Abstract:
OBJECTIVE:The cholesteryl ester transfer protein (CETP) plays a key role in the remodeling of triglyceride (TG)-rich and HDL particles. Sequence variations in the CETP gene may interfere with the effect of lipid-lowering treatment in type 2 diabetes. RESEARCH DESIGN AND METHODS:We performed a 30-week randomized double-blind placebo-controlled trial with atorvastatin 10 mg (A10) and 80 mg (A80) in 217 unrelated patients with diabetes. RESULTS:CETP TaqIB and A-629C polymorphisms were tightly concordant (P < 0.001). At baseline, B1B1 carriers had lower plasma HDL cholesterol (0.99 +/- 0.2 vs. 1.11 +/- 0.2 mmol/l, P < 0.05), higher CETP mass (2.62 +/- 0.8 vs. 2.05 +/- 0.4 mg/l, P < 0.001), and slightly increased, though not significant, plasma TGs (2.7 +/- 1.05 vs. 2.47 +/- 0.86, P = 0.34) compared with B2B2 carriers. Atorvastatin treatment significantly reduced CETP mass dose-dependently by 18% (A10) and 29% (A80; both vs. placebo P < 0.001, A10-A80 P < 0.001). CETP mass and activity were strongly correlated (r = 0.854, P < 0.0001). CETP TaqIB polymorphism appeared to modify the effect of atorvastatin on HDL cholesterol elevation (B1B1 7.2%, B1B2 6.1%, B2B2 0.5%; P < 0.05), TG reduction (B1B1 39.7%, B1B2 38.4%, B2B2 18.4%; P = 0.08), and CETP mass reduction (B1B1 32.1%, B1B2 29.6%, B2B2 21.9%; P = 0.27, NS). Similar results were obtained for the A-629C polymorphism. CONCLUSIONS:In conclusion, the B1B1/CC carriers of the CETP polymorphisms have a more atherogenic lipid profile, including low HDL, and they respond better to statin therapy. These results favor the hypothesis that CETP polymorphisms modify the effect of statin treatment and may help to identify patients who will benefit most from statin therapy.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
van Venrooij FV,Stolk RP,Banga JD,Sijmonsma TP,van Tol A,Erkelens DW,Dallinga-Thie GM,DALI Study Group.doi
10.2337/diacare.26.4.1216subject
Has Abstractpub_date
2003-04-01 00:00:00pages
1216-23issue
4eissn
0149-5992issn
1935-5548journal_volume
26pub_type
临床试验,杂志文章,多中心研究,随机对照试验相关文献
DIABETES CARE文献大全abstract::Fifty-one children with insulin-dependent diabetes mellitus (IDDM) and 24 healthy sibling controls were compared on one of two temperament questionnaires completed by parents. Children with IDDM did not provide a characteristic temperament profile or show any problem areas. A regression analysis to predict diabetic co...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.11.1.77
更新日期:1988-01-01 00:00:00
abstract::Diabetes is more common in older adults, has a high prevalence in long-term care (LTC) facilities, and is associated with significant disease burden and higher cost. The heterogeneity of this population with regard to comorbidities and overall health status is critical to establishing personalized goals and treatments...
journal_title:Diabetes care
pub_type: 杂志文章,实务指引,评审
doi:10.2337/dc15-2512
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVE:To describe the extent to which hyperglycemia, hypertension, and dyslipidemia are currently detected, treated, and controlled in U.S. veterans with diabetes with and without ischemic heart disease (IHD). RESEARCH DESIGN AND METHODS:A cohort of 3,769 veterans who self-reported diabetes and who received all he...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.27.suppl_2.b33
更新日期:2004-05-01 00:00:00
abstract::The acute effect of sulfonylurea drugs during long-term treatment was evaluated in two separate studies. In the first study, the levels of plasma glucose, insulin, and C-peptide were measured after intake of 10 mg glyburide alone or together with a standardized mixed meal in 10 non-insulin-dependent diabetes mellitus ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.13.3.26
更新日期:1990-08-01 00:00:00
abstract::Six hundred fifteen children (310 with diabetes, 106 nondiabetic siblings, and 199 nonsibling controls) were examined for the presence of joint contractures. Forty children had contractures: 8.4 per cent of those with diabetes and 4.6 per cent of those without diabetes. Contractures were present, however, in 9.4 per c...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.1.6.360
更新日期:1978-11-01 00:00:00
abstract:OBJECTIVE:This double-blind, placebo-controlled, randomized, multicenter, parallel-group study compared the efficacy, safety, and tolerability of Technosphere insulin with Technosphere powder as placebo in insulin-naive type 2 diabetic patients whose diabetes was suboptimally controlled with oral antidiabetic agents. ...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc08-0315
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:Pancreas size is reduced in patients at type 1 diabetes onset and in autoantibody (AAB)-positive donors without diabetes. We sought to determine whether pancreas volume (PV) imaging could improve understanding of the loss of pancreas size in first-degree relatives (FDRs) of patients with type 1 diabetes. We a...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc18-1512
更新日期:2019-02-01 00:00:00
abstract::OBJECTIVE We examine barriers to receiving recommended eye care among people aged ≥40 years with diagnosed diabetes. RESEARCH DESIGN AND METHODS We analyzed 2006-2010 Behavioral Risk Factor Surveillance System data from 22 states (n = 27,699). Respondents who had not sought eye care in the preceding 12 months were ask...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc13-1507
更新日期:2014-01-01 00:00:00
abstract::In a patient with hyperthyroidism and newly diagnosed insulin-dependent diabetes mellitus (IDDM), insulin action and clearance were studied before the initiation of antithyroid treatment and at 3-mo intervals for 1 yr thereafter. The sequential euglycemic clamp technique (5 mM) was used with insulin infusion rates of ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.12.5.319
更新日期:1989-05-01 00:00:00
abstract:OBJECTIVE:To examine the relationships between plasma 25-hydroxyvitamin D [25(OH)D] and in vivo insulin sensitivity and β-cell function relative to insulin sensitivity, disposition index (DI), in black and white youth. RESEARCH DESIGN AND METHODS:Plasma 25(OH)D concentrations were analyzed in banked specimens in healt...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc11-1825
更新日期:2012-03-01 00:00:00
abstract::Supine and standing heart rate and heart rate responses to deep breathing and standing up (the 30-to-15 ratio), indices of autonomic nervous function, were measured during each trimester and postpartum in 25 women with insulin-dependent diabetes and 10 nondiabetic women. The groups did not differ with respect to auton...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.10.6.748
更新日期:1987-11-01 00:00:00
abstract:OBJECTIVE:To investigate the prevalence of beta-cell autoantigen-reactive peripheral T-cells in type 1 diabetes, we developed an immunoglobulin-free enzyme-linked immunospot (ELISPOT) assay and assessed its usefulness for diagnosing this disease. RESEARCH DESIGN AND METHODS:Cellular immune responses to beta -cell auto...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.25.8.1390
更新日期:2002-08-01 00:00:00
abstract:OBJECTIVE:To compare three continuous glucose monitoring (CGM) devices in subjects with type 1 diabetes under closed-loop blood glucose (BG) control. RESEARCH DESIGN AND METHODS:Six subjects with type 1 diabetes (age 52 ± 14 years, diabetes duration 32 ± 14 years) each participated in two 51-h closed-loop BG control e...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-0070
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:The existence of an obese subgroup with a healthy metabolic profile and low diabetes risk has been proposed; yet long-term data are lacking. We aimed to investigate associations between combinations of BMI categories and metabolic syndrome and risk of type 2 diabetes in middle-aged men. RESEARCH DESIGN AND M...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc10-0955
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of diabetes in Tohono O'odham pregnancies, and to assess the efficacy of early prenatal diabetes screening in populations with high rates of diabetes. RESEARCH DESIGN AND METHODS:All Tohono O'odham women receiving prenatal care at the Sells Service Unit who delivered a viable baby...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.16.1.318
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:Left ventricular diastolic dysfunction (LVDD) is considered to be common in patients with type 2 diabetes mellitus (T2DM), but information on its progression over time is lacking. We studied the longitudinal development of left ventricular diastolic function (LVDF) and myocardial blood flow reserve in patient...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc14-0779
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that intra-abdominal fat plays a primary role over general adiposity for metabolic abnormalities and atherosclerosis. RESEARCH DESIGN AND METHODS:We cross-sectionally studied 849 Japanese men aged 50.3 +/- 8.5 years (range 20-78) with BMI 23.5 +/- 2.9 kg/m(2). Intimal-medial thickness ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.24.7.1248
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVE:Recent survey evidence suggests that sensory ataxia due to diabetic neuropathy may be a more frequent and serious problem than is commonly recognized. This view is further supported by research that confirms the major contribution of the somatosensory system to the control of posture. We therefore sought to d...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.17.12.1411
更新日期:1994-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the hospital care rendered to hyperglycemic individuals who did not have a diagnosis of diabetes before admission. RESEARCH DESIGN AND METHODS:A total of 1,034 consecutively hospitalized adult patients at a 750-bed inner-city teaching hospital were evaluated. Patients with one or more plasma gluc...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.21.2.246
更新日期:1998-02-01 00:00:00
abstract::We have developed computer programs in compiled BASIC for the IBM-PC and compatible microcomputers for use by physicians, paramedical personnel, and/or patients to assist with self-monitoring of blood glucose (SMBG) and self-adjustment of insulin dosage. The programs can potentially assist with patient education and m...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.9.1.61
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVE:The risk of cardiovascular death before the age of 40 is 20-fold higher in patients with type 1 diabetes mellitus (T1DM). Endothelial progenitor cells (EPCs) predict cardiovascular morbidity and mortality in patients without diabetes. We hypothesized that EPCs are modified in children with T1DM and are relate...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-1206
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:The current study aimed to determine in the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications cohort whether or not abnormal levels of markers of inflammation and endothelial dysfunction measured in samples collected at DCCT baseline were able to predict ...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc12-2521
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:Hypoxia plays a major pathogenic role in diabetic nephropathy (DN). We have investigated in this study the effect of hypoxia-inducible factor 1 α subunit (HIF1A) genetic polymorphisms on the development of DN. RESEARCH DESIGN AND METHODS:In 1,165 American type 1 diabetic patients with and without DN selected...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-1125
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:The results differ concerning randomized controlled trials of the effects of metformin on blood glucose regulation and body weight. To get a systematic overview, a meta-analysis of the efficacy of metformin was performed by comparing metformin with placebo and sulfonylurea. RESEARCH DESIGN AND METHODS:All ra...
journal_title:Diabetes care
pub_type: 杂志文章,meta分析
doi:10.2337/diacare.22.1.33
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:Women with breast cancer and diabetes face worse outcomes than those with breast cancer without diabetes; however, the contribution of comorbidity to these disparities remains unclear. We evaluated the impact of diabetes on receipt of cancer treatments as well as mortality while accounting for other comorbidi...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc17-2012
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:The provariant of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor (PPAR)gamma has been identified as a risk allele for type 2 diabetes. The purpose of the present study was to reveal a significant association with pre-diabetic phenotypes in nondiabetic individuals based on a systematic...
journal_title:Diabetes care
pub_type: 杂志文章,meta分析
doi:10.2337/dc06-0513
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVE:Major depressive disorder (MDD) and type 2 diabetes have independent adverse effects on sexual functioning (SF). Bupropion (BU) reportedly has few sexual side effects, but its use in diabetes has not been studied. RESEARCH DESIGN AND METHODS:This article reports a planned secondary analysis of SF in 90 patie...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc10-1714
更新日期:2011-02-01 00:00:00
abstract:OBJECTIVE:Epidemiological studies and randomized clinical trials have demonstrated in various populations that resting heart rate (RHR) was an independent predictor of cardiovascular (CV) risk and all-cause mortality. However, few data specifically evaluated the relationship between RHR and long-term CV and renal compl...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc11-2468
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:Some evidence suggests an inverse association between type 2 diabetes and androgens in men and a positive association between type 2 diabetes and androgens in women. The purpose of this community-based study was to evaluate sex differences in the association between endogenous total and bioavailable estrogen ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.23.7.912
更新日期:2000-07-01 00:00:00
abstract:OBJECTIVE:The racial impact on graft outcome is not well defined in diabetic recipients. The purpose of this study is to analyze our experience with kidney-alone (A) and kidney-pancreas (KP) transplantation in type 1 diabetic recipients and evaluate the impact of racial disparity on outcome. RESEARCH DESIGN AND METHOD...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.8.1310
更新日期:1997-08-01 00:00:00