Abstract：
OBJECTIVE:Endothelial markers endothelin 1 (ET-1) and von Willebrand factor (vWF) were assessed in patients with type 2 diabetes and dyslipidemia and in patients with hypercholesterolemia. RESEARCH DESIGN AND METHODS:In this case-control study, plasma ET-and vWF levels were measured by enzyme-linked immunosorbent assay in 35 normoalbuminuric type 2 diabetic patients with dyslipidemia (56+/-5 years), in 21 nondiabetic patients with hypercholesterolemia (52+/-7 years), and in 19 healthy control subjects (45+/-4 years). All of the individuals were normotensive and nonsmokers. Urinary albumin was measured by immunoturbidimetry. RESULTS:ET-1 levels were higher (P<0.0001) in type 2 diabetic dyslipidemic patients (1.62+/-0.73 pg/ml) than in both nondiabetic hypercholesterolemic patients (0.91+/-0.73 pg/ml) and control subjects (0.69+/-0.25 pg/ml). vWF levels were significantly increased (P = 0.02) in type 2 diabetic (185.49+/-72.1%) and hypercholesterolemic (163.29+/-50.7%) patients compared with control subjects (129.70+/-35.2%). In the multiple linear regression analysis. ET-1 was significantly associated (adjusted r2 = 0.42) with serum triglyceride levels (P<0.001), age (P<0.01), insulin sensitivity index (P<0.02), and albuminuria levels (P<0.04). vWF levels were associated (adjusted r2 = 0.22) with albuminuria (P<0.001), fibrinogen levels (P<0.02), and BMI (P<0.03). CONCLUSIONS:Compared with hypercholesterolemic patients, type 2 diabetic patients with dyslipidemia have increased levels of ET-1 and vWF which may indicate more pronounced endothelial injury. These findings appear to be related to components of the insulin resistance syndrome.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Seligman BG,Biolo A,Polanczyk CA,Gross JL,Clausell Ndoi
10.2337/diacare.23.9.1395subject
Has Abstractpub_date
2000-09-01 00:00:00pages
1395-400issue
9eissn
0149-5992issn
1935-5548journal_volume
23pub_type
杂志文章相关文献
DIABETES CARE文献大全abstract：OBJECTIVE:Moderate alcohol consumption is associated with reduced incidence of type 2 diabetes and cardiovascular mortality and increases adiponectin concentrations, but effects might differ according to sex and beverage consumed. RESEARCH DESIGN AND METHODS:A total of 72 healthy individuals (22-56 years) were enrolle...
journal_title：Diabetes care
pub_type： 杂志文章,随机对照试验
doi：10.2337/dc08-1723
更新日期：2009-06-01 00:00:00
abstract：OBJECTIVE:Fat metabolism is increasingly implicated in the pathogenesis of type 2 diabetes. Endurance training has been shown to prevent hepatic steatosis and to alter skeletal muscle fat metabolism, and regional free fatty acid (FFA) uptake adaptations were suggested as a mechanism. Thus, we tested whether endurance t...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/diacare.27.9.2172
更新日期：2004-09-01 00:00:00
abstract：OBJECTIVE:To assess the prevalence of diabetes and prediabetes and the associated risk factors in two Asian Indian populations living in different environments. RESEARCH DESIGN AND METHODS:We performed cross-sectional analyses, using representative samples of 2,305 Asian Indians aged 40-84 years living in Chennai, Ind...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/dc15-0032
更新日期：2015-07-01 00:00:00
abstract：OBJECTIVE:Gestational diabetes mellitus (GDM) is an increasingly prevalent risk factor for the development of type 2 diabetes in the mother and is responsible for morbidity in the child. To better identify women at risk of developing GDM we examined sociodemographic correlates and changes in the prevalence of GDM among...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/dc08-1038
更新日期：2008-12-01 00:00:00
abstract：OBJECTIVE:Recent studies show the importance of controlling blood glucose variability in relationship to both reducing hypoglycemia and attenuating the risk for cardiovascular and behavioral complications due to hyperglycemia. It is therefore important to design variability measures that are equally predictive of low a...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/dc06-1085
更新日期：2006-11-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to elucidate whether serum adiponectin is associated with progression of diabetic nephropathy in type 1 diabetic patients. RESEARCH DESIGN AND METHODS:This was a prospective follow-up study as a part of the nationwide Finnish Diabetic Nephropathy Study; 1,330 type 1 diabetic pat...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/dc07-2306
更新日期：2008-06-01 00:00:00
abstract：OBJECTIVE:To determine whether adolescents with type 1 diabetes have left ventricular functional changes at rest and during acute exercise and whether these changes are affected by metabolic control and diabetes duration. RESEARCH DESIGN AND METHODS:The study evaluated 53 adolescents with type 1 diabetes and 22 contro...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/dc11-2331
更新日期：2012-10-01 00:00:00
abstract：OBJECTIVE:To compare fenofibric acid (FA) + statin to respective monotherapies on the prevalence of metabolic syndrome and its diagnostic components in patients with mixed dyslipidemia. RESEARCH DESIGN AND METHODS:Post hoc analysis of over 2,000 metabolic syndrome patients administered either FA + low- or moderate-dos...
journal_title：Diabetes care
pub_type： 杂志文章,随机对照试验
doi：10.2337/dc10-0357
更新日期：2010-09-01 00:00:00
abstract：OBJECTIVE:To examine the relationship between disordered eating attitudes and behaviors, BMI, and glycemic control in adolescents with type 1 diabetes. RESEARCH DESIGN AND METHODS:In a cross-sectional design, 152 adolescents (ages 11-19 years) completed three scales from the Eating Disorders Inventory (EDI): Body Diss...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/diacare.24.4.678
更新日期：2001-04-01 00:00:00
abstract：:Third-party reimbursement for outpatient education services and for new health care technologies in diabetes is an issue of concern to educators, administrators, and others in the diabetes health care system. Reimbursement for outpatient education has been obtained from 11 Blue Cross/Blue Shield plans in nine states, ...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/diacare.7.3.291
更新日期：1984-05-01 00:00:00
abstract：OBJECTIVE:To evaluate the association between self-reported diabetes and the risk of breast cancer (BC) and its interaction with moderate-intensity physical activity in pre- and postmenopausal Mexican women. RESEARCH DESIGN AND METHODS:A population-based case-control study was conducted using 1,000 incident case subje...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/dc11-2362
更新日期：2012-12-01 00:00:00
abstract：OBJECTIVE:GLP-1 receptor agonists may provide an alternative to prandial insulin for advancing basal insulin therapy. Harmony 6 was a randomized, open-label, active-controlled trial testing once-weekly albiglutide vs. thrice-daily prandial insulin lispro as an add-on to titrated once-daily insulin glargine. RESEARCH D...
journal_title：Diabetes care
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.2337/dc14-0001
更新日期：2014-08-01 00:00:00
abstract：OBJECTIVE:Left ventricular diastolic dysfunction (LVDD) is considered to be common in patients with type 2 diabetes mellitus (T2DM), but information on its progression over time is lacking. We studied the longitudinal development of left ventricular diastolic function (LVDF) and myocardial blood flow reserve in patient...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/dc14-0779
更新日期：2014-11-01 00:00:00
abstract：OBJECTIVE:To examine determinants of racial/ethnic differences in diabetes incidence among postmenopausal women participating in the Women's Health Initiative. RESEARCH DESIGN AND METHODS:Data on race/ethnicity, baseline diabetes prevalence, and incident diabetes were obtained from 158,833 women recruited from 1993-19...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/dc12-0412
更新日期：2012-11-01 00:00:00
abstract：OBJECTIVE:In a few previous studies, cardiovascular disease (CVD) risk factors (RFs) have been shown to predict diabetes. Our objective was to determine whether the presence of CVD RFs predict the eventual development of diabetes after controlling for known RFs, such as directly measured insulin resistance and obesity....
journal_title：Diabetes care
pub_type： 杂志文章,多中心研究
doi：10.2337/diacare.27.9.2234
更新日期：2004-09-01 00:00:00
abstract：OBJECTIVE:To investigate whether dietary phylloquinone and menaquinones intakes are related to risk of type 2 diabetes. RESEARCH DESIGN AND METHODS:We used data from a prospective cohort study in 38,094 Dutch men and women, aged 20-70 years. Dietary phylloquinone and menaquinones intakes were assessed using a validate...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/dc09-2302
更新日期：2010-08-01 00:00:00
abstract：OBJECTIVE:The effect of a healthy lifestyle on diabetes-related dementia remains unknown. We examined whether an active lifestyle and rich social network may counteract the increased risk of dementia in people with diabetes. RESEARCH DESIGN AND METHODS:Dementia-free older adults from the Swedish National Study on Agin...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/dc18-1428
更新日期：2019-02-01 00:00:00
abstract：:The history of the National Diabetes Advisory Board is reviewed, particularly from the perspective of the role of the board in advancing diabetes care. In addition, its potential future activities in the arena of translating research advances, for example, the results of the Diabetes Control and Complications Trial (D...
journal_title：Diabetes care
pub_type： 杂志文章
doi：
更新日期：1994-06-01 00:00:00
abstract：OBJECTIVE:To examine the hypothesis that hyperinsulinemia among relatives of NIDDM probands will increase the prevalence of DLPs, we measured insulin levels and examined the frequency of DLPs among NIDDM pedigree members. RESEARCH DESIGN AND METHODS:We performed 2-h 75-g OGTTs and measured lipid and insulin levels of ...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/diacare.15.10.1285
更新日期：1992-10-01 00:00:00
abstract：OBJECTIVE:Ipragliflozin, a sodium-glucose cotransporter 2 inhibitor, stimulates glycosuria and lowers glycemia in patients with type 2 diabetes (T2DM). The objective of this study was to assess the pharmacodynamics of ipragliflozin in T2DM patients with impaired renal function. RESEARCH DESIGN AND METHODS:Glycosuria w...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/dc12-1503
更新日期：2013-05-01 00:00:00
abstract：OBJECTIVE:To determine whether ACE inhibitors (ACEi) and angiotensin receptor blockers (ARB) protect against lower-respiratory tract infections complicating type 2 diabetes. RESEARCH DESIGN AND METHODS:Of 1,732 participants with diabetes recruited to the longitudinal observational Fremantle Diabetes Study Phase II (FD...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/dc20-0895
更新日期：2020-09-01 00:00:00
abstract：OBJECTIVE:The relationship between coronary endothelial function and insulin resistance remains speculative. We sought to determine whether pioglitazone, an insulin-sensitizing peroxisome proliferator-activated receptor (PPAR)-gamma agonist, improves cardiac endothelial function in individuals with type 2 diabetes. RE...
journal_title：Diabetes care
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.2337/diacare.28.5.1145
更新日期：2005-05-01 00:00:00
abstract：OBJECTIVE:Advanced glycation end products (AGEs) are thought to have a role in the pathogenesis of diabetes complications. We recently reported the association between skin autofluorescence, as a measure of tissue AGE accumulation, and diabetic neuropathy in a selected diabetic population. In this study, we investigate...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/dc05-2173
更新日期：2006-12-01 00:00:00
abstract：:Morphologic characteristics of insulin precipitates were examined by both scanning and transmission electron microscopy. Insulin precipitate obtained after 1 wk of in vivo storage in an implanted dog reservoir was compared with insulin precipitate produced in vitro by isoelectric precipitation, acid-freeze-heat precip...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/diacare.5.1.25
更新日期：1982-01-01 00:00:00
abstract：OBJECTIVE:In general, breast-feeding positively influences development of psychomotor function and cognition in children. Offspring of diabetic mothers (ODM) have delayed psychomotor and cognitive development. Recently, we observed a dose-dependent negative effect of early neonatal ingestion of breast milk from diabeti...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/diacare.28.3.573
更新日期：2005-03-01 00:00:00
abstract：OBJECTIVE:To determine 1) whether participants in the Spanish Diabetes Self-Management Program (SDSMP), when compared at 6 months to randomized control subjects, would demonstrate improvements in health status, health behaviors, and self-efficacy; and 2) whether SDSMP participants receiving monthly automated telephone ...
journal_title：Diabetes care
pub_type： 杂志文章,随机对照试验
doi：10.2337/dc07-1313
更新日期：2008-03-01 00:00:00
abstract：OBJECTIVE:A key milestone in progress towards providing an efficacious and safe closed-loop artificial pancreas system for outpatient use is the development of fully automated, portable devices with fault detection capabilities to ensure patient safety. The ability to remotely monitor the operation of the closed-loop s...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/dc12-0761
更新日期：2012-11-01 00:00:00
abstract：OBJECTIVE:Previous reviews of the effect of oral antidiabetic (OAD) agents on A1C levels summarized studies with varying designs and methodological approaches. Using predetermined methodological criteria, we evaluated the effect of OAD agents on A1C levels. RESEARCH DESIGN AND METHODS:The Excerpta Medica (EMBASE), the...
journal_title：Diabetes care
pub_type： 杂志文章,meta分析,评审
doi：10.2337/dc09-1727
更新日期：2010-08-01 00:00:00
abstract：OBJECTIVE:Supplementation of type II diabetic diets with n-3 fatty acids (FAs) from fish oil (FO) has been associated with lowered triglyceride and VLDL levels, although reports of impaired glycemic control have limited their use. Effects of n-3FAs from nonmarine sources are less well documented. Therefore, an investig...
journal_title：Diabetes care
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.2337/diacare.19.5.463
更新日期：1996-05-01 00:00:00
abstract：OBJECTIVE:Diabetic nephropathy (DN) is a leading cause of end-stage renal disease (ESRD). Obstructive sleep apnea (OSA) is common in type 2 diabetes and increases oxidative stress. Hence, OSA could promote the development and progression of DN. RESEARCH DESIGN AND METHODS:This was a cohort study in adults with type 2 ...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/dc13-0450
更新日期：2013-11-01 00:00:00
