Abstract:
OBJECTIVE:Delayed gastric emptying and/or gastrointestinal symptoms occur in 30-50% of diabetic patients. Known contributing factors are autonomic neuropathy and acute hyperglycemia, but the role of gastric autoimmunity has never been investigated, although 15-20% of type 1 diabetic patients exhibit parietal cell antibodies (PCAs). We studied gastric motility in diabetes in relation to PCA status, autonomic nerve function, HbA(1c), thyroid-stimulating hormone (TSH), Helicobacter pylori (HP), acid production, and gastric histology. RESEARCH DESIGN AND METHODS:Gastric emptying of solids and liquids (measured by (13)C-octanoic acid and (13)C-glycine breath tests, respectively) was tested in euglycemic conditions in 42 type 1 diabetic patients (male/female: 29/13; 15 PCA+; mean age 40 +/- 15 years; mean HbA(1c) 7.8 +/- 0.9%). Gastrointestinal symptoms, autonomic nerve function (Ewing tests), PCA status (indirect immunofluorescence), gastric histology, and acid secretion (pentagastrin) were assessed. RESULTS:Solid gastric emptying was delayed in 40% and liquid emptying in 36% of patients. Gastric motility did not correlate with symptoms. PCA status, gastric morphology, and acid secretion were similar in those with and without gastroparesis. HbA(1c) level (beta = 1.34, P = 0.011) was the only risk factor for delayed solid emptying in a logistic regression model testing HbA(1c), autonomic nerve function, PCA, HP status, age, sex, diabetes duration, and TSH. Half-emptying time for liquids correlated with TSH level (r = 0.83, P < 0.0001) and autonomic neuropathy score (r = -0.79, P = 0.001). CONCLUSIONS:We found that approximately 50% of type 1 diabetic patients studied had delayed gastric emptying that did not correlate with symptoms. Gastric autoimmunity did not contribute to diabetic gastroparesis. Metabolic control was worse in patients with delayed solid emptying.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
De Block CE,De Leeuw IH,Pelckmans PA,Callens D,Máday E,Van Gaal LFdoi
10.2337/diacare.25.5.912subject
Has Abstractpub_date
2002-05-01 00:00:00pages
912-7issue
5eissn
0149-5992issn
1935-5548journal_volume
25pub_type
杂志文章相关文献
DIABETES CARE文献大全abstract:OBJECTIVE:We prospectively investigated in hypertensive patients with type 2 diabetes if bedtime treatment with ≥1 hypertension medications exerts better blood pressure control and cardiovascular risk reduction than conventional therapy, in which all medications are ingested in the morning. RESEARCH DESIGN AND METHODS...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc11-0297
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:Youth with type 1 diabetes face long-term risks of health complications of the disease. Little is known about patients' and parents' knowledge, acquisition of information, and family communication regarding these complications. This paper reports qualitative analyses of parental focus-group discussions of thi...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc07-2349
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVE:We aimed at analyzing the frequency, clinical characteristics, and trends associated with the occurrence of diabetic ketoacidosis (DKA) at the onset of type 1 diabetes on the basis of long-term follow-up data. RESEARCH DESIGN AND METHODS:A total of 106 pediatric diabetes centers in Germany and Austria partic...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-0553
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVE:The goal was to develop a new index of insulin sensitivity in patients with type 1 diabetes estimated from continuous glucose monitoring (CGM) and subcutaneous insulin delivery data under carefully controlled conditions. RESEARCH DESIGN AND METHODS:The database consists of 12 subjects with type 1 diabetes, s...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc13-1120
更新日期:2014-01-01 00:00:00
abstract::This study describes the pharmacokinetics of three intermediate-acting insulin preparations, NPH porcine insulin, NPH human insulin (recombinant DNA), and "Depot-A" insulin, a mixture of 20% regular and 80% NPH human insulin from Eli Lilly and Company. Metabolic healthy normal weight volunteers were selected for the s...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.5.2.s43
更新日期:1982-11-01 00:00:00
abstract:OBJECTIVE:Growth deferentiation factor-15 (GDF-15) is involved in inflammation and apoptosis. Expression is induced in the heart in response to ischemia and in atherosclerotic plaques. The aim of this study was to investigate GDF-15 levels in relation to all-cause mortality, cardiovascular mortality and morbidity, decl...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-2174
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVE:The role of adiponectin in the natural history of diabetes is not well characterized. We set out to characterize prediagnosis trajectories of adiponectin in individuals who develop type 2 diabetes. RESEARCH DESIGN AND METHODS:In a case-cohort study (335 incident diabetes case and 2,474 noncase subjects) nest...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc11-2263
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:To determine the occurrence of elevated fetal hemoglobin (HbF) among the diabetic population and determine the clinical situation of importance. RESEARCH DESIGN AND METHODS:A cross-sectional study was conducted. HbA1c and HbF were measured with high-performance liquid chromatography in 1,104 consecutive diab...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/diacare.17.8.828
更新日期:1994-08-01 00:00:00
abstract:OBJECTIVE:To determine whether impairments in neurocognitive functioning are detectable at type 1 diabetes diagnosis and associated with subsequent glycemic control. RESEARCH DESIGN AND METHODS:Children/adolescents (N = 147) aged 5-18 years completed neuropsychological testing during their inpatient hospitalization fo...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc14-0103
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVE:The aim was to explore relationships between work-related factors, work-related diabetes distress (WRDD), diabetes distress (measured by Problem Areas in Diabetes [PAID]-5 scale), intentional hyperglycemia at work (IHW), and glycemic control. RESEARCH DESIGN AND METHODS:A cross-sectional survey was conducted...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc18-1426
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:There is suggestive evidence linking hypoglycemia with cardiovascular disease, but few data have been collected in a community-based setting. Information is lacking on individual cardiovascular outcomes and cause-specific mortality. RESEARCH DESIGN AND METHODS:We conducted a prospective cohort analysis of 1,...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc17-1669
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:This study investigated whether intimacy and autonomy in mother-daughter interactions and relational aspects of the self are associated with metabolic control in adolescent girls with type 1 diabetes. RESEARCH DESIGN AND METHODS:This cross-sectional study included 88 girls with diabetes (mean age 14.9 +/- 2....
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.27.3.709
更新日期:2004-03-01 00:00:00
abstract:OBJECTIVE:To examine urinary levels of enterolactone and enterodiol, intestinal microbial metabolites of dietary lignans, in relation to type 2 diabetes (T2D) risk. RESEARCH DESIGN AND METHODS:Urinary concentrations of the lignan metabolites were assayed by liquid chromatography-mass spectrometry among 1,107 T2D and 1...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/dc13-2513
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:Despite good evidence and clinical practice guidelines, studies document that treatment of type 2 diabetes is less than optimal. Lack of resources or limited access may put patients in rural communities at particular risk for suboptimal care. RESEARCH DESIGN AND METHODS:We conducted a prospective, before/aft...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.26.11.3061
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVE:This study examined the prognostic significance of diabetes and microvascular complications in patients with heart failure with preserved ejection fraction (HFpEF). RESEARCH DESIGN AND METHODS:This analysis included 3,385 patients (mean age 69 ± 9.6 years; 49% male; 89% white) with HFpEF from the Treatment o...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2337/dc17-0755
更新日期:2018-01-01 00:00:00
abstract::There is increasing evidence that an ongoing cytokine-induced acute-phase response (sometimes called low-grade inflammation, but part of a widespread activation of the innate immune system) is closely involved in the pathogenesis of type 2 diabetes and associated complications such as dyslipidemia and atherosclerosis....
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.27.3.813
更新日期:2004-03-01 00:00:00
abstract:OBJECTIVE:To examine associations between A1C concentration and mortality in a New Zealand population. RESEARCH DESIGN AND METHODS:During a Hepatitis Foundation screening campaign for hepatitis B (1999-2001), participants were offered A1C testing. The participants were anonymously linked to the national mortality coll...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc07-2374
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVE:To examine the factors that determine the blood pressure response to enalapril and nifedipine monotherapy in the treatment of hypertension associated with non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS:After a 6-week placebo baseline period, 102 hypertensive NIDDM patients were ...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.18.7.1001
更新日期:1995-07-01 00:00:00
abstract:OBJECTIVE:The objective was to examine prospectively the association between low testosterone and sex hormone-binding globulin (SHBG) levels and the subsequent development of type 2 diabetes in men. RESEARCH DESIGN AND METHODS:Analyses were conducted on the cohort of the Massachusetts Male Aging Study, a population-ba...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.23.4.490
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVE:To determine whether intensive treatment and education strategies for type 2 diabetic patients with high-risk diabetic foot disease helps in preventing foot amputations. RESEARCH DESIGN AND METHODS:Participants included 4,872 consecutive type 2 diabetic patients (male-to-female ratio 3,422:1,450, mean (+/-SD...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.28.5.1019
更新日期:2005-05-01 00:00:00
abstract::In this study, 18 type I (insulin-dependent) diabetic subjects aged 22-35 yr (mean age 29.3) and within 10 yr of diagnosis (mean 7.7) performed a battery of cognitive and psychomotor tasks under conditions of hypoglycemia (50 mg/dl), normoglycemia (100 mg/dl), and hyperglycemia (300 mg/dl). Blood glucose levels during...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/diacare.12.3.193
更新日期:1989-03-01 00:00:00
abstract:OBJECTIVE:We aimed to identify hemoglobin A1c (HbA1c)-associated genetic variants and examine their implications for glycemic status evaluated by HbA1c in U.S. Hispanics/Latinos with diverse genetic ancestries. RESEARCH DESIGN AND METHODS:We conducted a genome-wide association study (GWAS) of HbA1c in 9,636 U.S. Hispa...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc19-0168
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:Abnormally elevated proinsulin secretion has been reported in type 2 and early type 1 diabetes when significant C-peptide is present. We questioned whether individuals with long-standing type 1 diabetes and low or absent C-peptide secretory capacity retained the ability to make proinsulin. RESEARCH DESIGN AN...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc17-2625
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:We investigated the effect of glimepiride, a third-generation sulfonylurea hypoglycemic agent, on insulin resistance in elderly patients with type 2 diabetes, in connection with plasma adiponectin and 8-epi-prostagrandin F2alpha (8-epi-PGF2alpha), an oxidative stress marker. RESEARCH DESIGN AND METHODS:A tot...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.26.2.285
更新日期:2003-02-01 00:00:00
abstract:OBJECTIVE:To summarize the frequency of physician adherence to consensus recommendations for prevention of diabetic complications. RESEARCH DESIGN AND METHODS:Survey data from a nationwide stratified probability sample of primary-care physicians were analyzed. Adherence to recommendations were reported by physician sp...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.16.11.1507
更新日期:1993-11-01 00:00:00
abstract:OBJECTIVE:Diabetic patients have a high prevalence of coronary artery disease (CAD), but timely diagnosis of CAD remains challenging. We assessed the ability of coronary computed tomography angiography (CCTA) to detect CAD in diabetic patients and to predict subsequent cardiac events. RESEARCH DESIGN AND METHODS:We an...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/dc09-2104
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:Recent data suggest that residential environment may influence health behaviors and outcomes. We assessed whether perception of neighborhood problems was associated with diabetes behaviors and outcomes. RESEARCH DESIGN AND METHODS:This cross-sectional analysis included 7,830 diabetic adults enrolled in Trans...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/dc07-1111
更新日期:2008-02-01 00:00:00
abstract::In a patient with hyperthyroidism and newly diagnosed insulin-dependent diabetes mellitus (IDDM), insulin action and clearance were studied before the initiation of antithyroid treatment and at 3-mo intervals for 1 yr thereafter. The sequential euglycemic clamp technique (5 mM) was used with insulin infusion rates of ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.12.5.319
更新日期:1989-05-01 00:00:00
abstract:OBJECTIVE:Numerous studies have suggested a decreased risk of cancer in patients with diabetes on metformin. Because different comparison groups were used, the effect magnitude is difficult to estimate. Therefore, the objective of this study was to further analyze whether, and to what extent, use of metformin is associ...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/dc11-0857
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:To investigate the association between vitamin D status, assessed by plasma 25-hydroxyvitamin D, and risk of incident diabetes. RESEARCH DESIGN AND METHODS:Prospective observational study with a mean follow-up of 2.7 years in the Diabetes Prevention Program (DPP), a multicenter trial comparing different stra...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc11-1795
更新日期:2012-03-01 00:00:00