Saaddine JB

更新日期：2014-01-01 00:00:00

abstract：:The American Diabetes Association (ADA) "Standards of Medical Care in Diabetes" includes ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Co...

journal_title：Diabetes care

authors： American Diabetes Association.

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:Obesity and type 2 diabetes mellitus (T2DM) are associated with altered food-related neuronal functions. Besides weight loss, substantial improvement of glucose metabolism in patients with T2DM can be achieved by bariatric surgery. We aimed to target the neuronal and behavioral correlates of improved glycemic...

journal_title：Diabetes care

authors： Frank S,Heinze JM,Fritsche A,Linder K,von Feilitzsch M,Königsrainer A,Häring HU,Veit R,Preissl H

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:Previous studies demonstrate that the metabolic syndrome is associated with distal symmetric polyneuropathy (DSP). We aimed to determine the magnitude of this effect and the precise components involved. RESEARCH DESIGN AND METHODS:We determined the symptomatic DSP prevalence in the Health, Aging, and Body Co...

journal_title：Diabetes care

authors： Callaghan BC,Xia R,Banerjee M,de Rekeneire N,Harris TB,Newman AB,Satterfield S,Schwartz AV,Vinik AI,Feldman EL,Strotmeyer ES,Health ABC Study.

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVE:The sympathetic nervous system and thiazolidinediones control lipid metabolism and have been implicated in body weight regulation. This study was conducted to determine whether the simultaneous activation of these two signaling systems might synergize to exert beneficial effects on the expression of key genes...

journal_title：Diabetes care

authors： Bogacka I,Gettys TW,de Jonge L,Nguyen T,Smith JM,Xie H,Greenway F,Smith SR

更新日期：2007-05-01 00:00:00

abstract：OBJECTIVE:To evaluate racial differences and factors associated with worse glycemic control in well-functioning older individuals with type 2 diabetes. Our hypothesis was that glycemic control would be worse among black than white diabetic individuals but that this association would be explained by differences in sever...

journal_title：Diabetes care

authors： de Rekeneire N,Rooks RN,Simonsick EM,Shorr RI,Kuller LH,Schwartz AV,Harris TB,Health, Aging and Body Composition Study.

更新日期：2003-07-01 00:00:00

abstract：OBJECTIVE:To explore mechanisms for hypertriglyceridemia in diabetic patients with microalbuminuria, we examined an association between heparin-releasable lipoprotein lipase (LPL) and the von Willebrand factor (vWF), based on the hypothesis that LPL bound to endothelium is decreased by generalized endothelial damage. ...

journal_title：Diabetes care

authors： Kashiwazaki K,Hirano T,Yoshino G,Kurokawa M,Tajima H,Adachi M

更新日期：1998-11-01 00:00:00

abstract：OBJECTIVE:To compare the cost and time to diagnosis associated with several screening strategies for diabetes in women with histories of gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS:We simulated screening for diabetes with fasting plasma glucose (FPG), a 2-h oral glucose tolerance test (OGTT), and ...

journal_title：Diabetes care

authors： Kim C,Herman WH,Vijan S

更新日期：2007-05-01 00:00:00

abstract：OBJECTIVE:To detect clinical correlates of cognitive abilities and white matter (WM) microstructural changes using diffusion tensor imaging (DTI) in young children with type 1 diabetes. RESEARCH DESIGN AND METHODS:Children, ages 3 to <10 years, with type 1 diabetes (n = 22) and age- and sex-matched healthy control sub...

journal_title：Diabetes care

authors： Aye T,Barnea-Goraly N,Ambler C,Hoang S,Schleifer K,Park Y,Drobny J,Wilson DM,Reiss AL,Buckingham BA

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:The International Diabetes Federation (IDF) has proposed a new definition of the metabolic syndrome that emphasizes central adiposity as determined by ethnic group-specific thresholds of waist circumference. The objective of this study was to estimate the prevalence of this syndrome using the IDF definition a...

journal_title：Diabetes care

authors： Ford ES

更新日期：2005-11-01 00:00:00

abstract：OBJECTIVE:The role of adiponectin in the natural history of diabetes is not well characterized. We set out to characterize prediagnosis trajectories of adiponectin in individuals who develop type 2 diabetes. RESEARCH DESIGN AND METHODS:In a case-cohort study (335 incident diabetes case and 2,474 noncase subjects) nest...

journal_title：Diabetes care

authors： Tabák AG,Carstensen M,Witte DR,Brunner EJ,Shipley MJ,Jokela M,Roden M,Kivimäki M,Herder C

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:To determine whether overweight Latino children with impaired fasting glucose (IFG) (> or = 100 mg/dl) have increased insulin resistance or decreased beta-cell function compared with those with normal fasting glucose (NFG). RESEARCH DESIGN AND METHODS:We studied 207 healthy overweight Latino children, aged 8...

journal_title：Diabetes care

authors： Weigensberg MJ,Ball GD,Shaibi GQ,Cruz ML,Goran MI

更新日期：2005-10-01 00:00:00

abstract：OBJECTIVE:Supplementation of type II diabetic diets with n-3 fatty acids (FAs) from fish oil (FO) has been associated with lowered triglyceride and VLDL levels, although reports of impaired glycemic control have limited their use. Effects of n-3FAs from nonmarine sources are less well documented. Therefore, an investig...

journal_title：Diabetes care

authors： McManus RM,Jumpson J,Finegood DT,Clandinin MT,Ryan EA

更新日期：1996-05-01 00:00:00

abstract：OBJECTIVE:Acarbose inhibits alpha-glucosidases of the small intestine and thus delays glucose release from complex carbohydrates. Therefore, its efficacy and acceptability as a first-line drug in non-insulin-dependent diabetes mellitus (NIDDM) insufficiently treated with diet alone was tested in a randomized double-bli...

journal_title：Diabetes care

authors： Hanefeld M,Fischer S,Schulze J,Spengler M,Wargenau M,Schollberg K,Fücker K

更新日期：1991-08-01 00:00:00

abstract：OBJECTIVE:We sought to test the hypothesis that a fixed-dose combination of trandolapril/verapamil-SR (T/V) is superior to a fixed-dose combination of losartan/hydrochlorothiazide (L/H) on glucose tolerance in hypertensive patients with impaired glucose tolerance (IGT). RESEARCH DESIGN AND METHODS:A prospective, rando...

journal_title：Diabetes care

authors： Bakris G,Molitch M,Hewkin A,Kipnes M,Sarafidis P,Fakouhi K,Bacher P,Sowers J,STAR Investigators.

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVE:We sought to determine whether levels of inflammatory markers and different cytokines are abnormal in nondiabetic offspring of type 2 diabetic subjects. RESEARCH DESIGN AND METHODS:Cytokine levels were measured in 19 healthy control subjects and 129 offspring of patients with type 2 diabetes (109 with normal...

journal_title：Diabetes care

authors： Ruotsalainen E,Salmenniemi U,Vauhkonen I,Pihlajamäki J,Punnonen K,Kainulainen S,Laakso M

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that microalbuminuria may show an independent statistical association with diabetic neuropathy. RESEARCH DESIGN AND METHODS:An observational study of a prospectively identified cohort was conducted at the University Medical Center. The cohort consisted of 78 consecutive diabetic patien...

journal_title：Diabetes care

authors： Bell DS,Ketchum CH,Robinson CA,Wagenknecht LE,Williams BT

更新日期：1992-04-01 00:00:00

abstract：:A state diabetes commission and university diabetes program in Kentucky jointly studied the social and economic impact of diabetes mellitus and its complications on the Commonwealth. This investigation revealed that diabetes was a more serious public health problem than previously supposed. Active, diagnosed diabetes ...

journal_title：Diabetes care

authors： Leichter SB,Hernandez C,Fisher A,Collins P,Courtney A

更新日期：1982-03-01 00:00:00