Impaired mitochondrial function and insulin resistance of skeletal muscle in mitochondrial diabetes.

abstract：OBJECTIVE:Although persistent hyperglycemia contributes greatly to the progression of diabetic micro- and macroangiopathy, microangiopathy progresses more rapidly than macroangiopathy in some type 2 diabetic patients, with the opposite being true in others. This study was conducted to identify factors responsible for s...

journal_title：Diabetes care

authors： Yamamoto M,Egusa G,Okubo M,Yamakido M

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVE:To evaluate whether there is a difference in the association between nonalcoholic fatty liver disease (NAFLD) and incident diabetes based on the presence of impaired fasting glucose. RESEARCH DESIGN AND METHODS:A total of 7,849 individuals (5,409 men and 2,440 women) without diabetes, who underwent comprehen...

journal_title：Diabetes care

authors： Bae JC,Rhee EJ,Lee WY,Park SE,Park CY,Oh KW,Park SW,Kim SW

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:Although initially effective, sulfonylureas are associated with poor glycemic durability, weight gain, and hypoglycemia. Dapagliflozin, a selective inhibitor of sodium-glucose cotransporter 2 (SGLT2), reduces hyperglycemia by increasing urinary glucose excretion independent of insulin and may cause fewer of t...

journal_title：Diabetes care

authors： Nauck MA,Del Prato S,Meier JJ,Durán-García S,Rohwedder K,Elze M,Parikh SJ

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVE:The purpose of this article was to compare the effects of cod protein to those of other animal proteins on insulin sensitivity in insulin-resistant human subjects. RESEARCH DESIGN AND METHODS:Insulin sensitivity (M/I) was assessed using a hyperinsulinemic-euglycemic clamp in 19 insulin-resistant subjects fed...

journal_title：Diabetes care

authors： Ouellet V,Marois J,Weisnagel SJ,Jacques H

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:We evaluated the prevalence of endothelial dysfunction as measured by flow-mediated dilatation (FMD) of the brachial artery and carotid intima-media thickness (c-IMT) in relationship to vascular inflammatory biomarkers in preadolescent children with type 1 diabetes. RESEARCH DESIGN AND METHODS:We studied 21 ...

journal_title：Diabetes care

authors： Babar GS,Zidan H,Widlansky ME,Das E,Hoffmann RG,Daoud M,Alemzadeh R

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:To understand why low-fat high-carbohydrate (CHO) diets lead to higher fasting and postprandial concentrations of triglyceride (TG)-rich lipoproteins in patients with non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS:Patients with NIDDM were placed randomly on diets containing eith...

journal_title：Diabetes care

authors： Chen YD,Coulston AM,Zhou MY,Hollenbeck CB,Reaven GM

更新日期：1995-01-01 00:00:00

abstract：:Since little is known regarding the appropriate time for preprandial insulin administration, we compared the effects of 30-min subcutaneous insulin infusions started 60 min, 30 min, and immediately before meal ingestion on postprandial plasma glucose and insulin profiles in eight subjects with insulin-dependent diabet...

journal_title：Diabetes care

authors： Dimitriadis GD,Gerich JE

更新日期：1983-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the effect of clinically obtainable improvements in metabolic control in patients with type 1 diabetes on biochemical cardiovascular risk factors. RESEARCH DESIGN AND METHODS:Blood and 24-h urinary samples were obtained from 49 patients with type 1 diabetes before and after a run-in period and af...

journal_title：Diabetes care

authors： Djurhuus MS,Henriksen JE,Klitgaard NA,Blaabjerg O,Thye-Rønn P,Altura BM,Altura BT,Beck-Nielsen H

更新日期：1999-04-01 00:00:00

abstract：OBJECTIVE:To examine urinary levels of enterolactone and enterodiol, intestinal microbial metabolites of dietary lignans, in relation to type 2 diabetes (T2D) risk. RESEARCH DESIGN AND METHODS:Urinary concentrations of the lignan metabolites were assayed by liquid chromatography-mass spectrometry among 1,107 T2D and 1...

journal_title：Diabetes care

authors： Sun Q,Wedick NM,Pan A,Townsend MK,Cassidy A,Franke AA,Rimm EB,Hu FB,van Dam RM

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:To compare pharmacokinetics (PK) and pharmacodynamics (PD) of insulin glargine in type 2 diabetes mellitus (T2DM) after evening versus morning administration. RESEARCH DESIGN AND METHODS:Ten T2DM insulin-treated persons were studied during 24-h euglycemic glucose clamp, after glargine injection (0.4 units/kg...

journal_title：Diabetes care

authors： Porcellati F,Lucidi P,Cioli P,Candeloro P,Marinelli Andreoli A,Marzotti S,Ambrogi M,Bolli GB,Fanelli CG

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:Our objective was to compare the performance of oral glucose tolerance tests (OGTTs) and multivariate models incorporating commonly available clinical variables in their ability to predict future cardiovascular disease (CVD). RESEARCH DESIGN AND METHODS:We randomly selected 2,662 Mexican-Americans and 1,595 ...

journal_title：Diabetes care

authors： Stern MP,Fatehi P,Williams K,Haffner SM

更新日期：2002-10-01 00:00:00

abstract：OBJECTIVE:To study the influence of position changes on 24-h ambulatory blood pressure (ABP) in normotensive or mildly hypertensive normoalbuminuric patients with type 1 diabetes. RESEARCH DESIGN AND METHODS:A cross-sectional evaluation of patients was staged according to the duration of diabetes (DD) and the presence...

journal_title：Diabetes care

authors： Benhamou PY,Mouret S,Quesada JL,Boizel R,Baguet JP,Halimi S,Mallion JM

更新日期：2001-09-01 00:00:00

abstract：OBJECTIVE:Transient neonatal diabetes mellitus 1 (TNDM1) is the most common cause of diabetes presenting at birth. Approximately 5% of the cases are due to recessive ZFP57 mutations, causing hypomethylation at the TNDM locus and other imprinted loci (HIL). This has consequences for patient care because it has impact on...

journal_title：Diabetes care

authors： Boonen SE,Mackay DJ,Hahnemann JM,Docherty L,Grønskov K,Lehmann A,Larsen LG,Haemers AP,Kockaerts Y,Dooms L,Vu DC,Ngoc CT,Nguyen PB,Kordonouri O,Sundberg F,Dayanikli P,Puthi V,Acerini C,Massoud AF,Tümer Z,Temple IK

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:To compare the influence on blood pressure, glucose, and lipid levels of a diet rich in monounsaturated fatty acids with an isocaloric, high-carbohydrate diet in 15 NIDDM subjects. RESEARCH DESIGN AND METHODS:A crossover design with diet interventions and wash-out periods of 3 wk was applied. The patients we...

journal_title：Diabetes care

authors： Rasmussen OW,Thomsen C,Hansen KW,Vesterlund M,Winther E,Hermansen K

更新日期：1993-12-01 00:00:00

abstract：OBJECTIVE:Type 1 diabetes mellitus causes increased carotid intima-media thickness (IMT) in adults. We evaluated IMT in young subjects with type 1 diabetes. RESEARCH DESIGN AND METHODS:Participants with type 1 diabetes (N = 402) were matched to controls (N = 206) by age, sex, and race or ethnicity. Anthropometric and ...

journal_title：Diabetes care

authors： Urbina EM,Dabelea D,D'Agostino RB Jr,Shah AS,Dolan LM,Hamman RF,Daniels SR,Marcovina S,Wadwa RP

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVE:Screening involves the presumptive identification of asymptomatic individuals at increased risk for unrecognized disease. We examined changes in screening practices for prediabetes and diabetes since January 2010, when HbA1c was first recommended as an option for screening and diagnosis. RESEARCH DESIGN AND ...

journal_title：Diabetes care

authors： Evron JM,Herman WH,McEwen LN

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVE:Conjugated linoleic acid (CLA) is a group of dietary fatty acids with antiobesity and antidiabetic effects in some animals. The trans10cis12 (t10c12) CLA isomer seems to cause these effects, including improved insulin sensitivity. Whether such isomer-specific effects occur in humans is unknown. The aim of thi...

journal_title：Diabetes care

authors： Risérus U,Arner P,Brismar K,Vessby B

更新日期：2002-09-01 00:00:00

abstract：:Diabetes is more common in older adults, has a high prevalence in long-term care (LTC) facilities, and is associated with significant disease burden and higher cost. The heterogeneity of this population with regard to comorbidities and overall health status is critical to establishing personalized goals and treatments...

journal_title：Diabetes care

authors： Munshi MN,Florez H,Huang ES,Kalyani RR,Mupanomunda M,Pandya N,Swift CS,Taveira TH,Haas LB

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to examine patient-reported outcomes in a controlled trial of a multifaceted provider-level intervention to improve quality of care for rural patients with type 2 diabetes. RESEARCH DESIGN AND METHODS:We conducted a before/after intervention study with concurrent controls in two rur...

journal_title：Diabetes care

authors： Maddigan SL,Majumdar SR,Guirguis LM,Lewanczuk RZ,Lee TK,Toth EL,Johnson JA

更新日期：2004-06-01 00:00:00

abstract：:To quantify the association of abnormal glucose tolerance with hypertension and postural hypotension, 2480 men and women aged 50-89 yr from a defined population were evaluated by oral glucose tolerance and measurements of supine, seated, and standing blood pressure. In both sexes, adults with impaired glucose toleranc...

journal_title：Diabetes care

authors： Reaven PD,Barrett-Connor EL,Browner DK

更新日期：1990-02-01 00:00:00

abstract：:We measured hemoglobin A1 (HbA1) and performed clean-catch urine cultures in 752 patients (411 men and 341 women) with non-insulin-dependent diabetes mellitus (NIDDM) attending an outpatient diabetes clinic. Prevalence of bacteriuria was significantly greater in diabetic women than in controls (9.1 vs. 5.0%, P less th...

journal_title：Diabetes care

authors： Schmitt JK,Fawcett CJ,Gullickson G

更新日期：1986-09-01 00:00:00

abstract：OBJECTIVE:To examine patients' views of the acceptability of and satisfaction with telephone care center support provided to improve blood glucose control in type 2 diabetes. RESEARCH DESIGN AND METHODS:The Pro-Active Call-Center Treatment Support (PACCTS) Trial randomized patients from 47 general practices in a depri...

journal_title：Diabetes care

authors： Long AF,Gambling T,Young RJ,Taylor J,Mason JM,PACCTS Team.

更新日期：2005-02-01 00:00:00

abstract：OBJECTIVE:Mortality from acute diabetes-related events is greatly raised in young adults with type 1 diabetes. Psychosocial and socioeconomic risk factors are examined for deaths from acute events separately from deaths due to other causes. RESEARCH DESIGN AND METHODS:This study had a nested case-control design. The c...

journal_title：Diabetes care

authors： Laing SP,Jones ME,Swerdlow AJ,Burden AC,Gatling W

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVE:Individuals with type 2 diabetes have high risk of late-life cognitive impairment, yet little is known about strategies to modify risk. Targeting insulin resistance and vascular complications-both associated with cognitive decline-may be a productive approach. We investigated whether dietary fat, which modula...

journal_title：Diabetes care

authors： Devore EE,Stampfer MJ,Breteler MM,Rosner B,Kang JH,Okereke O,Hu FB,Grodstein F

更新日期：2009-04-01 00:00:00

abstract：OBJECTIVE:Strict glycemic control in people with insulin-dependent diabetes mellitus (IDDM) reduces the risk of microvascular complications, but improvements in control are also associated with weight gain. Fears about the mortality risks of obesity may limit the acceptability of tight control. Therefore, we examined m...

journal_title：Diabetes care

authors： Chaturvedi N,Stevens LK,Fuller JH

更新日期：1995-06-01 00:00:00

abstract：OBJECTIVE:While there is growing evidence on the effectiveness of structured care for diabetic patients in trial settings, standard population level evaluations may misestimate intervention benefits due to patient selection. In order to account for potential biases in measuring intervention benefits, we tested the impa...

journal_title：Diabetes care

authors： Chevreul K,Brunn M,Cadier B,Nolte E,Durand-Zaleski I

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:To determine the effect of diabetes on thyroid hormone and thyroxine-binding globulin (TBG) concentrations during puberty. RESEARCH DESIGN AND METHODS:Total thyroxine (TT4), free thyroxine (FT4), and TBG levels of 171 thyroid microsomal antibody-negative subjects with normal thyroid-stimulating hormone (TSH)...

journal_title：Diabetes care

authors： Connors MH,Dunger DB,Chapel H,Jefferson I,Jowett TP,Edwards PR

更新日期：1996-03-01 00:00:00

abstract：OBJECTIVE:To determine whether increasing doses (amounts) of beta-glucan present in an extruded breakfast cereal affect the glycemic and insulinemic responses in eight NIDDM subjects, compared with the same responses after a continental breakfast (bread, milk, cheese, ham). RESEARCH DESIGN AND METHODS:Breakfast cereal...

journal_title：Diabetes care

authors： Tappy L,Gügolz E,Würsch P

更新日期：1996-08-01 00:00:00

abstract：:The availability of insulin analogs has offered insulin replacement strategies that are proposed to more closely mimic normal human physiology. Specifically, there are a considerable number of reports demonstrating that prandial insulin analogs (lispro, aspart, glulisine) have pharmacokinetic and pharmacodynamic profi...

journal_title：Diabetes care

authors： Davidson MB

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:This study investigated whether glucose readings from a sensor sampling in interstitial fluid differ substantially from blood glucose (BG) values measured at the same time. RESEARCH DESIGN AND METHODS:We have evaluated the relationship between BG and glucose extracted from interstitial fluid using the GlucoW...

journal_title：Diabetes care

authors： Kulcu E,Tamada JA,Reach G,Potts RO,Lesho MJ

更新日期：2003-08-01 00:00:00