Increased plasma levels of endothelin 1 and von Willebrand factor in patients with type 2 diabetes and dyslipidemia.


OBJECTIVE:Endothelial markers endothelin 1 (ET-1) and von Willebrand factor (vWF) were assessed in patients with type 2 diabetes and dyslipidemia and in patients with hypercholesterolemia. RESEARCH DESIGN AND METHODS:In this case-control study, plasma ET-and vWF levels were measured by enzyme-linked immunosorbent assay in 35 normoalbuminuric type 2 diabetic patients with dyslipidemia (56+/-5 years), in 21 nondiabetic patients with hypercholesterolemia (52+/-7 years), and in 19 healthy control subjects (45+/-4 years). All of the individuals were normotensive and nonsmokers. Urinary albumin was measured by immunoturbidimetry. RESULTS:ET-1 levels were higher (P<0.0001) in type 2 diabetic dyslipidemic patients (1.62+/-0.73 pg/ml) than in both nondiabetic hypercholesterolemic patients (0.91+/-0.73 pg/ml) and control subjects (0.69+/-0.25 pg/ml). vWF levels were significantly increased (P = 0.02) in type 2 diabetic (185.49+/-72.1%) and hypercholesterolemic (163.29+/-50.7%) patients compared with control subjects (129.70+/-35.2%). In the multiple linear regression analysis. ET-1 was significantly associated (adjusted r2 = 0.42) with serum triglyceride levels (P<0.001), age (P<0.01), insulin sensitivity index (P<0.02), and albuminuria levels (P<0.04). vWF levels were associated (adjusted r2 = 0.22) with albuminuria (P<0.001), fibrinogen levels (P<0.02), and BMI (P<0.03). CONCLUSIONS:Compared with hypercholesterolemic patients, type 2 diabetic patients with dyslipidemia have increased levels of ET-1 and vWF which may indicate more pronounced endothelial injury. These findings appear to be related to components of the insulin resistance syndrome.


Diabetes Care


Diabetes care


Seligman BG,Biolo A,Polanczyk CA,Gross JL,Clausell N




Has Abstract


2000-09-01 00:00:00












  • Fatty acid composition of serum lipid fractions in type 2 diabetic patients with microalbuminuria.

    abstract:OBJECTIVE:To determine the fatty acid composition of serum phospholipid, triglyceride, and cholesterol ester fractions and to analyze the lipid profile of microalbuminuric type 2 diabetic patients. RESEARCH DESIGN AND METHODS:A case-control study was conducted with 72 patients: 37 were normoalbuminuric (urinary albumi...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Perassolo MS,Almeida JC,Prá RL,Mello VD,Maia AL,Moulin CC,Camargo JL,Zelmanovitz T,Azevedo MJ,Gross JL

    更新日期:2003-03-01 00:00:00

  • Diabetes research in the Department of Veterans Affairs.

    abstract:OBJECTIVE:To provide an overview of the Department of Veterans Affairs (VA) research activities, highlighting diabetes-related research. RESEARCH DESIGN AND METHODS:Diabetes is an important component of the VA research portfolio. All four VA research services support aspects of diabetes research. VA diabetes research ...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Reiber GE,Boyko EJ

    更新日期:2004-05-01 00:00:00

  • Effect of pregnancy on autonomic nervous function and heart rate in diabetic and nondiabetic women.

    abstract::Supine and standing heart rate and heart rate responses to deep breathing and standing up (the 30-to-15 ratio), indices of autonomic nervous function, were measured during each trimester and postpartum in 25 women with insulin-dependent diabetes and 10 nondiabetic women. The groups did not differ with respect to auton...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Airaksinen KE,Salmela PI,Ikäheimo MJ,Kirkinen P,Linnaluoto MK,Takkunen JT

    更新日期:1987-11-01 00:00:00

  • Validation of a counseling strategy to promote the adoption and the maintenance of physical activity by type 2 diabetic subjects.

    abstract:OBJECTIVE:There is enough evidence that physical activity is an effective therapeutic tool in the management of type 2 diabetes. The present study was designed to validate a counseling strategy that could be used by physicians in their daily outpatient practice to promote the adoption and maintenance of physical activi...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Di Loreto C,Fanelli C,Lucidi P,Murdolo G,De Cicco A,Parlanti N,Santeusanio F,Brunetti P,De Feo P

    更新日期:2003-02-01 00:00:00

  • Nocturnal cortisol release during hypoglycemia in diabetes.

    abstract::Nocturnal hypoglycemia in insulin-treated diabetic persons is often difficult to recognize clinically. It has been suggested that a useful biochemical test to demonstrate this would be the increased excretion of cortisol in the urine during the overnight period. However, of six diabetic persons who had nocturnal hypog...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Scott RS,Scandrett MS

    更新日期:1981-09-01 00:00:00

  • Impact of oral antihyperglycemic therapy on all-cause mortality among patients with diabetes in the Veterans Health Administration.

    abstract:OBJECTIVE:The objective of this analysis was to evaluate the impact of several classes of oral antihyperglycemic therapy relative to sulfonylurea monotherapy on all-cause mortality among a cohort of patients with diabetes from the Veterans Health Administration (VHA). RESEARCH DESIGN AND METHODS:A retrospective cohort...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Kahler KH,Rajan M,Rhoads GG,Safford MM,Demissie K,Lu SE,Pogach LM

    更新日期:2007-07-01 00:00:00

  • Circulating levels of adipocyte and epidermal fatty acid-binding proteins in relation to nephropathy staging and macrovascular complications in type 2 diabetic patients.

    abstract:OBJECTIVE:To investigate the relationships of serum adipocyte fatty acid-binding protein (A-FABP) and epidermal fatty acid-binding protein (E-FABP) with renal dysfunction and macrovascular complications in type 2 diabetic patients. RESEARCH DESIGN AND METHODS:The associations of serum A-FABP and E-FABP with markers of...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Yeung DC,Xu A,Tso AW,Chow WS,Wat NM,Fong CH,Tam S,Sham PC,Lam KS

    更新日期:2009-01-01 00:00:00

  • Insulin analogs--is there a compelling case to use them? No!

    abstract::The availability of insulin analogs has offered insulin replacement strategies that are proposed to more closely mimic normal human physiology. Specifically, there are a considerable number of reports demonstrating that prandial insulin analogs (lispro, aspart, glulisine) have pharmacokinetic and pharmacodynamic profi...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Davidson MB

    更新日期:2014-06-01 00:00:00

  • Regional primary care team to deliver best-practice diabetes care: a needs-driven health workforce model reflecting a biopsychosocial construct of health.

    abstract:OBJECTIVE:Best-practice diabetes care can reduce the burden of diabetes and associated health care costs. But this requires access to a multidisciplinary team with the right skill mix. We applied a needs-driven evidence-based health workforce model to describe the primary care team required to support best-practice dia...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Segal L,Leach MJ,May E,Turnbull C

    更新日期:2013-07-01 00:00:00

  • The SEE Study: Safety, Efficacy, and Equity of Implementing Autonomous Artificial Intelligence for Diagnosing Diabetic Retinopathy in Youth.

    abstract:OBJECTIVE:Diabetic retinopathy (DR) is a leading cause of vision loss worldwide. Screening for DR is recommended in children and adolescents, but adherence is poor. Recently, autonomous artificial intelligence (AI) systems have been developed for early detection of DR and have been included in the American Diabetes Ass...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Wolf RM,Liu TYA,Thomas C,Prichett L,Zimmer Galler I,Smith K,Abramoff MD,Channa R

    更新日期:2021-01-21 00:00:00

  • The Impact of Diabetes on Breast Cancer Treatments and Outcomes: A Population-Based Study.

    abstract:OBJECTIVE:Women with breast cancer and diabetes face worse outcomes than those with breast cancer without diabetes; however, the contribution of comorbidity to these disparities remains unclear. We evaluated the impact of diabetes on receipt of cancer treatments as well as mortality while accounting for other comorbidi...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Lega IC,Austin PC,Fischer HD,Fung K,Krzyzanowska MK,Amir E,Lipscombe LL

    更新日期:2018-04-01 00:00:00

  • Diabetes is associated with dramatically decreased survival in female but not male subjects with cystic fibrosis.

    abstract:OBJECTIVE:Survival analysis was performed on a prospectively followed cohort of patients with cystic fibrosis (CF) to determine the impact of the development of diabetes on survival. RESEARCH DESIGN AND METHODS:Clinical data were retrieved for patients diagnosed with CF-related diabetes (CFRD) at the Minnesota CF Cent...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Milla CE,Billings J,Moran A

    更新日期:2005-09-01 00:00:00

  • Effect of ezetimibe on hepatic fat, inflammatory markers, and apolipoprotein B-100 kinetics in insulin-resistant obese subjects on a weight loss diet.

    abstract:OBJECTIVE:Nonalcoholic fatty liver disease is highly prevalent in obese and type 2 diabetic individuals and is strongly associated with dyslipidemia and inflammation. Weight loss and/or pharmacotherapy are commonly used to correct these abnormalities. RESEARCH DESIGN AND METHODS:We performed a 16-week intervention tri...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验


    authors: Chan DC,Watts GF,Gan SK,Ooi EM,Barrett PH

    更新日期:2010-05-01 00:00:00

  • The validation of a diabetes patient knowledge test.

    abstract::Diabetes knowledge tests, used in conjunction with measures of patient attitudes and behaviors, can provide a useful basis for assessing educational needs and designing appropriate instructional experiences. Accurate decisions require instruments that measure patient knowledge of diabetes and its management with high ...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Hess GE,Davis WK

    更新日期:1983-11-01 00:00:00

  • Peroxisome proliferator-activated receptor γ polymorphism Pro12Ala Is associated with nephropathy in type 2 diabetes: evidence from meta-analysis of 18 studies.

    abstract:OBJECTIVE:Insulin resistance plays a part in diabetic nephropathy (DN). The association between the peroxisome proliferator-activated receptor γ Pro to Ala alteration at codon 12 (Pro12Ala) polymorphism and the risk of insulin resistance has been confirmed. The association between the polymorphism and DN risk has also ...

    journal_title:Diabetes care

    pub_type: 杂志文章,meta分析


    authors: Zhang H,Zhu S,Chen J,Tang Y,Hu H,Mohan V,Venkatesan R,Wang J,Chen H

    更新日期:2012-06-01 00:00:00

  • Advancing basal insulin replacement in type 2 diabetes inadequately controlled with insulin glargine plus oral agents: a comparison of adding albiglutide, a weekly GLP-1 receptor agonist, versus thrice-daily prandial insulin lispro.

    abstract:OBJECTIVE:GLP-1 receptor agonists may provide an alternative to prandial insulin for advancing basal insulin therapy. Harmony 6 was a randomized, open-label, active-controlled trial testing once-weekly albiglutide vs. thrice-daily prandial insulin lispro as an add-on to titrated once-daily insulin glargine. RESEARCH D...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Rosenstock J,Fonseca VA,Gross JL,Ratner RE,Ahrén B,Chow FC,Yang F,Miller D,Johnson SL,Stewart MW,Leiter LA,Harmony 6 Study Group.

    更新日期:2014-08-01 00:00:00

  • Diabetes, inflammation, and functional decline in older adults: findings from the Health, Aging and Body Composition (ABC) study.

    abstract:OBJECTIVE:Age, diabetes, and elevated inflammatory markers independently increase the risk of functional decline. We examined the effect of C-reactive protein (CRP) and interleukin-6 (IL-6) on the incident mobility limitation in older adults with and without diabetes. RESEARCH DESIGN AND METHODS:We analyzed data from ...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Figaro MK,Kritchevsky SB,Resnick HE,Shorr RI,Butler J,Shintani A,Penninx BW,Simonsick EM,Goodpaster BH,Newman AB,Schwartz AV,Harris TB

    更新日期:2006-09-01 00:00:00

  • Differential association between biomarkers of subclinical inflammation and painful polyneuropathy: results from the KORA F4 study.

    abstract:OBJECTIVE:Inflammatory processes have been implicated in the pathogenesis of painful neuropathy in rodents, but the relationship between inflammatory biomarkers and painful distal sensorimotor polyneuropathy (DSPN) has not been assessed in population-based studies. Therefore, we investigated whether circulating levels ...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Herder C,Bongaerts BW,Rathmann W,Heier M,Kowall B,Koenig W,Thorand B,Roden M,Meisinger C,Ziegler D

    更新日期:2015-01-01 00:00:00

  • Binding of biosynthetic human insulin to erythrocytes of normal and insulin-dependent diabetic subjects: comparison with pork and human pancreatic insulin.

    abstract::Biosynthetic human insulin (BHI) was compared with highly purified human pancreatic and pork insulin with regard to its ability to bind to erythrocytes of normal and insulin-dependent diabetic subjects (type I diabetes). The binding affinity or capacity of erythrocyte from both normal and diabetic subjects were compar...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Bachmann W,Sieger C,Lacher F,Lotz N

    更新日期:1981-03-01 00:00:00

  • Food insecurity and glycemic control among low-income patients with type 2 diabetes.

    abstract:OBJECTIVE:To determine whether food insecurity--the inability to reliably afford safe and nutritious food--is associated with poor glycemic control and whether this association is mediated by difficulty following a healthy diet, diabetes self-efficacy, or emotional distress related to diabetes. RESEARCH DESIGN AND MET...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Seligman HK,Jacobs EA,López A,Tschann J,Fernandez A

    更新日期:2012-02-01 00:00:00

  • Non-insulin-dependent diabetes: 10-year outcome in relation to initial response to diet and subsequent sulfonylurea therapy.

    abstract::Thirty-eight non-insulin-dependent diabetic patients within 130% of desirable body weight were given a 100-g oral glucose tolerance test (OGTT) at diagnosis and after at least 1 mo of dietary treatment with energy and carbohydrate restriction. Thirteen "responders" showed an improvement in fasting blood glucose, gluco...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章


    authors: Sönksen PH,Lowy C,Perkins JR,Lim HS

    更新日期:1984-05-01 00:00:00

  • Insomnia with objective short sleep duration is associated with type 2 diabetes: A population-based study.

    abstract:OBJECTIVE:We examined the joint effects of insomnia and objective short sleep duration, the combination of which is associated with higher morbidity, on diabetes risk. RESEARCH DESIGN AND METHODS:A total of 1,741 men and women randomly selected from Central Pennsylvania were studied in the sleep laboratory. Insomnia w...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Vgontzas AN,Liao D,Pejovic S,Calhoun S,Karataraki M,Bixler EO

    更新日期:2009-11-01 00:00:00

  • Incidence of stroke according to presence of diabetic nephropathy and severe diabetic retinopathy in patients with type 1 diabetes.

    abstract:OBJECTIVE:Type 1 diabetes is associated with a markedly increased risk of stroke, but only a few studies on the incidence of stroke in type 1 diabetes exist. Therefore, we assessed the incidence of stroke in patients with type 1 diabetes and studied the impact of diabetic nephropathy (DN) and severe diabetic retinopath...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究


    authors: Hägg S,Thorn LM,Putaala J,Liebkind R,Harjutsalo V,Forsblom CM,Gordin D,Tatlisumak T,Groop PH,FinnDiane Study Group.

    更新日期:2013-12-01 00:00:00

  • Association of Cardiometabolic Multimorbidity and Depression With Cardiovascular Events in Early-Onset Adult Type 2 Diabetes: A Multiethnic Study in the U.S.

    abstract:OBJECTIVE:To evaluate the temporal patterns of cardiometabolic multimorbidity (CM) and depression in White Caucasians (WCs) and African Americans (AAs) with early-onset type 2 diabetes and their impact on long-term atherosclerotic cardiovascular disease (ASCVD). RESEARCH DESIGN AND METHODS:From U.S. electronic medical...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Dibato JE,Montvida O,Zaccardi F,Sargeant JA,Davies MJ,Khunti K,Paul SK

    更新日期:2021-01-01 00:00:00

  • The effect of ruboxistaurin on nephropathy in type 2 diabetes.

    abstract:OBJECTIVE:Ruboxistaurin selectively inhibits protein kinase C-beta and ameliorates kidney disease in animal models of diabetes. The purpose of this study was to evaluate the effects of ruboxistaurin on diabetic nephropathy in humans. RESEARCH DESIGN AND METHODS:A randomized, double-blind, placebo-controlled, multicent...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Tuttle KR,Bakris GL,Toto RD,McGill JB,Hu K,Anderson PW

    更新日期:2005-11-01 00:00:00

  • Diabetic peripheral neuropathy is associated with increased arterial stiffness without changes in carotid intima-media thickness in type 2 diabetes.

    abstract:OBJECTIVE:This study was conducted to investigate the association of diabetic peripheral neuropathy (DPN) with both arterial stiffness and intima-media thickness (IMT). RESEARCH DESIGN AND METHODS:We conducted a cross-sectional analysis of 731 subjects with type 2 diabetes. DPN was diagnosed on the basis of neuropathi...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Kim ES,Moon SD,Kim HS,Lim DJ,Cho JH,Kwon HS,Ahn CW,Yoon KH,Kang MI,Cha BY,Son HY

    更新日期:2011-06-01 00:00:00

  • Use of Antihyperglycemic Medications in U.S. Adults: An Analysis of the National Health and Nutrition Examination Survey.

    abstract:OBJECTIVE:1) To examine trends in the use of diabetes medications and 2) to determine whether physicians individualize diabetes treatment as recommended by the American Diabetes Association (ADA). RESEARCH DESIGN AND METHODS:We conducted a retrospective, cross-sectional analysis of 2003-2016 National Health and Nutrit...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Le P,Chaitoff A,Misra-Hebert AD,Ye W,Herman WH,Rothberg MB

    更新日期:2020-06-01 00:00:00

  • Early-morning hyperglycemia in diabetic individuals treated with continuous subcutaneous insulin infusion.

    abstract::Significantly early-morning hyperglycemia was observed in insulin-dependent diabetic individuals who were otherwise well controlled while receiving a continuous subcutaneous insulin infusion (CSII) at standard doses. We measured the levels of the five key counterregulatory hormones (CRH) throughout the night for a tot...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Geffner ME,Frank HJ,Kaplan SA,Lippe BM,Levin SR

    更新日期:1983-03-01 00:00:00

  • Correlation of fingerstick blood glucose measurements with GlucoWatch biographer glucose results in young subjects with type 1 diabetes.

    abstract:OBJECTIVE:The purpose of this study was to compare measurements of glucose obtained via iontophoretic extraction with the GlucoWatch automatic glucose biographer (Cygnus, Inc., Redwood City, CA) with capillary blood glucose values that were determined 1) in a controlled outpatient clinic setting and 2) in a home settin...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章


    authors: Garg SK,Potts RO,Ackerman NR,Fermi SJ,Tamada JA,Chase HP

    更新日期:1999-10-01 00:00:00

  • Perception of neighborhood problems, health behaviors, and diabetes outcomes among adults with diabetes in managed care: the Translating Research Into Action for Diabetes (TRIAD) study.

    abstract:OBJECTIVE:Recent data suggest that residential environment may influence health behaviors and outcomes. We assessed whether perception of neighborhood problems was associated with diabetes behaviors and outcomes. RESEARCH DESIGN AND METHODS:This cross-sectional analysis included 7,830 diabetic adults enrolled in Trans...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究


    authors: Gary TL,Safford MM,Gerzoff RB,Ettner SL,Karter AJ,Beckles GL,Brown AF

    更新日期:2008-02-01 00:00:00