Renal hemodynamics and albumin excretion rate in patients with diabetes secondary to acquired pancreatic disease.

Abstract:

:OBJECTIVE--To assess kidney function and AER in patients with PD. RESEARCH DESIGN AND METHODS--Thirty-three patients with PD (age 52 +/- 7 yr, duration of disease 11 +/- 6 yr, BMI 24 +/- 3 kg/m2) and 33 patients with IDDM were matched for sex, BMI, and duration of disease. GFR and RPF were determined by single injection of [51Cr]EDTA and [125I]hippurate. AER was measured by radioimmunoassay in a single timed overnight urine collection. RESULTS--GFR and RPF were, respectively, 113 +/- 35 and 441 +/- 145 ml.min-1.73 m2 in patients with PD and 123 +/- 30 and 549 +/- 94 (P < 0.001) in IDDM. FF was significantly higher in patients with PD (0.26 +/- 0.05 vs. 0.22 +/- 0.03; P < 0.001). Prevalence of hyperfiltration (GFR > 135 ml.min-1.1.73 m2) was similar in both groups (30% in patients with PD vs. 28% in those with IDDM). Geometric mean of urinary AER was 10.4 micrograms/min (range 1-186) in patients with PD and 11.2 (1-198) in IDDM patients. Some 30.3% of patients with PD and 18% of those with IDDM were microalbuminuric (AER > 20 micrograms/min). By multiple regression analysis, AER was significantly related to systolic (P < 0.04) and diastolic blood pressure (P < 0.01) and to BMI (P < 0.03) in patients with PD. Retinopathy was more frequent in microalbuminuric patients with PD than in those without elevated AER. CONCLUSIONS--We suggest that early renal abnormalities occur similarly in patients with PD and IDDM.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Tiengo A,Briani G,Scaldaferri E,Riva F,Jori E,Sgnaolin E,Fenato R,D'Ambrosio M,Fioretto P,Nosadini R

doi

10.2337/diacare.15.11.1591

subject

Has Abstract,Author List Incomplete

pub_date

1992-11-01 00:00:00

pages

1591-7

issue

11

eissn

0149-5992

issn

1935-5548

journal_volume

15

pub_type

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    pub_type: 临床试验,杂志文章,随机对照试验

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    pub_type: 杂志文章

    doi:10.2337/diacare.21.8.1317

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    pub_type: 杂志文章

    doi:10.2337/dc07-1304

    authors: Brandner JM,Zacheja S,Houdek P,Moll I,Lobmann R

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  • Risk Factors for Kidney Disease in Type 1 Diabetes.

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    pub_type: 杂志文章

    doi:10.2337/dc18-2062

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  • Mortality trends in subjects with and without diabetes during 33 years of follow-up.

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    pub_type: 杂志文章

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