Detection of microalbuminuria. Receiver operating characteristic curve analysis favors albumin-to-creatinine ratio over albumin concentration.

Abstract:

OBJECTIVE:To compare albumin-to-creatinine ratio (ACR) and albumin concentration (ALB) for detection of microalbuminuria using precise data on CIs for sensitivity and specificity and to determine sex- and age-specific discriminator values for ACR. RESEARCH DESIGN AND METHODS:All consecutive patients investigated for the presence of microalbuminuria with timed overnight urine collection were included in the study. Results from 1.171 men and 1,223 women were eligible for evaluation. Albumin excretion rate (the reference procedure), ALB, and ACR were compared by receiver operating characteristic (ROC) curve analysis. Age- and sex-specific discriminator values were established. Sensitivity and specificity were determined, and their CIs were compared with those calculated from data presented in the literature. RESULTS:Sensitivity and specificity were 89% (range, 85-92) and 90% (88-92), respectively, for women, and 90% (87-93) and 89% (86-91), respectively, for men, at a discriminator value of 15 mg/l for the ALB. This discriminator value did not show any relationship to sex or age. For the ACR, which depends on sex, the sensitivity and specificity were 94% (92-96) and 92% (91-94), respectively, at 2.5 g/mol for women and 94% (92-97) and 93% (91-95), respectively, at 1.8 g/mol for men. The discriminator value for the ACR appears to depend on age in both men and women. CONCLUSIONS:ROC curve analysis clearly shows that the ACR performs better than the ALB in screening for microalbuminuria. However, in contrast to the ALB, the ACR needs sex- and age-specific discriminator values.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Bakker AJ

doi

10.2337/diacare.22.2.307

subject

Has Abstract

pub_date

1999-02-01 00:00:00

pages

307-13

issue

2

eissn

0149-5992

issn

1935-5548

journal_volume

22

pub_type

杂志文章
  • Inhaled Technosphere Insulin Versus Inhaled Technosphere Placebo in Insulin-Naïve Subjects With Type 2 Diabetes Inadequately Controlled on Oral Antidiabetes Agents.

    abstract:OBJECTIVE:To investigate the efficacy and safety of prandial Technosphere inhaled insulin (TI), an inhaled insulin with a distinct time action profile, in insulin-naïve type 2 diabetes (T2D) inadequately controlled on oral antidiabetes agents (OADs). RESEARCH DESIGN AND METHODS:Subjects with T2D with HbA1c levels ≥7.5...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2337/dc15-0629

    authors: Rosenstock J,Franco D,Korpachev V,Shumel B,Ma Y,Baughman R,Amin N,McGill JB,Affinity 2 Study Group.

    更新日期:2015-12-01 00:00:00

  • Circulating levels of adipocyte and epidermal fatty acid-binding proteins in relation to nephropathy staging and macrovascular complications in type 2 diabetic patients.

    abstract:OBJECTIVE:To investigate the relationships of serum adipocyte fatty acid-binding protein (A-FABP) and epidermal fatty acid-binding protein (E-FABP) with renal dysfunction and macrovascular complications in type 2 diabetic patients. RESEARCH DESIGN AND METHODS:The associations of serum A-FABP and E-FABP with markers of...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc08-1333

    authors: Yeung DC,Xu A,Tso AW,Chow WS,Wat NM,Fong CH,Tam S,Sham PC,Lam KS

    更新日期:2009-01-01 00:00:00

  • Diabetes and Prediabetes and Risk of Hospitalization: The Atherosclerosis Risk in Communities (ARIC) Study.

    abstract:OBJECTIVE:To examine the magnitude and types of hospitalizations among persons with prediabetes, undiagnosed diabetes, and diagnosed diabetes. RESEARCH DESIGN AND METHODS:This study included 13,522 participants in the Atherosclerosis Risk in Communities (ARIC) study (mean age 57 years, 56% female, 24% black, 18% with ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc15-1335

    authors: Schneider AL,Kalyani RR,Golden S,Stearns SC,Wruck L,Yeh HC,Coresh J,Selvin E

    更新日期:2016-05-01 00:00:00

  • Survey of physician practice behaviors related to diabetes mellitus in the U.S. Physician adherence to consensus recommendations.

    abstract:OBJECTIVE:To summarize the frequency of physician adherence to consensus recommendations for prevention of diabetic complications. RESEARCH DESIGN AND METHODS:Survey data from a nationwide stratified probability sample of primary-care physicians were analyzed. Adherence to recommendations were reported by physician sp...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.16.11.1507

    authors: Kenny SJ,Smith PJ,Goldschmid MG,Newman JM,Herman WH

    更新日期:1993-11-01 00:00:00

  • Infant feeding in relation to islet autoimmunity and type 1 diabetes in genetically susceptible children: the MIDIA Study.

    abstract:OBJECTIVE:We aimed to study the association of breast-feeding duration and age at the introduction of solid foods with the risk of islet autoimmunity and type 1 diabetes in genetically susceptible children. RESEARCH DESIGN AND METHODS:Newborns were recruited from the Norwegian general population during 2001-2007. Afte...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc14-1130

    authors: Lund-Blix NA,Stene LC,Rasmussen T,Torjesen PA,Andersen LF,Rønningen KS

    更新日期:2015-02-01 00:00:00

  • Well-being and treatment satisfaction in older people with diabetes.

    abstract:OBJECTIVE:To measure well-being and treatment satisfaction and their correlates in older people with diabetes. RESEARCH DESIGN AND METHODS:A postal survey was conducted of 1,000 diabetic patients aged > or = 60 years, representing 56% of the resident older diabetic population in an inner-city health district with a la...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.21.6.930

    authors: Petterson T,Lee P,Hollis S,Young B,Newton P,Dornan T

    更新日期:1998-06-01 00:00:00

  • The hypertensions of diabetes.

    abstract::Patients with diabetes mellitus may have any one of several forms of hypertension. These include essential hypertension, systolic hypertension of three varieties, the hypertension associated with diabetic nephropathy ("diabetic hypertension"), and the hypertension associated with neuropathy (supine hypertension with o...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.5.1.50

    authors: Christlieb AR

    更新日期:1982-01-01 00:00:00

  • Increased 24-h energy expenditure in type 2 diabetes.

    abstract:OBJECTIVE:The aim of this study was to determine whether overweight and obese individuals with type 2 diabetes have higher basal and 24-h energy expenditure compared with healthy control subjects before and after adjustment for body composition, spontaneous physical activity (SPA), sex, and age. RESEARCH DESIGN AND ME...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.27.10.2416

    authors: Bitz C,Toubro S,Larsen TM,Harder H,Rennie KL,Jebb SA,Astrup A

    更新日期:2004-10-01 00:00:00

  • Markers of Collagen Formation and Degradation Reflect Renal Function and Predict Adverse Outcomes in Patients With Type 1 Diabetes.

    abstract:OBJECTIVE:Patients with type 1 diabetes (T1D) have a higher risk of developing chronic kidney disease, cardiovascular events (CVEs), and mortality than the general population. We hypothesized that two previously published biomarkers, namely PRO-C6, a biomarker of collagen type VI formation, and C3M, a biomarker of coll...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc18-2599

    authors: Pilemann-Lyberg S,Rasmussen DGK,Hansen TW,Tofte N,Winther SA,Holm Nielsen S,Theilade S,Karsdal MA,Genovese F,Rossing P

    更新日期:2019-09-01 00:00:00

  • Erythromycin derivative improves gastric emptying and insulin requirement in diabetic patients with gastroparesis.

    abstract:OBJECTIVE:To evaluate the effect of the erythromycin derivative EM523L on gastric emptying and postprandial insulin requirement in insulin-dependent diabetic patients with severe gastroparesis. RESEARCH DESIGN AND METHODS:In six IDDM patients with severe gastroparesis (two men and four women, mean age 44.5 years [rang...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/diacare.20.7.1134

    authors: Ishii M,Nakamura T,Kasai F,Baba T,Takebe K

    更新日期:1997-07-01 00:00:00

  • Racial variation in the control of diabetes among elderly medicare managed care beneficiaries.

    abstract:OBJECTIVE:To examine racial variation in the poor control of GHb, a GHb value >9.5%, or GHb not tested in 1999 among Medicare beneficiaries aged 65-75 years enrolled in managed care plans. RESEARCH DESIGN AND METHODS:The National Committee on Quality Assurance provides person-level data regarding diabetes care service...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.26.12.3250

    authors: McBean AM,Huang Z,Virnig BA,Lurie N,Musgrave D

    更新日期:2003-12-01 00:00:00

  • Association of ACE gene polymorphism with arterial stiffness in patients with type 2 diabetes.

    abstract:OBJECTIVE:To assess the relationship between the insertion (I)/deletion (D) polymorphism of the ACE gene and arterial distensibility in patients with type 2 diabetes and healthy control subjects. RESEARCH DESIGN AND METHODS:Aortic and carotid arterial distensibility were evaluated by measuring aortic pulse-wave veloci...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.22.11.1858

    authors: Taniwaki H,Kawagishi T,Emoto M,Shoji T,Hosoi M,Kogawa K,Nishizawa Y,Morii H

    更新日期:1999-11-01 00:00:00

  • Personalized management of hyperglycemia in type 2 diabetes: reflections from a Diabetes Care Editors' Expert Forum.

    abstract::In June 2012, 13 thought leaders convened in a Diabetes Care Editors' Expert Forum to discuss the concept of personalized medicine in the wake of a recently published American Diabetes Association/European Association for the Study of Diabetes position statement calling for a patient-centered approach to hyperglycemia...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc13-0512

    authors: Raz I,Riddle MC,Rosenstock J,Buse JB,Inzucchi SE,Home PD,Del Prato S,Ferrannini E,Chan JC,Leiter LA,Leroith D,Defronzo R,Cefalu WT

    更新日期:2013-06-01 00:00:00

  • Beneficial effects of viscous dietary fiber from Konjac-mannan in subjects with the insulin resistance syndrome: results of a controlled metabolic trial.

    abstract:OBJECTIVE:Dietary fiber has recently received recognition for reducing the risk of developing diabetes and heart disease. The implication is that it may have therapeutic benefit in prediabetic metabolic conditions. To test this hypothesis, we investigated the effect of supplementing a high-carbohydrate diet with fiber ...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.2337/diacare.23.1.9

    authors: Vuksan V,Sievenpiper JL,Owen R,Swilley JA,Spadafora P,Jenkins DJ,Vidgen E,Brighenti F,Josse RG,Leiter LA,Xu Z,Novokmet R

    更新日期:2000-01-01 00:00:00

  • Risk Factors for Kidney Disease in Type 1 Diabetes.

    abstract:OBJECTIVE:In type 1 diabetes (T1D), the course of microalbuminuria is unpredictable and timing of glomerular filtration rate (GFR) loss is uncertain. Thus, there is a need to identify the risk factors associated with the development of more advanced stages of kidney disease through large, long-term systematic analysis....

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc18-2062

    authors: Perkins BA,Bebu I,de Boer IH,Molitch M,Tamborlane W,Lorenzi G,Herman W,White NH,Pop-Busui R,Paterson AD,Orchard T,Cowie C,Lachin JM,Diabetes Control and Complications Trial (DCCT)\/Epidemiology of Diabetes Interventions and Com

    更新日期:2019-05-01 00:00:00

  • A comparative effectiveness analysis of three continuous glucose monitors.

    abstract:OBJECTIVE:To compare three continuous glucose monitoring (CGM) devices in subjects with type 1 diabetes under closed-loop blood glucose (BG) control. RESEARCH DESIGN AND METHODS:Six subjects with type 1 diabetes (age 52 ± 14 years, diabetes duration 32 ± 14 years) each participated in two 51-h closed-loop BG control e...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc12-0070

    authors: Damiano ER,El-Khatib FH,Zheng H,Nathan DM,Russell SJ

    更新日期:2013-02-01 00:00:00

  • Advancing basal insulin replacement in type 2 diabetes inadequately controlled with insulin glargine plus oral agents: a comparison of adding albiglutide, a weekly GLP-1 receptor agonist, versus thrice-daily prandial insulin lispro.

    abstract:OBJECTIVE:GLP-1 receptor agonists may provide an alternative to prandial insulin for advancing basal insulin therapy. Harmony 6 was a randomized, open-label, active-controlled trial testing once-weekly albiglutide vs. thrice-daily prandial insulin lispro as an add-on to titrated once-daily insulin glargine. RESEARCH D...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2337/dc14-0001

    authors: Rosenstock J,Fonseca VA,Gross JL,Ratner RE,Ahrén B,Chow FC,Yang F,Miller D,Johnson SL,Stewart MW,Leiter LA,Harmony 6 Study Group.

    更新日期:2014-08-01 00:00:00

  • Periodontal infection, systemic inflammation, and insulin resistance: results from the continuous National Health and Nutrition Examination Survey (NHANES) 1999-2004.

    abstract:OBJECTIVE:Adverse microbial exposures might contribute to diabetogenesis. We hypothesized that clinical periodontal disease (a manifestation of microbial exposures in dysbiotic biofilms) would be related to insulin resistance among diabetes-free participants. The roles of inflammatory mediation and effect modification ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc12-0072

    authors: Demmer RT,Squillaro A,Papapanou PN,Rosenbaum M,Friedewald WT,Jacobs DR Jr,Desvarieux M

    更新日期:2012-11-01 00:00:00

  • Randomized cross-over trial of insulin glargine plus lispro or NPH insulin plus regular human insulin in adolescents with type 1 diabetes on intensive insulin regimens.

    abstract:OBJECTIVE:To compare blood glucose control and incidence of nocturnal hypoglycemia in adolescents with type 1 diabetes on multiple injection regimens managed with either an insulin analog combination or NPH insulin plus regular human insulin. RESEARCH DESIGN AND METHODS:In a randomized cross-over study, 28 adolescents...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.26.3.799

    authors: Murphy NP,Keane SM,Ong KK,Ford-Adams M,Edge JA,Acerini CL,Dunger DB

    更新日期:2003-03-01 00:00:00

  • Dietary fat intake predicts 1-year change in body fat in adolescent girls with type 1 diabetes.

    abstract:OBJECTIVE:The purpose of this study was to determine whether objectively measured physical activity and dietary macronutrient intake differentially predict body fat in adolescent girls with type 1 diabetes and control girls. RESEARCH DESIGN AND METHODS:This study comprised 23 girls (12-19 years) with type 1 diabetes a...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc05-2318

    authors: Särnblad S,Ekelund U,Aman J

    更新日期:2006-06-01 00:00:00

  • Increased Liver Fatty Acid Uptake Is Partly Reversed and Liver Fat Content Normalized After Bariatric Surgery.

    abstract:OBJECTIVE:Changes in liver fatty acid metabolism are important in understanding the mechanisms of diabetes remission and metabolic changes after bariatric surgery. RESEARCH DESIGN AND METHODS:Liver fatty acid uptake (LFU), blood flow, and fat content (LFC) were measured in 25 obese subjects before bariatric surgery an...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/dc17-0738

    authors: Immonen H,Hannukainen JC,Kudomi N,Pihlajamäki J,Saunavaara V,Laine J,Salminen P,Lehtimäki T,Pham T,Iozzo P,Nuutila P

    更新日期:2018-02-01 00:00:00

  • Smoking and mortality among women with type 2 diabetes: The Nurses' Health Study cohort.

    abstract:OBJECTIVE:To assess the relationship between cigarette smoking and mortality among women with type 2 diabetes in the Nurses' Health Study cohort. RESEARCH DESIGN AND METHODS:The Nurses' Health Study, a prospective cohort of U.S. female registered nurses, included 7,401 women with type 2 diabetes diagnosed at baseline ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.24.12.2043

    authors: Al-Delaimy WK,Willett WC,Manson JE,Speizer FE,Hu FB

    更新日期:2001-12-01 00:00:00

  • Medication adherence and racial differences in A1C control.

    abstract:OBJECTIVE:The purpose of this study was to examine medication adherence and other self-management practices as potential determinants of higher glycemic risk among black relative to white patients. RESEARCH DESIGN AND METHODS:We used a retrospective, longitudinal repeated-measures design to model the contribution of m...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/dc07-1924

    authors: Adams AS,Trinacty CM,Zhang F,Kleinman K,Grant RW,Meigs JB,Soumerai SB,Ross-Degnan D

    更新日期:2008-05-01 00:00:00

  • Evolution of abnormal plasma glucagon responses to mixed-meal feedings in youth with type 1 diabetes during the first 2 years after diagnosis.

    abstract:OBJECTIVE:To examine the evolution of the dysregulated glucagon responses to mixed-meal tolerance tests (MMTTs) in youth with recent-onset type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS:MMTTs were performed in 25 youth (9-18 years of age) with 1.5-12 months disease duration (year 1); 22 subjects were restudied 1 y...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/dc13-2612

    authors: Sherr J,Tsalikian E,Fox L,Buckingham B,Weinzimer S,Tamborlane WV,White NH,Arbelaez AM,Kollman C,Ruedy KJ,Cheng P,Beck RW,Diabetes Research in Children Network.

    更新日期:2014-06-01 00:00:00

  • Moderate intake of n-3 fatty acids for 2 months has no detrimental effect on glucose metabolism and could ameliorate the lipid profile in type 2 diabetic men. Results of a controlled study.

    abstract:OBJECTIVE:To evaluate the effect of a moderate dose of fish oil on glycemic control and in vivo insulin action in type 2 diabetic men with elevated plasma triacylglycerols and to determine the effect of the same treatment on gene expression of GLUT4, lipoprotein lipase (LPL), and hormone-sensitive lipase (HSL) in the a...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.21.5.717

    authors: Luo J,Rizkalla SW,Vidal H,Oppert JM,Colas C,Boussairi A,Guerre-Millo M,Chapuis AS,Chevalier A,Durand G,Slama G

    更新日期:1998-05-01 00:00:00

  • Lactation Duration and Long-term Risk for Incident Type 2 Diabetes in Women With a History of Gestational Diabetes Mellitus.

    abstract:OBJECTIVE:We examined the association of lactation duration with incident type 2 diabetes among women with a history of gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS:We monitored 4,372 women with a history of GDM participating in the Nurses' Health Study II for incident type 2 diabetes over 25 years...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc19-2237

    authors: Ley SH,Chavarro JE,Li M,Bao W,Hinkle SN,Wander PL,Rich-Edwards J,Olsen S,Vaag A,Damm P,Grunnet LG,Mills JL,Hu FB,Zhang C

    更新日期:2020-04-01 00:00:00

  • Pioglitazone Improves Left Ventricular Diastolic Function in Subjects With Diabetes.

    abstract:OBJECTIVE:To examine the effect of pioglitazone on myocardial insulin sensitivity and left ventricular (LV) function in patients with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS:Twelve subjects with T2D and 12 with normal glucose tolerance received a euglycemic insulin clamp. Myocardial glucose uptake (MGU) and...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc17-0078

    authors: Clarke GD,Solis-Herrera C,Molina-Wilkins M,Martinez S,Merovci A,Cersosimo E,Chilton RJ,Iozzo P,Gastaldelli A,Abdul-Ghani M,DeFronzo RA

    更新日期:2017-11-01 00:00:00

  • Association between fine particulate matter and diabetes prevalence in the U.S.

    abstract:OBJECTIVE:Recent studies have drawn attention to the adverse effects of ambient air pollutants such as particulate matter 2.5 (PM2.5) on human health. We evaluated the association between PM2.5 exposure and diabetes prevalence in the U.S. and explored factors that may influence this relationship. RESEARCH DESIGN AND M...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc10-0698

    authors: Pearson JF,Bachireddy C,Shyamprasad S,Goldfine AB,Brownstein JS

    更新日期:2010-10-01 00:00:00

  • Microalbuminuria associated with diabetic neuropathy.

    abstract:OBJECTIVE:To test the hypothesis that microalbuminuria may show an independent statistical association with diabetic neuropathy. RESEARCH DESIGN AND METHODS:An observational study of a prospectively identified cohort was conducted at the University Medical Center. The cohort consisted of 78 consecutive diabetic patien...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.15.4.528

    authors: Bell DS,Ketchum CH,Robinson CA,Wagenknecht LE,Williams BT

    更新日期:1992-04-01 00:00:00

  • Impact of a natural disaster on diabetes: exacerbation of disparities and long-term consequences.

    abstract:OBJECTIVE:To examine the impact of Hurricane Katrina on the health of individuals with diabetes. RESEARCH DESIGN AND METHODS:This was an observational study in 1,795 adults with an A1C measurement 6 months before and 6-16 months after Hurricane Katrina in three health care systems: private (Tulane University Hospital ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-0670

    authors: Fonseca VA,Smith H,Kuhadiya N,Leger SM,Yau CL,Reynolds K,Shi L,McDuffie RH,Thethi T,John-Kalarickal J

    更新日期:2009-09-01 00:00:00