Common cholesteryl ester transfer protein gene polymorphisms and the effect of atorvastatin therapy in type 2 diabetes.

Abstract:

OBJECTIVE:The cholesteryl ester transfer protein (CETP) plays a key role in the remodeling of triglyceride (TG)-rich and HDL particles. Sequence variations in the CETP gene may interfere with the effect of lipid-lowering treatment in type 2 diabetes. RESEARCH DESIGN AND METHODS:We performed a 30-week randomized double-blind placebo-controlled trial with atorvastatin 10 mg (A10) and 80 mg (A80) in 217 unrelated patients with diabetes. RESULTS:CETP TaqIB and A-629C polymorphisms were tightly concordant (P < 0.001). At baseline, B1B1 carriers had lower plasma HDL cholesterol (0.99 +/- 0.2 vs. 1.11 +/- 0.2 mmol/l, P < 0.05), higher CETP mass (2.62 +/- 0.8 vs. 2.05 +/- 0.4 mg/l, P < 0.001), and slightly increased, though not significant, plasma TGs (2.7 +/- 1.05 vs. 2.47 +/- 0.86, P = 0.34) compared with B2B2 carriers. Atorvastatin treatment significantly reduced CETP mass dose-dependently by 18% (A10) and 29% (A80; both vs. placebo P < 0.001, A10-A80 P < 0.001). CETP mass and activity were strongly correlated (r = 0.854, P < 0.0001). CETP TaqIB polymorphism appeared to modify the effect of atorvastatin on HDL cholesterol elevation (B1B1 7.2%, B1B2 6.1%, B2B2 0.5%; P < 0.05), TG reduction (B1B1 39.7%, B1B2 38.4%, B2B2 18.4%; P = 0.08), and CETP mass reduction (B1B1 32.1%, B1B2 29.6%, B2B2 21.9%; P = 0.27, NS). Similar results were obtained for the A-629C polymorphism. CONCLUSIONS:In conclusion, the B1B1/CC carriers of the CETP polymorphisms have a more atherogenic lipid profile, including low HDL, and they respond better to statin therapy. These results favor the hypothesis that CETP polymorphisms modify the effect of statin treatment and may help to identify patients who will benefit most from statin therapy.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

van Venrooij FV,Stolk RP,Banga JD,Sijmonsma TP,van Tol A,Erkelens DW,Dallinga-Thie GM,DALI Study Group.

doi

10.2337/diacare.26.4.1216

subject

Has Abstract

pub_date

2003-04-01 00:00:00

pages

1216-23

issue

4

eissn

0149-5992

issn

1935-5548

journal_volume

26

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
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    authors: Munshi MN,Florez H,Huang ES,Kalyani RR,Mupanomunda M,Pandya N,Swift CS,Taveira TH,Haas LB

    更新日期:2016-02-01 00:00:00

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    authors: Smith NL,Chen L,Au DH,McDonell M,Fihn SD

    更新日期:2004-05-01 00:00:00

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    journal_title:Diabetes care

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    authors: Faber OK,Beck-Nielsen H,Binder C,Butzer P,Damsgaard EM,Froland F,Hjollund E,Lindskov HO,Melander A,Pedersen O

    更新日期:1990-08-01 00:00:00

  • Joint contractures in patients with juvenile diabetes and their siblings.

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    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.1.6.360

    authors: Traisman HS,Traisman ES,Marr TJ,Wise J

    更新日期:1978-11-01 00:00:00

  • Efficacy and safety of Technosphere inhaled insulin compared with Technosphere powder placebo in insulin-naive type 2 diabetes suboptimally controlled with oral agents.

    abstract:OBJECTIVE:This double-blind, placebo-controlled, randomized, multicenter, parallel-group study compared the efficacy, safety, and tolerability of Technosphere insulin with Technosphere powder as placebo in insulin-naive type 2 diabetic patients whose diabetes was suboptimally controlled with oral antidiabetic agents. ...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

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    authors: Rosenstock J,Bergenstal R,Defronzo RA,Hirsch IB,Klonoff D,Boss AH,Kramer D,Petrucci R,Yu W,Levy B,0008 Study Group.

    更新日期:2008-11-01 00:00:00

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    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc18-1512

    authors: Campbell-Thompson ML,Filipp SL,Grajo JR,Nambam B,Beegle R,Middlebrooks EH,Gurka MJ,Atkinson MA,Schatz DA,Haller MJ

    更新日期:2019-02-01 00:00:00

  • Barriers to eye care among people aged 40 years and older with diagnosed diabetes, 2006-2010.

    abstract::OBJECTIVE We examine barriers to receiving recommended eye care among people aged ≥40 years with diagnosed diabetes. RESEARCH DESIGN AND METHODS We analyzed 2006-2010 Behavioral Risk Factor Surveillance System data from 22 states (n = 27,699). Respondents who had not sought eye care in the preceding 12 months were ask...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc13-1507

    authors: Chou CF,Sherrod CE,Zhang X,Barker LE,Bullard KM,Crews JE,Saaddine JB

    更新日期:2014-01-01 00:00:00

  • Increased insulin action and clearance in hyperthyroid newly diagnosed IDDM patient. Restoration to normal with antithyroid treatment.

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    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.12.5.319

    authors: Nijs HG,Radder JK,Frölich M,Krans HM

    更新日期:1989-05-01 00:00:00

  • 25-hydroxyvitamin D concentrations and in vivo insulin sensitivity and β-cell function relative to insulin sensitivity in black and white youth.

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    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-1825

    authors: Rajakumar K,de las Heras J,Lee S,Holick MF,Arslanian SA

    更新日期:2012-03-01 00:00:00

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    abstract::Supine and standing heart rate and heart rate responses to deep breathing and standing up (the 30-to-15 ratio), indices of autonomic nervous function, were measured during each trimester and postpartum in 25 women with insulin-dependent diabetes and 10 nondiabetic women. The groups did not differ with respect to auton...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.10.6.748

    authors: Airaksinen KE,Salmela PI,Ikäheimo MJ,Kirkinen P,Linnaluoto MK,Takkunen JT

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  • Detection of GAD65-reactive T-Cells in type 1 diabetes by immunoglobulin-free ELISPOT assays.

    abstract:OBJECTIVE:To investigate the prevalence of beta-cell autoantigen-reactive peripheral T-cells in type 1 diabetes, we developed an immunoglobulin-free enzyme-linked immunospot (ELISPOT) assay and assessed its usefulness for diagnosing this disease. RESEARCH DESIGN AND METHODS:Cellular immune responses to beta -cell auto...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.25.8.1390

    authors: Kotani R,Nagata M,Moriyama H,Nakayama M,Yamada K,Chowdhury SA,Chakrabarty S,Jin Z,Yasuda H,Yokono K

    更新日期:2002-08-01 00:00:00

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    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc12-0070

    authors: Damiano ER,El-Khatib FH,Zheng H,Nathan DM,Russell SJ

    更新日期:2013-02-01 00:00:00

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    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc10-0955

    authors: Arnlöv J,Sundström J,Ingelsson E,Lind L

    更新日期:2011-01-01 00:00:00

  • Diabetes mellitus in Tohon O'odham pregnancies.

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    pub_type: 杂志文章

    doi:10.2337/diacare.16.1.318

    authors: Livingston RC,Bachman-Carter K,Frank C,Mason WB

    更新日期:1993-01-01 00:00:00

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    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc14-0779

    authors: Venskutonyte L,Jarnert C,Rydén L,Kjellström B

    更新日期:2014-11-01 00:00:00

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    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.24.7.1248

    authors: Takami R,Takeda N,Hayashi M,Sasaki A,Kawachi S,Yoshino K,Takami K,Nakashima K,Akai A,Yamakita N,Yasuda K

    更新日期:2001-07-01 00:00:00

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    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.17.12.1411

    authors: Simoneau GG,Ulbrecht JS,Derr JA,Becker MB,Cavanagh PR

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    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.21.2.246

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    更新日期:1998-02-01 00:00:00

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    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.9.1.61

    authors: Pernick NL,Rodbard D

    更新日期:1986-01-01 00:00:00

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    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc12-1206

    authors: Hörtenhuber T,Rami-Mehar B,Satler M,Nagl K,Höbaus C,Höllerl F,Koppensteiner R,Schernthaner G,Schober E,Schernthaner GH

    更新日期:2013-06-01 00:00:00

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    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc12-2521

    authors: Lopes-Virella MF,Baker NL,Hunt KJ,Cleary PA,Klein R,Virella G,DCCT\/EDIC Research Group.

    更新日期:2013-08-01 00:00:00

  • Impact of the hypoxia-inducible factor-1 α (HIF1A) Pro582Ser polymorphism on diabetes nephropathy.

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    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc12-1125

    authors: Gu HF,Zheng X,Abu Seman N,Gu T,Botusan IR,Sunkari VG,Lokman EF,Brismar K,Catrina SB

    更新日期:2013-02-01 00:00:00

  • Efficacy of metformin in the treatment of NIDDM. Meta-analysis.

    abstract:OBJECTIVE:The results differ concerning randomized controlled trials of the effects of metformin on blood glucose regulation and body weight. To get a systematic overview, a meta-analysis of the efficacy of metformin was performed by comparing metformin with placebo and sulfonylurea. RESEARCH DESIGN AND METHODS:All ra...

    journal_title:Diabetes care

    pub_type: 杂志文章,meta分析

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    authors: Johansen K

    更新日期:1999-01-01 00:00:00

  • The Impact of Diabetes on Breast Cancer Treatments and Outcomes: A Population-Based Study.

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    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc17-2012

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    更新日期:2018-04-01 00:00:00

  • Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma with Pre-diabetic phenotypes: meta-analysis of 57 studies on nondiabetic individuals.

    abstract:OBJECTIVE:The provariant of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor (PPAR)gamma has been identified as a risk allele for type 2 diabetes. The purpose of the present study was to reveal a significant association with pre-diabetic phenotypes in nondiabetic individuals based on a systematic...

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    pub_type: 杂志文章,meta分析

    doi:10.2337/dc06-0513

    authors: Tönjes A,Scholz M,Loeffler M,Stumvoll M

    更新日期:2006-11-01 00:00:00

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    pub_type: 杂志文章

    doi:10.2337/dc10-1714

    authors: Sayuk GS,Gott BM,Nix BD,Lustman PJ

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    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-2468

    authors: Miot A,Ragot S,Hammi W,Saulnier PJ,Sosner P,Piguel X,Torremocha F,Marechaud R,Hadjadj S

    更新日期:2012-10-01 00:00:00

  • Sex differences in the association of endogenous sex hormone levels and glucose tolerance status in older men and women.

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    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.23.7.912

    authors: Goodman-Gruen D,Barrett-Connor E

    更新日期:2000-07-01 00:00:00

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    pub_type: 杂志文章

    doi:10.2337/diacare.20.8.1310

    authors: Douzdjian V,Bhaskar SS,Baliga PK,Gugliuzza KK,Rajagopalan PR

    更新日期:1997-08-01 00:00:00