Abstract:
OBJECTIVE:Recent survey evidence suggests that sensory ataxia due to diabetic neuropathy may be a more frequent and serious problem than is commonly recognized. This view is further supported by research that confirms the major contribution of the somatosensory system to the control of posture. We therefore sought to determine the effects of significant diabetic distal symmetrical polyneuropathy on the control of posture. RESEARCH DESIGN AND METHODS:Fifty-one subjects, divided into three groups, participated in this study. Seventeen had diabetes and significant sensory neuropathy, 17 had diabetes and no neuropathy, and 17 had neither diabetes nor neuropathy. The subjects were matched across groups, and stringent exclusion criteria were applied. Postural stability during quiet standing was measured using a force platform. In addition to electrophysiological and quantitative sensory tests of neuropathy, a number of physical and functional characteristics were measured for all subjects. RESULTS:Postural instability was found to be significantly associated with sensory neuropathy, but not with diabetes per se. Patients with sensory neuropathy demonstrated between 66 and 117% more instability than did control subjects (depending on the testing condition). Based on multiple linear regression analyses, the most significant correlates of instability were the quantitative sensory measures of neuropathy and age. CONCLUSIONS:The loss of sensory perception secondary to diabetic distal symmetrical sensory neuropathy has a markedly detrimental effect on postural stability. The deficit is greatest when visual or vestibular cues are absent or degraded. Patients with neuropathy need to be informed of the postural consequences of this condition to limit the potential morbidity caused by falls.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Simoneau GG,Ulbrecht JS,Derr JA,Becker MB,Cavanagh PRdoi
10.2337/diacare.17.12.1411subject
Has Abstractpub_date
1994-12-01 00:00:00pages
1411-21issue
12eissn
0149-5992issn
1935-5548journal_volume
17pub_type
杂志文章相关文献
DIABETES CARE文献大全abstract:OBJECTIVE:The incidence rate of childhood type 1 diabetes is thought to be increasing; however, Danish studies have not confirmed this. Using a national diabetes register initiated in 1996 and two previous regional incidence studies, we studied the age-specific incidence of type 1 diabetes over 30 years. Here, we descr...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.25.12.2197
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of the erythromycin derivative EM523L on gastric emptying and postprandial insulin requirement in insulin-dependent diabetic patients with severe gastroparesis. RESEARCH DESIGN AND METHODS:In six IDDM patients with severe gastroparesis (two men and four women, mean age 44.5 years [rang...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/diacare.20.7.1134
更新日期:1997-07-01 00:00:00
abstract:OBJECTIVE:A long-term health economic analysis was performed to establish the cost-effectiveness of real-time continuous glucose monitoring (RT-CGM) (Dexcom G6) versus self-monitoring of blood glucose (SMBG) alone in U.K.-based patients with type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS:The analysis used the IQVI...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc19-2213
更新日期:2020-10-01 00:00:00
abstract::Use of continuous subcutaneous insulin infusion requires continuing available care by skilled professionals, careful selection of patients, meticulous patient monitoring, and provisions for recording and reporting experiences. Insulin pumps prescribed by a physician within these guidelines are a part of treatment and ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.8.5.516
更新日期:1985-09-01 00:00:00
abstract:OBJECTIVE:To investigate whether dietary phylloquinone and menaquinones intakes are related to risk of type 2 diabetes. RESEARCH DESIGN AND METHODS:We used data from a prospective cohort study in 38,094 Dutch men and women, aged 20-70 years. Dietary phylloquinone and menaquinones intakes were assessed using a validate...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-2302
更新日期:2010-08-01 00:00:00
abstract:OBJECTIVE:To evaluate weight loss and cardiometabolic risk reduction achieved through an adapted Diabetes Prevention Program intervention among adults at high risk for cardiovascular disease (CVD) and diabetes. RESEARCH DESIGN AND METHODS:Eight health care facilities implemented a group-based lifestyle intervention be...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc10-0862
更新日期:2010-12-01 00:00:00
abstract:OBJECTIVE:To explore the nature of functional impairment in older people with diabetes. RESEARCH DESIGN AND METHODS:A population-based case-control study with detailed assessment of diabetes and functional status was undertaken. RESULTS:Altogether, 403 case subjects and 403 matched control subjects were studied (medi...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/dc07-1784
更新日期:2008-02-01 00:00:00
abstract::Type 1 diabetes (T1D) and celiac disease (CeD) cluster in families and can occur in the same individual. Genetic loci have been associated with susceptibility to both diseases. Our aim was to explore the genetic differences between individuals developing both these diseases (double autoimmunity) versus those with only...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dcs15-2007
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:This trial compared the efficacy and safety of the first oral glucagon-like peptide 1 (GLP-1) receptor agonist, oral semaglutide, as monotherapy with placebo in patients with type 2 diabetes managed by diet and exercise alone. Two estimands addressed two efficacy-related questions: a treatment policy estimand...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc19-0749
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:To investigate factors related to glycemic management among members of a professional cycling team with type 1 diabetes over a 7-day Union Cycliste Internationale World Tour stage race. RESEARCH DESIGN AND METHODS:An observational evaluation of possible factors related to glycemic management and performance ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc19-2302
更新日期:2020-05-01 00:00:00
abstract::A film test for the rapid detection of plasma/serum 3-hydroxybutyrate (3-OHB) has been developed. The film contains NAD, nitro blue tetrazolium, 3-OHB dehydrogenase, and diaphorase, and the surface is coated with modified biomembrane and can detect 50-1500 microM 3-OHB within 2-3 min. One drop or 50 microliters of pla...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.13.5.522
更新日期:1990-05-01 00:00:00
abstract::The readability of written instructional materials for diabetic patients is an important consideration in their use. We assessed the readability of six commonly used patient teaching guides on diabetic self-care. In addition, two pamphlets developed by our program for diabetic patients with fifth to tenth grade readin...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.4.6.627
更新日期:1981-11-01 00:00:00
abstract::A diabetic woman presented with diabetic ketoacidosis after demonstrating immediate-type hypersensitivity to heterologous insulin. She had had interrupted insulin therapy in the past. Insulin requirements during the course of treatment for the acidosis suggested marked resistance, with 50,000 U of insulin needed in th...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.7.3.276
更新日期:1984-05-01 00:00:00
abstract:OBJECTIVE:To investigate the possibility that leptin levels may be predictive of the risk of ischemic heart disease (IHD) through the relationship of leptin to body fat. RESEARCH DESIGN AND METHODS:The Quebec Cardiovascular Study cohort consisted of 2,103 French-Canadian men without IHD in 1985 who were followed until...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.21.5.782
更新日期:1998-05-01 00:00:00
abstract::To evaluate the importance of dialysis in the determination of glycosylated hemoglobin (HbA1), we studied blood glucose and HbA1 in 38 insulin-dependent diabetic children during a morning fast and again 6 h postprandially. We used two methods to determine glycosylated hemoglobin: (1) the conventional macrocolumn metho...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.4.5.551
更新日期:1981-09-01 00:00:00
abstract::This paper provides some historical aspects on the research and development of Humulin (rDNA origin), the first human health-care product derived from rDNA technology more than a decade ago. Also referred to as biosynthetic human insulin, Humulin is currently produced via the human proinsulin route, using an Escherich...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.16.3.133
更新日期:1993-12-01 00:00:00
abstract:OBJECTIVE:To compare the effects of repaglinide, glipizide, and glibenclamide on insulin secretion and postprandial glucose after a single standard 500-kcal test meal. RESEARCH DESIGN AND METHODS:A total of 12 type 2 diabetic patients with early diabetes (mean HbA(1c) of 6.1%) and 12 matched control subjects were enro...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.2337/diacare.25.8.1271
更新日期:2002-08-01 00:00:00
abstract:OBJECTIVE:To determine the frequency of IDDM risk-associated HLA-DQ beta alleles in New Zealanders with IDDM and nondiabetic control subjects, and to examine these as susceptibility markers in relation to IDDM incidence. RESEARCH DESIGN AND METHODS:HLA-DQ beta typing was conducted in 55 juvenile-onset IDDM subjects di...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.16.8.1179
更新日期:1993-08-01 00:00:00
abstract:OBJECTIVE:Diabetes is associated with oxidative stress and increased mortality, but a possible correlation between leukocyte-endothelium interactions, oxidative stress, and silent myocardial ischemia (SMI) is yet to be confirmed. RESEARCH DESIGN AND METHODS:Mitochondrial dysfunction and interactions between leukocytes...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-1224
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:To create a simple prediction rule that could perform as well as the 2-h postchallenge plasma glucose (PCPG) test to predict those at risk for diabetes. We created a prediction rule in one sample and prospectively validated it for incident diabetes in a separate cohort. RESEARCH DESIGN AND METHODS:A cross-se...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.28.2.404
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVE:To determine whether the use of glyburide is associated with an increased risk of cancer compared with the use of other second-generation sulfonylureas among patients with type 2 diabetes. RESEARCH DESIGN AND METHODS:The U.K. Clinical Practice Research Datalink was used to conduct a cohort study among 52,600...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc15-1358
更新日期:2015-11-01 00:00:00
abstract::Fifty-one children with insulin-dependent diabetes mellitus (IDDM) and 24 healthy sibling controls were compared on one of two temperament questionnaires completed by parents. Children with IDDM did not provide a characteristic temperament profile or show any problem areas. A regression analysis to predict diabetic co...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.11.1.77
更新日期:1988-01-01 00:00:00
abstract::Severe hypoglycemia (SH) is a significant problem for many patients with type I diabetes and presents a major barrier to optimal diabetes control. A critical task facing diabetes research is to understand, predict, and reduce the risk of SH in insulin-treated patients. The purpose of this article is to propose a biops...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.4.661
更新日期:1997-04-01 00:00:00
abstract:OBJECTIVE:To evaluate the brain's responses to painful visceral and somatic stimuli in diabetic patients with gastrointestinal symptoms. RESEARCH DESIGN AND METHODS:The sensitivity to electrical esophageal and median nerve stimulations was assessed in 15 healthy volunteers and 14 type 1 diabetic patients with autonomi...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-0324
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVE:Youth with type 1 diabetes face long-term risks of health complications of the disease. Little is known about patients' and parents' knowledge, acquisition of information, and family communication regarding these complications. This paper reports qualitative analyses of parental focus-group discussions of thi...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc07-2349
更新日期:2008-08-01 00:00:00
abstract::Significantly early-morning hyperglycemia was observed in insulin-dependent diabetic individuals who were otherwise well controlled while receiving a continuous subcutaneous insulin infusion (CSII) at standard doses. We measured the levels of the five key counterregulatory hormones (CRH) throughout the night for a tot...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.6.2.135
更新日期:1983-03-01 00:00:00
abstract::OBJECTIVE--To determine the prevalence of non-insulin-dependent diabetes mellitus (NIDDM), impaired glucose tolerance (IGT), and hypertension in a rural community of Bangladesh. RESEARCH DESIGN AND METHODS--A cluster sampling of 1,005 subjects > 15 years of age in the rural community of Dohar was investigated. Capilla...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.18.4.555
更新日期:1995-04-01 00:00:00
abstract::Nine healthy volunteers with normal body weights were injected subcutaneously with 125I-labeled soluble human insulin (10 U) in one thigh and 133Xe in the contralateral thigh for the measurement of subcutaneous blood flow on 2 consecutive mornings. On one of the days, standardized massage of both injection sites was p...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.9.6.570
更新日期:1986-11-01 00:00:00
abstract:OBJECTIVE:To elucidate whether serum adiponectin is associated with renal function, low-grade inflammatory markers, metabolic control, and insulin resistance in type 1 diabetic patients with and without nephropathy. RESEARCH DESIGN AND METHODS:A total of 189 type 1 diabetic patients from the Finnish Diabetic Nephropat...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.28.6.1410
更新日期:2005-06-01 00:00:00
abstract::The complexity of the several pathogenic pathways that cause hypertension and vascular disease and the prolonged interval that appears to predate clinical morbidity have hindered inquiry into the association between GDM and vascular disorders. As a forme fruste of later type 2 diabetes, GDM-affected gravidas are ident...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/dc07-s224
更新日期:2007-07-01 00:00:00