Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma with Pre-diabetic phenotypes: meta-analysis of 57 studies on nondiabetic individuals.

Abstract:

OBJECTIVE:The provariant of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor (PPAR)gamma has been identified as a risk allele for type 2 diabetes. The purpose of the present study was to reveal a significant association with pre-diabetic phenotypes in nondiabetic individuals based on a systematic meta-analysis of all available published evidence. RESEARCH DESIGN AND METHODS:We performed a classical meta-analysis of data from approximately 32,000 nondiabetic subjects in 57 studies to assess the effect of the Pro12Ala polymorphism on pre-diabetic traits. RESULTS:In the global comparison, there were no differences in BMI, glucose, insulin, or homeostasis model assessment of insulin resistance between the Pro/Pro and X/Ala genotype. However, in the Caucasian subgroup, the X/Ala genotype was associated with significantly increased BMI. In the obese subgroup (BMI >30 kg/m(2)), fasting glucose (P = 0.041) and insulin resistance (by homeostasis model analysis) (P = 0.020) were significantly greater in the Pro/Pro group. In subjects with the homozygous Ala/Ala genotype, fasting insulin was significantly lower compared with the Pro/Pro genotype (P = 0.040, N(Ala/Ala) = 154). CONCLUSIONS:Across all studies, the Pro12Ala polymorphism had no significant effect on diabetes-related traits. Only in selected subgroups, such as Caucasians and obese subjects, did we see an association of the Ala allele with greater BMI and greater insulin sensitivity. This demonstrates the importance for appropriate stratification of analyses by environmental or other genetic factors. Meta-analysis of Ala/Ala homozygotes more clearly demonstrated the association with greater insulin sensitivity of carriers of the Ala allele.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Tönjes A,Scholz M,Loeffler M,Stumvoll M

doi

10.2337/dc06-0513

subject

Has Abstract

pub_date

2006-11-01 00:00:00

pages

2489-97

issue

11

eissn

0149-5992

issn

1935-5548

pii

29/11/2489

journal_volume

29

pub_type

杂志文章,meta分析
  • Novel use and utility of integrated electronic health records to assess rates of prediabetes recognition and treatment: brief report from an integrated electronic health records pilot study.

    abstract:OBJECTIVE:This study uses novel methods to examine the frequency of diagnosis and treatment of prediabetes in real-world clinical settings using electronic health record (EHR) data. RESEARCH DESIGN AND METHODS:We identified a cohort of 358,120 adults with incident prediabetes (fasting plasma glucose [FPG] 100-125 mg/d...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc13-1223

    authors: Schmittdiel JA,Adams SR,Segal J,Griffin MR,Roumie CL,Ohnsorg K,Grant RW,O'Connor PJ

    更新日期:2014-02-01 00:00:00

  • Personal-model beliefs and social-environmental barriers related to diabetes self-management.

    abstract:OBJECTIVE:The specific aims of the present study were to report on the level of personal beliefs and social and environmental barriers across different regimen areas and patient subgroups and on the relationship of personal models and perceived barriers to the level of self-management. RESEARCH DESIGN AND METHODS:This...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.20.4.556

    authors: Glasgow RE,Hampson SE,Strycker LA,Ruggiero L

    更新日期:1997-04-01 00:00:00

  • Risk factors for the development of type II diabetes among men enrolled in the usual care group of the Multiple Risk Factor Intervention Trial.

    abstract:OBJECTIVE:To study the association between selected risk factors and the subsequent incidence of type II diabetes over a 5-yr period. RESEARCH DESIGN AND METHODS:Between 1973 and 1976, a cohort of men from 22 clinical centers throughout the U.S. enrolled in the Usual Care group of the Multiple Risk Factor Intervention...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.2337/diacare.16.10.1331

    authors: Shaten BJ,Smith GD,Kuller LH,Neaton JD

    更新日期:1993-10-01 00:00:00

  • Coincidence of a novel KCNJ11 missense variant R365H with a paternally inherited 6q24 duplication in a patient with transient neonatal diabetes.

    abstract:OBJECTIVE:Neonatal diabetes is a heterogeneous group of disorders with diabetes manifestation in the first 6 months of life. The most common etiology in permanent neonatal diabetes is mutations of the ATP-sensitive K(+) channel subunits; in transient neonatal diabetes, chromosome 6q24 abnormalities are the most common ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc08-0549

    authors: Staník J,Lethby M,Flanagan SE,Gasperíková D,Milosovicová B,Lever M,Bullman H,Zubcevic L,Hattersley AT,Ellard S,Ashcroft FM,Klimes I

    更新日期:2008-09-01 00:00:00

  • Expression of matrix metalloproteinases, cytokines, and connexins in diabetic and nondiabetic human keratinocytes before and after transplantation into an ex vivo wound-healing model.

    abstract:OBJECTIVE:Wound healing is known to require a well-organized balance of numerous factors, e.g., cytokines, matrix metalloproteinases (MMPs), and their inhibitors, as well as direct cell-cell communication (connexins). Disruption of this balance may lead to the formation of chronic wounds such as diabetic foot ulcers. T...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc07-1304

    authors: Brandner JM,Zacheja S,Houdek P,Moll I,Lobmann R

    更新日期:2008-01-01 00:00:00

  • A randomized trial of an intervention to improve self-care behaviors of African-American women with type 2 diabetes: impact on physical activity.

    abstract:OBJECTIVE:To determine whether a culturally appropriate clinic- and community-based intervention for African-American women with type 2 diabetes will increase moderate-intensity physical activity (PA). RESEARCH DESIGN AND METHODS:In this randomized controlled trial conducted at seven practices in central North Carolin...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.25.9.1576

    authors: Keyserling TC,Samuel-Hodge CD,Ammerman AS,Ainsworth BE,Henríquez-Roldán CF,Elasy TA,Skelly AH,Johnston LF,Bangdiwala SI

    更新日期:2002-09-01 00:00:00

  • Influence of hepatic steatosis (fatty liver) on severity and composition of dyslipidemia in type 2 diabetes.

    abstract:OBJECTIVE:The objective of this study was to examine the associations between the severity of hepatic steatosis and dyslipidemia in type 2 diabetes, including circulating apolipoprotein B100 (apoB) concentrations and lipoprotein particle size and numbers. RESEARCH DESIGN AND METHODS:Computed tomography imaging was use...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc06-0455

    authors: Toledo FG,Sniderman AD,Kelley DE

    更新日期:2006-08-01 00:00:00

  • Intensive replacement of basal insulin in patients with type 1 diabetes given rapid-acting insulin analog at mealtime: a 3-month comparison between administration of NPH insulin four times daily and glargine insulin at dinner or bedtime.

    abstract:OBJECTIVE:To establish differences in blood glucose between different regimens of optimized basal insulin substitution in type 1 diabetic patients given lispro insulin at meals, i.e., NPH injected four times a day versus glargine insulin once daily at dinner or at bedtime. RESEARCH DESIGN AND METHODS:A total of 51 pat...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.26.5.1490

    authors: Rossetti P,Pampanelli S,Fanelli C,Porcellati F,Costa E,Torlone E,Scionti L,Bolli GB

    更新日期:2003-05-01 00:00:00

  • Strict Preanalytical Oral Glucose Tolerance Test Blood Sample Handling Is Essential for Diagnosing Gestational Diabetes Mellitus.

    abstract:OBJECTIVE:Preanalytical processing of blood samples can affect plasma glucose measurement because ongoing glycolysis by cells prior to centrifugation can lower its concentration. In June 2017, ACT Pathology changed the processing of oral glucose tolerance test (OGTT) blood samples for pregnant women from a delayed to a...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc20-0304

    authors: Potter JM,Hickman PE,Oakman C,Woods C,Nolan CJ

    更新日期:2020-07-01 00:00:00

  • Incidence of stroke according to presence of diabetic nephropathy and severe diabetic retinopathy in patients with type 1 diabetes.

    abstract:OBJECTIVE:Type 1 diabetes is associated with a markedly increased risk of stroke, but only a few studies on the incidence of stroke in type 1 diabetes exist. Therefore, we assessed the incidence of stroke in patients with type 1 diabetes and studied the impact of diabetic nephropathy (DN) and severe diabetic retinopath...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/dc13-0669

    authors: Hägg S,Thorn LM,Putaala J,Liebkind R,Harjutsalo V,Forsblom CM,Gordin D,Tatlisumak T,Groop PH,FinnDiane Study Group.

    更新日期:2013-12-01 00:00:00

  • Comparison of a multiple daily insulin injection regimen (basal once-daily glargine plus mealtime lispro) and continuous subcutaneous insulin infusion (lispro) in type 1 diabetes: a randomized open parallel multicenter study.

    abstract:OBJECTIVE:Insulin pump therapy (continuous subcutaneous insulin infusion [CSII]) and multiple daily injections (MDIs) with insulin glargine as basal insulin and mealtime insulin lispro have not been prospectively compared in people naïve to either regimen in a multicenter study. We aimed to help close that deficiency. ...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2337/dc08-1874

    authors: Bolli GB,Kerr D,Thomas R,Torlone E,Sola-Gazagnes A,Vitacolonna E,Selam JL,Home PD

    更新日期:2009-07-01 00:00:00

  • Glucose as the Fifth Vital Sign: A Randomized Controlled Trial of Continuous Glucose Monitoring in a Non-ICU Hospital Setting.

    abstract:OBJECTIVE:The current standard for hospital glucose management is point-of-care (POC) testing. We conducted a randomized controlled trial of real-time continuous glucose monitoring (RT-CGM) compared with POC in a non-intensive care unit (ICU) hospital setting. RESEARCH DESIGN AND METHODS:A total of 110 adults with typ...

    journal_title:Diabetes care

    pub_type: 评论,杂志文章

    doi:10.2337/dc20-1016

    authors: Fortmann AL,Spierling Bagsic SR,Talavera L,Garcia IM,Sandoval H,Hottinger A,Philis-Tsimikas A

    更新日期:2020-11-01 00:00:00

  • Unrecognized diabetes among hospitalized patients.

    abstract:OBJECTIVE:To evaluate the hospital care rendered to hyperglycemic individuals who did not have a diagnosis of diabetes before admission. RESEARCH DESIGN AND METHODS:A total of 1,034 consecutively hospitalized adult patients at a 750-bed inner-city teaching hospital were evaluated. Patients with one or more plasma gluc...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.21.2.246

    authors: Levetan CS,Passaro M,Jablonski K,Kass M,Ratner RE

    更新日期:1998-02-01 00:00:00

  • Survey of physician practice behaviors related to diabetes mellitus in the U.S. Physician adherence to consensus recommendations.

    abstract:OBJECTIVE:To summarize the frequency of physician adherence to consensus recommendations for prevention of diabetic complications. RESEARCH DESIGN AND METHODS:Survey data from a nationwide stratified probability sample of primary-care physicians were analyzed. Adherence to recommendations were reported by physician sp...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.16.11.1507

    authors: Kenny SJ,Smith PJ,Goldschmid MG,Newman JM,Herman WH

    更新日期:1993-11-01 00:00:00

  • Insulin-based versus triple oral therapy for newly diagnosed type 2 diabetes: which is better?

    abstract:OBJECTIVE:Early use of insulin after diagnosis of type 2 diabetes is met with resistance because of associated weight gain, hypoglycemia, and fear of decreased compliance and quality of life (QoL). RESEARCH DESIGN AND METHODS:In treatment-naive patients with newly diagnosed type 2 diabetes, insulin and metformin were ...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc09-0653

    authors: Lingvay I,Legendre JL,Kaloyanova PF,Zhang S,Adams-Huet B,Raskin P

    更新日期:2009-10-01 00:00:00

  • Smoking and mortality among women with type 2 diabetes: The Nurses' Health Study cohort.

    abstract:OBJECTIVE:To assess the relationship between cigarette smoking and mortality among women with type 2 diabetes in the Nurses' Health Study cohort. RESEARCH DESIGN AND METHODS:The Nurses' Health Study, a prospective cohort of U.S. female registered nurses, included 7,401 women with type 2 diabetes diagnosed at baseline ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.24.12.2043

    authors: Al-Delaimy WK,Willett WC,Manson JE,Speizer FE,Hu FB

    更新日期:2001-12-01 00:00:00

  • Advancing basal insulin replacement in type 2 diabetes inadequately controlled with insulin glargine plus oral agents: a comparison of adding albiglutide, a weekly GLP-1 receptor agonist, versus thrice-daily prandial insulin lispro.

    abstract:OBJECTIVE:GLP-1 receptor agonists may provide an alternative to prandial insulin for advancing basal insulin therapy. Harmony 6 was a randomized, open-label, active-controlled trial testing once-weekly albiglutide vs. thrice-daily prandial insulin lispro as an add-on to titrated once-daily insulin glargine. RESEARCH D...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2337/dc14-0001

    authors: Rosenstock J,Fonseca VA,Gross JL,Ratner RE,Ahrén B,Chow FC,Yang F,Miller D,Johnson SL,Stewart MW,Leiter LA,Harmony 6 Study Group.

    更新日期:2014-08-01 00:00:00

  • Management of dyslipidemia in NIDDM.

    abstract::Coronary heart disease is the leading cause of death among patients with non-insulin-dependent diabetes mellitus (NIDDM). NIDDM patients have a high frequency of dyslipidemia, which along with obesity, hypertension, and hyperglycemia may contribute significantly to accelerated coronary atherosclerosis. Because risk fa...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/diacare.13.2.153

    authors: Garg A,Grundy SM

    更新日期:1990-02-01 00:00:00

  • Effect of raloxifene on serum triglycerides in women with a history of hypertriglyceridemia while on oral estrogen therapy.

    abstract:OBJECTIVE:Raloxifene hydrochloride is a selective estrogen receptor modulator that to date has not been shown to cause hypertriglyceridemia in normal, diabetic, or hypertriglyceridemic women. This study was designed to assess the effect of raloxifene on serum triglycerides in postmenopausal women who have a history of ...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/diacare.28.7.1555

    authors: Carr MC,Knopp RH,Brunzell JD,Wheeler BS,Zhu X,Lakshmanan M,Rosen AS,Anderson PW

    更新日期:2005-07-01 00:00:00

  • Comparison of plasma glucose and plasma free insulin during CSII and intensified conventional insulin therapy.

    abstract::The plasma glucose and plasma free insulin profiles of six totally insulin-dependent diabetic patients were compared during periods of 4 days in hospital under a conventional insulin therapy (ICIT) comprising 4 daily injections of regular insulin and under continuous subcutaneous insulin infusion (CSII). Two profiles ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.6.1.1

    authors: Buysschaert M,Marchand E,Ketelslegers JM,Lambert AE

    更新日期:1983-01-01 00:00:00

  • Hyperglycemia and Adverse Pregnancy Outcome Follow-up Study (HAPO FUS): Maternal Gestational Diabetes Mellitus and Childhood Glucose Metabolism.

    abstract:OBJECTIVE:Whether hyperglycemia in utero less than overt diabetes is associated with altered childhood glucose metabolism is unknown. We examined associations of gestational diabetes mellitus (GDM) not confounded by treatment with childhood glycemia in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) cohort. RES...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc18-1646

    authors: Lowe WL Jr,Scholtens DM,Kuang A,Linder B,Lawrence JM,Lebenthal Y,McCance D,Hamilton J,Nodzenski M,Talbot O,Brickman WJ,Clayton P,Ma RC,Tam WH,Dyer AR,Catalano PM,Lowe LP,Metzger BE,HAPO Follow-up Study Cooperative Res

    更新日期:2019-03-01 00:00:00

  • Pubertal growth in IDDM is determined by HbA1c levels, sex, and bone age.

    abstract:OBJECTIVE:In cross-sectional studies of subjects with IDDM, the relationship between suboptimal pubertal growth, glycemic control, and abnormal insulin-like growth factor I (IGF-I) levels has proved difficult to define. The objective of this study was to examine these relationships in a longitudinal prospective study. ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.21.5.831

    authors: Ahmed ML,Connors MH,Drayer NM,Jones JS,Dunger DB

    更新日期:1998-05-01 00:00:00

  • Bacille Calmette-Guérin vaccination and incidence of IDDM in Montreal, Canada.

    abstract:OBJECTIVE:To describe the association between Bacille Calmette-Guérin (BCG) vaccination and IDDM development in two different case-control series (A and B) in Montreal. RESEARCH DESIGN AND METHODS:Case-control series A comprised 93 IDDM cases and 2,903 control subjects who participated in a community-based tuberculin ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.20.5.767

    authors: Parent ME,Siemiatycki J,Menzies R,Fritschi L,Colle E

    更新日期:1997-05-01 00:00:00

  • Mechanisms of Sodium-Glucose Cotransporter 2 Inhibition: Insights From Large-Scale Proteomics.

    abstract:OBJECTIVE:To assess the effects of empagliflozin, a selective sodium-glucose cotransporter 2 (SGLT2) inhibitor, on broad biological systems through proteomics. RESEARCH DESIGN AND METHODS:Aptamer-based proteomics was used to quantify 3,713 proteins in 144 paired plasma samples obtained from 72 participants across the ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc20-0456

    authors: Ferrannini E,Murthy AC,Lee YH,Muscelli E,Weiss S,Ostroff RM,Sattar N,Williams SA,Ganz P

    更新日期:2020-09-01 00:00:00

  • High incidence of childhood type 1 diabetes in Liguria, Italy, from 1989 to 1998.

    abstract:OBJECTIVE:Assessing updated incidence of type 1 diabetes in 0- to 14-year-old children in Liguria, a Northwest region of Italy. RESEARCH DESIGN AND METHODS:Incident cases were recorded prospectively from 1989 to 1998. Incidence rates (IRs) were standardized to the 1999 world population using the direct method. The ind...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.26.6.1786

    authors: Cotellessa M,Barbieri P,Mazzella M,Bonassi S,Minicucci L,Lorini R

    更新日期:2003-06-01 00:00:00

  • Treatment of diabetic ketoacidosis with subcutaneous insulin aspart.

    abstract:OBJECTIVE:In this prospective, randomized, open trial, we compared the efficacy and safety of aspart insulin given subcutaneously at different time intervals to a standard low-dose intravenous (IV) infusion protocol of regular insulin in patients with uncomplicated diabetic ketoacidosis (DKA). RESEARCH DESIGN AND METH...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.27.8.1873

    authors: Umpierrez GE,Cuervo R,Karabell A,Latif K,Freire AX,Kitabchi AE

    更新日期:2004-08-01 00:00:00

  • Long-term metformin use is associated with decreased risk of breast cancer.

    abstract:OBJECTIVE:To evaluate whether use of oral hypoglycemic agents is associated with an altered breast cancer risk in women. RESEARCH DESIGN AND METHODS:Using the U.K.-based General Practice Research Database, we conducted a nested case-control analysis among 22,621 female users of oral antidiabetes drugs with type 2 diab...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-1791

    authors: Bodmer M,Meier C,Krähenbühl S,Jick SS,Meier CR

    更新日期:2010-06-01 00:00:00

  • Acute complications and drug misuse are important causes of death for children and young adults with type 1 diabetes: results from the Yorkshire Register of diabetes in children and young adults.

    abstract:OBJECTIVE:To examine mortality rates and causes of death among subjects diagnosed with type 1 diabetes aged

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc07-2029

    authors: Feltbower RG,Bodansky HJ,Patterson CC,Parslow RC,Stephenson CR,Reynolds C,McKinney PA

    更新日期:2008-05-01 00:00:00

  • Diabetes Distress, Intentional Hyperglycemia at Work, and Glycemic Control Among Workers With Type 1 Diabetes.

    abstract:OBJECTIVE:The aim was to explore relationships between work-related factors, work-related diabetes distress (WRDD), diabetes distress (measured by Problem Areas in Diabetes [PAID]-5 scale), intentional hyperglycemia at work (IHW), and glycemic control. RESEARCH DESIGN AND METHODS:A cross-sectional survey was conducted...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc18-1426

    authors: Hansen UM,Skinner T,Olesen K,Willaing I

    更新日期:2019-05-01 00:00:00

  • Oxygen Therapy in Myocardial Infarction Patients With or Without Diabetes: A Predefined Subgroup Analysis From the DETO2X-AMI Trial.

    abstract:OBJECTIVE:To determine the effects of oxygen therapy in myocardial infarction (MI) patients with and without diabetes. RESEARCH DESIGN AND METHODS:In the Determination of the Role of Oxygen in Suspected Acute Myocardial Infarction (DETO2X-AMI) trial, 6,629 normoxemic patients with suspected MI were randomized to oxyge...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc19-0590

    authors: Nyström T,James SK,Lindahl B,Östlund O,Erlinge D,Herlitz J,Omerovic E,Mellbin L,Alfredsson J,Fröbert O,Jernberg T,Hofmann R,DETO2X-SWEDEHEART Investigators.

    更新日期:2019-11-01 00:00:00