A health economic model to assess the long-term effects and cost-effectiveness of orlistat in obese type 2 diabetic patients.

abstract：:This paper provides some historical aspects on the research and development of Humulin (rDNA origin), the first human health-care product derived from rDNA technology more than a decade ago. Also referred to as biosynthetic human insulin, Humulin is currently produced via the human proinsulin route, using an Escherich...

journal_title：Diabetes care

authors： Chance RE,Frank BH

更新日期：1993-12-01 00:00:00

abstract：:A small and inexpensive computer was programmed to assist patients in making decisions regarding insulin delivery using constant subcutaneous infusion systems. Insulin dosage was based on gender, pre- and postprandial blood glucose, between-meal blood glucose, patient weight, time of day, and when appropriate, the car...

journal_title：Diabetes care

authors： Chanoch LH,Jovanovic L,Peterson CM

更新日期：1985-03-01 00:00:00

abstract：OBJECTIVE:Type 2 diabetes is a heterogeneous disease in which both beta-cell dysfunction and insulin resistance are pathogenetic factors. Disproportionate hyperproinsulinemia (elevated proinsulin/insulin) is another abnormality in type 2 diabetes whose mechanism is unknown. Increased demand due to obesity and/or insuli...

journal_title：Diabetes care

authors： Røder ME,Dinesen B,Hartling SG,Houssa P,Vestergaard H,Sodoyez-Goffaux F,Binder C

更新日期：1999-04-01 00:00:00

abstract：:In a 10-yr prospective population study 406 subjects who were 70 yr old received an oral glucose tolerance test. Of these subjects 169 were retested at 80. Three sets of diagnostic criteria were evaluated, of which the WHO criteria are recommended for screening studies in this age group. The prevalences of diabetes me...

journal_title：Diabetes care

authors： Agner E,Thorsteinsson B,Eriksen M

更新日期：1982-11-01 00:00:00

abstract：:It had been suggested that long-term lowering of blood glucose by sulfonylureas in non-insulin-dependent (NIDD) diabetes is not due to a sustained increase in insulin secretion. We have re-examined this question. Thirteen nonobese NIDD patients not controlled on diet alone were studied prospectively on treatment with ...

journal_title：Diabetes care

authors： Elkeles RS,Heding LG,Paisey RB

更新日期：1982-07-01 00:00:00

abstract：OBJECTIVE:To evaluate safety and efficacy of DiaPep277 in preserving β-cell function in type 1 diabetic patients. RESEARCH DESIGN AND METHODS:DIA-AID 1 is a multinational, phase 3, balanced-randomized, double-blind, placebo-controlled, parallel-group clinical study. Newly diagnosed patients (N = 457, aged 16-45 years)...

journal_title：Diabetes care

authors： Raz I,Ziegler AG,Linn T,Schernthaner G,Bonnici F,Distiller LA,Giordano C,Giorgino F,de Vries L,Mauricio D,Procházka V,Wainstein J,Elias D,Avron A,Tamir M,Eren R,Peled D,Dagan S,Cohen IR,Pozzilli P,DIA-AID 1 Writin

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:To describe the changes in demographics, antidiabetic treatment, and glycemic control among the prevalent U.S. adult diagnosed type 2 diabetes population between the National Health and Nutrition Examination Survey (NHANES) III (1988-1994) and the initial release of NHANES 1999-2000. RESEARCH DESIGN AND METH...

journal_title：Diabetes care

authors： Koro CE,Bowlin SJ,Bourgeois N,Fedder DO

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:To study the metabolic effect and the variability of the effect elicited by inhalation of 87.2 U insulin powder combined with an absorption enhancer. The metabolic effect was compared with that of 10.2 U regular insulin injected subcutaneously and of 5.5 U regular insulin given intravenously RESEARCH DESIGN ...

journal_title：Diabetes care

authors： Heinemann L,Klappoth W,Rave K,Hompesch B,Linkeschowa R,Heise T

更新日期：2000-09-01 00:00:00

abstract：OBJECTIVE:Observational studies have associated metformin use with a decreased risk of lung cancer incidence in patients with type 2 diabetes, but the studies had important methodological shortcomings. The objective of this study was to determine whether metformin use is associated with a decreased risk of lung cancer ...

journal_title：Diabetes care

authors： Smiechowski BB,Azoulay L,Yin H,Pollak MN,Suissa S

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:Longitudinal changes in GAD antibody (Ab) and ICA512/IA-2 (ICA512) Ab were examined in relation to age at the onset of diabetes and autoimmunity against the thyroid gland. RESEARCH DESIGN AND METHODS:GADAb, ICA512Ab, and antithyroid autoantibody were examined at onset in 40 juvenile-onset IDDM patients (17 m...

journal_title：Diabetes care

authors： Yokota I,Matsuda J,Naito E,Ito M,Shima K,Kuroda Y

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:Depression is associated with morbidity, mortality, and decreased quality of life and is a well-established complication among people with diabetes. Little is known about the prevalence and correlates of depressive symptoms among older adults living in rural communities, particularly among ethnic minority gro...

journal_title：Diabetes care

authors： Bell RA,Smith SL,Arcury TA,Snively BM,Stafford JM,Quandt SA

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVE:To determine whether elderly individuals with type 2 diabetes or impaired glucose tolerance are at increased risk for cognitive impairment compared with individuals with normal glucose tolerance. RESEARCH DESIGN AND METHODS:Elderly Hispanic individuals (n = 414) and non-Hispanic white individuals (n = 469) a...

journal_title：Diabetes care

authors： Lindeman RD,Romero LJ,LaRue A,Yau CL,Schade DS,Koehler KM,Baumgartner RN,Garry PJ,New Mexico Elder Health Survey.

更新日期：2001-09-01 00:00:00

abstract：OBJECTIVE:The goal was to develop a new index of insulin sensitivity in patients with type 1 diabetes estimated from continuous glucose monitoring (CGM) and subcutaneous insulin delivery data under carefully controlled conditions. RESEARCH DESIGN AND METHODS:The database consists of 12 subjects with type 1 diabetes, s...

journal_title：Diabetes care

authors： Schiavon M,Dalla Man C,Kudva YC,Basu A,Cobelli C

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:The specific aims of the present study were to report on the level of personal beliefs and social and environmental barriers across different regimen areas and patient subgroups and on the relationship of personal models and perceived barriers to the level of self-management. RESEARCH DESIGN AND METHODS:This...

journal_title：Diabetes care

authors： Glasgow RE,Hampson SE,Strycker LA,Ruggiero L

更新日期：1997-04-01 00:00:00

abstract：OBJECTIVE:To investigate whether the risk for autoimmune diabetes in adults differs between socioeconomic groups and to compare such risk with that for type 2 diabetes. RESEARCH DESIGN AND METHODS:The inhabitants of the Norwegian county of Nord-Trøndelag were investigated by questionnaires and clinical examinations on...

journal_title：Diabetes care

authors： Olsson L,Ahlbom A,Grill V,Midthjell K,Carlsson S

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:This national, population-based study reports diabetes incidence based on oral glucose tolerance tests (OGTTs) and identifies risk factors for diabetes in Australians. RESEARCH DESIGN AND METHODS:The Australian Diabetes, Obesity and Lifestyle Study followed-up 5,842 participants over 5 years. Normal glycemia...

journal_title：Diabetes care

authors： Magliano DJ,Barr EL,Zimmet PZ,Cameron AJ,Dunstan DW,Colagiuri S,Jolley D,Owen N,Phillips P,Tapp RJ,Welborn TA,Shaw JE

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVE:To investigate whether peripheral neuropathy (PN), as part of the microangiopathic complex, affects bone mineral density (BMD) of the peripheral or the axial skeleton in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS:Three study groups were examined. Group 1 comprised 21 males with type 1 diabete...

journal_title：Diabetes care

authors： Rix M,Andreassen H,Eskildsen P

更新日期：1999-05-01 00:00:00

abstract：OBJECTIVE:Women with diabetes have a high incidence and complication rate of urinary tract infections (UTIs). Our aims were to compare current treatment strategies with respect to recurrence rates in women with diabetes with those without diabetes. RESEARCH DESIGN AND METHODS:We used a Dutch registration database cont...

journal_title：Diabetes care

authors： Schneeberger C,Stolk RP,Devries JH,Schneeberger PM,Herings RM,Geerlings SE

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVE:To examine the acute glucose-lowering effects of aerobic exercise in children and adolescents with type 1 diabetes. RESEARCH DESIGN AND METHODS:Fifty children and adolescents with type 1 diabetes (ages 10 to <18 years) were studied during exercise. The 75-min exercise session consisted of four 15-min periods...

journal_title：Diabetes care

authors： Tansey MJ,Tsalikian E,Beck RW,Mauras N,Buckingham BA,Weinzimer SA,Janz KF,Kollman C,Xing D,Ruedy KJ,Steffes MW,Borland TM,Singh RJ,Tamborlane WV,Diabetes Research in Children Network (DirecNet) Study Group.

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:The association between changes in triglyceride concentrations over time and diabetes is unknown. We assessed whether two triglyceride determinations obtained 5 years apart can predict incident type 2 diabetes. RESEARCH DESIGN AND METHODS:Triglyceride levels at baseline (time 1) and 5 years later (time 2), f...

journal_title：Diabetes care

authors： Tirosh A,Shai I,Bitzur R,Kochba I,Tekes-Manova D,Israeli E,Shochat T,Rudich A

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVE:To compare diabetes care and outcomes among Haitians, African Americans, and non-Hispanic whites. RESEARCH DESIGN AND METHODS:We analyzed data from 715 Haitian, 1,472 African American, and 466 non-Hispanic white adults with diabetes using χ² testing and multiple logistic regression. RESULTS:Haitians had a h...

journal_title：Diabetes care

authors： Vimalananda VG,Rosenzweig JL,Cabral HJ,David MM,Lasser KE

更新日期：2011-01-01 00:00:00

abstract：:The economic burden of diabetes in the U.S. is now more than 90 billion dollars per year (113-115). In the diabetes community, there is a feeling that aggressive measures to detect diabetes in earlier stages may be warranted. Regardless of whether evidence is convincing that there are benefits from early detection of ...

journal_title：Diabetes care

authors： Engelgau MM,Aubert RE,Thompson TJ,Herman WH

更新日期：1995-12-01 00:00:00

abstract：OBJECTIVE:Use of automated bolus advisors is associated with improved glycemic control in patients treated with insulin pump therapy. We conducted a study to assess the impact of using an insulin bolus advisor embedded in a blood glucose (BG) meter on glycemic control and treatment satisfaction in patients treated with...

journal_title：Diabetes care

authors： Ziegler R,Cavan DA,Cranston I,Barnard K,Ryder J,Vogel C,Parkin CG,Koehler W,Vesper I,Petersen B,Schweitzer MA,Wagner RS

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVE:Recurrence of plantar foot ulcers is a common and major problem in diabetes but not well understood. Foot biomechanics and patient behavior may be important. The aim was to identify risk factors for ulcer recurrence and to establish targets for ulcer prevention. RESEARCH DESIGN AND METHODS:As part of a footw...

journal_title：Diabetes care

authors： Waaijman R,de Haart M,Arts ML,Wever D,Verlouw AJ,Nollet F,Bus SA

更新日期：2014-06-01 00:00:00

abstract：:The prevalence of carotid artery occlusive disease (CAOD) in a population of adults with diabetes mellitus was determined, and factors associated with its presence were identified. By oculoplethysmography and phonoangiography, 20% of the population studied had detectable CAOD. Univariate analyses revealed that patient...

journal_title：Diabetes care

authors： Kuebler TW,Bendick PJ,Fineberg SE,Markand ON,Norton JA Jr,Vinicor FN,Clark CM Jr

更新日期：1983-05-01 00:00:00

abstract：OBJECTIVE:The cholesteryl ester transfer protein (CETP) plays a key role in the remodeling of triglyceride (TG)-rich and HDL particles. Sequence variations in the CETP gene may interfere with the effect of lipid-lowering treatment in type 2 diabetes. RESEARCH DESIGN AND METHODS:We performed a 30-week randomized double...

journal_title：Diabetes care

authors： van Venrooij FV,Stolk RP,Banga JD,Sijmonsma TP,van Tol A,Erkelens DW,Dallinga-Thie GM,DALI Study Group.

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVE:To explore the hypothesis that a relationship exists between free radical activity and abnormalities in hemostasis in NIDDM. RESEARCH DESIGN AND METHODS:The use of the total radical-trapping antioxidant parameter (TRAP) has very recently been proposed to explore the antioxidant property of a plasma and their...

journal_title：Diabetes care

authors： Ceriello A,Bortolotti N,Pirisi M,Crescentini A,Tonutti L,Motz E,Russo A,Giacomello R,Stel G,Taboga C

更新日期：1997-10-01 00:00:00

abstract：:This study describes the pharmacokinetics of three intermediate-acting insulin preparations, NPH porcine insulin, NPH human insulin (recombinant DNA), and "Depot-A" insulin, a mixture of 20% regular and 80% NPH human insulin from Eli Lilly and Company. Metabolic healthy normal weight volunteers were selected for the s...

journal_title：Diabetes care

authors： Bottermann P,Gyaram H,Wahl K,Ermler R,Lebender A

更新日期：1982-11-01 00:00:00

abstract：OBJECTIVE:To assess the efficacy and safety of initial combination therapy with sitagliptin and metformin in patients with type 2 diabetes and inadequate glycemic control on diet and exercise. RESEARCH DESIGN AND METHODS:In a 24-week, randomized, double-blind, placebo-controlled, parallel-group study, 1,091 patients w...

journal_title：Diabetes care

authors： Goldstein BJ,Feinglos MN,Lunceford JK,Johnson J,Williams-Herman DE,Sitagliptin 036 Study Group.

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVE:To determine whether adolescents with type 1 diabetes have left ventricular functional changes at rest and during acute exercise and whether these changes are affected by metabolic control and diabetes duration. RESEARCH DESIGN AND METHODS:The study evaluated 53 adolescents with type 1 diabetes and 22 contro...

journal_title：Diabetes care

authors： Gusso S,Pinto TE,Baldi JC,Robinson E,Cutfield WS,Hofman PL

更新日期：2012-10-01 00:00:00