Nonselective loss of contrast sensitivity in visual system testing in early type I diabetes.

abstract：OBJECTIVE:To determine the association between nonalcoholic fatty liver disease and the risk for development of diabetes. RESEARCH DESIGN AND METHODS:We conducted an observational cohort study in male workers > or = 40 years old in a Japanese company from 1997 to 2005. We excluded workers with alcohol intake > or = 20...

journal_title：Diabetes care

authors： Shibata M,Kihara Y,Taguchi M,Tashiro M,Otsuki M

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:To investigate the effects of metformin on glycemic control, insulin resistance, and risk factors for cardiovascular disease in NIDDM subjects from two ethnic groups (Caucasian and Asian) with different risks of cardiovascular disease. RESEARCH DESIGN AND METHODS:A total of 27 subjects with NIDDM (17 Caucasi...

journal_title：Diabetes care

authors： Nagi DK,Yudkin JS

更新日期：1993-04-01 00:00:00

abstract：OBJECTIVE:This trial compared the efficacy and safety of the first oral glucagon-like peptide 1 (GLP-1) receptor agonist, oral semaglutide, as monotherapy with placebo in patients with type 2 diabetes managed by diet and exercise alone. Two estimands addressed two efficacy-related questions: a treatment policy estimand...

journal_title：Diabetes care

authors： Aroda VR,Rosenstock J,Terauchi Y,Altuntas Y,Lalic NM,Morales Villegas EC,Jeppesen OK,Christiansen E,Hertz CL,Haluzík M,PIONEER 1 Investigators.

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:To determine whether clinically significant differences exist in fasting blood glucose (BG) at the forearm, palm, and thigh relative to the fingertip; to assess the impact of prandial status by comparing BG between alternative sites and the fingertip at several time intervals after carbohydrate intake; to ass...

journal_title：Diabetes care

authors： Bina DM,Anderson RL,Johnson ML,Bergenstal RM,Kendall DM

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVE:To examine the impact of Hurricane Katrina on the health of individuals with diabetes. RESEARCH DESIGN AND METHODS:This was an observational study in 1,795 adults with an A1C measurement 6 months before and 6-16 months after Hurricane Katrina in three health care systems: private (Tulane University Hospital ...

journal_title：Diabetes care

authors： Fonseca VA,Smith H,Kuhadiya N,Leger SM,Yau CL,Reynolds K,Shi L,McDuffie RH,Thethi T,John-Kalarickal J

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the utility of GAD antibodies (GADAs) and islet antigen-2 antibodies (IA-2As) in prediction of type 1 diabetes over 27 years in the general population and to assess the 6-year rates of seroconversion. RESEARCH DESIGN AND METHODS:A total of 3,475 nondiabetic subjects aged 3-18 years were sampled i...

journal_title：Diabetes care

authors： Knip M,Korhonen S,Kulmala P,Veijola R,Reunanen A,Raitakari OT,Viikari J,Akerblom HK

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:Diabetes is a predictor of both coronary artery disease (CAD) and heart failure. It is unknown to what extent the association between diabetes and heart failure is influenced by other risk factors for heart failure. RESEARCH DESIGN AND METHODS:We evaluated the association of diabetes and A1C with incident he...

journal_title：Diabetes care

authors： van Melle JP,Bot M,de Jonge P,de Boer RA,van Veldhuisen DJ,Whooley MA

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:We examined the effect of intrauterine diabetes exposure (IDE) on the incidence of diabetic end-stage renal disease (ESRD) in Pima Indians with type 2 diabetes. RESEARCH DESIGN AND METHODS:Individuals were followed from their first diabetic examination until December 2006, death, ESRD, or age of 45 years. R...

journal_title：Diabetes care

authors： Pavkov ME,Hanson RL,Knowler WC,Sievers ML,Bennett PH,Nelson RG

更新日期：2010-11-01 00:00:00

abstract：OBJECTIVE:In 2010, the American Heart Association defined seven metrics (smoking, BMI, physical activity, diet, total cholesterol, blood pressure, and fasting plasma glucose) for ideal cardiovascular health (ICH). Subsequent studies have shown that the prevalence of achieving these metrics is very low in the general po...

journal_title：Diabetes care

authors： Alman AC,Maahs DM,Rewers MJ,Snell-Bergeon JK

更新日期：2014-02-01 00:00:00

abstract：:Whereas self-monitoring of blood glucose (SMBG) is the recommended source of information on which to make self-care decisions, patients frequently use estimates of their own blood glucose (BG). This study evaluated whether patients with insulin-dependent diabetes mellitus (IDDM) could learn to improve accuracy of BG e...

journal_title：Diabetes care

authors： Cox DJ,Gonder-Frederick LA,Lee JH,Julian DM,Carter WR,Clarke WL

更新日期：1989-05-01 00:00:00

abstract：OBJECTIVE:Individuals with type 2 diabetes are particularly vulnerable to cardiovascular disease. Insulin resistance is a major determinant of this increased risk and is a potential therapeutic target. This study was undertaken to establish the natural biological variation of insulin resistance in individuals with type...

journal_title：Diabetes care

authors： Jayagopal V,Kilpatrick ES,Jennings PE,Hepburn DA,Atkin SL

更新日期：2002-11-01 00:00:00

abstract：:To quantify the association of abnormal glucose tolerance with hypertension and postural hypotension, 2480 men and women aged 50-89 yr from a defined population were evaluated by oral glucose tolerance and measurements of supine, seated, and standing blood pressure. In both sexes, adults with impaired glucose toleranc...

journal_title：Diabetes care

authors： Reaven PD,Barrett-Connor EL,Browner DK

更新日期：1990-02-01 00:00:00

abstract：OBJECTIVE:Emerging evidence suggests that peripheral neuropathy begins in the early stages of diabetes pathogenesis. Our objective was to describe the prevalence of peripheral neuropathy and nerve dysfunction according to glucose tolerance and metabolic syndrome status and examine how these conditions are associated wi...

journal_title：Diabetes care

authors： Lee CC,Perkins BA,Kayaniyil S,Harris SB,Retnakaran R,Gerstein HC,Zinman B,Hanley AJ

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVE:This study was performed to evaluate whether an additional dose of NPH insulin at lunchtime might overcome the deleterious effects of waning basal insulinemia on pre-dinner and evening glucose values during insulin lispro intensive therapy with once daily basal insulin at night. RESEARCH DESIGN AND METHODS:T...

journal_title：Diabetes care

authors： Stades AM,Hoekstra JB,van den Tweel I,Erkelens DW,Holleman F,STABILITY Study Group.

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVE:We examined the association of lactation duration with incident type 2 diabetes among women with a history of gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS:We monitored 4,372 women with a history of GDM participating in the Nurses' Health Study II for incident type 2 diabetes over 25 years...

journal_title：Diabetes care

authors： Ley SH,Chavarro JE,Li M,Bao W,Hinkle SN,Wander PL,Rich-Edwards J,Olsen S,Vaag A,Damm P,Grunnet LG,Mills JL,Hu FB,Zhang C

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:To compare pharmacokinetics (PK) and pharmacodynamics (PD) of insulin glargine in type 2 diabetes mellitus (T2DM) after evening versus morning administration. RESEARCH DESIGN AND METHODS:Ten T2DM insulin-treated persons were studied during 24-h euglycemic glucose clamp, after glargine injection (0.4 units/kg...

journal_title：Diabetes care

authors： Porcellati F,Lucidi P,Cioli P,Candeloro P,Marinelli Andreoli A,Marzotti S,Ambrogi M,Bolli GB,Fanelli CG

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:To longitudinally characterize changes in insulin sensitivity in obese women during and after pregnancy. RESEARCH DESIGN AND METHODS:Six glucose-tolerant obese women underwent a 4-h euglycemic-hyperinsulinemic (500-600 pmol/l) clamping during the second (22.5 +/- 2 weeks [mean +/- SD]) and third trimester (3...

journal_title：Diabetes care

authors： Sivan E,Chen X,Homko CJ,Reece EA,Boden G

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVE:Adjunctive-to-insulin therapy with sodium-glucose cotransporter 2 (SGLT2) inhibition may improve glycemic control in type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS:We evaluated the glycemic efficacy and safety of empagliflozin 25 mg daily in 40 patients treated for 8 weeks in a single-arm open-label proo...

journal_title：Diabetes care

authors： Perkins BA,Cherney DZ,Partridge H,Soleymanlou N,Tschirhart H,Zinman B,Fagan NM,Kaspers S,Woerle HJ,Broedl UC,Johansen OE

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVE:We sought to examine the mechanisms by which the addition of glargine insulin or rosiglitazone improves glycemic control in type 2 diabetic subjects poorly controlled on maximally effective doses of metformin plus sulfonylurea. RESEARCH DESIGN AND METHODS:Subjects (aged 47 +/- 11 years, BMI 31 +/- 5 kg/m(2),...

journal_title：Diabetes care

authors： Triplitt C,Glass L,Miyazaki Y,Wajcberg E,Gastaldelli A,De Filippis E,Cersosimo E,DeFronzo RA

更新日期：2006-11-01 00:00:00

abstract：OBJECTIVE:We investigated whether islet autoantibody profile, HLA-DQ genotype, and age influenced a 20-year progression to diabetes from first autoantibody positivity (autoAb+) in first-degree relatives of patients with type 1 diabetes. RESEARCH DESIGN AND METHODS:Persistently islet autoAb+ siblings and offspring (n =...

journal_title：Diabetes care

authors： Gorus FK,Balti EV,Messaaoui A,Demeester S,Van Dalem A,Costa O,Dorchy H,Mathieu C,Van Gaal L,Keymeulen B,Pipeleers DG,Weets I,Belgian Diabetes Registry.

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that intra-abdominal fat plays a primary role over general adiposity for metabolic abnormalities and atherosclerosis. RESEARCH DESIGN AND METHODS:We cross-sectionally studied 849 Japanese men aged 50.3 +/- 8.5 years (range 20-78) with BMI 23.5 +/- 2.9 kg/m(2). Intimal-medial thickness ...

journal_title：Diabetes care

authors： Takami R,Takeda N,Hayashi M,Sasaki A,Kawachi S,Yoshino K,Takami K,Nakashima K,Akai A,Yamakita N,Yasuda K

更新日期：2001-07-01 00:00:00

abstract：OBJECTIVE:HER2/ErbB2 is a member of the epidermal growth factor receptor family. It is widely used as a tumor marker, but it also has recently been associated with insulin resistance. Both ErbB2 and diabetes have been associated with cancer; however, the relationship between ErbB2 and diabetes has not been well explore...

journal_title：Diabetes care

authors： Muhammad IF,Borné Y,Bao X,Melander O,Orho-Melander M,Nilsson PM,Nilsson J,Engström G

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:Hyperinsulinemic euglycemia, or insulin resistance syndrome (IRS), is associated with increased morbidity and mortality. Although thought to be associated with proinflammatory states, little work has been done in this area. Here, we determined the impact of IRS on functional, biochemical, metabolic, and infla...

journal_title：Diabetes care

authors： Banks WA,Willoughby LM,Thomas DR,Morley JE

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVE:High triglyceride (TG) levels and low HDL cholesterol (HDL-C) levels are risk factors for cardiovascular disease. It is unclear whether this relationship depends on glycemic dysregulation, sex, or LDL cholesterol (LDL-C) level. RESEARCH DESIGN AND METHODS:We studied 3,216 participants (40% men, 41% with diab...

journal_title：Diabetes care

authors： Lee JS,Chang PY,Zhang Y,Kizer JR,Best LG,Howard BV

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVE:To determine the prevalence of type 2 diabetes and impaired fasting glycemia (IFG) in a tribal population of Bangladesh. RESEARCH DESIGN AND METHODS:A cluster sampling of 1,287 tribal subjects of age > or =20 years was investigated. They live in a hilly area of Khagrachari in the far northeast of Bangladesh....

journal_title：Diabetes care

authors： Abu Sayeed M,Mahtab H,Akter Khanam P,Abul Ahsan K,Banu A,Rashid AN,Azad Khan AK

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVE:To evaluate the relationship between renal function, ambulatory blood pressure (AMBP), and glycemic control in microalbuminuric IDDM patients compared with normoalbuminuric patients. RESEARCH DESIGN AND METHODS:Nineteen male patients (age 33 +/- 6 years) with slight microalbuminuria (UAE 20-70 micrograms/min...

journal_title：Diabetes care

authors： Poulsen PL,Juhl B,Ebbehøj E,Klein F,Christiansen C,Mogensen CE

更新日期：1997-03-01 00:00:00

abstract：OBJECTIVE:To prospectively determine risk factors for foot infection in a cohort of people with diabetes. RESEARCH DESIGN AND METHODS:We evaluated then followed 1,666 consecutive diabetic patients enrolled in a managed care-based outpatient clinic in a 2-year longitudinal outcomes study. At enrollment, patients underw...

journal_title：Diabetes care

authors： Lavery LA,Armstrong DG,Wunderlich RP,Mohler MJ,Wendel CS,Lipsky BA

更新日期：2006-06-01 00:00:00

abstract：OBJECTIVE:With increasing life expectancy in the U.S., it is important to know whether a longer life expectancy means a longer healthy life span or a prolonged period of later-life morbidity. This study examines changes in lifetime without diabetes, a leading cause of morbidity in later life. RESEARCH DESIGN AND METHO...

journal_title：Diabetes care

authors： Cunningham SA,Riosmena F,Wang J,Boyle JP,Rolka DB,Geiss LS

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to determine the effect of 24 weeks of treatment with 45 mg/day pioglitazone on peripheral skin blood flow (SkBF) and skin nitric oxide (NO) production in vivo in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS:This was a randomized, parallel, cross-over, double-blind...

journal_title：Diabetes care

authors： Vinik AI,Ullal J,Parson HK,Barlow PM,Casellini CM

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVE:To investigate the association between stature-related measurements (height, leg length, and leg length-to-height ratio) and adiposity, insulin resistance, and glucose intolerance. RESEARCH DESIGN AND METHODS:We conducted a cross-sectional analysis of a nationally representative sample of 7,424 adults aged 4...

journal_title：Diabetes care

authors： Asao K,Kao WH,Baptiste-Roberts K,Bandeen-Roche K,Erlinger TP,Brancati FL

更新日期：2006-07-01 00:00:00