Young Children Have Higher Variability of Insulin Requirements: Observations During Hybrid Closed-Loop Insulin Delivery.

abstract：OBJECTIVE:Because the bovine serum albumin residues 126-144 (ABBOS) have been reported to be responsible for the autoimmune reaction directed against pancreatic islet cells, it was our aim to study the potential survival of the ABBOS epitope during digestion in the gastrointestinal tract. RESEARCH DESIGN AND METHODS:E...

journal_title：Diabetes care

authors： Alting AC,Meijer RJ,van Beresteijn EC

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVE:To test the conclusion that there is no association between multiple episodes of severe hypoglycemia and cognitive decrements by reanalyzing the data from the Diabetes Control and Complications Trial (DCCT) with psychometrically validated cognitive factors and to conduct a novel analysis of the association be...

journal_title：Diabetes care

authors： Austin EJ,Deary IJ

更新日期：1999-08-01 00:00:00

abstract：:Twenty-eight patients with type I diabetes mellitus, legally blind as a result of proliferative retinopathy, were recruited into a program designed to teach and evaluate tactile methods for self-monitoring of blood glucose (SMBG). Vision ranged from "blind" to "able to read large print." Techniques with wipe-off strip...

journal_title：Diabetes care

authors： Prior JC,Alojado NC,Hunt JA,Begg IS

更新日期：1984-07-01 00:00:00

abstract：OBJECTIVE:Bimodality in the distribution of glucose has been used to define the cut point for the diagnosis of diabetes. Previous studies on bimodality have primarily been in populations with a high prevalence of type 2 diabetes, including one study in a white Caucasian population. All studies included participants wit...

journal_title：Diabetes care

authors： Vistisen D,Colagiuri S,Borch-Johnsen K,DETECT-2 Collaboration.

更新日期：2009-03-01 00:00:00

abstract：:This review focuses on recent advances in molecular biology as they pertain to the insulin gene and diabetes mellitus. The structure of the human insulin gene is examined, and factors related to its normal functioning in the beta cells of the pancreas are explored. DNA polymorphisms near the insulin locus and their re...

journal_title：Diabetes care

authors： Permutt MA,Chirgwin J,Rotwein P,Giddings S

更新日期：1984-07-01 00:00:00

abstract：OBJECTIVE:The role of fibrosis in early progressive renal decline in type 2 diabetes is unknown. Circulating WFDC2 (WAP four-disulfide core domain protein 2) and matrix metalloproteinase 7 (MMP-7; Matrilysin) are postulated to be biomarkers of renal fibrosis. This study examined an association of circulating levels of ...

journal_title：Diabetes care

authors： Ihara K,Skupien J,Kobayashi H,Md Dom ZI,Wilson JM,O'Neil K,Badger HS,Bowsman LM,Satake E,Breyer MD,Duffin KL,Krolewski AS

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVE:We have previously shown that 300 kcal from glucose intake induces a significant increase in reactive oxygen species (ROS) generation and nuclear factor-kappaB (NF-kappaB) binding in the circulating mononuclear cells in healthy normal subjects. We hypothesized that the intake of 300 calories as orange juice o...

journal_title：Diabetes care

authors： Ghanim H,Mohanty P,Pathak R,Chaudhuri A,Sia CL,Dandona P

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:This study evaluated the feasibility, safety, and efficacy of day-and-night hybrid closed-loop insulin delivery in adolescents with type 1 diabetes under free-living conditions. RESEARCH DESIGN AND METHODS:In an open-label randomized crossover study, 12 suboptimally controlled adolescents on insulin pump the...

journal_title：Diabetes care

authors： Tauschmann M,Allen JM,Wilinska ME,Thabit H,Acerini CL,Dunger DB,Hovorka R

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:To provide reliable data on the incidence of insulin-dependent diabetes mellitus (IDDM) in children (< 15 years of age) in Avellaneda, Argentina. RESEARCH DESIGN AND METHODS:A registry was established in Avellaneda, Argentina. The first registry was started in 1989, retrospective data collection was updated ...

journal_title：Diabetes care

authors： Sereday MS,Martí ML,Damiano MM,Moser ME

更新日期：1994-09-01 00:00:00

abstract：:The concept of gestational diabetes goes back at least to 1946. Over the years, sophistication has increased regarding the pathophysiology of this condition. However, there is not universal agreement on how to diagnose gestational diabetes. The most widely used diagnostic criteria in the U.S. were validated by their p...

journal_title：Diabetes care

authors： Coustan DR,Carpenter MW

更新日期：1998-08-01 00:00:00

abstract：OBJECTIVE:The primary outcome is to evaluate the relationship between diabetes distress and decisional conflict regarding diabetes care in patients with diabetes and two or more comorbidities. Secondary outcomes include the relationships between diabetes distress and quality of life and patient perception of chronic il...

journal_title：Diabetes care

authors： Bruno BA,Choi D,Thorpe KE,Yu CH

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:To examine the evolution of the dysregulated glucagon responses to mixed-meal tolerance tests (MMTTs) in youth with recent-onset type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS:MMTTs were performed in 25 youth (9-18 years of age) with 1.5-12 months disease duration (year 1); 22 subjects were restudied 1 y...

journal_title：Diabetes care

authors： Sherr J,Tsalikian E,Fox L,Buckingham B,Weinzimer S,Tamborlane WV,White NH,Arbelaez AM,Kollman C,Ruedy KJ,Cheng P,Beck RW,Diabetes Research in Children Network.

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:The aim was to explore relationships between work-related factors, work-related diabetes distress (WRDD), diabetes distress (measured by Problem Areas in Diabetes [PAID]-5 scale), intentional hyperglycemia at work (IHW), and glycemic control. RESEARCH DESIGN AND METHODS:A cross-sectional survey was conducted...

journal_title：Diabetes care

authors： Hansen UM,Skinner T,Olesen K,Willaing I

更新日期：2019-05-01 00:00:00

abstract：:This study describes the pharmacokinetics of three intermediate-acting insulin preparations, NPH porcine insulin, NPH human insulin (recombinant DNA), and "Depot-A" insulin, a mixture of 20% regular and 80% NPH human insulin from Eli Lilly and Company. Metabolic healthy normal weight volunteers were selected for the s...

journal_title：Diabetes care

authors： Bottermann P,Gyaram H,Wahl K,Ermler R,Lebender A

更新日期：1982-11-01 00:00:00

abstract：OBJECTIVE:Diabetes is a predictor of both coronary artery disease (CAD) and heart failure. It is unknown to what extent the association between diabetes and heart failure is influenced by other risk factors for heart failure. RESEARCH DESIGN AND METHODS:We evaluated the association of diabetes and A1C with incident he...

journal_title：Diabetes care

authors： van Melle JP,Bot M,de Jonge P,de Boer RA,van Veldhuisen DJ,Whooley MA

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:To investigate whether the fall in soluble L-selectin (sL-selectin) level constitutes a marker for myocardial ischemia. RESEARCH DESIGN AND METHODS:The levels of soluble forms of adhesion molecules, i.e., intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), E-selectin (sE...

journal_title：Diabetes care

authors： Albertini JP,Valensi P,Lormeau B,Vaysse J,Attali JR,Gattegno L

更新日期：1999-12-01 00:00:00

abstract：OBJECTIVE:To characterize physiologic subtypes of gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS:Insulin sensitivity and secretion were estimated in 809 women at 24-30 weeks' gestation, using oral glucose tolerance test-based indices. In women with GDM (8.3%), defects in insulin sensitivity or secret...

journal_title：Diabetes care

authors： Powe CE,Allard C,Battista MC,Doyon M,Bouchard L,Ecker JL,Perron P,Florez JC,Thadhani R,Hivert MF

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVE:In 2010, the American Diabetes Association (ADA) added hemoglobin A1c (A1C) to the guidelines for diagnosing type 2 diabetes. However, existing models for predicting diabetes risk were developed prior to the widespread adoption of A1C. Thus, it remains unknown how well existing diabetes risk prediction models...

journal_title：Diabetes care

authors： Lacy ME,Wellenius GA,Carnethon MR,Loucks EB,Carson AP,Luo X,Kiefe CI,Gjelsvik A,Gunderson EP,Eaton CB,Wu WC

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVE:Supplementation of type II diabetic diets with n-3 fatty acids (FAs) from fish oil (FO) has been associated with lowered triglyceride and VLDL levels, although reports of impaired glycemic control have limited their use. Effects of n-3FAs from nonmarine sources are less well documented. Therefore, an investig...

journal_title：Diabetes care

authors： McManus RM,Jumpson J,Finegood DT,Clandinin MT,Ryan EA

更新日期：1996-05-01 00:00:00

abstract：:Use of continuous subcutaneous insulin infusion requires continuing available care by skilled professionals, careful selection of patients, meticulous patient monitoring, and provisions for recording and reporting experiences. Insulin pumps prescribed by a physician within these guidelines are a part of treatment and ...

journal_title：Diabetes care

authors：

更新日期：1985-09-01 00:00:00

abstract：OBJECTIVE:Endothelial markers endothelin 1 (ET-1) and von Willebrand factor (vWF) were assessed in patients with type 2 diabetes and dyslipidemia and in patients with hypercholesterolemia. RESEARCH DESIGN AND METHODS:In this case-control study, plasma ET-and vWF levels were measured by enzyme-linked immunosorbent assa...

journal_title：Diabetes care

authors： Seligman BG,Biolo A,Polanczyk CA,Gross JL,Clausell N

更新日期：2000-09-01 00:00:00

abstract：OBJECTIVE:Success after islet transplantation can be defined in terms of insulin independence, C-peptide secretion, or glycemic control. These measures are interdependent and all need to be considered in evaluating beta-cell function after islet transplantation. For the current study, a composite beta-score was develop...

journal_title：Diabetes care

authors： Ryan EA,Paty BW,Senior PA,Lakey JR,Bigam D,Shapiro AM

更新日期：2005-02-01 00:00:00

abstract：:The etiology of impotence in the diabetic population has not been clearly defined. To assess this problem, 24 impotent diabetic subjects, 21 nonimpotent diabetic subjects, and 10 subjects with psychogenic impotence were compared with nocturnal monitoring of penile tumescence and rigidity, penile arterial blood flow, a...

journal_title：Diabetes care

authors： Daniels JS

更新日期：1989-07-01 00:00:00

abstract：OBJECTIVE:To evaluate whether plasma levels of free fatty acids (FFAs) are independently associated with incidence of type 2 diabetes. RESEARCH DESIGN AND METHODS:A case-cohort design was used to randomly select 580 incident cases of diabetes and 566 noncases from 10,275 African-American and white men and women in the...

journal_title：Diabetes care

authors： Pankow JS,Duncan BB,Schmidt MI,Ballantyne CM,Couper DJ,Hoogeveen RC,Golden SH,Atherosclerosis Risk in Communities Study.

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:To assess the prevalence of diabetes and prediabetes and the associated risk factors in two Asian Indian populations living in different environments. RESEARCH DESIGN AND METHODS:We performed cross-sectional analyses, using representative samples of 2,305 Asian Indians aged 40-84 years living in Chennai, Ind...

journal_title：Diabetes care

authors： Gujral UP,Narayan KM,Pradeepa RG,Deepa M,Ali MK,Anjana RM,Kandula NR,Mohan V,Kanaya AM

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:We investigated the effect of glimepiride, a third-generation sulfonylurea hypoglycemic agent, on insulin resistance in elderly patients with type 2 diabetes, in connection with plasma adiponectin and 8-epi-prostagrandin F2alpha (8-epi-PGF2alpha), an oxidative stress marker. RESEARCH DESIGN AND METHODS:A tot...

journal_title：Diabetes care

authors： Tsunekawa T,Hayashi T,Suzuki Y,Matsui-Hirai H,Kano H,Fukatsu A,Nomura N,Miyazaki A,Iguchi A

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVE:To evaluate the relationship between renal function, ambulatory blood pressure (AMBP), and glycemic control in microalbuminuric IDDM patients compared with normoalbuminuric patients. RESEARCH DESIGN AND METHODS:Nineteen male patients (age 33 +/- 6 years) with slight microalbuminuria (UAE 20-70 micrograms/min...

journal_title：Diabetes care

authors： Poulsen PL,Juhl B,Ebbehøj E,Klein F,Christiansen C,Mogensen CE

更新日期：1997-03-01 00:00:00

abstract：:The relationship of two aspects of family life to metabolic control were examined as part of a longitudinal study of school-aged children with newly diagnosed insulin-dependent diabetes mellitus (IDDM). Glycosylated hemoglobin level was the primary index of metabolic control; weight-adjusted insulin dosage served as a...

journal_title：Diabetes care

authors： Kovacs M,Kass RE,Schnell TM,Goldston D,Marsh J

更新日期：1989-06-01 00:00:00

abstract：OBJECTIVE:Several methods have been proposed to evaluate insulin sensitivity from the data obtained from the oral glucose tolerance test (OGTT). However, the validity of these indices has not been rigorously evaluated by comparing them with the direct measurement of insulin sensitivity obtained with the euglycemic insu...

journal_title：Diabetes care

authors： Matsuda M,DeFronzo RA

更新日期：1999-09-01 00:00:00

abstract：OBJECTIVE:Recent studies show the importance of controlling blood glucose variability in relationship to both reducing hypoglycemia and attenuating the risk for cardiovascular and behavioral complications due to hyperglycemia. It is therefore important to design variability measures that are equally predictive of low a...

journal_title：Diabetes care

authors： Kovatchev BP,Otto E,Cox D,Gonder-Frederick L,Clarke W

更新日期：2006-11-01 00:00:00