Significant synergistic effect of peroxisome proliferator-activated receptor gamma C-2821T and diabetes on the risk of ischemic stroke.

abstract：OBJECTIVE:The relative roles of insulin resistance and beta-cell dysfunction in the pathogenesis of impaired glucose tolerance (IGT) and type 2 diabetes are debated. First-degree relatives of individuals with type 2 diabetes are at increased risk of developing hyperglycemia. RESEARCH DESIGN AND METHODS:We evaluated th...

journal_title：Diabetes care

authors： Cnop M,Vidal J,Hull RL,Utzschneider KM,Carr DB,Schraw T,Scherer PE,Boyko EJ,Fujimoto WY,Kahn SE

更新日期：2007-03-01 00:00:00

abstract：:The role of hyperinsulinemia in the pathogenesis of triglyceride (TG) and VLDL over-production in insulin-resistant states remains controversial. While studies in humans and animals have generally suggested that chronic hyperinsulinemia facilitates VLDL production, particularly in the presence of an abundant supply of...

journal_title：Diabetes care

authors： Lewis GF,Steiner G

更新日期：1996-04-01 00:00:00

abstract：OBJECTIVE:Altered immune reactivity precedes and accompanies type 1 and type 2 diabetes. We hypothesized that the metabolic phenotype relates to the systemic cellular immune status. RESEARCH DESIGN AND METHODS:A total of 194 metabolically well-controlled patients with type 1 diabetes (n = 62, mean diabetes duration 1....

journal_title：Diabetes care

authors： Menart-Houtermans B,Rütter R,Nowotny B,Rosenbauer J,Koliaki C,Kahl S,Simon MC,Szendroedi J,Schloot NC,Roden M,German Diabetes Study Group.

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVE:To verify what information from oral glucose tolerance tests (OGTTs) independently predicts mortality. RESEARCH DESIGN AND METHODS:A total of 1,401 initially nondiabetic participants from the Baltimore Longitudinal Study of Aging aged 17-95 years underwent one or more OGTTs (median 2, range 1-8), with insuli...

journal_title：Diabetes care

authors： Metter EJ,Windham BG,Maggio M,Simonsick EM,Ling SM,Egan JM,Ferrucci L

更新日期：2008-05-01 00:00:00

abstract：:We have examined insulin and glucagon degrading activities of muscle and fat tissues in 11 subjects (4 lean controls, 3 insulin-resistant obese subjects, 2 non-insulin-dependent diabetic subjects, and 2 insulin-treated diabetic subjects) and correlated degrading activity with (1) basal insulin level and (2) state of i...

journal_title：Diabetes care

authors： Kitabchi AE,Stentz FB,Cole C,Duckworth WC

更新日期：1979-09-01 00:00:00

abstract：OBJECTIVE:Treatment guidelines for diabetes have become increasingly stringent as most research shows that more aggressive intervention reduces the risks for complications. Community data on the effect of these interventions are lacking. RESEARCH DESIGN AND METHODS:Changes in the pharmacologic treatment of diabetes, b...

journal_title：Diabetes care

authors： Looker HC,Krakoff J,Andre V,Kobus K,Nelson RG,Knowler WC,Hanson RL

更新日期：2010-11-01 00:00:00

abstract：:Significantly early-morning hyperglycemia was observed in insulin-dependent diabetic individuals who were otherwise well controlled while receiving a continuous subcutaneous insulin infusion (CSII) at standard doses. We measured the levels of the five key counterregulatory hormones (CRH) throughout the night for a tot...

journal_title：Diabetes care

authors： Geffner ME,Frank HJ,Kaplan SA,Lippe BM,Levin SR

更新日期：1983-03-01 00:00:00

abstract：OBJECTIVE:Screening involves the presumptive identification of asymptomatic individuals at increased risk for unrecognized disease. We examined changes in screening practices for prediabetes and diabetes since January 2010, when HbA1c was first recommended as an option for screening and diagnosis. RESEARCH DESIGN AND ...

journal_title：Diabetes care

authors： Evron JM,Herman WH,McEwen LN

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate alcohol consumption in relation to the incidence of type 2 diabetes. RESEARCH DESIGN AND METHODS:The study population consisted of 22778 twins of the Finnish Twin Cohort. This cohort was compiled in 1975 and includes all same-sexed twins born in Finland before 1958. I...

journal_title：Diabetes care

authors： Carlsson S,Hammar N,Grill V,Kaprio J

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVE:Limited data exist on the association between in utero exposure to maternal diabetes and obesity and type 2 diabetes in diverse youth. These associations were explored in African-American, Hispanic, and non-Hispanic white youth participating in the SEARCH Case-Control Study. RESEARCH DESIGN AND METHODS:A tot...

journal_title：Diabetes care

authors： Dabelea D,Mayer-Davis EJ,Lamichhane AP,D'Agostino RB Jr,Liese AD,Vehik KS,Narayan KM,Zeitler P,Hamman RF

更新日期：2008-07-01 00:00:00

abstract：:Biosynthetic human insulin (BHI) was compared with highly purified human pancreatic and pork insulin with regard to its ability to bind to erythrocytes of normal and insulin-dependent diabetic subjects (type I diabetes). The binding affinity or capacity of erythrocyte from both normal and diabetic subjects were compar...

journal_title：Diabetes care

authors： Bachmann W,Sieger C,Lacher F,Lotz N

更新日期：1981-03-01 00:00:00

abstract：OBJECTIVE:The goal of this study was to determine whether the haptoglobin (Hp) genotype was predictive of restenosis and major adverse cardiac events (MACEs) after percutaneous transluminal coronary angioplasty (PTCA) in individuals with diabetes. RESEARCH DESIGN AND METHODS:A consecutive series of 935 diabetic patien...

journal_title：Diabetes care

authors： Roguin A,Koch W,Kastrati A,Aronson D,Schomig A,Levy AP

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVE:To quantify age-related variability of insulin needs during day and night closed-loop insulin delivery. RESEARCH DESIGN AND METHODS:We retrospectively analyzed data from hybrid closed-loop studies involving young children (1-6 years old, n = 20), children (7-12 years, n = 21), adolescents (13-17 years, n = 1...

journal_title：Diabetes care

authors： Dovc K,Boughton C,Tauschmann M,Thabit H,Bally L,Allen JM,Acerini CL,Arnolds S,de Beaufort C,Bergenstal RM,Campbell F,Criego A,Dunger DB,Elleri D,Evans ML,Fröhlich-Reiterer E,Hofer S,Kapellen T,Leelarathna L,Pieber T

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:To understand why low-fat high-carbohydrate (CHO) diets lead to higher fasting and postprandial concentrations of triglyceride (TG)-rich lipoproteins in patients with non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS:Patients with NIDDM were placed randomly on diets containing eith...

journal_title：Diabetes care

authors： Chen YD,Coulston AM,Zhou MY,Hollenbeck CB,Reaven GM

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:We evaluated the safety and efficacy of day-and-night fully closed-loop insulin therapy using faster (Faster-CL) compared with standard insulin aspart (Standard-CL) in young adults with type 1 diabetes. RESEARCH DESIGN AND METHODS:In a double-blind, randomized, crossover trial, 20 participants with type 1 di...

journal_title：Diabetes care

authors： Dovc K,Piona C,Yeşiltepe Mutlu G,Bratina N,Jenko Bizjan B,Lepej D,Nimri R,Atlas E,Muller I,Kordonouri O,Biester T,Danne T,Phillip M,Battelino T

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:To assess effectiveness of inpatient hybrid closed-loop control (HCLC) followed by outpatient sensor-augmented pump (SAP) therapy initiated within 7 days of diagnosis of type 1 diabetes on the preservation of β-cell function at 1 year. RESEARCH DESIGN AND METHODS:Sixty-eight individuals (mean age 13.3 ± 5.7 ...

journal_title：Diabetes care

authors： Buckingham B,Beck RW,Ruedy KJ,Cheng P,Kollman C,Weinzimer SA,DiMeglio LA,Bremer AA,Slover R,Tamborlane WV,Diabetes Research in Children Network (DirecNet) Study Group.,Type 1 Diabetes TrialNet Study Group.

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVE:To address whether hemodynamic responses in the cerebral arteries and OAs may be altered in patients with diabetic retinopathy. We used TCD to evaluate the effects of changes in BP, posture, and exercise on MCA and OA blood flow velocities. RESEARCH DESIGN AND METHODS:We evaluated 13 patients with BDR, 19 wi...

journal_title：Diabetes care

authors： Albert SG,Gomez CR,Russell S,Chaitman BR,Bernbaum M,Kong BA

更新日期：1993-02-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to evaluate the effects of a combination weight loss program using intermittent low-calorie diets, energy-controlled meal replacement products, and sibutramine on weight loss, diabetes control, and cardiovascular risk factors in overweight or obese subjects with type 2 diabetes. ...

journal_title：Diabetes care

authors： Redmon JB,Raatz SK,Reck KP,Swanson JE,Kwong CA,Fan Q,Thomas W,Bantle JP

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVE:Regular physical activity (PA) reduces the risk of developing type 2 diabetes, and different subtypes of dysglycemia have shown different associations with PA. To better understand the associations of PA and glucose homeostasis, we examined the association of objectively measured PA energy expenditure (PAEE) ...

journal_title：Diabetes care

authors： Hansen AL,Carstensen B,Helge JW,Johansen NB,Gram B,Christiansen JS,Brage S,Lauritzen T,Jørgensen ME,Aadahl M,Witte DR,ADDITION-Denmark Steering Committee.

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVE:To determine whether folate metabolism in pregnant diabetic women is significantly different from that in pregnant nondiabetic women, thus predisposing them to having offspring with major congenital anomalies. RESEARCH DESIGN AND METHODS:A total of 31 pregnant diabetic women and 54 pregnant nondiabetic contr...

journal_title：Diabetes care

authors： Kaplan JS,Iqbal S,England BG,Zawacki CM,Herman WH

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVE:Intensive lifestyle intervention significantly reduced diabetes incidence among the participants in the Finnish Diabetes Prevention Study. We investigated whether and to what extent risk factors for type 2 diabetes and other baseline characteristics of the study participants modified the effectiveness of the ...

journal_title：Diabetes care

authors： Lindström J,Peltonen M,Eriksson JG,Aunola S,Hämäläinen H,Ilanne-Parikka P,Keinänen-Kiukaanniemi S,Uusitupa M,Tuomilehto J,Finnish Diabetes Prevention Study (DPS) Group.

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVE:Patients with type 1 diabetes (T1D) have a higher risk of developing chronic kidney disease, cardiovascular events (CVEs), and mortality than the general population. We hypothesized that two previously published biomarkers, namely PRO-C6, a biomarker of collagen type VI formation, and C3M, a biomarker of coll...

journal_title：Diabetes care

authors： Pilemann-Lyberg S,Rasmussen DGK,Hansen TW,Tofte N,Winther SA,Holm Nielsen S,Theilade S,Karsdal MA,Genovese F,Rossing P

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:To assess the efficacy and safety of initial combination therapy with sitagliptin and metformin in patients with type 2 diabetes and inadequate glycemic control on diet and exercise. RESEARCH DESIGN AND METHODS:In a 24-week, randomized, double-blind, placebo-controlled, parallel-group study, 1,091 patients w...

journal_title：Diabetes care

authors： Goldstein BJ,Feinglos MN,Lunceford JK,Johnson J,Williams-Herman DE,Sitagliptin 036 Study Group.

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVE:To examine patients' views of the acceptability of and satisfaction with telephone care center support provided to improve blood glucose control in type 2 diabetes. RESEARCH DESIGN AND METHODS:The Pro-Active Call-Center Treatment Support (PACCTS) Trial randomized patients from 47 general practices in a depri...

journal_title：Diabetes care

authors： Long AF,Gambling T,Young RJ,Taylor J,Mason JM,PACCTS Team.

更新日期：2005-02-01 00:00:00

abstract：OBJECTIVE:The goal was to assess the 1-year efficacy and safety of the addition of pioglitazone or metformin to existing sulfonylurea (SU) therapy in patients with inadequately controlled type 2 diabetes. RESEARCH DESIGN AND METHODS:In this multicenter, double-blind study, patients were randomized to receive either pi...

journal_title：Diabetes care

authors： Hanefeld M,Brunetti P,Schernthaner GH,Matthews DR,Charbonnel BH,QUARTET Study Group.

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:Wound healing is known to require a well-organized balance of numerous factors, e.g., cytokines, matrix metalloproteinases (MMPs), and their inhibitors, as well as direct cell-cell communication (connexins). Disruption of this balance may lead to the formation of chronic wounds such as diabetic foot ulcers. T...

journal_title：Diabetes care

authors： Brandner JM,Zacheja S,Houdek P,Moll I,Lobmann R

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:To examine the hypothesis that hyperinsulinemia among relatives of NIDDM probands will increase the prevalence of DLPs, we measured insulin levels and examined the frequency of DLPs among NIDDM pedigree members. RESEARCH DESIGN AND METHODS:We performed 2-h 75-g OGTTs and measured lipid and insulin levels of ...

journal_title：Diabetes care

authors： Schumacher MC,Maxwell TM,Wu LL,Hunt SC,Williams RR,Elbein SC

更新日期：1992-10-01 00:00:00

abstract：OBJECTIVE:To assess the efficacy and safety of topical human recombinant basic fibroblast growth factor (bFGF) on the healing of diabetic neurotrophic foot ulcers. RESEARCH DESIGN AND METHODS:Seventeen diabetic patients suffering from chronic neuropathic ulcer of the plantar surface of the foot entered a pilot, random...

journal_title：Diabetes care

authors： Richard JL,Parer-Richard C,Daures JP,Clouet S,Vannereau D,Bringer J,Rodier M,Jacob C,Comte-Bardonnet M

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:We have demonstrated high heritability of insulin secretion measured as acute insulin response to glucose times insulin sensitivity (disposition index). Furthermore, we showed that obese normoglycemic family members of a type 2 diabetic proband failed to compensate for the insulin resistance of obesity by inc...

journal_title：Diabetes care

authors： Elbein SC,Sun J,Scroggin E,Teng K,Hasstedt SJ

更新日期：2001-03-01 00:00:00

abstract：:Whereas self-monitoring of blood glucose (SMBG) is the recommended source of information on which to make self-care decisions, patients frequently use estimates of their own blood glucose (BG). This study evaluated whether patients with insulin-dependent diabetes mellitus (IDDM) could learn to improve accuracy of BG e...

journal_title：Diabetes care

authors： Cox DJ,Gonder-Frederick LA,Lee JH,Julian DM,Carter WR,Clarke WL

更新日期：1989-05-01 00:00:00