The Impact of Diabetes on Breast Cancer Treatments and Outcomes: A Population-Based Study.

Abstract:

OBJECTIVE:Women with breast cancer and diabetes face worse outcomes than those with breast cancer without diabetes; however, the contribution of comorbidity to these disparities remains unclear. We evaluated the impact of diabetes on receipt of cancer treatments as well as mortality while accounting for other comorbidities. RESEARCH DESIGN AND METHODS:Ontario administrative databases were used to compare the rate of receipt of breast cancer treatments between women with and without diabetes. We also performed adjusted cause-specific hazard models to account for comorbidities when evaluating differences in treatments received and mortality outcomes between the two groups. RESULTS:Women with diabetes and stage III breast cancer were slightly less likely to receive chemotherapy (relative risk [RR] 0.93 [95% CI 0.89-0.97]), although this difference was not significant when we adjusted for comorbidities (adjusted hazard ratio [aHR] 1.03 [95% CI 0.93-1.13]). We saw similar trends for receipt of guideline-adherent radiotherapy (RR 0.97 [0.95-0.99], aHR 0.98 [0.94-1.02]). All-cause mortality was increased in women with diabetes after adjusting for comorbidities (aHR 1.16 [1.06-1.27]), but breast cancer-specific mortality was not increased overall. Women with a longer duration of diabetes and those with preexisting cardiovascular disease had increased all-cause and cancer-specific mortality. CONCLUSIONS:Although cancer treatments received were similar between women with and without diabetes, breast cancer-specific mortality remains higher among women with diabetes who have longer diabetes duration or preexisting cardiovascular disease. This study uncovers new information about key risk factors for poorer prognosis in women with diabetes and breast cancer.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Lega IC,Austin PC,Fischer HD,Fung K,Krzyzanowska MK,Amir E,Lipscombe LL

doi

10.2337/dc17-2012

subject

Has Abstract

pub_date

2018-04-01 00:00:00

pages

755-761

issue

4

eissn

0149-5992

issn

1935-5548

pii

dc17-2012

journal_volume

41

pub_type

杂志文章
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    abstract::Limited weight loss following jejunoileal bypass in 24 diabetic persons who were still distinctly overweight five to ten months after a mean weight decrease of 78 lbs. was accompanied by a return of normal fasting glucose and insulin levels, normal insulin responses, and a decrease in glucose intolerance. The glucose ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.1.3.158

    authors: Ahmad U,Danowski TS,Nolan S,Stephan T,Sunder JH,Bahl VK

    更新日期:1978-05-01 00:00:00

  • Hepatocyte growth factor and clinical diabetes in postmenopausal women.

    abstract:OBJECTIVE:To investigate the association between circulating levels of hepatocyte growth factor (HGF), a mesenchymal-derived pleiotrophic factor that is elevated in obesity, and the prevalence of type 2 diabetes. RESEARCH DESIGN AND METHODS:A cross-sectional analysis among 892 postmenopausal women within the Women's H...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc10-0710

    authors: Rajpathak SN,Wassertheil-Smoller S,Crandall J,Liu S,Ho GY

    更新日期:2010-09-01 00:00:00

  • Beneficial effects of a soy-based dietary supplement on lipid levels and cardiovascular risk markers in type 2 diabetic subjects.

    abstract:OBJECTIVE:Consumption of soy protein has recently been shown to improve the blood lipid levels in nondiabetic subjects. The purpose of this study was to evaluate if a dietary supplement of soy protein, isoflavones, and cotyledon fiber (Abalon) affects cardiovascular risk markers, blood glucose, and insulin levels in ty...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.24.2.228

    authors: Hermansen K,Søndergaard M,Høie L,Carstensen M,Brock B

    更新日期:2001-02-01 00:00:00

  • Closing the gap: the problem of diabetes mellitus in the United States. The Carter Center of Emory University.

    abstract::Diabetes mellitus is a major public health problem and a leading cause of death, disability, and cost in the United States. We review the epidemiology of diabetes and its complications, the costs of diabetes, and discuss intervention strategies to reduce the burden of diabetes in the United States. ...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/diacare.8.4.391

    authors:

    更新日期:1985-07-01 00:00:00

  • Association of NAD(P)H oxidase p22 phox gene variation with advanced carotid atherosclerosis in Japanese type 2 diabetes.

    abstract:OBJECTIVE:To evaluate the association between the C242T polymorphism of the p22 phox gene, an essential component of NAD(P)H oxidase in the vasculature, with intima-media thickness (IMT) of the carotid artery and risk factors for atherosclerosis in type 2 diabetic subjects. RESEARCH DESIGN AND METHODS:C242T polymorphi...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.26.2.458

    authors: Hayaishi-Okano R,Yamasaki Y,Kajimoto Y,Sakamoto K,Ohtoshi K,Katakami N,Kawamori D,Miyatsuka T,Hatazaki M,Hazama Y,Hori M

    更新日期:2003-02-01 00:00:00

  • Effect of race on outcome after kidney and kidney-pancreas transplantation in type 1 diabetic patients.

    abstract:OBJECTIVE:The racial impact on graft outcome is not well defined in diabetic recipients. The purpose of this study is to analyze our experience with kidney-alone (A) and kidney-pancreas (KP) transplantation in type 1 diabetic recipients and evaluate the impact of racial disparity on outcome. RESEARCH DESIGN AND METHOD...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.20.8.1310

    authors: Douzdjian V,Bhaskar SS,Baliga PK,Gugliuzza KK,Rajagopalan PR

    更新日期:1997-08-01 00:00:00

  • Serum xylosyltransferase activity in diabetic patients as a possible marker of reduced proteoglycan biosynthesis.

    abstract:OBJECTIVE:Proteoglycan metabolism is altered in diabetic patients. The xylosyltransferases (XTs) are the initial and rate-limiting enzymes in the biosynthesis of the glycosaminoglycan chains in proteoglycans. Here, we analyzed whether the changed proteoglycan metabolism leads to altered serum XT levels in diabetic pati...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc08-0909

    authors: Götting C,Kuhn J,Kleesiek K

    更新日期:2008-10-01 00:00:00

  • Erythrocyte sodium-lithium countertransport activity in non-nephropathic diabetic twins.

    abstract:OBJECTIVE:It has proved difficult to separate the role of the diabetic state as distinct from its complications in causing the elevation in erythrocyte sodium-lithium (Na-Li) countertransport activity that has been observed in diabetes. The present study sought to isolate the impact of diabetes on the countertransporte...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.19.1.32

    authors: Hardman TC,Dubrey SW,Leslie RD,Lant AF

    更新日期:1996-01-01 00:00:00

  • Non-insulin-dependent diabetes: 10-year outcome in relation to initial response to diet and subsequent sulfonylurea therapy.

    abstract::Thirty-eight non-insulin-dependent diabetic patients within 130% of desirable body weight were given a 100-g oral glucose tolerance test (OGTT) at diagnosis and after at least 1 mo of dietary treatment with energy and carbohydrate restriction. Thirteen "responders" showed an improvement in fasting blood glucose, gluco...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:

    authors: Sönksen PH,Lowy C,Perkins JR,Lim HS

    更新日期:1984-05-01 00:00:00

  • Enhancing blood glucose awareness in adolescents and young adults with IDDM.

    abstract:OBJECTIVE:To determine the effectiveness of an intervention program designed to improve blood glucose awareness. RESEARCH DESIGN AND METHODS:Eight young-adult outpatients (mean age 22 yr) and six adolescent inpatients (mean age 14.5 yr) with insulin-dependent diabetes mellitus participated in the intervention program....

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.14.1.1

    authors: Nurick MA,Johnson SB

    更新日期:1991-01-01 00:00:00

  • Cancer arising after pancreas and/or kidney transplantation in a series of 99 diabetic patients.

    abstract:OBJECTIVE:Recipients of solid organ transplants have an increased risk of developing certain types of malignancies as compared with the general population. The majority of the literature has reported on neoplasms in kidney and heart transplant recipients. RESEARCH DESIGN AND METHODS:We describe 9 neoplasms occurring i...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.20.3.272

    authors: Martinenghi S,Dell'Antonio G,Secchi A,Di Carlo V,Pozza G

    更新日期:1997-03-01 00:00:00

  • Sexual dysfunction in Jordanian diabetic women.

    abstract:OBJECTIVE:To estimate the prevalence of female sexual dysfunction (FSD) in diabetic and nondiabetic Jordanian women. RESEARCH DESIGN AND METHODS:Data were collected from 1,137 married women using the Arabic translation of the Female Sexual Function Index questionnaire. RESULTS:Prevalence of sexual dysfunction in diab...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc08-0081

    authors: Abu Ali RM,Al Hajeri RM,Khader YS,Shegem NS,Ajlouni KM

    更新日期:2008-08-01 00:00:00

  • Psychosocial correlates of survival in diabetes.

    abstract::The goal of this research was to quantify the relationships between patient survival and a set of explanatory variables in a randomly selected sample of community-based patients with non-insulin-dependent diabetes mellitus (NIDDM). The sample included 343 patients with NIDDM initially entered into the study in 1981-19...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.11.7.538

    authors: Davis WK,Hess GE,Hiss RG

    更新日期:1988-07-01 00:00:00

  • Effect of intensive compared with standard glycemia treatment strategies on mortality by baseline subgroup characteristics: the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial.

    abstract:OBJECTIVE:To determine if baseline subgroups in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial can be identified for whom intensive compared with standard glycemia treatment had different effects on all-cause mortality. RESEARCH DESIGN AND METHODS:Exploratory post hoc intention-to-treat compariso...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2337/dc09-1471

    authors: Calles-Escandón J,Lovato LC,Simons-Morton DG,Kendall DM,Pop-Busui R,Cohen RM,Bonds DE,Fonseca VA,Ismail-Beigi F,Banerji MA,Failor A,Hamilton B

    更新日期:2010-04-01 00:00:00

  • Evidence of reduced β-cell function in Asian Indians with mild dysglycemia.

    abstract:OBJECTIVE:To examine β-cell function across a spectrum of glycemia among Asian Indians, a population experiencing type 2 diabetes development at young ages despite low BMI. RESEARCH DESIGN AND METHODS:One-thousand two-hundred sixty-four individuals without known diabetes in the Diabetes Community Lifestyle Improvement...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc12-2290

    authors: Staimez LR,Weber MB,Ranjani H,Ali MK,Echouffo-Tcheugui JB,Phillips LS,Mohan V,Narayan KM

    更新日期:2013-09-01 00:00:00

  • Relative Pancreas Volume Is Reduced in First-Degree Relatives of Patients With Type 1 Diabetes.

    abstract:OBJECTIVE:Pancreas size is reduced in patients at type 1 diabetes onset and in autoantibody (AAB)-positive donors without diabetes. We sought to determine whether pancreas volume (PV) imaging could improve understanding of the loss of pancreas size in first-degree relatives (FDRs) of patients with type 1 diabetes. We a...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc18-1512

    authors: Campbell-Thompson ML,Filipp SL,Grajo JR,Nambam B,Beegle R,Middlebrooks EH,Gurka MJ,Atkinson MA,Schatz DA,Haller MJ

    更新日期:2019-02-01 00:00:00

  • Glucose and insulin measurements from the oral glucose tolerance test and mortality prediction.

    abstract:OBJECTIVE:To verify what information from oral glucose tolerance tests (OGTTs) independently predicts mortality. RESEARCH DESIGN AND METHODS:A total of 1,401 initially nondiabetic participants from the Baltimore Longitudinal Study of Aging aged 17-95 years underwent one or more OGTTs (median 2, range 1-8), with insuli...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc07-2102

    authors: Metter EJ,Windham BG,Maggio M,Simonsick EM,Ling SM,Egan JM,Ferrucci L

    更新日期:2008-05-01 00:00:00

  • Can proopiomelanocortin methylation be used as an early predictor of metabolic syndrome?

    abstract:OBJECTIVE:The objectives of this study were to compare early predictive marker of the metabolic syndrome with proopiomelanocortin (POMC) methylation status and to determine the association among birth weight, ponderal index, and cord blood methylation status. RESEARCH DESIGN AND METHODS:We collected pregnancy outcome ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc13-1012

    authors: Yoo JY,Lee S,Lee HA,Park H,Park YJ,Ha EH,Kim YJ

    更新日期:2014-01-01 00:00:00

  • Gut microbiota metabolites of dietary lignans and risk of type 2 diabetes: a prospective investigation in two cohorts of U.S. women.

    abstract:OBJECTIVE:To examine urinary levels of enterolactone and enterodiol, intestinal microbial metabolites of dietary lignans, in relation to type 2 diabetes (T2D) risk. RESEARCH DESIGN AND METHODS:Urinary concentrations of the lignan metabolites were assayed by liquid chromatography-mass spectrometry among 1,107 T2D and 1...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/dc13-2513

    authors: Sun Q,Wedick NM,Pan A,Townsend MK,Cassidy A,Franke AA,Rimm EB,Hu FB,van Dam RM

    更新日期:2014-01-01 00:00:00

  • A comparison of the effects of n-3 fatty acids from linseed oil and fish oil in well-controlled type II diabetes.

    abstract:OBJECTIVE:Supplementation of type II diabetic diets with n-3 fatty acids (FAs) from fish oil (FO) has been associated with lowered triglyceride and VLDL levels, although reports of impaired glycemic control have limited their use. Effects of n-3FAs from nonmarine sources are less well documented. Therefore, an investig...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.19.5.463

    authors: McManus RM,Jumpson J,Finegood DT,Clandinin MT,Ryan EA

    更新日期:1996-05-01 00:00:00

  • Acceptability and satisfaction with a telecarer approach to the management of type 2 diabetes.

    abstract:OBJECTIVE:To examine patients' views of the acceptability of and satisfaction with telephone care center support provided to improve blood glucose control in type 2 diabetes. RESEARCH DESIGN AND METHODS:The Pro-Active Call-Center Treatment Support (PACCTS) Trial randomized patients from 47 general practices in a depri...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.28.2.283

    authors: Long AF,Gambling T,Young RJ,Taylor J,Mason JM,PACCTS Team.

    更新日期:2005-02-01 00:00:00

  • The role of the National Diabetes Advisory Board in diabetes management.

    abstract::The history of the National Diabetes Advisory Board is reviewed, particularly from the perspective of the role of the board in advancing diabetes care. In addition, its potential future activities in the arena of translating research advances, for example, the results of the Diabetes Control and Complications Trial (D...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:

    authors: Genuth SM

    更新日期:1994-06-01 00:00:00

  • Participating in Mental, Social, and Physical Leisure Activities and Having a Rich Social Network Reduce the Incidence of Diabetes-Related Dementia in a Cohort of Swedish Older Adults.

    abstract:OBJECTIVE:The effect of a healthy lifestyle on diabetes-related dementia remains unknown. We examined whether an active lifestyle and rich social network may counteract the increased risk of dementia in people with diabetes. RESEARCH DESIGN AND METHODS:Dementia-free older adults from the Swedish National Study on Agin...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc18-1428

    authors: Marseglia A,Wang HX,Rizzuto D,Fratiglioni L,Xu W

    更新日期:2019-02-01 00:00:00

  • Effect of socioeconomic status on mortality among people with type 2 diabetes: a study from the Scottish Diabetes Research Network Epidemiology Group.

    abstract:OBJECTIVE:The study objective was to describe the effect of socioeconomic status (SES) on mortality among people with type 2 diabetes. RESEARCH DESIGN AND METHODS:We used a population-based national electronic diabetes database for 35- to 84-year-olds in Scotland for 2001-2007 linked to mortality records. SES was deri...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc10-1862

    authors: Walker JJ,Livingstone SJ,Colhoun HM,Lindsay RS,McKnight JA,Morris AD,Petrie JR,Philip S,Sattar N,Wild SH,Scottish Diabetes Research Network Epidemiology Group.

    更新日期:2011-05-01 00:00:00

  • Temporal variation in incidence of IDDM in Canterbury, New Zealand.

    abstract:OBJECTIVES:To establish the statistical significance of observed variations over the last decade in the incidence of insulin-dependent diabetes mellitus (IDDM) in the 0- to 19-yr-old age-group and to determine whether incidence has increased in Canterbury, New Zealand. RESEARCH DESIGN AND METHODS:The Canterbury, New Z...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.15.7.895

    authors: Scott RS,Brown LJ,Darlow BA,Forbes LV,Moore MP

    更新日期:1992-07-01 00:00:00

  • Markers of insulin resistance are strong risk factors for retinopathy incidence in type 1 diabetes.

    abstract:OBJECTIVE:To determine the incidence of retinopathy and the relative importance of its risk factors in type 1 diabetes. RESEARCH DESIGN AND METHODS:This is a 7.3-year follow-up of 764 of 1,215 (63%) people with type 1 diabetes across Europe, aged 15-60 years at baseline with no retinopathy (the EURODIAB Prospective Co...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.24.2.284

    authors: Chaturvedi N,Sjoelie AK,Porta M,Aldington SJ,Fuller JH,Songini M,Kohner EM,EURODIAB Prospective Complications Study.

    更新日期:2001-02-01 00:00:00

  • Etiological approach to characterization of diabetes type: the SEARCH for Diabetes in Youth Study.

    abstract:OBJECTIVE:To describe an etiologic approach to classification of diabetes types in youth based on the 1997 American Diabetes Association (ADA) framework, using data from the SEARCH for Diabetes in Youth Study. RESEARCH DESIGN AND METHODS:SEARCH conducted a comprehensive assessment of 2,291 subjects aged <20 years with...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc10-2324

    authors: Dabelea D,Pihoker C,Talton JW,D'Agostino RB Jr,Fujimoto W,Klingensmith GJ,Lawrence JM,Linder B,Marcovina SM,Mayer-Davis EJ,Imperatore G,Dolan LM,SEARCH for Diabetes in Youth Study.

    更新日期:2011-07-01 00:00:00

  • IDDM incidence in a multiracial population. The Hawaii IDDM Registry, 1980-1990.

    abstract:OBJECTIVE:The Hawaii IDDM Registry was created to determine the incidence rate of IDDM among children aged < 15 years of Oahu between 1980 and 1990. Because of the multiracial population living in Hawaii, it is an ideal state in which to study the effect of migration on IDDM incidence. RESEARCH DESIGN AND METHODS:Data...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.20.6.983

    authors: Patrick SL,Kadohiro JK,Waxman SH,Curb JD,Orchard TJ,Dorman JS,Kuller LH,LaPorte RE

    更新日期:1997-06-01 00:00:00

  • Similar insulin sensitivity in NIDDM patients with normo- and microalbuminuria.

    abstract:OBJECTIVE:To investigate whether insulin resistance and microalbuminuria are associated in non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS:Insulin sensitivity was assessed using a hyperinsulinemic euglycemic clamp in 11 normoalbuminuric and 9 microalbuminuric NIDDM patients matched for sex...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.18.6.834

    authors: Nielsen S,Schmitz O,Orskov H,Mogensen CE

    更新日期:1995-06-01 00:00:00

  • Epidemiology and treatment of diabetic ketoacidosis in a community population.

    abstract::We evaluated the epidemiology of diabetic ketoacidosis in the period 1960-1979. In Frederiksborg County, Denmark, the incidence of ketoacidosis at the county hospital increased from 60 per 100,000 in the period 1943-1963 to 120 per 100,000 in the period 1960-1979. In the investigation period we found an increasing inc...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.7.6.528

    authors: Ellemann K,Soerensen JN,Pedersen L,Edsberg B,Andersen OO

    更新日期:1984-11-01 00:00:00