Moderate intake of n-3 fatty acids for 2 months has no detrimental effect on glucose metabolism and could ameliorate the lipid profile in type 2 diabetic men. Results of a controlled study.

Abstract:

OBJECTIVE:To evaluate the effect of a moderate dose of fish oil on glycemic control and in vivo insulin action in type 2 diabetic men with elevated plasma triacylglycerols and to determine the effect of the same treatment on gene expression of GLUT4, lipoprotein lipase (LPL), and hormone-sensitive lipase (HSL) in the abdominal adipose tissue. RESEARCH DESIGN AND METHODS:A total of 12 type 2 diabetic men were randomly allocated to 2 months of 6 g daily of either fish oil or sunflower oil, separated by a 2-month washout interval, in a double-blind crossover design. RESULTS:For glucose metabolism, 2 months of fish oil supplementation compared with sunflower oil led to similar fasting plasma insulin, glucose, and HbA1c. Basal hepatic glucose production did not increase after fish oil. There was no difference in insulin suppression of hepatic glucose production nor in insulin stimulation of whole-body glucose disposal measured by the euglycemic-hyperinsulinemic clamp. Fish oil did not ameliorate the low mRNA level of GLUT4 in adipose tissue of these patients. For lipid profile, fish oil lowered plasma triacylglycerol more than sunflower oil (P < 0.05) and tended to increase the amount of mRNA of both LPL and HSL in adipose tissue. CONCLUSIONS:A moderate dose of fish oil did not lead to deleterious effects on glycemic control or whole-body insulin sensitivity in type 2 diabetic men, with preserved triacylglycerol-lowering capacities.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Luo J,Rizkalla SW,Vidal H,Oppert JM,Colas C,Boussairi A,Guerre-Millo M,Chapuis AS,Chevalier A,Durand G,Slama G

doi

10.2337/diacare.21.5.717

subject

Has Abstract

pub_date

1998-05-01 00:00:00

pages

717-24

issue

5

eissn

0149-5992

issn

1935-5548

journal_volume

21

pub_type

临床试验,杂志文章,随机对照试验
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    abstract::This study examined the effect of age on the posthepatic delivery of oral glucose (PHDG) during steady-state conditions. We used an intravenous-oral modification of the euglycemic insulin-clamp technique to assess PHDG in six men aged 24-39 yr (young) and eight men aged 65-83 yr (old). Each subject underwent two studi...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.12.6.394

    authors: Tonino RP,Minaker KL,Rowe JW

    更新日期:1989-06-01 00:00:00

  • Gestational diabetes mellitus: NICE for the U.S.? A comparison of the American Diabetes Association and the American College of Obstetricians and Gynecologists guidelines with the U.K. National Institute for Health and Clinical Excellence guidelines.

    abstract:OBJECTIVE:To compare recent U.S. and U.K. guidelines on gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS:The guidelines from the American Diabetes Association, the American College of Obstetricians and Gynecologists, and the National Institute for Health and Clinical Excellence (NICE) in the U.K. were ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-1376

    authors: Simmons D,McElduff A,McIntyre HD,Elrishi M

    更新日期:2010-01-01 00:00:00

  • Metabolic implications of body fat distribution.

    abstract::Insulin resistance is the cornerstone for the development of non-insulin-dependent diabetes mellitus (NIDDM). Free fatty acids (FFAs) cause insulin resistance in muscle and liver and increase hepatic gluconeogenesis and lipoprotein production and perhaps decrease hepatic clearance of insulin. It is suggested that the ...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/diacare.14.12.1132

    authors: Björntorp P

    更新日期:1991-12-01 00:00:00

  • Dietary fat intake predicts 1-year change in body fat in adolescent girls with type 1 diabetes.

    abstract:OBJECTIVE:The purpose of this study was to determine whether objectively measured physical activity and dietary macronutrient intake differentially predict body fat in adolescent girls with type 1 diabetes and control girls. RESEARCH DESIGN AND METHODS:This study comprised 23 girls (12-19 years) with type 1 diabetes a...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc05-2318

    authors: Särnblad S,Ekelund U,Aman J

    更新日期:2006-06-01 00:00:00

  • Current Challenges and Opportunities in the Prevention and Management of Diabetic Foot Ulcers.

    abstract::Diabetic foot ulcers remain a major health care problem. They are common, result in considerable suffering, frequently recur, and are associated with high mortality, as well as considerable health care costs. While national and international guidance exists, the evidence base for much of routine clinical care is thin....

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/dc17-1836

    authors: Jeffcoate WJ,Vileikyte L,Boyko EJ,Armstrong DG,Boulton AJM

    更新日期:2018-04-01 00:00:00

  • Exploratory trial of intranasal administration of glucagon-like peptide-1 in Japanese patients with type 2 diabetes.

    abstract:OBJECTIVE:This study aimed to assess the efficacy and safety of our newly developed nasal glucagon-like peptide-1 (GLP-1) compound and injector. RESEARCH DESIGN AND METHODS:Twenty-six patients with type 2 diabetes were enrolled in this double-blind placebo-controlled study. The nasal compound containing 1.2 mg of huma...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc13-0690

    authors: Ueno H,Mizuta M,Shiiya T,Tsuchimochi W,Noma K,Nakashima N,Fujihara M,Nakazato M

    更新日期:2014-07-01 00:00:00

  • 7. Diabetes Technology: Standards of Medical Care in Diabetes-2020.

    abstract::The American Diabetes Association (ADA) "Standards of Medical Care in Diabetes" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practic...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/dc20-S007

    authors: American Diabetes Association.

    更新日期:2020-01-01 00:00:00

  • On the association between diabetes and mental disorders in a community sample: results from the German National Health Interview and Examination Survey.

    abstract:OBJECTIVE:To determine the relationship between mental disorders and diabetes in a representative community sample. RESEARCH DESIGN AND METHODS:This was a cross-sectional study. Data on diabetes and HbA(1c) values were obtained by structured questionnaires and by laboratory assessments. Current psychiatric disorders w...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.26.6.1841

    authors: Kruse J,Schmitz N,Thefeld W,German National Health Interview and Examination Survey.

    更新日期:2003-06-01 00:00:00

  • Reimbursement issues in diabetes.

    abstract::Third-party reimbursement for outpatient education services and for new health care technologies in diabetes is an issue of concern to educators, administrators, and others in the diabetes health care system. Reimbursement for outpatient education has been obtained from 11 Blue Cross/Blue Shield plans in nine states, ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.7.3.291

    authors: Sinnock P,Bauer DW

    更新日期:1984-05-01 00:00:00

  • Psychosocial correlates of survival in diabetes.

    abstract::The goal of this research was to quantify the relationships between patient survival and a set of explanatory variables in a randomly selected sample of community-based patients with non-insulin-dependent diabetes mellitus (NIDDM). The sample included 343 patients with NIDDM initially entered into the study in 1981-19...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.11.7.538

    authors: Davis WK,Hess GE,Hiss RG

    更新日期:1988-07-01 00:00:00

  • Declining Rates of Hospitalization for Selected Cardiovascular Disease Conditions Among Adults Aged ≥35 Years With Diagnosed Diabetes, U.S., 1998-2014.

    abstract:OBJECTIVE:Reductions in heart attack and stroke hospitalizations are well documented in the U.S. population with diabetes. We extended trend analyses to other cardiovascular disease (CVD) conditions, including stroke by type, and used four additional years of data. RESEARCH DESIGN AND METHODS:Using 1998-2014 National ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc17-1259

    authors: Burrows NR,Li Y,Gregg EW,Geiss LS

    更新日期:2018-02-01 00:00:00

  • Effect of temperament on metabolic control in children with diabetes mellitus.

    abstract::Fifty-one children with insulin-dependent diabetes mellitus (IDDM) and 24 healthy sibling controls were compared on one of two temperament questionnaires completed by parents. Children with IDDM did not provide a characteristic temperament profile or show any problem areas. A regression analysis to predict diabetic co...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.11.1.77

    authors: Rovet JF,Ehrlich RM

    更新日期:1988-01-01 00:00:00

  • Impact of peripheral neuropathy on bone density in patients with type 1 diabetes.

    abstract:OBJECTIVE:To investigate whether peripheral neuropathy (PN), as part of the microangiopathic complex, affects bone mineral density (BMD) of the peripheral or the axial skeleton in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS:Three study groups were examined. Group 1 comprised 21 males with type 1 diabete...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.22.5.827

    authors: Rix M,Andreassen H,Eskildsen P

    更新日期:1999-05-01 00:00:00

  • Normalization of the IGF-IGFBP axis by sustained nightly insulinization in type 1 diabetes.

    abstract:OBJECTIVE:We sought to test the hypothesis that start of insulin glargine with sustained nightly insulin action results in changes in circulating concentrations of IGF-I and IGF binding proteins (IGFBPs) in adolescents with type 1 diabetes-changes that may support improvement of A1C. RESEARCH DESIGN AND METHODS:Twelve...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc06-2328

    authors: Ekström K,Salemyr J,Zachrisson I,Carlsson-Skwirut C,Ortqvist E,Bang P

    更新日期:2007-06-01 00:00:00

  • Initiating exercise programs for patients with non-insulin-dependent diabetes.

    abstract::Considerable attention has been focused on the importance of physical activity in improving the diabetic state in obese, non-insulin-dependent diabetic patients. Because this patient population tends to be sedentary, this challenge requires an active effort involving the patient and health-care providers. The latter m...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.3.5.627

    authors: Beeken RK

    更新日期:1980-09-01 00:00:00

  • Optimal insulin delivery for the pregnant diabetic patient.

    abstract::It is now possible to virtually normalize ambient blood glucose levels in insulin-dependent diabetic women during pregnancy. Successful programs have been developed that utilize home blood glucose monitoring, physiologic delivery of insulin, and quantitation of caloric intake carefully matched to insulin dosage. The r...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:

    authors: Jovanovic L,Peterson CM

    更新日期:1982-05-01 00:00:00

  • Effects of peer-group intervention on metabolic control of adolescents with IDDM. Randomized outpatient study.

    abstract::In children with insulin-dependent diabetes mellitus (IDDM), deterioration in metabolic control frequently occurs during early adolescence. To prevent this predictable increase in blood glucose levels, we randomly assigned young adolescents with IDDM to an intervention based on problem solving with self-monitoring of ...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.12.3.179

    authors: Anderson BJ,Wolf FM,Burkhart MT,Cornell RG,Bacon GE

    更新日期:1989-03-01 00:00:00

  • Health Care Utilization and Burden of Diabetic Ketoacidosis in the U.S. Over the Past Decade: A Nationwide Analysis.

    abstract:OBJECTIVE:Diabetes is one of the most common chronic diseases and a leading cause of morbidity and mortality in the U.S. Although our ability to treat diabetes and its associated complications has significantly improved, presentation with uncontrolled diabetes leading to ketoacidosis remains a significant problem. RES...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc17-1379

    authors: Desai D,Mehta D,Mathias P,Menon G,Schubart UK

    更新日期:2018-08-01 00:00:00

  • Familial aggregation of medial arterial calcification in Pima Indians with and without diabetes.

    abstract:OBJECTIVE:Little is known about medial arterial calcification (MAC) other than its association with age, sex, diabetes, and diabetes complications. Familial aggregation of this disorder was studied to determine the importance of potential genetic factors and to assess whether such familial aggregation was independent o...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.19.9.968

    authors: Narayan KM,Pettitt DJ,Hanson RL,Bennett PH,Fernandes RJ,De Courten M,Rose FA,Knowler WC

    更新日期:1996-09-01 00:00:00

  • Asian Americans: diabetes prevalence across U.S. and World Health Organization weight classifications.

    abstract:OBJECTIVE:To compare diabetes prevalence among Asian Americans by World Health Organization and U.S. BMI classifications. RESEARCH DESIGN AND METHODS:Data on Asian American adults (n = 7,414) from the National Health Interview Survey for 1997-2005 were analyzed. Diabetes prevalence was estimated across weight and ethn...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-0573

    authors: Oza-Frank R,Ali MK,Vaccarino V,Narayan KM

    更新日期:2009-09-01 00:00:00

  • Life years lost and lifetime health care expenditures associated with diabetes in the U.S., National Health Interview Survey, 1997-2000.

    abstract:OBJECTIVE:This study analyzed the lifetime health care expenditures and life years lost associated with diabetes in the U.S. RESEARCH DESIGN AND METHODS:Data from the National Health Interview Survey (NHIS), the Medical Expenditure Panel Survey from 1997 to 2000, and the NHIS Linked Mortality Public-use Files with a m...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc14-1453

    authors: Leung MY,Pollack LM,Colditz GA,Chang SH

    更新日期:2015-03-01 00:00:00

  • Health-related quality of life and treatment satisfaction in Dutch patients with type 2 diabetes.

    abstract:OBJECTIVE:To estimate the health-related quality of life (HRQOL) and treatment satisfaction for patients with type 2 diabetes in the Netherlands and to examine which patient characteristics are associated with quality of life and treatment satisfaction. RESEARCH DESIGN AND METHODS:For a sample of 1,348 type 2 diabetes...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/diacare.25.3.458

    authors: Redekop WK,Koopmanschap MA,Stolk RP,Rutten GE,Wolffenbuttel BH,Niessen LW

    更新日期:2002-03-01 00:00:00

  • Dissociation of insulin absorption and blood flow during massage of a subcutaneous injection site.

    abstract::Nine healthy volunteers with normal body weights were injected subcutaneously with 125I-labeled soluble human insulin (10 U) in one thigh and 133Xe in the contralateral thigh for the measurement of subcutaneous blood flow on 2 consecutive mornings. On one of the days, standardized massage of both injection sites was p...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.9.6.570

    authors: Linde B

    更新日期:1986-11-01 00:00:00

  • Prevalence of isthmic lumbar spondylolisthesis in nondiabetic subjects and NIDDM patients.

    abstract:OBJECTIVE:To compare the prevalence of lumbar spondylolytic spondylolisthesis (LSS) in nondiabetic and diabetic subjects. RESEARCH DESIGN AND METHODS:A cross-sectional study of 1,147 randomly selected nondiabetic subjects and 892 non-insulin-dependent diabetes mellitus (NIDDM) patients, 45-64 years of age. LSS was dia...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.17.6.592

    authors: Virta L,Rönnemaa T,Laakso M

    更新日期:1994-06-01 00:00:00

  • Efficacy and safety of switching from the DPP-4 inhibitor sitagliptin to the human GLP-1 analog liraglutide after 52 weeks in metformin-treated patients with type 2 diabetes: a randomized, open-label trial.

    abstract:OBJECTIVE:To assess the efficacy and safety of switching from sitagliptin to liraglutide in metformin-treated adults with type 2 diabetes. RESEARCH DESIGN AND METHODS:In an open-label trial, participants randomized to receive either liraglutide (1.2 or 1.8 mg/day) or sitagliptin (100 mg/day), each added to metformin, ...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc11-2113

    authors: Pratley RE,Nauck MA,Bailey T,Montanya E,Filetti S,Garber AJ,Thomsen AB,Furber S,Davies M,1860-LIRA-DPP-4 Study Group.

    更新日期:2012-10-01 00:00:00

  • A Genome-Wide Association Study Identifies Blood Disorder-Related Variants Influencing Hemoglobin A1c With Implications for Glycemic Status in U.S. Hispanics/Latinos.

    abstract:OBJECTIVE:We aimed to identify hemoglobin A1c (HbA1c)-associated genetic variants and examine their implications for glycemic status evaluated by HbA1c in U.S. Hispanics/Latinos with diverse genetic ancestries. RESEARCH DESIGN AND METHODS:We conducted a genome-wide association study (GWAS) of HbA1c in 9,636 U.S. Hispa...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc19-0168

    authors: Moon JY,Louie TL,Jain D,Sofer T,Schurmann C,Below JE,Lai CQ,Aviles-Santa ML,Talavera GA,Smith CE,Petty LE,Bottinger EP,Chen YI,Taylor KD,Daviglus ML,Cai J,Wang T,Tucker KL,Ordovás JM,Hanis CL,Loos RJF,Schneiderm

    更新日期:2019-09-01 00:00:00

  • Effect of training status on regional disposal of circulating free fatty acids in the liver and skeletal muscle during physiological hyperinsulinemia.

    abstract:OBJECTIVE:Fat metabolism is increasingly implicated in the pathogenesis of type 2 diabetes. Endurance training has been shown to prevent hepatic steatosis and to alter skeletal muscle fat metabolism, and regional free fatty acid (FFA) uptake adaptations were suggested as a mechanism. Thus, we tested whether endurance t...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.27.9.2172

    authors: Iozzo P,Takala T,Oikonen V,Bergman J,Grönroos T,Ferrannini E,Nuutila P,Knuuti J

    更新日期:2004-09-01 00:00:00

  • Trends in Emergency Department Visits and Inpatient Admissions for Hyperglycemic Crises in Adults With Diabetes in the U.S., 2006-2015.

    abstract:OBJECTIVE:To report U.S. national population-based rates and trends in diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar state (HHS) among adults, in both the emergency department (ED) and inpatient settings. RESEARCH DESIGN AND METHODS:We analyzed data from 1 January 2006 through 30 September 2015 from the N...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc19-2449

    authors: Benoit SR,Hora I,Pasquel FJ,Gregg EW,Albright AL,Imperatore G

    更新日期:2020-05-01 00:00:00

  • Hypogonadotropic Hypogonadism in Men With Diabesity.

    abstract::One-third of men with obesity or type 2 diabetes have subnormal free testosterone concentrations. The lower free testosterone concentrations are observed in obese men at all ages, including adolescents at completion of puberty. The gonadotropin concentrations in these males are inappropriately normal; thus, these pati...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/dc17-2510

    authors: Dhindsa S,Ghanim H,Batra M,Dandona P

    更新日期:2018-07-01 00:00:00

  • Electron microscopy of insulin precipitates.

    abstract::Morphologic characteristics of insulin precipitates were examined by both scanning and transmission electron microscopy. Insulin precipitate obtained after 1 wk of in vivo storage in an implanted dog reservoir was compared with insulin precipitate produced in vitro by isoelectric precipitation, acid-freeze-heat precip...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.5.1.25

    authors: Schade DS,Eaton RP,DeLongo J,Saland LC,Ladman AJ,Carlson GA

    更新日期:1982-01-01 00:00:00