Abstract:
OBJECTIVE:We investigated the natural history of glucokinase (GCK)-related maturity-onset diabetes of the young type 2 (MODY2), notably the factors associated with deterioration of hyperglycemia over time. RESEARCH DESIGN AND METHODS:We report an 11-year follow-up of glucose tolerance and indexes of insulin secretion and insulin sensitivity derived from oral glucose tolerance tests in 33 MODY2 subjects. RESULTS:The variation between tests of glucose tolerance (expressed as the area under the glucose curve) was 6.9 +/- 3.2% (mean +/- SEM), but individual results ranged from -20 to 61%. Deterioration of glucose tolerance between tests was associated with decreased insulin sensitivity, while insulin secretion remained stable. CONCLUSIONS:Glucose tolerance can remain stable over many years in subjects with MODY2 due to the relative stability of the GCK-related beta-cell defect. However, the development of insulin resistance may have an important role in the deterioration of the glucose tolerance and in the long-term evolution of the disorder.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Martin D,Bellanné-Chantelot C,Deschamps I,Froguel P,Robert JJ,Velho Gdoi
10.2337/dc07-2017subject
Has Abstractpub_date
2008-07-01 00:00:00pages
1321-3issue
7eissn
0149-5992issn
1935-5548pii
dc07-2017journal_volume
31pub_type
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