Abstract:
OBJECTIVE:To evaluate the association between self-reported diabetes and the risk of breast cancer (BC) and its interaction with moderate-intensity physical activity in pre- and postmenopausal Mexican women. RESEARCH DESIGN AND METHODS:A population-based case-control study was conducted using 1,000 incident case subjects and 1,074 control subjects. Blood samples and information on health, diet, physical activity, and anthropometric measurements were obtained. RESULTS:The association between diabetes and BC risk decreased with increasing tertiles of moderate-intensity physical activity (odds ratio [OR] = 4.9 [95% CI 2.3-10.8]; 3.0 [1.3-6.9]; and 1.0 [0.1-9.2], respectively, for each tertile) (test for interaction = 0.04). Compared with the women in the lowest tertiles, increased risk was observed in those premenopausal women with the highest serum C-peptide, IGF-1, and IGF-1 binding protein 3 levels. CONCLUSIONS:Moderate-intensity physical activity can substantially ameliorate the increased BC risk in diabetic women.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Torres-Mejía G,Angeles-Llerenas A,Ortega-Olvera C,Lazcano-Ponce E,Ziv E,Pulido-Rodríguez J,García-Solis Mde J,Murillo-Zamora E,Vázquez-Lara J,Romieu Idoi
10.2337/dc11-2362subject
Has Abstractpub_date
2012-12-01 00:00:00pages
2500-2issue
12eissn
0149-5992issn
1935-5548pii
dc11-2362journal_volume
35pub_type
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