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The use of an automated, portable glucose control system for overnight glucose control in adolescents and young adults with type 1 diabetes.

Abstract：

OBJECTIVE:A key milestone in progress towards providing an efficacious and safe closed-loop artificial pancreas system for outpatient use is the development of fully automated, portable devices with fault detection capabilities to ensure patient safety. The ability to remotely monitor the operation of the closed-loop system would facilitate future physician-supervised home studies. RESEARCH DESIGN AND METHODS:This study was designed to investigate the efficacy and safety of a fully automated, portable, closed-loop system. The Medtronic Portable Glucose Control System (PGCS) consists of two subcutaneous glucose sensors, a control algorithm based on proportional-integral-derivative with insulin feedback operating from a BlackBerry Storm smartphone platform, Bluetooth radiofrequency translator, and an off-the-shelf Medtronic Paradigm Veo insulin pump. Participants with type 1 diabetes using insulin pump therapy underwent two consecutive nights of in-clinic, overnight, closed-loop control after a baseline open-loop assessment. RESULTS:Eight participants attended for 16 overnight studies. The PGCS maintained mean overnight plasma glucose levels of 6.4 ± 1.7 mmol/L (115 ± 31 mg/dL). The proportion of time with venous plasma glucose <3.9, between 3.9 and 8 (70 and 144 mg/dL), and >8 mmol/L was 7, 78, and 15%, respectively. The proportion of time the sensor glucose values were maintained between 3.9 and 8 mmol/L was greater for closed-loop than open-loop (84.5 vs. 46.7%; P < 0.0001), and time spent <3.3 mmol/L was also reduced (0.9 vs. 3%; P < 0.0001). CONCLUSIONS:These results suggest that the PGCS, an automated closed-loop device, is safe and effective in achieving overnight glucose control in patients with type 1 diabetes.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

O'Grady MJ,Retterath AJ,Keenan DB,Kurtz N,Cantwell M,Spital G,Kremliovsky MN,Roy A,Davis EA,Jones TW,Ly TT

doi

10.2337/dc12-0761

subject

Has Abstract

pub_date

2012-11-01 00:00:00

pages

2182-7

issue

eissn

0149-5992

issn

1935-5548

pii

dc12-0761

journal_volume

pub_type

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The use of an automated, portable glucose control system for overnight glucose control in adolescents and young adults with type 1 diabetes.