Glycemic control from 1988 to 2000 among U.S. adults diagnosed with type 2 diabetes: a preliminary report.

Abstract:

OBJECTIVE:To describe the changes in demographics, antidiabetic treatment, and glycemic control among the prevalent U.S. adult diagnosed type 2 diabetes population between the National Health and Nutrition Examination Survey (NHANES) III (1988-1994) and the initial release of NHANES 1999-2000. RESEARCH DESIGN AND METHODS:The study population was derived from NHANES III (n = 1,215) and NHANES 1999-2000 (n = 372) subjects who reported a diagnosis of type 2 diabetes with available data on diabetes medication and HbA(1c). Four therapeutic regimens were defined: diet only, insulin only, oral antidiabetic drugs (OADs) only, or OADs plus insulin. Multiple logistic regression was used to examine changes in antidiabetic regimens and glycemic control rates over time, adjusted for demographic and clinical risk factors. The outcome measure for glycemic control was HbA(1c). Glycemic control rates were defined as the proportion of type 2 diabetic patients with HbA(1c) level <7%. RESULTS:Dietary treatment in individuals with diabetes decreased as the sole therapy from 27.4 to 20.2% between the surveys. Insulin use also decreased from 24.2 to 16.4%, while those on OADs only increased from 45.4 to 52.5%. Combination of OADs and insulin increased from 3.1 to 11.0%. Glycemic control rates declined from 44.5% in NHANES III (1988-1994) to 35.8% in NHANES 1999-2000. CONCLUSIONS:Treatment regimens among U.S. adults diagnosed with type 2 diabetes have changed substantially over the past 10 years. However, a decrease in glycemic control rates was also observed during this time period. This trend may contribute to increased rates of macrovascular and microvascular diabetic complications, which may impact health care costs. Our data support the public health message of implementation of early, aggressive management of diabetes.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Koro CE,Bowlin SJ,Bourgeois N,Fedder DO

doi

10.2337/diacare.27.1.17

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

17-20

issue

1

eissn

0149-5992

issn

1935-5548

journal_volume

27

pub_type

杂志文章
  • Postural instability in patients with diabetic sensory neuropathy.

    abstract:OBJECTIVE:Recent survey evidence suggests that sensory ataxia due to diabetic neuropathy may be a more frequent and serious problem than is commonly recognized. This view is further supported by research that confirms the major contribution of the somatosensory system to the control of posture. We therefore sought to d...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.17.12.1411

    authors: Simoneau GG,Ulbrecht JS,Derr JA,Becker MB,Cavanagh PR

    更新日期:1994-12-01 00:00:00

  • A pregnancy and postpartum lifestyle intervention in women with gestational diabetes mellitus reduces diabetes risk factors: a feasibility randomized control trial.

    abstract:OBJECTIVE:To pilot, among women with gestational diabetes mellitus (GDM), the feasibility of a prenatal/postpartum intervention to modify diet and physical activity similar to the Diabetes Prevention Program. The intervention was delivered by telephone, and support for breastfeeding was addressed. RESEARCH DESIGN AND ...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc10-2221

    authors: Ferrara A,Hedderson MM,Albright CL,Ehrlich SF,Quesenberry CP Jr,Peng T,Feng J,Ching J,Crites Y

    更新日期:2011-07-01 00:00:00

  • Should Restrictions Be Relaxed for Metformin Use in Chronic Kidney Disease? Yes, They Should Be Relaxed! What's the Fuss?

    abstract::Metformin is and has been considered as first-line therapy for type 2 diabetes for over a quarter of a century. Like other biguanides, metformin can cause a lactic acidosis that is exceptionally rare but fatal. The likelihood of metformin-associated lactic acidosis is substantially higher in patients with kidney impai...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc15-2534

    authors: Bakris GL,Molitch ME

    更新日期:2016-07-01 00:00:00

  • Controversies for Glucose Control Targets in Type 2 Diabetes: Exposing the Common Ground.

    abstract::Glycated hemoglobin targets have been given in guidelines for the last three decades, mostly without change at around 6.5-7.0% (47-53 mmol/mol). Personalization of such targets has also long been advocated, but often with little and inappropriate guidance. More recently some have suggested higher targets might be indi...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/dci19-0002

    authors: Home P

    更新日期:2019-09-01 00:00:00

  • Dissociation of microangiopathy and macroangiopathy in patients with type 2 diabetes.

    abstract:OBJECTIVE:Although persistent hyperglycemia contributes greatly to the progression of diabetic micro- and macroangiopathy, microangiopathy progresses more rapidly than macroangiopathy in some type 2 diabetic patients, with the opposite being true in others. This study was conducted to identify factors responsible for s...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.21.9.1451

    authors: Yamamoto M,Egusa G,Okubo M,Yamakido M

    更新日期:1998-09-01 00:00:00

  • Improvements in patient-reported outcomes associated with an intervention to enhance quality of care for rural patients with type 2 diabetes: results of a controlled trial.

    abstract:OBJECTIVE:The aim of this study was to examine patient-reported outcomes in a controlled trial of a multifaceted provider-level intervention to improve quality of care for rural patients with type 2 diabetes. RESEARCH DESIGN AND METHODS:We conducted a before/after intervention study with concurrent controls in two rur...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.2337/diacare.27.6.1306

    authors: Maddigan SL,Majumdar SR,Guirguis LM,Lewanczuk RZ,Lee TK,Toth EL,Johnson JA

    更新日期:2004-06-01 00:00:00

  • Fasting plasma free fatty acids and risk of type 2 diabetes: the atherosclerosis risk in communities study.

    abstract:OBJECTIVE:To evaluate whether plasma levels of free fatty acids (FFAs) are independently associated with incidence of type 2 diabetes. RESEARCH DESIGN AND METHODS:A case-cohort design was used to randomly select 580 incident cases of diabetes and 566 noncases from 10,275 African-American and white men and women in the...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.27.1.77

    authors: Pankow JS,Duncan BB,Schmidt MI,Ballantyne CM,Couper DJ,Hoogeveen RC,Golden SH,Atherosclerosis Risk in Communities Study.

    更新日期:2004-01-01 00:00:00

  • Impact of diabetes on physical function in older people.

    abstract:OBJECTIVE:To explore the nature of functional impairment in older people with diabetes. RESEARCH DESIGN AND METHODS:A population-based case-control study with detailed assessment of diabetes and functional status was undertaken. RESULTS:Altogether, 403 case subjects and 403 matched control subjects were studied (medi...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/dc07-1784

    authors: Sinclair AJ,Conroy SP,Bayer AJ

    更新日期:2008-02-01 00:00:00

  • Combined effect of nonalcoholic fatty liver disease and impaired fasting glucose on the development of type 2 diabetes: a 4-year retrospective longitudinal study.

    abstract:OBJECTIVE:To evaluate whether there is a difference in the association between nonalcoholic fatty liver disease (NAFLD) and incident diabetes based on the presence of impaired fasting glucose. RESEARCH DESIGN AND METHODS:A total of 7,849 individuals (5,409 men and 2,440 women) without diabetes, who underwent comprehen...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc10-1991

    authors: Bae JC,Rhee EJ,Lee WY,Park SE,Park CY,Oh KW,Park SW,Kim SW

    更新日期:2011-03-01 00:00:00

  • Incremental value of the pancreas allograft to the survival of simultaneous pancreas-kidney transplant recipients.

    abstract:OBJECTIVE:To quantify the incremental survival benefit of the pancreas allograft in simultaneous pancreas-kidney (SPK) transplant recipients. RESEARCH DESIGN AND METHODS:Data from the national transplant database from 2000 to 2007 were analyzed. SPK recipients who had functioning allografts to 1-year post transplant (...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc08-1718

    authors: Salvalaggio PR,Dzebisashvili N,Pinsky B,Schnitzler MA,Burroughs TE,Graff R,Axelrod DA,Brennan DC,Lentine KL

    更新日期:2009-04-01 00:00:00

  • Prediction of diabetes based on baseline metabolic characteristics in individuals at high risk.

    abstract:OBJECTIVE:Individuals with impaired glucose tolerance (IGT) are at high risk for developing type 2 diabetes mellitus (T2DM). We examined which characteristics at baseline predicted the development of T2DM versus maintenance of IGT or conversion to normal glucose tolerance. RESEARCH DESIGN AND METHODS:We studied 228 su...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc13-0520

    authors: Defronzo RA,Tripathy D,Schwenke DC,Banerji M,Bray GA,Buchanan TA,Clement SC,Henry RR,Kitabchi AE,Mudaliar S,Ratner RE,Stentz FB,Musi N,Reaven PD,Gastaldelli A,ACT NOW Study.

    更新日期:2013-11-01 00:00:00

  • 9. Pharmacologic Approaches to Glycemic Treatment: Standards of Medical Care in Diabetes-2021.

    abstract::The American Diabetes Association (ADA) "Standards of Medical Care in Diabetes" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practic...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/dc21-S009

    authors: American Diabetes Association.

    更新日期:2021-01-01 00:00:00

  • Nonadherence to Insulin Therapy Detected by Bluetooth-Enabled Pen Cap Is Associated With Poor Glycemic Control.

    abstract:OBJECTIVE:To objectively evaluate adherence to timing and dosing of insulin by using Bluetooth pen caps and examine factors related to adherence. RESEARCH DESIGN AND METHODS:Bluetooth-enabled insulin pen caps were used in younger (ages 18-35 years) and older (ages ≥65 years) adults on two or more insulin injections pe...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc18-1631

    authors: Munshi MN,Slyne C,Greenberg JM,Greaves T,Lee A,Carl S,Atakov-Castillo A,Toschi E

    更新日期:2019-06-01 00:00:00

  • A prognostic role of mean 24-h pulse pressure level for cardiovascular events in type 2 diabetic subjects under 60 years of age.

    abstract:OBJECTIVE:To assess the prognostic role of ambulatory 24-h pulse pressure (PP) on various vascular events in relatively young type 2 diabetic subjects under 60 years of age. RESEARCH DESIGN AND METHODS:In this prospective study, 237 type 2 diabetic subjects without any history of vascular complications were analyzed. ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.28.1.95

    authors: Nakano S,Konishi K,Furuya K,Uehara K,Nishizawa M,Nakagawa A,Kigoshi T,Uchida K

    更新日期:2005-01-01 00:00:00

  • Characteristics associated with maintenance of mean A1C

    abstract:OBJECTIVE:To assess the success and baseline predictors of maintaining glycemic control for up to 5 years of therapy using basal insulin glargine or standard glycemic care in people with dysglycemia treated with zero or one oral glucose-lowering agents. RESEARCH DESIGN AND METHODS:Data from 12,537 participants in the ...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc12-2238

    authors: ORIGIN Trial Investigators.

    更新日期:2013-10-01 00:00:00

  • Longitudinal development of left ventricular diastolic function in patients with type 2 diabetes.

    abstract:OBJECTIVE:Left ventricular diastolic dysfunction (LVDD) is considered to be common in patients with type 2 diabetes mellitus (T2DM), but information on its progression over time is lacking. We studied the longitudinal development of left ventricular diastolic function (LVDF) and myocardial blood flow reserve in patient...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc14-0779

    authors: Venskutonyte L,Jarnert C,Rydén L,Kjellström B

    更新日期:2014-11-01 00:00:00

  • Diabetes with the 3243 mitochondrial tRNALeu(UUR) mutation. Characteristic neuroimaging findings.

    abstract:OBJECTIVE:To investigate the basis of central nervous system dysfunction in diabetes associated with the 3243 mitochondrial tRNA mutation, we studied neuroimaging findings in patients with this disease. RESEARCH DESIGN AND METHODS:We screened 205 diabetic patients. Those patients who had the 3243 mutation in leukocyte...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.19.7.739

    authors: Suzuki Y,Hata T,Miyaoka H,Atsumi Y,Kadowaki H,Taniyama M,Kadowaki T,Odawara M,Tanaka Y,Asahina T,Matsuoka K

    更新日期:1996-07-01 00:00:00

  • Long-term Cost-Effectiveness of Dexcom G6 Real-time Continuous Glucose Monitoring Versus Self-Monitoring of Blood Glucose in Patients With Type 1 Diabetes in the U.K.

    abstract:OBJECTIVE:A long-term health economic analysis was performed to establish the cost-effectiveness of real-time continuous glucose monitoring (RT-CGM) (Dexcom G6) versus self-monitoring of blood glucose (SMBG) alone in U.K.-based patients with type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS:The analysis used the IQVI...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc19-2213

    authors: Roze S,Isitt J,Smith-Palmer J,Javanbakht M,Lynch P

    更新日期:2020-10-01 00:00:00

  • Variations of ambulatory blood pressure with position in patients with type 1 diabetes: influence of disease duration and microangiopathy in a pilot study.

    abstract:OBJECTIVE:To study the influence of position changes on 24-h ambulatory blood pressure (ABP) in normotensive or mildly hypertensive normoalbuminuric patients with type 1 diabetes. RESEARCH DESIGN AND METHODS:A cross-sectional evaluation of patients was staged according to the duration of diabetes (DD) and the presence...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.24.9.1624

    authors: Benhamou PY,Mouret S,Quesada JL,Boizel R,Baguet JP,Halimi S,Mallion JM

    更新日期:2001-09-01 00:00:00

  • Absorption kinetics and biologic effects of subcutaneously injected insulin preparations.

    abstract::This paper describes systematic studies on the absorption kinetics of exogenous insulin from its subcutaneous tissue depot in 52 male nonobese volunteers (age 20-30 yr). Five experimental protocols were used: effect of changing injection site, effect of temperature change and local massage, effect of aprotinin and hum...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.5.2.77

    authors: Berger M,Cüppers HJ,Hegner H,Jörgens V,Berchtold P

    更新日期:1982-03-01 00:00:00

  • Effect of High-Deductible Insurance on High-Acuity Outcomes in Diabetes: A Natural Experiment for Translation in Diabetes (NEXT-D) Study.

    abstract:OBJECTIVE:High-deductible health plans (HDHPs) are now the predominant commercial health insurance benefit in the U.S. We sought to determine the effects of HDHPs on emergency department and hospital care, adverse outcomes, and total health care expenditures among patients with diabetes. RESEARCH DESIGN AND METHODS:We...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc17-1183

    authors: Wharam JF,Zhang F,Eggleston EM,Lu CY,Soumerai SB,Ross-Degnan D

    更新日期:2018-05-01 00:00:00

  • Diabetic peripheral neuropathy is associated with increased arterial stiffness without changes in carotid intima-media thickness in type 2 diabetes.

    abstract:OBJECTIVE:This study was conducted to investigate the association of diabetic peripheral neuropathy (DPN) with both arterial stiffness and intima-media thickness (IMT). RESEARCH DESIGN AND METHODS:We conducted a cross-sectional analysis of 731 subjects with type 2 diabetes. DPN was diagnosed on the basis of neuropathi...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc10-2222

    authors: Kim ES,Moon SD,Kim HS,Lim DJ,Cho JH,Kwon HS,Ahn CW,Yoon KH,Kang MI,Cha BY,Son HY

    更新日期:2011-06-01 00:00:00

  • 25-hydroxyvitamin D concentrations and in vivo insulin sensitivity and β-cell function relative to insulin sensitivity in black and white youth.

    abstract:OBJECTIVE:To examine the relationships between plasma 25-hydroxyvitamin D [25(OH)D] and in vivo insulin sensitivity and β-cell function relative to insulin sensitivity, disposition index (DI), in black and white youth. RESEARCH DESIGN AND METHODS:Plasma 25(OH)D concentrations were analyzed in banked specimens in healt...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-1825

    authors: Rajakumar K,de las Heras J,Lee S,Holick MF,Arslanian SA

    更新日期:2012-03-01 00:00:00

  • Impact of diabetes on long-term survival after acute myocardial infarction: comparability of risk with prior myocardial infarction.

    abstract:OBJECTIVE:To determine the effect of diabetes on long-term survival after acute myocardial infarction and to compare its effect with that of a previous myocardial infarction. RESEARCH DESIGN AND METHODS:In a prospective cohort study, we followed 1,935 patients hospitalized with a confirmed acute myocardial infarction ...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/diacare.24.8.1422

    authors: Mukamal KJ,Nesto RW,Cohen MC,Muller JE,Maclure M,Sherwood JB,Mittleman MA

    更新日期:2001-08-01 00:00:00

  • Age at onset and the risk of proliferative retinopathy in type 1 diabetes.

    abstract:OBJECTIVE:Age at onset of type 1 diabetes influences the risk of microvascular complications. However, the long-term risk of proliferative retinopathy within the wide spectrum of age at onset of type 1 diabetes is less well known. RESEARCH DESIGN AND METHODS:A sample of 1,117 consecutively recruited patients was drawn...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-2278

    authors: Hietala K,Harjutsalo V,Forsblom C,Summanen P,Groop PH,FinnDiane Study Group.

    更新日期:2010-06-01 00:00:00

  • Ocular Anti-VEGF therapy for diabetic retinopathy: the role of VEGF in the pathogenesis of diabetic retinopathy.

    abstract::Diabetic retinopathy is the leading cause of visual impairment and preventable blindness, and represents a significant socioeconomic cost for health care systems worldwide. Therefore, new approaches beyond current standards of diabetes care are needed. Based on the crucial pathogenic role of vascular endothelial growt...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/dc13-2002

    authors: Simó R,Sundstrom JM,Antonetti DA

    更新日期:2014-04-01 00:00:00

  • The Bidirectional Association Between Depression and Severe Hypoglycemic and Hyperglycemic Events in Type 1 Diabetes.

    abstract:OBJECTIVE:Severe hyperglycemia and hypoglycemia ("severe dysglycemia") are serious complications of type 1 diabetes (T1D). Depression has been associated with severe dysglycemia in type 2 diabetes but has not been thoroughly examined specifically in T1D. We evaluated bidirectional associations between depression and se...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc17-1566

    authors: Gilsanz P,Karter AJ,Beeri MS,Quesenberry CP Jr,Whitmer RA

    更新日期:2018-03-01 00:00:00

  • Electronic Documentation of Lifestyle Counseling and Glycemic Control in Patients With Diabetes.

    abstract:OBJECTIVE:To establish quantitative characteristics of lifestyle counseling documentation associated with improved glycemic control in patients with diabetes. RESEARCH DESIGN AND METHODS:We retrospectively studied 10,870 hyperglycemic (HbA1c ≥7.0% [53 mmol/mol]) adults with diabetes followed at primary care practices ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc14-2016

    authors: Hosomura N,Goldberg SI,Shubina M,Zhang M,Turchin A

    更新日期:2015-07-01 00:00:00

  • Long-term follow-up of oral glucose tolerance test-derived glucose tolerance and insulin secretion and insulin sensitivity indexes in subjects with glucokinase mutations (MODY2).

    abstract:OBJECTIVE:We investigated the natural history of glucokinase (GCK)-related maturity-onset diabetes of the young type 2 (MODY2), notably the factors associated with deterioration of hyperglycemia over time. RESEARCH DESIGN AND METHODS:We report an 11-year follow-up of glucose tolerance and indexes of insulin secretion ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc07-2017

    authors: Martin D,Bellanné-Chantelot C,Deschamps I,Froguel P,Robert JJ,Velho G

    更新日期:2008-07-01 00:00:00

  • Effect of raloxifene on serum triglycerides in women with a history of hypertriglyceridemia while on oral estrogen therapy.

    abstract:OBJECTIVE:Raloxifene hydrochloride is a selective estrogen receptor modulator that to date has not been shown to cause hypertriglyceridemia in normal, diabetic, or hypertriglyceridemic women. This study was designed to assess the effect of raloxifene on serum triglycerides in postmenopausal women who have a history of ...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/diacare.28.7.1555

    authors: Carr MC,Knopp RH,Brunzell JD,Wheeler BS,Zhu X,Lakshmanan M,Rosen AS,Anderson PW

    更新日期:2005-07-01 00:00:00