Plasma 25-hydroxyvitamin D and progression to diabetes in patients at risk for diabetes: an ancillary analysis in the Diabetes Prevention Program.

abstract：OBJECTIVE:The objective of this study was to examine the associations between the severity of hepatic steatosis and dyslipidemia in type 2 diabetes, including circulating apolipoprotein B100 (apoB) concentrations and lipoprotein particle size and numbers. RESEARCH DESIGN AND METHODS:Computed tomography imaging was use...

journal_title：Diabetes care

authors： Toledo FG,Sniderman AD,Kelley DE

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVE:People with type 2 diabetes are at increased risk of age-related cognitive decline and dementia. Hypoglycemia is a candidate risk factor, but the direction of association between episodes of severe hypoglycemia and cognitive decline in type 2 diabetes remains uncertain. RESEARCH DESIGN AND METHODS:In the Edi...

journal_title：Diabetes care

authors： Feinkohl I,Aung PP,Keller M,Robertson CM,Morling JR,McLachlan S,Deary IJ,Frier BM,Strachan MW,Price JF,Edinburgh Type 2 Diabetes Study (ET2DS) Investigators.

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:To estimate the long-run mortality effects of Hurricanes Katrina and Rita on seniors with diabetes. RESEARCH DESIGN AND METHODS:We performed a retrospective cohort analysis of Medicare enrollment and claims data covering four states and ∼10 years. Affected individuals were identified by whether they lived in...

journal_title：Diabetes care

authors： Quast T,Andel R,Sadhu AR

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE:Ipragliflozin, a sodium-glucose cotransporter 2 inhibitor, stimulates glycosuria and lowers glycemia in patients with type 2 diabetes (T2DM). The objective of this study was to assess the pharmacodynamics of ipragliflozin in T2DM patients with impaired renal function. RESEARCH DESIGN AND METHODS:Glycosuria w...

journal_title：Diabetes care

authors： Ferrannini E,Veltkamp SA,Smulders RA,Kadokura T

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVE:To determine the characteristics that influence glycemic control among insulin-using adults with type 2 diabetes. RESEARCH DESIGN AND METHODS:We studied all 1,333 eligible members of a large not-for-profit health maintenance organization who responded to a 1997 survey. We tested associations among demographi...

journal_title：Diabetes care

authors： Nichols GA,Hillier TA,Javor K,Brown JB

更新日期：2000-03-01 00:00:00

abstract：OBJECTIVE:To describe an etiologic approach to classification of diabetes types in youth based on the 1997 American Diabetes Association (ADA) framework, using data from the SEARCH for Diabetes in Youth Study. RESEARCH DESIGN AND METHODS:SEARCH conducted a comprehensive assessment of 2,291 subjects aged <20 years with...

journal_title：Diabetes care

authors： Dabelea D,Pihoker C,Talton JW,D'Agostino RB Jr,Fujimoto W,Klingensmith GJ,Lawrence JM,Linder B,Marcovina SM,Mayer-Davis EJ,Imperatore G,Dolan LM,SEARCH for Diabetes in Youth Study.

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVE:Insulin pump therapy (continuous subcutaneous insulin infusion [CSII]) and multiple daily injections (MDIs) with insulin glargine as basal insulin and mealtime insulin lispro have not been prospectively compared in people naïve to either regimen in a multicenter study. We aimed to help close that deficiency. ...

journal_title：Diabetes care

authors： Bolli GB,Kerr D,Thomas R,Torlone E,Sola-Gazagnes A,Vitacolonna E,Selam JL,Home PD

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVE:To determine whether women with pregestational diabetes obtained long-term benefits from an intensive diabetes management program during pregnancy. RESEARCH DESIGN AND METHODS:Women with pregestational diabetes who had attended an intensive diabetes management program in pregnancy between 1991 and 1999 were ...

journal_title：Diabetes care

authors： Feig DS,Cleave B,Tomlinson G

更新日期：2006-03-01 00:00:00

abstract：:To examine the clinical role of BAYm 1099, 15 diet-treated non-insulin-dependent diabetic (NIDDM) subjects were randomized to start drug (50 mg 3 times/day) or placebo after a 4-wk run-in period in a double-blind crossover study. Treatment periods (4 wk) were separated by a 2-wk washout period. During the last week of...

journal_title：Diabetes care

authors： Samad AH,Ty Willing TS,Alberti KG,Taylor R

更新日期：1988-04-01 00:00:00

abstract：OBJECTIVE:Low plasma testosterone levels are associated with hyperinsulinemia and glucose intolerance in men. However, it is unclear whether these abnormalities are related to the concomitant alteration in regional adipose tissue (AT) accumulation associated with reduced androgen levels. RESEARCH DESIGN AND METHODS:We...

journal_title：Diabetes care

authors： Tchernof A,Després JP,Dupont A,Bélanger A,Nadeau A,Prud'homme D,Moorjani S,Lupien PJ,Labrie F

更新日期：1995-03-01 00:00:00

abstract：OBJECTIVE:To investigate the association between circulating levels of hepatocyte growth factor (HGF), a mesenchymal-derived pleiotrophic factor that is elevated in obesity, and the prevalence of type 2 diabetes. RESEARCH DESIGN AND METHODS:A cross-sectional analysis among 892 postmenopausal women within the Women's H...

journal_title：Diabetes care

authors： Rajpathak SN,Wassertheil-Smoller S,Crandall J,Liu S,Ho GY

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:We investigated whether islet autoantibody profile, HLA-DQ genotype, and age influenced a 20-year progression to diabetes from first autoantibody positivity (autoAb+) in first-degree relatives of patients with type 1 diabetes. RESEARCH DESIGN AND METHODS:Persistently islet autoAb+ siblings and offspring (n =...

journal_title：Diabetes care

authors： Gorus FK,Balti EV,Messaaoui A,Demeester S,Van Dalem A,Costa O,Dorchy H,Mathieu C,Van Gaal L,Keymeulen B,Pipeleers DG,Weets I,Belgian Diabetes Registry.

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVE:To examine glycemic control for the prevention of retinopathy in early diagnosed Japanese NIDDM patients. RESEARCH DESIGN AND METHODS:There were 137 patients with NIDDM but without retinopathy who first visited our facility from 1983-1985. Their age at diagnosis ranged from 30-65 years, with a disease durati...

journal_title：Diabetes care

authors： Nakagami T,Kawahara R,Hori S,Omori Y

更新日期：1997-04-01 00:00:00

abstract：OBJECTIVE:Type 1 diabetes has been associated with factors related to welfare and social class. During the past decade, Lithuania has experienced a transition period, leading to dramatic changes in the socioeconomic structure of the society. RESEARCH DESIGN AND METHODS:Incidence in the group aged 0-39 years by urban-r...

journal_title：Diabetes care

authors： Pundziute-Lyckå A,Urbonaite B,Ostrauskas R,Zalinkevicius R,Dahlquist GG

更新日期：2003-03-01 00:00:00

abstract：OBJECTIVE:We have demonstrated high heritability of insulin secretion measured as acute insulin response to glucose times insulin sensitivity (disposition index). Furthermore, we showed that obese normoglycemic family members of a type 2 diabetic proband failed to compensate for the insulin resistance of obesity by inc...

journal_title：Diabetes care

authors： Elbein SC,Sun J,Scroggin E,Teng K,Hasstedt SJ

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to examine the association of physical activity and cardiovascular fitness (CVF) with insulin sensitivity in a nationally representative sample of U.S. youth. RESEARCH DESIGN AND METHODS:The study included 1,783 U.S. adolescents (11% Mexican American, 14% non-Hispanic black, 63%...

journal_title：Diabetes care

authors： Imperatore G,Cheng YJ,Williams DE,Fulton J,Gregg EW

更新日期：2006-07-01 00:00:00

abstract：OBJECTIVE:To determine whether a culturally appropriate clinic- and community-based intervention for African-American women with type 2 diabetes will increase moderate-intensity physical activity (PA). RESEARCH DESIGN AND METHODS:In this randomized controlled trial conducted at seven practices in central North Carolin...

journal_title：Diabetes care

authors： Keyserling TC,Samuel-Hodge CD,Ammerman AS,Ainsworth BE,Henríquez-Roldán CF,Elasy TA,Skelly AH,Johnston LF,Bangdiwala SI

更新日期：2002-09-01 00:00:00

abstract：:Two-thirds of all deaths in developed countries are caused by the major noncommunicable diseases, e.g., cardiovascular disease, cancer, and non-insulin-dependent diabetes mellitus (NIDDM). There is increasing evidence that these diseases are a consequence of life-style change, and they have a number of risk factors in...

journal_title：Diabetes care

authors： Zimmet PZ

更新日期：1988-03-01 00:00:00

abstract：:Regulation of gene transcription is a major action of insulin. Most of the greater than 20 examples of this effect involve the stimulation of transcription, but a few involve an inhibition. The inhibition of transcription of the phosphoenolpyruvate carboxykinase (PEPCK) gene has been studied in detail. Most of this ef...

journal_title：Diabetes care

authors： O'Brien RM,Granner DK

更新日期：1990-03-01 00:00:00

abstract：OBJECTIVE:To clarify the contribution of the Asp905Tyr polymorphism of the muscle-specific glycogen-targeting subunit of protein phosphatase 1 (PP1G) to insulin resistance and related diseases. RESEARCH DESIGN AND METHODS:We investigated the Asp905Tyr polymorphism of the PPP1R3 gene, which encodes the muscle-specific ...

journal_title：Diabetes care

authors： Shen GQ,Ikegami H,Kawaguchi Y,Fujisawa T,Hamada Y,Ueda H,Shintani M,Nojima K,Kawabata Y,Yamada K,Babaya N,Ogihara T

更新日期：1998-07-01 00:00:00

abstract：OBJECTIVE:To determine whether reducing triglyceride concentrations in humans reduces serum insulin levels and consider the implications of this for the insulin resistance of hypertriglyceridemia. RESEARCH DESIGN AND METHODS:Insulin and glucose levels were determined during an oral glucose tolerance test (OGTT) in 14 ...

journal_title：Diabetes care

authors： Steiner G

更新日期：1991-11-01 00:00:00

abstract：OBJECTIVE:The objective of the present analysis was to evaluate the association of alanine aminotransferase (ALT) with directly measured insulin sensitivity (S(i)) in a large, multiethnic cohort of U.S. adults and to determine whether ALT adds to existing metabolic risk definitions in identifying subjects with insulin ...

journal_title：Diabetes care

authors： Hanley AJ,Wagenknecht LE,Festa A,D'Agostino RB Jr,Haffner SM

更新日期：2007-07-01 00:00:00

abstract：:In search of possible interactions between plastic tubings used for insulin-pump treatment and commercial regular insulin preparations, various catheter sets made from polyvinyl chloride (PVC), polyethylene (PE), and nylon plastics were perfused at 30 degrees C in a laboratory setting for up to 72 h. The perfused insu...

journal_title：Diabetes care

authors： Chantelau E,Lange G,Gasthaus M,Boxberger M,Berger M

更新日期：1987-05-01 00:00:00

abstract：OBJECTIVE:Statins may reduce the risk of diabetic polyneuropathy (DPN) as a result of lipid-lowering and anti-inflammatory effects, but statins have also been associated with neurotoxicity. We examined whether statin therapy affects the risk of DPN. RESEARCH DESIGN AND METHODS:We identified all Danish patients with in...

journal_title：Diabetes care

authors： Kristensen FP,Christensen DH,Callaghan BC,Kahlert J,Knudsen ST,Sindrup SH,Feldman EL,Østergaard L,Andersen H,Jensen TS,Sørensen HT,Thomsen RW

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:To study the effect of vitamin E supplementation on platelet hyperaggregability in type 1 diabetic patients. RESEARCH DESIGN AND METHODS:Written informed consent according to the Institutional Review Board on Human Experimentation guidelines was obtained from diabetic patients (n = 29) and their age-matched ...

journal_title：Diabetes care

authors： Jain SK,Krueger KS,McVie R,Jaramillo JJ,Palmer M,Smith T

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVE:To compare platelet plasminogen activator inhibitor 1 (PAI-1) release in type II diabetic patients and healthy control subjects. RESEARCH DESIGN AND METHODS:We studied a group of 27 diabetic patients and a group of 16 nondiabetic control subjects. Whole-blood platelet aggregation, defined as a decrease in pl...

journal_title：Diabetes care

authors： Jokl R,Klein RL,Lopes-Virella MF,Colwell JA

更新日期：1995-08-01 00:00:00

abstract：OBJECTIVE:To provide a description of the clinical characteristics that distinguish individuals who withhold insulin for weight control from those who do not. Some individuals with insulin-dependent diabetes mellitus (IDDM) control their weight by withholding insulin and purging excessive calories. This process places ...

journal_title：Diabetes care

authors： Biggs MM,Basco MR,Patterson G,Raskin P

更新日期：1994-10-01 00:00:00

abstract：OBJECTIVE:This study evaluated the feasibility, safety, and efficacy of day-and-night hybrid closed-loop insulin delivery in adolescents with type 1 diabetes under free-living conditions. RESEARCH DESIGN AND METHODS:In an open-label randomized crossover study, 12 suboptimally controlled adolescents on insulin pump the...

journal_title：Diabetes care

authors： Tauschmann M,Allen JM,Wilinska ME,Thabit H,Acerini CL,Dunger DB,Hovorka R

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:Independent association of chronic kidney disease (CKD) and proliferative diabetic retinopathy (PDR) with cardiovascular disease (CVD) has not been established. In the Joslin 50-Year Medalist study, characterizing individuals with type 1 diabetes for 50 years or more, we examined the associations of CKD and P...

journal_title：Diabetes care

authors： Gordin D,Harjutsalo V,Tinsley L,Fickweiler W,Sun JK,Forsblom C,Amenta PS,Pober D,D'Eon S,Khatri M,Stillman IE,Groop PH,Keenan HA,King GL

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:Foot ulceration is a serious complication of diabetes, and new techniques that can predict wound healing may prove very helpful. We tested the ability of medical hyperspectral technology (HT), a novel diagnostic scanning technique that can quantify tissue oxy- and deoxyhemoglobin to predict diabetic foot ulce...

journal_title：Diabetes care

authors： Khaodhiar L,Dinh T,Schomacker KT,Panasyuk SV,Freeman JE,Lew R,Vo T,Panasyuk AA,Lima C,Giurini JM,Lyons TE,Veves A

更新日期：2007-04-01 00:00:00