Abstract:
OBJECTIVE:To evaluate whether plasma levels of free fatty acids (FFAs) are independently associated with incidence of type 2 diabetes. RESEARCH DESIGN AND METHODS:A case-cohort design was used to randomly select 580 incident cases of diabetes and 566 noncases from 10,275 African-American and white men and women in the Atherosclerosis Risk in Communities study, aged 45-64 years and without prevalent diabetes at the baseline exam. Incident diabetes was ascertained at three exams over 9 years of follow-up. FFA levels were measured in plasma samples collected at the baseline exam. RESULTS:At baseline, FFA level was inversely associated with height and positively associated with female sex, BMI, waist circumference, waist-to-hip ratio, heart rate, plasma triglycerides, and an inflammation score quantifying levels of six systemic inflammation markers. Relative risks for incident diabetes (fourth vs. first quartile of FFAs) were increased in a basic model adjusted for age, sex, race, and center (hazard ratio 1.68, 95% CI 1.20-2.34) and in a model further adjusted for baseline fasting glucose, insulin, BMI, waist circumference, triglycerides, and the inflammation score (1.63, 1.04-2.57). Relative risks associated with a greater FFA level were lowest among those of normal weight and highest among the obese, but a formal test of interaction between FFAs and BMI was not statistically significant. CONCLUSIONS:Individuals with higher fasting levels of plasma FFAs were at modestly higher risk of type 2 diabetes in this cohort of middle-aged adults.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Pankow JS,Duncan BB,Schmidt MI,Ballantyne CM,Couper DJ,Hoogeveen RC,Golden SH,Atherosclerosis Risk in Communities Study.doi
10.2337/diacare.27.1.77subject
Has Abstractpub_date
2004-01-01 00:00:00pages
77-82issue
1eissn
0149-5992issn
1935-5548journal_volume
27pub_type
杂志文章相关文献
DIABETES CARE文献大全abstract:OBJECTIVE:To compare recent U.S. and U.K. guidelines on gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS:The guidelines from the American Diabetes Association, the American College of Obstetricians and Gynecologists, and the National Institute for Health and Clinical Excellence (NICE) in the U.K. were ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-1376
更新日期:2010-01-01 00:00:00
abstract::This commentary/review briefly considers the diverse criteria recommended for classification of overweight infants. Macrosomia continues to be a vexing problem for both obstetricians and pediatricians. Among the various techniques possible for use in assessing body composition, none are more practical than body weight...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.22.7.1201
更新日期:1999-07-01 00:00:00
abstract:OBJECTIVE:Inflammatory markers predict type 2 diabetes and relate to the metabolic syndrome. Gestational diabetes mellitus (GDM) predicts type 2 diabetes and may be part of this syndrome. To examine the association of inflammatory markers with GDM, we investigated total sialic acid (TSA) in women with and without previ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.25.8.1331
更新日期:2002-08-01 00:00:00
abstract:OBJECTIVE:High birth weight is a risk factor for neonatal complications. It is not known if the risk differs with body proportionality. The primary aim of this study was to determine the risk of adverse pregnancy outcome in relation to body proportionality in large-for-gestational-age (LGA) infants stratified by matern...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc13-0899
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:To determine the occurrence of elevated fetal hemoglobin (HbF) among the diabetic population and determine the clinical situation of importance. RESEARCH DESIGN AND METHODS:A cross-sectional study was conducted. HbA1c and HbF were measured with high-performance liquid chromatography in 1,104 consecutive diab...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/diacare.17.8.828
更新日期:1994-08-01 00:00:00
abstract:OBJECTIVE:In a few previous studies, cardiovascular disease (CVD) risk factors (RFs) have been shown to predict diabetes. Our objective was to determine whether the presence of CVD RFs predict the eventual development of diabetes after controlling for known RFs, such as directly measured insulin resistance and obesity....
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.27.9.2234
更新日期:2004-09-01 00:00:00
abstract:OBJECTIVE:To promote foot screening of inpatients with diabetes, we simplified sensory testing to lightly touching the tips of the first, third, and fifth toes (the Ipswich Touch Test [IpTT]). RESEARCH DESIGN AND METHODS:Respective performances of the IpTT and 10-g monofilament (MF) were compared with a vibration perc...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc11-0156
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:This study assessed the ability to distinguish between type 1 diabetes-affected individuals and their unaffected relatives using HLA and single nucleotide polymorphism (SNP) genotypes. RESEARCH DESIGN AND METHODS:Eight models, ranging from only the high-risk DR3/DR4 genotype to all significantly associated H...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc12-2284
更新日期:2013-09-01 00:00:00
abstract::The goal of this study was to evaluate a program of resistance weight training on cardiovascular risk factors, blood glucose management, and overall strength in diabetic subjects. A randomized crossover design was performed on eight male type I (insulin-dependent) diabetic subjects (mean +/- SD age 31 +/- 3.5 yr, heig...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.13.10.1039
更新日期:1990-10-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to increase the cross-state comparability of diabetes mortality statistics related in the U.S. and Mexico. RESEARCH DESIGN AND METHODS:We used multinomial logistic regression to estimate the effects of individual and community factors on a death for which diabetes was recorded as on...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc07-1370
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:To examine the contribution of nerve-axon reflex-related vasodilation to total acetylcholine-induced vasodilation in the skin of normal and diabetic subjects. RESEARCH DESIGN AND METHODS:The skin microcirculation was evaluated at the forearm level in 69 healthy subjects and 42 nonneuropathic diabetic patient...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.24.2.344
更新日期:2001-02-01 00:00:00
abstract::OBJECTIVE Using a nationally representative sample of the civilian noninstitutionalized U.S. population, we estimated trends in diabetes prevalence across cohorts born 1910-1989 and provide the first estimates of age-specific diabetes incidence using nationally representative, measured data. RESEARCH DESIGN AND METHOD...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc13-1982
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to determine the prevalence of diabetes in pregnancy (gestational diabetes mellitus [GDM] and NIDDM) and to identify risk factors in the development of GDM in a native population in northwestern Ontario, Canada. RESEARCH DESIGN AND METHODS:A retrospective analysis of 1,305 singl...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.9.1422
更新日期:1997-09-01 00:00:00
abstract:OBJECTIVE:Psychophysical methods in patients with diabetes mellitus reveal deficits of central or foveal vision. Our aim was to evaluate the contrast-sensitivity thresholds in 24 insulin-dependent (type I) diabetic patients with a short disease duration and without retinopathy, taking into account metabolic control. R...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.15.5.620
更新日期:1992-05-01 00:00:00
abstract:OBJECTIVE:To examine psychometric properties of the Self-Care Inventory-revised (SCI-R), a self-report measure of perceived adherence to diabetes self-care recommendations, among adults with diabetes. RESEARCH DESIGN AND METHODS:We used three data sets of adult type 1 and type 2 diabetic patients to examine psychometr...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.28.6.1346
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVE:To investigate the relation between total fish, type of fish (lean and fatty), and eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) intake and risk of type 2 diabetes in a population-based cohort. RESEARCH DESIGN AND METHODS:The analysis included 4,472 Dutch participants aged >or=55 years without d...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-1042
更新日期:2009-11-01 00:00:00
abstract::The etiology of impotence in the diabetic population has not been clearly defined. To assess this problem, 24 impotent diabetic subjects, 21 nonimpotent diabetic subjects, and 10 subjects with psychogenic impotence were compared with nocturnal monitoring of penile tumescence and rigidity, penile arterial blood flow, a...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.12.7.449
更新日期:1989-07-01 00:00:00
abstract:OBJECTIVE:We aimed to study the association of breast-feeding duration and age at the introduction of solid foods with the risk of islet autoimmunity and type 1 diabetes in genetically susceptible children. RESEARCH DESIGN AND METHODS:Newborns were recruited from the Norwegian general population during 2001-2007. Afte...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc14-1130
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVE:In cross-sectional studies of subjects with IDDM, the relationship between suboptimal pubertal growth, glycemic control, and abnormal insulin-like growth factor I (IGF-I) levels has proved difficult to define. The objective of this study was to examine these relationships in a longitudinal prospective study. ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.21.5.831
更新日期:1998-05-01 00:00:00
abstract::High-density lipoprotein (HDL) cholesterol is known to be low in patients with diabetes mellitus. Low HDL levels are correlated with premature cardiovascular mortality in several major epidemiologic studies and many investigators believe increases in HDL cholesterol may reduce the risk of coronary heart disease. We ev...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.8.4.343
更新日期:1985-07-01 00:00:00
abstract::OBJECTIVE Previous studies have demonstrated aberrant glucagon physiology in the setting of type 1 diabetes (T1D) but have not addressed the potential impact of ambient glycemia on this glucagon response. Thus, our objective was to evaluate the impact of euglycemia versus hyperglycemia on the glucagon response to an o...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc13-2339
更新日期:2014-04-01 00:00:00
abstract::A representative sample of 817 American women aged 20-44 yr who were not pregnant and had no medical history of diabetes were given 75-g 2-h oral glucose tolerance tests (OGTTs). Although these conditions are somewhat different from those recommended for pregnant women (100 g glucose, 3-h OGTT), 3.8% of the women migh...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.11.5.402
更新日期:1988-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the brain's responses to painful visceral and somatic stimuli in diabetic patients with gastrointestinal symptoms. RESEARCH DESIGN AND METHODS:The sensitivity to electrical esophageal and median nerve stimulations was assessed in 15 healthy volunteers and 14 type 1 diabetic patients with autonomi...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-0324
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVE:To investigate whether self-rated health profiles compiled using the EuroQol group's visual analog scale (EQ VAS) are independent predictors of vascular events and major complications in people with type 2 diabetes after controlling for standard clinical risk factors. RESEARCH DESIGN AND METHODS:The study is...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc07-1391
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVE:To characterize the relationship of subclinical and clinical eating disorders to HbA1c values in women with IDDM. RESEARCH DESIGN AND METHODS:Ninety women with IDDM (18-46 years of age) were recruited from diabetes clinics throughout Connecticut and Massachusetts. Subjects were categorized into one of three ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.2.182
更新日期:1997-02-01 00:00:00
abstract::Urinary albumin excretion rate (radial immunodiffusion), glomerular filtration rate (GFR) (single-shot 51Cr-EDTA technique), and arterial blood pressure (BP) were measured in 12 juvenile-onset, insulin-dependent diabetic patients with persistent proteinuria (greater than 0.5 g/day) due to diabetic nephropathy. Mean ag...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.4.4.459
更新日期:1981-07-01 00:00:00
abstract::Pregnancy induces complex changes in energy metabolism, manifested clinically by insulin resistance, low fasting blood glucose levels, and proneness to ketosis. It is quite unusual for pregnant women who do not have type I diabetes to progress from ketosis to frank ketoacidosis, although this phenomenon is common in l...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.6.922
更新日期:1997-06-01 00:00:00
abstract:OBJECTIVE:Blood pressure control can reduce the risk of coronary heart disease (CHD) among diabetic patients; however, it is not known whether the lowest risk of CHD is among diabetic patients with the lowest blood pressure level. RESEARCH DESIGN AND METHODS:We performed a prospective cohort study (2000-2009) on diabe...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc13-0189
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:We examined the association between high blood pressure and incident type 2 diabetes in African Americans and whites aged 35-54 years at baseline. RESEARCH DESIGN AND METHODS:We combined data from the Atherosclerosis Risk in Communities (ARIC) study, the Coronary Artery Risk Development in Young Adults (CARD...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc10-1786
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:To compare three continuous glucose monitoring (CGM) devices in subjects with type 1 diabetes under closed-loop blood glucose (BG) control. RESEARCH DESIGN AND METHODS:Six subjects with type 1 diabetes (age 52 ± 14 years, diabetes duration 32 ± 14 years) each participated in two 51-h closed-loop BG control e...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-0070
更新日期:2013-02-01 00:00:00