Remembering Statins: Do Statins Have Adverse Cognitive Effects?

abstract：OBJECTIVE:Oxidative stress has been shown to be increased in the postprandial period in patients with diabetes and has been implicated in the pathogenesis of micro- and macrovascular complications. The aim of this post hoc analysis was to assess the effects of pramlintide, an amylin analog shown to reduce postprandial ...

journal_title：Diabetes care

authors： Ceriello A,Piconi L,Quagliaro L,Wang Y,Schnabel CA,Ruggles JA,Gloster MA,Maggs DG,Weyer C

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVE:Alterations of pancreatic β-cell cholesterol content may contribute to β-cell dysfunction. Two important determinants of intracellular cholesterol content are the ATP-binding cassette (ABC) transporters A1 (ABCA1) and -G1 (ABCG1). Whether genetic variation in ABCA1 and ABCG1 predicts risk of type 2 diabetes i...

journal_title：Diabetes care

authors： Schou J,Tybjærg-Hansen A,Møller HJ,Nordestgaard BG,Frikke-Schmidt R

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:To compare pharmacokinetics (PK) and pharmacodynamics (PD) of insulin glargine in type 2 diabetes mellitus (T2DM) after evening versus morning administration. RESEARCH DESIGN AND METHODS:Ten T2DM insulin-treated persons were studied during 24-h euglycemic glucose clamp, after glargine injection (0.4 units/kg...

journal_title：Diabetes care

authors： Porcellati F,Lucidi P,Cioli P,Candeloro P,Marinelli Andreoli A,Marzotti S,Ambrogi M,Bolli GB,Fanelli CG

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:Glycated hemoglobin (HbA1c) is positively associated with cardiovascular disease (CVD), although evidence is primarily observational. Mendelian randomization studies have only examined its relation with subtypes of CVD. We examined the relation of HbA1c with CVD and its subtypes in the UK Biobank using Mendel...

journal_title：Diabetes care

authors： Au Yeung SL,Luo S,Schooling CM

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the effect of the erythromycin derivative EM523L on gastric emptying and postprandial insulin requirement in insulin-dependent diabetic patients with severe gastroparesis. RESEARCH DESIGN AND METHODS:In six IDDM patients with severe gastroparesis (two men and four women, mean age 44.5 years [rang...

journal_title：Diabetes care

authors： Ishii M,Nakamura T,Kasai F,Baba T,Takebe K

更新日期：1997-07-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to estimate how much at-risk individuals are willing to pay for type 2 diabetes primary prevention programs. RESEARCH DESIGN AND METHODS:An Internet-based, choice-format conjoint survey was presented to individuals at elevated risk for type 2 diabetes. Hypothetical diabetes risk...

journal_title：Diabetes care

authors： Johnson FR,Manjunath R,Mansfield CA,Clayton LJ,Hoerger TJ,Zhang P

更新日期：2006-06-01 00:00:00

abstract：:Due to the inherent pharmacokinetic properties of available insulins, normoglycemia is rarely, if ever, achieved in insulin-dependent diabetic patients without compromising their quality of life. Subcutaneous insulin absorption is influenced by many factors, among which the associated state of insulin (hexameric) in p...

journal_title：Diabetes care

authors： Brange J,Owens DR,Kang S,Vølund A

更新日期：1990-09-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to assess the association of inflammation with hyperglycemia (impaired fasting glucose [IFG]/impaired glucose tolerance [IGT]) and diabetes in older individuals. RESEARCH DESIGN AND METHODS:Baseline data from the Health, Aging and Body Composition study included 3,075 well-fun...

journal_title：Diabetes care

authors： de Rekeneire N,Peila R,Ding J,Colbert LH,Visser M,Shorr RI,Kritchevsky SB,Kuller LH,Strotmeyer ES,Schwartz AV,Vellas B,Harris TB

更新日期：2006-08-01 00:00:00

abstract：:Seventeen diabetic subjects requiring insulin and who exhibited glycemic stability over a 9-12-mo control period received 5 g of pectin with each meal and at bedtime for 3 mo. Hemoglobin A1c (HbA1c) and glycosylated serum protein were measured in each patient on multiple occasions to assess glycemic control. No clear-...

journal_title：Diabetes care

authors： Gardner DF,Schwartz L,Krista M,Merimee TJ

更新日期：1984-03-01 00:00:00

abstract：OBJECTIVE:To test the conclusion that there is no association between multiple episodes of severe hypoglycemia and cognitive decrements by reanalyzing the data from the Diabetes Control and Complications Trial (DCCT) with psychometrically validated cognitive factors and to conduct a novel analysis of the association be...

journal_title：Diabetes care

authors： Austin EJ,Deary IJ

更新日期：1999-08-01 00:00:00

abstract：OBJECTIVE:To determine the incidence of retinopathy and the relative importance of its risk factors in type 1 diabetes. RESEARCH DESIGN AND METHODS:This is a 7.3-year follow-up of 764 of 1,215 (63%) people with type 1 diabetes across Europe, aged 15-60 years at baseline with no retinopathy (the EURODIAB Prospective Co...

journal_title：Diabetes care

authors： Chaturvedi N,Sjoelie AK,Porta M,Aldington SJ,Fuller JH,Songini M,Kohner EM,EURODIAB Prospective Complications Study.

更新日期：2001-02-01 00:00:00

abstract：OBJECTIVE:The current study aimed to investigate whether microalbuminuria or moderately decreased glomerular filtration rate (GFR) is a better predictor for the development and progression of retinopathy in type 2 diabetic patients. RESEARCH DESIGN AND METHODS:Type 2 diabetic patients without cardiovascular diseases, ...

journal_title：Diabetes care

authors： Chen YH,Chen HS,Tarng DC

更新日期：2012-04-01 00:00:00

abstract：:It had been suggested that long-term lowering of blood glucose by sulfonylureas in non-insulin-dependent (NIDD) diabetes is not due to a sustained increase in insulin secretion. We have re-examined this question. Thirteen nonobese NIDD patients not controlled on diet alone were studied prospectively on treatment with ...

journal_title：Diabetes care

authors： Elkeles RS,Heding LG,Paisey RB

更新日期：1982-07-01 00:00:00

abstract：:OBJECTIVE--To assess kidney function and AER in patients with PD. RESEARCH DESIGN AND METHODS--Thirty-three patients with PD (age 52 +/- 7 yr, duration of disease 11 +/- 6 yr, BMI 24 +/- 3 kg/m2) and 33 patients with IDDM were matched for sex, BMI, and duration of disease. GFR and RPF were determined by single injecti...

journal_title：Diabetes care

authors： Tiengo A,Briani G,Scaldaferri E,Riva F,Jori E,Sgnaolin E,Fenato R,D'Ambrosio M,Fioretto P,Nosadini R

更新日期：1992-11-01 00:00:00

abstract：OBJECTIVE:In a previous study, we found observational evidence of improvement in beta-cell function when rosiglitazone was added to a failing oral antihyperglycemic regimen consisting of sulfonylureas and metformin. To confirm our previous observations, we designed and performed a prospective, randomized, and controlle...

journal_title：Diabetes care

authors： Ovalle F,Bell DS

更新日期：2004-11-01 00:00:00

abstract：OBJECTIVE:The specific aims of the present study were to report on the level of personal beliefs and social and environmental barriers across different regimen areas and patient subgroups and on the relationship of personal models and perceived barriers to the level of self-management. RESEARCH DESIGN AND METHODS:This...

journal_title：Diabetes care

authors： Glasgow RE,Hampson SE,Strycker LA,Ruggiero L

更新日期：1997-04-01 00:00:00

abstract：:To investigate vascular responses in insulin-dependent diabetic patients both with and without retinopathy, we have assessed vasodilation by forearm transcutaneous pO2 measurement after 10 min of ischemia produced by a sphygmomanometer cuff. Diabetic patients with proliferative retinopathy had a delayed vasodilatory r...

journal_title：Diabetes care

authors： Haitas B,Barnes A,Shogry ME,Weindling M,Rolfe P,Turner RC

更新日期：1984-01-01 00:00:00

abstract：:In June 2012, 13 thought leaders convened in a Diabetes Care Editors' Expert Forum to discuss the concept of personalized medicine in the wake of a recently published American Diabetes Association/European Association for the Study of Diabetes position statement calling for a patient-centered approach to hyperglycemia...

journal_title：Diabetes care

authors： Raz I,Riddle MC,Rosenstock J,Buse JB,Inzucchi SE,Home PD,Del Prato S,Ferrannini E,Chan JC,Leiter LA,Leroith D,Defronzo R,Cefalu WT

更新日期：2013-06-01 00:00:00

abstract：:OBJECTIVE We evaluated relationships of oral glucose tolerance testing (OGTT)-derived measures of insulin sensitivity and pancreatic β-cell function with indices of diabetes complications in a cross-sectional study of patients with type 2 diabetes who are free of overt cardiovascular or renal disease. RESEARCH DESIGN ...

journal_title：Diabetes care

authors： Mulvey CK,McNeill AM,Girman CJ,Churchill TW,Terembula K,Ferguson JF,Shah R,Mehta NN,Qasim AN,Rickels MR,Reilly MP

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:This study used qualitative interviews with black and Latino participants with diabetes to further understanding about types of foods eaten, food preparation, sources of foods and meals, communication with providers, and effects of race and ethnicity on eating in this population. RESEARCH DESIGN AND METHODS:...

journal_title：Diabetes care

authors： Breland JY,McAndrew LM,Gross RL,Leventhal H,Horowitz CR

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVE:In diabetes, the persistence of hyperglycemia has been reported to cause increased production of oxygen free radicals through glucose autooxidation and nonenzymatic glycation. The aim of this study was to determine whether oxidative cellular damage occurs at the clinical onset of diabetes and in later stages ...

journal_title：Diabetes care

authors： Domínguez C,Ruiz E,Gussinye M,Carrascosa A

更新日期：1998-10-01 00:00:00

abstract：OBJECTIVE:To determine whether biomarkers of inflammation and endothelial dysfunction are associated with the development of kidney dysfunction and the time frame of their association. RESEARCH DESIGN AND METHODS:Biomarkers were measured at four time points during 28 years of treatment and follow-up in patients with t...

journal_title：Diabetes care

authors： Baker NL,Hunt KJ,Stevens DR,Jarai G,Rosen GD,Klein RL,Virella G,Lopes-Virella MF,DCCT\/EDIC Research Group.

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:To examine urinary levels of enterolactone and enterodiol, intestinal microbial metabolites of dietary lignans, in relation to type 2 diabetes (T2D) risk. RESEARCH DESIGN AND METHODS:Urinary concentrations of the lignan metabolites were assayed by liquid chromatography-mass spectrometry among 1,107 T2D and 1...

journal_title：Diabetes care

authors： Sun Q,Wedick NM,Pan A,Townsend MK,Cassidy A,Franke AA,Rimm EB,Hu FB,van Dam RM

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:The incidence rate of childhood type 1 diabetes is thought to be increasing; however, Danish studies have not confirmed this. Using a national diabetes register initiated in 1996 and two previous regional incidence studies, we studied the age-specific incidence of type 1 diabetes over 30 years. Here, we descr...

journal_title：Diabetes care

authors： Svensson J,Carstensen B,Mølbak A,Christau B,Mortensen HB,Nerup J,Borch-Johnsen K

更新日期：2002-12-01 00:00:00

abstract：:In children with insulin-dependent diabetes mellitus (IDDM), deterioration in metabolic control frequently occurs during early adolescence. To prevent this predictable increase in blood glucose levels, we randomly assigned young adolescents with IDDM to an intervention based on problem solving with self-monitoring of ...

journal_title：Diabetes care

authors： Anderson BJ,Wolf FM,Burkhart MT,Cornell RG,Bacon GE

更新日期：1989-03-01 00:00:00

abstract：OBJECTIVE:The intraoral tactile sensitivity (ITS) of diabetic and nondiabetic subjects was compared. The effects of age, ethnicity, sex, and intraoral site were considered. RESEARCH DESIGN AND METHODS:The sample comprised 589 participants of the Oral Health: San Antonio Longitudinal Study of Aging. A total of 107 subj...

journal_title：Diabetes care

authors： Shinkai RS,Hatch JP,Cornell JE,Yeh CK

更新日期：2004-04-01 00:00:00

abstract：OBJECTIVE:To assess the contemporaneous prevalence of diabetic peripheral neuropathy (DPN) in people with type 1 diabetes (T1D) in Scotland and study its cross-sectional association with risk factors and other diabetic complications. RESEARCH DESIGN AND METHODS:We analyzed data from a large representative sample of ad...

journal_title：Diabetes care

authors： Jeyam A,McGurnaghan SJ,Blackbourn LAK,McKnight JM,Green F,Collier A,McKeigue PM,Colhoun HM,SDRNT1BIO Investigators.

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:To evaluate whether use of oral hypoglycemic agents is associated with an altered breast cancer risk in women. RESEARCH DESIGN AND METHODS:Using the U.K.-based General Practice Research Database, we conducted a nested case-control analysis among 22,621 female users of oral antidiabetes drugs with type 2 diab...

journal_title：Diabetes care

authors： Bodmer M,Meier C,Krähenbühl S,Jick SS,Meier CR

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:Diabetes is the leading cause of nontraumatic lower-limb amputations in the U.S., but no research has prospectively examined associations between limb-specific measurements and amputation risk among patients without foot ulcer. We investigated amputation risk by limb in relation to the same limb- and person-l...

journal_title：Diabetes care

authors： Boyko EJ,Seelig AD,Ahroni JH

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:Global usage of bariatric surgery has been dictated for the past quarter century by National Institutes of Health recommendations restricting these operations to individuals with a BMI ≥35 kg/m(2). Strong evidence now demonstrates that bariatric procedures markedly improve or cause remission of type 2 diabete...

journal_title：Diabetes care

authors： Cummings DE,Cohen RV

更新日期：2016-06-01 00:00:00