Abstract:
OBJECTIVE:The objective of this analysis was to evaluate the impact of several classes of oral antihyperglycemic therapy relative to sulfonylurea monotherapy on all-cause mortality among a cohort of patients with diabetes from the Veterans Health Administration (VHA). RESEARCH DESIGN AND METHODS:A retrospective cohort study using data obtained from the VHA Diabetes Epidemiology Cohort was used. Users of oral antihyperglycemic therapy were classified into the following cohorts: sulfonylurea monotherapy, metformin monotherapy, metformin plus sulfonylurea, thiazolidinedione (TZD) use alone or in combination with other oral agents (TZD users), and no drug therapy. All-cause mortality was the outcome of interest. Multivariate mixed models incorporating a propensity score to account for imbalance among cohorts were used to estimate drug effects on mortality with associated 95% CIs. RESULTS:A total of 39,721 patients with diabetes were included in the study. Adjusted odds ratios and 95% CIs for all-cause mortality were 0.87 (0.68-1.10) for metformin monotherapy users, 0.92 (0.82-1.05) for metformin plus sulfonylurea users, and 1.04 (0.75-1.46) for TZD users, relative to sulfonylurea monotherapy users. CONCLUSIONS:We did not find any significant drug effect on all-cause mortality for any oral treatment cohorts relative to sulfonylurea oral monotherapy.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Kahler KH,Rajan M,Rhoads GG,Safford MM,Demissie K,Lu SE,Pogach LMdoi
10.2337/dc06-2272subject
Has Abstractpub_date
2007-07-01 00:00:00pages
1689-93issue
7eissn
0149-5992issn
1935-5548pii
dc06-2272journal_volume
30pub_type
杂志文章相关文献
DIABETES CARE文献大全abstract::Enzymatic electrodes are described for the specific and sensitive determination of glucose in blood. The probes are based on the conversion of B-D-glucose by glucose oxidase chemically attached to the surface of a Pt electrode. The peroxide liberated is sensed by measurement of the current generated at +0.7 volts vs. ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.5.3.181
更新日期:1982-05-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the frequency of sympathetic versus parasympathetic neuropathy among type 1 and type 2 diabetic patients. RESEARCH DESIGN AND METHODS:There were 43 patients with type 1 and 17 with type 2 diabetes who were investigated. Sympathetic nerve function was assessed by measurem...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.27.12.2936
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVE:To determine whether intensive treatment and education strategies for type 2 diabetic patients with high-risk diabetic foot disease helps in preventing foot amputations. RESEARCH DESIGN AND METHODS:Participants included 4,872 consecutive type 2 diabetic patients (male-to-female ratio 3,422:1,450, mean (+/-SD...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.28.5.1019
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVE:To determine whether women with pregestational diabetes obtained long-term benefits from an intensive diabetes management program during pregnancy. RESEARCH DESIGN AND METHODS:Women with pregestational diabetes who had attended an intensive diabetes management program in pregnancy between 1991 and 1999 were ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.29.03.06.dc05-1731
更新日期:2006-03-01 00:00:00
abstract:OBJECTIVE:Glycated hemoglobin (HbA1c) is positively associated with cardiovascular disease (CVD), although evidence is primarily observational. Mendelian randomization studies have only examined its relation with subtypes of CVD. We examined the relation of HbA1c with CVD and its subtypes in the UK Biobank using Mendel...
journal_title:Diabetes care
pub_type: 杂志文章,meta分析
doi:10.2337/dc18-0289
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:To examine the effect of prior meal ingestion on the glucose, insulin, and C-peptide response to a 50-g glucose challenge test in the third trimester of pregnancy. RESEARCH DESIGN AND METHODS:Ten pregnant women with gestational diabetes mellitus and 12 nondiabetic pregnant control subjects matched for age an...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.16.12.1551
更新日期:1993-12-01 00:00:00
abstract:OBJECTIVE:To determine the safety and efficacy of the long-acting insulin analog, insulin glargine, as a component of basal bolus therapy in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS:Patients with type 1 diabetes receiving basal-bolus insulin treatment with NPH human insulin and insulin lispro were ra...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.2337/diacare.23.11.1666
更新日期:2000-11-01 00:00:00
abstract:OBJECTIVE:In 2010, the American Diabetes Association (ADA) added hemoglobin A1c (A1C) to the guidelines for diagnosing type 2 diabetes. However, existing models for predicting diabetes risk were developed prior to the widespread adoption of A1C. Thus, it remains unknown how well existing diabetes risk prediction models...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/dc15-0509
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVE:We prospectively investigated in hypertensive patients with type 2 diabetes if bedtime treatment with ≥1 hypertension medications exerts better blood pressure control and cardiovascular risk reduction than conventional therapy, in which all medications are ingested in the morning. RESEARCH DESIGN AND METHODS...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc11-0297
更新日期:2011-06-01 00:00:00
abstract::This review focuses on recent advances in molecular biology as they pertain to the insulin gene and diabetes mellitus. The structure of the human insulin gene is examined, and factors related to its normal functioning in the beta cells of the pancreas are explored. DNA polymorphisms near the insulin locus and their re...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.7.4.386
更新日期:1984-07-01 00:00:00
abstract:OBJECTIVE:Plasma copeptin, a surrogate for vasopressin, was associated with albuminuria in population-based studies. These associations are consistent with the effect of vasopressin on albuminuria observed in humans and rodents. The objective of this study was to determine whether plasma copeptin is an independent mark...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc13-0683
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:To assess the dose-ranging efficacy and safety of LX4211, a dual inhibitor of sodium-glucose cotransporter (SGLT) 1 and SGLT2, in type 2 diabetes. RESEARCH DESIGN AND METHODS:Type 2 diabetic patients inadequately controlled on metformin were randomly assigned to 75 mg once daily, 200 mg once daily, 200 mg tw...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2337/dc14-0890
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVE:To evaluate glycemia and metrics of glucose variability in youth with type 1 diabetes, and to assess patterns of 24-h glucose variability according to pubertal status. RESEARCH DESIGN AND METHODS:Metrics of glycemia, glucose variability, and glucose patterns were assessed by using 4 weeks of continuous gluco...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc19-0083
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:Recent studies suggest that air pollution plays a role in type 2 diabetes (T2D) incidence and mortality. The underlying physiological mechanisms have yet to be established. We hypothesized that air pollution adversely affects insulin sensitivity and secretion and serum lipid levels. RESEARCH DESIGN AND METHO...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc15-1795
更新日期:2016-04-01 00:00:00
abstract::The etiology of impotence in the diabetic population has not been clearly defined. To assess this problem, 24 impotent diabetic subjects, 21 nonimpotent diabetic subjects, and 10 subjects with psychogenic impotence were compared with nocturnal monitoring of penile tumescence and rigidity, penile arterial blood flow, a...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.12.7.449
更新日期:1989-07-01 00:00:00
abstract:OBJECTIVE:To determine whether a culturally appropriate clinic- and community-based intervention for African-American women with type 2 diabetes will increase moderate-intensity physical activity (PA). RESEARCH DESIGN AND METHODS:In this randomized controlled trial conducted at seven practices in central North Carolin...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.25.9.1576
更新日期:2002-09-01 00:00:00
abstract:OBJECTIVE:To provide information about possible subclinical damage of the cochlear outer hair cells (OHCs) by means of transiently evoked otoacoustic emissions (TEOAEs) and distortion-product otoacoustic emissions (DPOAEs) in subjects with IDDM. RESEARCH DESIGN AND METHODS:TEOAEs and DPOAEs were recorded in 47 IDDM pa...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.21.8.1317
更新日期:1998-08-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to examine the association of physical activity and cardiovascular fitness (CVF) with insulin sensitivity in a nationally representative sample of U.S. youth. RESEARCH DESIGN AND METHODS:The study included 1,783 U.S. adolescents (11% Mexican American, 14% non-Hispanic black, 63%...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc06-0426
更新日期:2006-07-01 00:00:00
abstract::A semiclosed loop, bedside insulin infusion system using a simple basal infusion algorithm consisting of a linear transition between two insulin delivery rates as blood glucose (BG) increases has been developed. A theoretical study using computer simulation has now been undertaken to examine the effect of BG sampling ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.8.6.553
更新日期:1985-11-01 00:00:00
abstract:OBJECTIVE:This study aimed to assess the direct cost incurred by diabetic subjects who were in different income groups in urban and rural India, as well as to examine the changing trends of costs in the urban setting from 1998 to 2005. RESEARCH DESIGN AND METHODS:A total of 556 diabetic subjects from various urban and...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc06-0144
更新日期:2007-02-01 00:00:00
abstract:OBJECTIVE:To describe the impact of abdominal obesity and hepatic insulin resistance on phase-specific glycemic responses in older women. RESEARCH DESIGN AND METHODS:We studied 23 healthy older women (60-88 years old). Abdominal obesity was defined by an abdominal circumference > or =95 cm. Plasma glucose and insulin ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-1365
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:The performance of glycated hemoglobin (HbA1c) and fasting plasma glucose (FPG) was compared in screening for diabetes by an oral glucose tolerance test (OGTT) in patients undergoing coronary angiography (CAG). RESEARCH DESIGN AND METHODS:Patients without known diabetes admitted for CAG were eligible. OGTT a...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-1434
更新日期:2013-05-01 00:00:00
abstract::The acute effect of sulfonylurea drugs during long-term treatment was evaluated in two separate studies. In the first study, the levels of plasma glucose, insulin, and C-peptide were measured after intake of 10 mg glyburide alone or together with a standardized mixed meal in 10 non-insulin-dependent diabetes mellitus ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.13.3.26
更新日期:1990-08-01 00:00:00
abstract:OBJECTIVE:To investigate whether self-rated health profiles compiled using the EuroQol group's visual analog scale (EQ VAS) are independent predictors of vascular events and major complications in people with type 2 diabetes after controlling for standard clinical risk factors. RESEARCH DESIGN AND METHODS:The study is...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc07-1391
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVE:Dietary protein is an important modulator of glucose metabolism. However, studies regarding the association between dietary protein intake and gestational diabetes mellitus (GDM) risk are sparse. This study was to examine the association. RESEARCH DESIGN AND METHODS:Our study included 21,457 singleton pregna...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-2018
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the prevalence of NIDDM and IGT in the urban and rural areas in southern India. RESEARCH DESIGN AND METHODS:Two populations of the same ethnic background, but different socioeconomic background were chosen for this study. Nine-hundred urban people and 1038 rural subjects were studied. Fasting and...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.15.10.1348
更新日期:1992-10-01 00:00:00
abstract:OBJECTIVE:Best-practice diabetes care can reduce the burden of diabetes and associated health care costs. But this requires access to a multidisciplinary team with the right skill mix. We applied a needs-driven evidence-based health workforce model to describe the primary care team required to support best-practice dia...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-1793
更新日期:2013-07-01 00:00:00
abstract::Fifty-one children with insulin-dependent diabetes mellitus (IDDM) and 24 healthy sibling controls were compared on one of two temperament questionnaires completed by parents. Children with IDDM did not provide a characteristic temperament profile or show any problem areas. A regression analysis to predict diabetic co...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.11.1.77
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:To investigate the association between neck circumference and central obesity, overweight, and metabolic syndrome in Chinese individuals with type 2 diabetes. RESEARCH DESIGN AND METHODS:A total of 3,182 diabetic subjects (aged 20-80 years) were recruited from 15 community health centers in Beijing using a m...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc10-0798
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVE:To assess the costs and project the potential lifetime cost-effectiveness of the ongoing Autoimmunity Screening for Kids (ASK) program, a large-scale, presymptomatic type 1 diabetes screening program for children and adolescents in the metropolitan Denver region. RESEARCH DESIGN AND METHODS:We report the res...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc19-2003
更新日期:2020-07-01 00:00:00