Valsartan improves {beta}-cell function and insulin sensitivity in subjects with impaired glucose metabolism: a randomized controlled trial.


OBJECTIVE:Recently, the Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research Trial demonstrated that treatment with the angiotensin receptor blocker (ARB) valsartan for 5 years resulted in a relative reduction of 14% in the incidence of type 2 diabetes in subjects with impaired glucose metabolism (IGM). We investigated whether improvements in β-cell function and/or insulin sensitivity underlie these preventive effects of the ARB valsartan in the onset of type 2 diabetes. RESEARCH DESIGN AND METHODS:In this randomized controlled, double-blind, two-center study, the effects of 26 weeks of valsartan (320 mg daily; n = 40) or placebo (n = 39) on β-cell function and insulin sensitivity were assessed in subjects with impaired fasting glucose and/or impaired glucose tolerance, using a combined hyperinsulinemic-euglycemic and hyperglycemic clamp with subsequent arginine stimulation and a 2-h 75-g oral glucose tolerance test (OGTT). Treatment effects were analyzed using ANCOVA, adjusting for center, glucometabolic status, and sex. RESULTS:Valsartan increased first-phase (P = 0.028) and second-phase (P = 0.002) glucose-stimulated insulin secretion compared with placebo, whereas the enhanced arginine-stimulated insulin secretion was comparable between groups (P = 0.25). In addition, valsartan increased the OGTT-derived insulinogenic index (representing first-phase insulin secretion after an oral glucose load; P = 0.027). Clamp-derived insulin sensitivity was significantly increased with valsartan compared with placebo (P = 0.049). Valsartan treatment significantly decreased systolic and diastolic blood pressure compared with placebo (P < 0.001). BMI remained unchanged in both treatment groups (P = 0.89). CONCLUSIONS:Twenty-six weeks of valsartan treatment increased glucose-stimulated insulin release and insulin sensitivity in normotensive subjects with IGM. These findings may partly explain the beneficial effects of valsartan in the reduced incidence of type 2 diabetes.


Diabetes Care


Diabetes care


van der Zijl NJ,Moors CC,Goossens GH,Hermans MM,Blaak EE,Diamant M




Has Abstract


2011-04-01 00:00:00














  • Severe hypoglycemia and cognitive decline in older people with type 2 diabetes: the Edinburgh type 2 diabetes study.

    abstract:OBJECTIVE:People with type 2 diabetes are at increased risk of age-related cognitive decline and dementia. Hypoglycemia is a candidate risk factor, but the direction of association between episodes of severe hypoglycemia and cognitive decline in type 2 diabetes remains uncertain. RESEARCH DESIGN AND METHODS:In the Edi...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Feinkohl I,Aung PP,Keller M,Robertson CM,Morling JR,McLachlan S,Deary IJ,Frier BM,Strachan MW,Price JF,Edinburgh Type 2 Diabetes Study (ET2DS) Investigators.

    更新日期:2014-02-01 00:00:00

  • Evidence of reduced β-cell function in Asian Indians with mild dysglycemia.

    abstract:OBJECTIVE:To examine β-cell function across a spectrum of glycemia among Asian Indians, a population experiencing type 2 diabetes development at young ages despite low BMI. RESEARCH DESIGN AND METHODS:One-thousand two-hundred sixty-four individuals without known diabetes in the Diabetes Community Lifestyle Improvement...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Staimez LR,Weber MB,Ranjani H,Ali MK,Echouffo-Tcheugui JB,Phillips LS,Mohan V,Narayan KM

    更新日期:2013-09-01 00:00:00

  • An analysis of dynamic forces transmitted through the foot in diabetic neuropathy.

    abstract:OBJECTIVE:Biomechanical studies in diabetic neuropathy have clearly demonstrated abnormal foot pressures, but information on other aspects of gait is limited. This study aimed to investigate and describe the forces transmitted through the foot during walking in diabetic subjects with varying degrees of peripheral neuro...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Shaw JE,van Schie CH,Carrington AL,Abbott CA,Boulton AJ

    更新日期:1998-11-01 00:00:00

  • Neck circumference positively related with central obesity, overweight, and metabolic syndrome in Chinese subjects with type 2 diabetes: Beijing Community Diabetes Study 4.

    abstract:OBJECTIVE:To investigate the association between neck circumference and central obesity, overweight, and metabolic syndrome in Chinese individuals with type 2 diabetes. RESEARCH DESIGN AND METHODS:A total of 3,182 diabetic subjects (aged 20-80 years) were recruited from 15 community health centers in Beijing using a m...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Yang GR,Yuan SY,Fu HJ,Wan G,Zhu LX,Bu XL,Zhang JD,Du XP,Li YL,Ji Y,Gu XN,Li Y,Beijing Community Diabetes Study Group.

    更新日期:2010-11-01 00:00:00

  • Stroke in the diabetic patient.

    abstract::A higher prevalence of stroke is found in the patient with both diagnosed and undiagnosed diabetes and glucose intolerance. Because of local cerebral acidosis caused by ischemia and hyperglycemia, morbidity and mortality from a stroke are increased. Most studies show that individuals with admission serum glucose > 120...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审


    authors: Bell DS

    更新日期:1994-03-01 00:00:00

  • Self-monitoring of blood glucose without a meter.

    abstract::We studied the reliability of the Chemstrip system in the self-monitoring of blood glucose by diabetic patients. A total of 453 blood glucose values obtained by 38 diabetic patients using Chemstrip were compared with the glucose values of the same blood samples measured with a conventional laboratory method. We found ...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Birch K,Hildebrandt P,Marshall MO,Sestoft L

    更新日期:1981-05-01 00:00:00

  • Impact of BMI and the metabolic syndrome on the risk of diabetes in middle-aged men.

    abstract:OBJECTIVE:The existence of an obese subgroup with a healthy metabolic profile and low diabetes risk has been proposed; yet long-term data are lacking. We aimed to investigate associations between combinations of BMI categories and metabolic syndrome and risk of type 2 diabetes in middle-aged men. RESEARCH DESIGN AND M...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Arnlöv J,Sundström J,Ingelsson E,Lind L

    更新日期:2011-01-01 00:00:00

  • Relationship of blood thromboxane-B2 (TxB2) with lipid peroxides and effect of vitamin E and placebo supplementation on TxB2 and lipid peroxide levels in type 1 diabetic patients.

    abstract:OBJECTIVE:To study the effect of vitamin E supplementation on platelet hyperaggregability in type 1 diabetic patients. RESEARCH DESIGN AND METHODS:Written informed consent according to the Institutional Review Board on Human Experimentation guidelines was obtained from diabetic patients (n = 29) and their age-matched ...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Jain SK,Krueger KS,McVie R,Jaramillo JJ,Palmer M,Smith T

    更新日期:1998-09-01 00:00:00

  • Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin: a randomized, 52-week, double-blind, active-controlled noninferiority trial.

    abstract:OBJECTIVE:Although initially effective, sulfonylureas are associated with poor glycemic durability, weight gain, and hypoglycemia. Dapagliflozin, a selective inhibitor of sodium-glucose cotransporter 2 (SGLT2), reduces hyperglycemia by increasing urinary glucose excretion independent of insulin and may cause fewer of t...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验


    authors: Nauck MA,Del Prato S,Meier JJ,Durán-García S,Rohwedder K,Elze M,Parikh SJ

    更新日期:2011-09-01 00:00:00

  • Efficacy and safety of switching from the DPP-4 inhibitor sitagliptin to the human GLP-1 analog liraglutide after 52 weeks in metformin-treated patients with type 2 diabetes: a randomized, open-label trial.

    abstract:OBJECTIVE:To assess the efficacy and safety of switching from sitagliptin to liraglutide in metformin-treated adults with type 2 diabetes. RESEARCH DESIGN AND METHODS:In an open-label trial, participants randomized to receive either liraglutide (1.2 or 1.8 mg/day) or sitagliptin (100 mg/day), each added to metformin, ...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验


    authors: Pratley RE,Nauck MA,Bailey T,Montanya E,Filetti S,Garber AJ,Thomsen AB,Furber S,Davies M,1860-LIRA-DPP-4 Study Group.

    更新日期:2012-10-01 00:00:00

  • Treatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome.

    abstract:OBJECTIVE:Conjugated linoleic acid (CLA) is a group of dietary fatty acids with antiobesity and antidiabetic effects in some animals. The trans10cis12 (t10c12) CLA isomer seems to cause these effects, including improved insulin sensitivity. Whether such isomer-specific effects occur in humans is unknown. The aim of thi...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Risérus U,Arner P,Brismar K,Vessby B

    更新日期:2002-09-01 00:00:00

  • Prevalence and correlates of depressive symptoms among rural older African Americans, Native Americans, and whites with diabetes.

    abstract:OBJECTIVE:Depression is associated with morbidity, mortality, and decreased quality of life and is a well-established complication among people with diabetes. Little is known about the prevalence and correlates of depressive symptoms among older adults living in rural communities, particularly among ethnic minority gro...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Bell RA,Smith SL,Arcury TA,Snively BM,Stafford JM,Quandt SA

    更新日期:2005-04-01 00:00:00

  • Is incretin-based therapy ready for the care of hospitalized patients with type 2 diabetes?: The time has come for GLP-1 receptor agonists!

    abstract::Significant data suggest that overt hyperglycemia, either observed with or without a prior diagnosis of diabetes, contributes to an increase in mortality and morbidity in hospitalized patients. In this regard, goal-directed insulin therapy has remained as the standard of care for achieving and maintaining glycemic con...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Schwartz S,DeFronzo RA

    更新日期:2013-07-01 00:00:00

  • Multicenter evaluation of the Micral-Test II test strip, an immunologic rapid test for the detection of microalbuminuria.

    abstract:OBJECTIVE:To assess the performance of the Micral-Test II immunologic test strip for the detection of microalbuminuria, a multicenter evaluation in eight European study sites was performed. RESEARCH DESIGN AND METHODS:Using both the Micral-Test II test strip and the routine method for the determination of albumin conc...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究


    authors: Mogensen CE,Viberti GC,Peheim E,Kutter D,Hasslacher C,Hofmann W,Renner R,Bojestig M,Poulsen PL,Scott G,Thoma J,Kuefer J,Nilsson B,Gambke B,Mueller P,Steinbiss J,Willamowski KD

    更新日期:1997-11-01 00:00:00

  • Can new-onset diabetes after kidney transplant be prevented?

    abstract::Because the negative consequences of new-onset diabetes mellitus after transplantation (NODAT) diminish the significant gains of kidney transplantation, it is imperative to develop clinical interventions to reduce the incidence of NODAT. In this review, we discuss whether intensive lifestyle interventions that delay o...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审


    authors: Chakkera HA,Weil EJ,Pham PT,Pomeroy J,Knowler WC

    更新日期:2013-05-01 00:00:00

  • Biphasic insulin aspart 30/70: pharmacokinetics and pharmacodynamics compared with once-daily biphasic human insulin and Basal-bolus therapy.

    abstract::OBJECTIVE Pharmacological profiles of biphasic insulin aspart 30/70 (BIAsp 30) once daily (OD), twice daily (b.i.d.), and three times daily (t.i.d.) were compared with other insulin regimens in two crossover glucose clamp studies of insulin-treated type 2 diabetic patients. RESEARCH DESIGNS AND METHODS Study 1 consist...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Heise T,Heinemann L,Hövelmann U,Brauns B,Nosek L,Haahr HL,Olsen KJ

    更新日期:2009-08-01 00:00:00

  • Efficacy of metformin in the treatment of NIDDM. Meta-analysis.

    abstract:OBJECTIVE:The results differ concerning randomized controlled trials of the effects of metformin on blood glucose regulation and body weight. To get a systematic overview, a meta-analysis of the efficacy of metformin was performed by comparing metformin with placebo and sulfonylurea. RESEARCH DESIGN AND METHODS:All ra...

    journal_title:Diabetes care

    pub_type: 杂志文章,meta分析


    authors: Johansen K

    更新日期:1999-01-01 00:00:00

  • Vital signs, QT prolongation, and newly diagnosed cardiovascular disease during severe hypoglycemia in type 1 and type 2 diabetic patients.

    abstract::OBJECTIVE To assess vital signs, QT intervals, and newly diagnosed cardiovascular disease during severe hypoglycemia in diabetic patients. RESEARCH DESIGN AND METHODS From January 2006 to March 2012, we conducted a retrospective cohort study to assess type 1 and type 2 diabetic patients with severe hypoglycemia at a n...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Tsujimoto T,Yamamoto-Honda R,Kajio H,Kishimoto M,Noto H,Hachiya R,Kimura A,Kakei M,Noda M

    更新日期:2014-01-01 00:00:00

  • Affinity sensor: a new technique for developing implantable sensors for glucose and other metabolites.

    abstract::We describe affinity sensors for monitoring various metabolites in blood plasma by optical means. The principle of detection is similar to that used in radioimmunoassays and is based on the competitive binding of a particular metabolite and a fluorescein-labeled analogue with receptor sites specific for the metabolite...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Schultz JS,Mansouri S,Goldstein IJ

    更新日期:1982-05-01 00:00:00

  • Relationship of insulin resistance and related metabolic variables to coronary artery disease: a mathematical analysis.

    abstract:OBJECTIVE:People with diabetes have an increased risk of coronary artery disease (CAD). An unanswered question is what portion of CAD can be attributed to insulin resistance, related metabolic variables, and other known CAD risk factors. RESEARCH DESIGN AND METHODS:The Archimedes model was used to estimate the proport...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Eddy D,Schlessinger L,Kahn R,Peskin B,Schiebinger R

    更新日期:2009-02-01 00:00:00

  • Glucagon response to oral glucose challenge in type 1 diabetes: lack of impact of euglycemia.

    abstract::OBJECTIVE Previous studies have demonstrated aberrant glucagon physiology in the setting of type 1 diabetes (T1D) but have not addressed the potential impact of ambient glycemia on this glucagon response. Thus, our objective was to evaluate the impact of euglycemia versus hyperglycemia on the glucagon response to an o...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Kramer CK,Borgoño CA,Van Nostrand P,Retnakaran R,Zinman B

    更新日期:2014-04-01 00:00:00

  • Non-insulin-dependent diabetes: 10-year outcome in relation to initial response to diet and subsequent sulfonylurea therapy.

    abstract::Thirty-eight non-insulin-dependent diabetic patients within 130% of desirable body weight were given a 100-g oral glucose tolerance test (OGTT) at diagnosis and after at least 1 mo of dietary treatment with energy and carbohydrate restriction. Thirteen "responders" showed an improvement in fasting blood glucose, gluco...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章


    authors: Sönksen PH,Lowy C,Perkins JR,Lim HS

    更新日期:1984-05-01 00:00:00

  • Sex disparities in treatment of cardiac risk factors in patients with type 2 diabetes.

    abstract:OBJECTIVE:Diabetes eliminates the protective effect of female sex on the risk of coronary heart disease (CHD). We assessed sex differences in the treatment of CHD risk factors among patients with diabetes. RESEARCH DESIGN AND METHODS:A cross-sectional analysis included 3,849 patients with diabetes treated in five acad...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究


    authors: Wexler DJ,Grant RW,Meigs JB,Nathan DM,Cagliero E

    更新日期:2005-03-01 00:00:00

  • Increased urinary endothelin-1-like immunoreactivity excretion in NIDDM patients with albuminuria.

    abstract:OBJECTIVE:To determine the urinary endothelin-1-like immunoreactivity (ET-1-LI) in non-insulin-dependent diabetes mellitus (NIDDM) patients and to investigate whether urinary ET-1-LI excretion is elevated in patients with albuminuria. RESEARCH DESIGN AND METHODS:Urinary ET-1-LI substance was determined by radioimmunoa...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Lee YJ,Shin SJ,Tsai JH

    更新日期:1994-04-01 00:00:00

  • Hepatocyte growth factor and clinical diabetes in postmenopausal women.

    abstract:OBJECTIVE:To investigate the association between circulating levels of hepatocyte growth factor (HGF), a mesenchymal-derived pleiotrophic factor that is elevated in obesity, and the prevalence of type 2 diabetes. RESEARCH DESIGN AND METHODS:A cross-sectional analysis among 892 postmenopausal women within the Women's H...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Rajpathak SN,Wassertheil-Smoller S,Crandall J,Liu S,Ho GY

    更新日期:2010-09-01 00:00:00

  • Predictive effects of urinary liver-type fatty acid-binding protein for deteriorating renal function and incidence of cardiovascular disease in type 2 diabetic patients without advanced nephropathy.

    abstract:OBJECTIVE:To improve prognosis, it is important to predict the incidence of renal failure and cardiovascular disease in type 2 diabetic patients before the progression to advanced nephropathy. We investigated the predictive effects of urinary liver-type fatty acid-binding protein (L-FABP), which is associated with rena...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Araki S,Haneda M,Koya D,Sugaya T,Isshiki K,Kume S,Kashiwagi A,Uzu T,Maegawa H

    更新日期:2013-05-01 00:00:00

  • Effects of Vitamin D Supplementation on Insulin Sensitivity and Insulin Secretion in Subjects With Type 2 Diabetes and Vitamin D Deficiency: A Randomized Controlled Trial.

    abstract:OBJECTIVE:In observational studies, low vitamin D levels are associated with type 2 diabetes (T2D), impaired glucose metabolism, insulin sensitivity, and insulin secretion. We evaluated the efficacy of vitamin D supplementation on insulin sensitivity and insulin secretion in subjects with T2D and low vitamin D (25-hydr...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验


    authors: Gulseth HL,Wium C,Angel K,Eriksen EF,Birkeland KI

    更新日期:2017-07-01 00:00:00

  • Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.

    abstract:OBJECTIVE:Several methods have been proposed to evaluate insulin sensitivity from the data obtained from the oral glucose tolerance test (OGTT). However, the validity of these indices has not been rigorously evaluated by comparing them with the direct measurement of insulin sensitivity obtained with the euglycemic insu...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Matsuda M,DeFronzo RA

    更新日期:1999-09-01 00:00:00

  • Risk factors for foot infections in individuals with diabetes.

    abstract:OBJECTIVE:To prospectively determine risk factors for foot infection in a cohort of people with diabetes. RESEARCH DESIGN AND METHODS:We evaluated then followed 1,666 consecutive diabetic patients enrolled in a managed care-based outpatient clinic in a 2-year longitudinal outcomes study. At enrollment, patients underw...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究


    authors: Lavery LA,Armstrong DG,Wunderlich RP,Mohler MJ,Wendel CS,Lipsky BA

    更新日期:2006-06-01 00:00:00

  • Plasma Fucosylated Glycans and C-Reactive Protein as Biomarkers of HNF1A-MODY in Young Adult-Onset Nonautoimmune Diabetes.

    abstract:OBJECTIVE:Maturity-onset diabetes of the young (MODY) due to variants in HNF1A is the most common type of monogenic diabetes. Frequent misdiagnosis results in missed opportunity to use sulfonylureas as first-line treatment. A nongenetic biomarker could improve selection of subjects for genetic testing and increase diag...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Juszczak A,Pavić T,Vučković F,Bennett AJ,Shah N,Pape Medvidović E,Groves CJ,Šekerija M,Chandler K,Burrows C,Rojnić Putarek N,Vučić Lovrenčić M,Ćuća Knežević J,James TJ,Gloyn AL,Lauc G,McCarthy MI,Owen KR,Gornik O

    更新日期:2019-01-01 00:00:00