Abstract:
OBJECTIVE:Obesity is a well-known risk factor for vitamin D deficiency. We evaluated the interrelationship between vitamin D status, body size, and glucose homeostasis, measured by HbA1c (A1C). RESEARCH DESIGN AND METHODS:Data are from the survey of the 45-year-old 1958 British birth cohort (2002-2004). Information on A1C, 25-hydroxyvitamin D [25(OH)D; an indicator of vitamin D status], and BMI was collected from 7,198 Caucasian subjects. RESULTS:25(OH)D was < 75 nmol/l in 80% of the obese subjects (BMI > or = 30 kg/m2) versus 68% of the other subjects (P < 0.0001). Serum 25(OH)D decreased and A1C increased by increasing BMI (P < 0.0001 for both comparisons). There was a nonlinear association between 25(OH)D and A1C: a steep linear decrease in A1C by 25(OH)D until 65 nmol/l and only smaller decreases with further increases. There was evidence for effect modification by BMI in the association between 25(OH)D and A1C (P < 0.0001), and differences appeared stronger for participants with higher compared with lower BMIs. After adjustment for sex, season, geographical location, physical activity, and social class, percent change in A1C by 10-nmol/l increase in 25(OH)D was -0.21 (95% CI -0.31 to -0.11) for BMI < 25 kg/m2, -0.25 (-0.37 to -0.13) for BMI 25-29.9 kg/m2, -0.65 (-0.95 to -0.34) for BMI 30-34.9 kg/m2, and -1.37 (-2.09 to -0.64) for BMI > or = 35 kg/m2. CONCLUSIONS:Body size was a strong determinant for 25(OH)D, with concentrations being suboptimal in most obese participants. Randomized controlled trials [using dosages sufficient to improve 25(OH)D also for the obese] are required to determine whether clinically relevant improvements in glucose metabolism can be obtained by vitamin D supplementation.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Hyppönen E,Power Cdoi
10.2337/dc06-0946subject
Has Abstractpub_date
2006-10-01 00:00:00pages
2244-6issue
10eissn
0149-5992issn
1935-5548pii
29/10/2244journal_volume
29pub_type
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