Abstract:
OBJECTIVE:HER2/ErbB2 is a member of the epidermal growth factor receptor family. It is widely used as a tumor marker, but it also has recently been associated with insulin resistance. Both ErbB2 and diabetes have been associated with cancer; however, the relationship between ErbB2 and diabetes has not been well explored. The aim of this population-based cohort study was to assess the association between plasma ErbB2 and incidence of diabetes. RESEARCH DESIGN AND METHODS:The study population included participants from the Malmö Diet and Cancer-Cardiovascular Cohort (age range 46-68 years). After excluding participants with a history of diabetes and those missing data for ErbB2 and other covariates, the final study population consisted of 4,220 individuals. Incidence of diabetes was followed through linkages to local and national registers. Cox proportional hazards regression was used to assess the incidence of diabetes in relation to quartiles of ErbB2, adjusted for potential confounders. RESULTS:Plasma ErbB2 was significantly and positively associated with glucose, insulin, and HbA1c after being adjusted for potential confounding factors. During a mean ± SD follow-up period of 20.20 ± 5.90 years, 615 participants (14.6%) were diagnosed with new-onset diabetes. Individuals with high levels of ErbB2 had a significantly higher risk of diabetes than those with low levels of ErbB2. The multivariable-adjusted hazard ratio was 1.31 (95% CI 1.03-1.66; P < 0.05) for the highest versus the lowest quartile of ErbB2 and was 1.15 (95% CI 1.05-1.25; P < 0.05) per 1-SD increase in ErbB2. CONCLUSIONS:Elevated levels of ErbB2 are associated with increased incidence of diabetes.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Muhammad IF,Borné Y,Bao X,Melander O,Orho-Melander M,Nilsson PM,Nilsson J,Engström Gdoi
10.2337/dc18-2556subject
Has Abstractpub_date
2019-08-01 00:00:00pages
1582-1588issue
8eissn
0149-5992issn
1935-5548pii
dc18-2556journal_volume
42pub_type
杂志文章相关文献
DIABETES CARE文献大全abstract:OBJECTIVE:Early use of insulin after diagnosis of type 2 diabetes is met with resistance because of associated weight gain, hypoglycemia, and fear of decreased compliance and quality of life (QoL). RESEARCH DESIGN AND METHODS:In treatment-naive patients with newly diagnosed type 2 diabetes, insulin and metformin were ...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc09-0653
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVE:To characterize metabolic effects of troglitazone in type 2 diabetic, obese, and lean subjects, and examine the effects of troglitazone 2-3 weeks after discontinuation. RESEARCH DESIGN AND METHODS:Nine type 2 diabetic, nine obese, and nine lean subjects underwent baseline metabolic studies including an 8-h m...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/diacare.23.1.64
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:The performance of glycated hemoglobin (HbA1c) and fasting plasma glucose (FPG) was compared in screening for diabetes by an oral glucose tolerance test (OGTT) in patients undergoing coronary angiography (CAG). RESEARCH DESIGN AND METHODS:Patients without known diabetes admitted for CAG were eligible. OGTT a...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-1434
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:The symptoms of 430 type 2 diabetic patients were determined by a self-administered questionnaire before entry into the U.K. Prospective Diabetes Study. RESEARCH DESIGN AND METHODS:Entry into the trial followed 2 months of dietary treatment for newly diagnosed patients with type 2 diabetes. Forty symptoms wi...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.21.1.111
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:It is known that continuous glucose monitoring (CGM) systems can lower mean glucose compared with episodic self-monitoring of blood glucose. Implantable CGM systems may provide additional benefits. RESEARCH DESIGN AND METHODS:We studied the Eversense (Senseonics Inc.) implantable CGM sensor in 71 participant...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,多中心研究
doi:10.2337/dc16-1525
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:To estimate the prevalence of female sexual dysfunction (FSD) in diabetic and nondiabetic Jordanian women. RESEARCH DESIGN AND METHODS:Data were collected from 1,137 married women using the Arabic translation of the Female Sexual Function Index questionnaire. RESULTS:Prevalence of sexual dysfunction in diab...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc08-0081
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVE:Platelet hyperfunction is a typical feature of the prothrombotic state that frequently complicates the natural history of diabetes. In uremia, a bleeding diathesis is present, which principally involves the primary phase of hemostasis. Thus, in patients with uremia of diabetic origin, the infrequent coexisten...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.19.10.1062
更新日期:1996-10-01 00:00:00
abstract:OBJECTIVE:In patients with clinical hemochromatosis, the frequency of diabetes ranges from 20 to 50%, and the heterozygosity for the C282Y mutation in the HFE gene might be associated with an increased risk for diabetes. There are also some reports that suggest that iron overload might cause diabetic nephropathy. RESE...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.24.7.1187
更新日期:2001-07-01 00:00:00
abstract::OBJECTIVE--To determine the prevalence of non-insulin-dependent diabetes mellitus (NIDDM), impaired glucose tolerance (IGT), and hypertension in a rural community of Bangladesh. RESEARCH DESIGN AND METHODS--A cluster sampling of 1,005 subjects > 15 years of age in the rural community of Dohar was investigated. Capilla...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.18.4.555
更新日期:1995-04-01 00:00:00
abstract::In a 10-yr prospective population study 406 subjects who were 70 yr old received an oral glucose tolerance test. Of these subjects 169 were retested at 80. Three sets of diagnostic criteria were evaluated, of which the WHO criteria are recommended for screening studies in this age group. The prevalences of diabetes me...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.5.6.600
更新日期:1982-11-01 00:00:00
abstract:OBJECTIVE:Various organizations have highlighted the need to examine whether abdominal obesity cut points are appropriate for identification of cardiovascular risk among ethnic minority adults, particularly Hispanic/Latino adults living in Western societies. This study aimed 1) to establish optimal definitions for abdo...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc19-1855
更新日期:2020-08-01 00:00:00
abstract::To evaluate the development of autonomic neuropathy, 23 patients with a moderate (group A) and 18 patients with a long (group B) duration of diabetes and without symptoms of autonomic neuropathy were re-investigated 6 yr after the initial studies. Autonomic nerve function was evaluated from heart reactions to deep bre...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.8.2.129
更新日期:1985-03-01 00:00:00
abstract:OBJECTIVE:We developed a scale to serve as a potential end point for 6-month glycemic progression (PS6M) toward type 1 diabetes (T1D) in autoantibody-positive relatives of individuals with T1D. RESEARCH DESIGN AND METHODS:The PS6M was developed from Diabetes Prevention Trial-Type 1 (DPT-1) data and tested in the Trial...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc14-2787
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:There is considerable interest in identifying biomarkers that predict high risk for the development of macrovascular complications in patients with diabetes. Therefore, the longitudinal association between subclinical atherosclerosis as measured by internal carotid artery intima-media thickness (IMT) and acut...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc14-2877
更新日期:2015-07-01 00:00:00
abstract::The plasma glucose and plasma free insulin profiles of six totally insulin-dependent diabetic patients were compared during periods of 4 days in hospital under a conventional insulin therapy (ICIT) comprising 4 daily injections of regular insulin and under continuous subcutaneous insulin infusion (CSII). Two profiles ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.6.1.1
更新日期:1983-01-01 00:00:00
abstract::OBJECTIVE--To determine and compare the abilities of various anthropometric measurements to predict the development of non-insulin-dependent diabetes mellitus (NIDDM) in Pima Indian men and women. RESEARCH DESIGN AND METHODS--A total of 290 male and 443 female Pima Indians were followed for up to 6 years for the devel...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.18.4.435
更新日期:1995-04-01 00:00:00
abstract:OBJECTIVE:To investigate whether the risk for autoimmune diabetes in adults differs between socioeconomic groups and to compare such risk with that for type 2 diabetes. RESEARCH DESIGN AND METHODS:The inhabitants of the Norwegian county of Nord-Trøndelag were investigated by questionnaires and clinical examinations on...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc10-1061
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:To examine by meta-analysis the relationship between cardiovascular autonomic neuropathy (CAN) and risk of mortality in individuals with diabetes. RESEARCH DESIGN AND METHODS:We searched Medline for English-language articles published from 1966 to 2001. Fifteen studies having a baseline assessment of cardiov...
journal_title:Diabetes care
pub_type: 杂志文章,meta分析
doi:10.2337/diacare.26.6.1895
更新日期:2003-06-01 00:00:00
abstract:OBJECTIVE:Observational studies have associated metformin use with a decreased risk of lung cancer incidence in patients with type 2 diabetes, but the studies had important methodological shortcomings. The objective of this study was to determine whether metformin use is associated with a decreased risk of lung cancer ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-0740
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:The intraoral tactile sensitivity (ITS) of diabetic and nondiabetic subjects was compared. The effects of age, ethnicity, sex, and intraoral site were considered. RESEARCH DESIGN AND METHODS:The sample comprised 589 participants of the Oral Health: San Antonio Longitudinal Study of Aging. A total of 107 subj...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.27.4.869
更新日期:2004-04-01 00:00:00
abstract:OBJECTIVE:Monozygotic twins are usually discordant (only one twin affected) for type 1 diabetes. Discordance for disease between such twins implies a role for nongenetically determined factors but could also be influenced by a decreased load of diabetes susceptibility genes. The aim of this study was to determine wheth...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.24.5.838
更新日期:2001-05-01 00:00:00
abstract::OBJECTIVE--To assess the relationship between family history and different types of obesity and change in obesity in a longitudinal population study. RESEARCH DESIGN AND METHODS--A longitudinal population study of 1462 randomly selected women (38-60 yr old) was conducted in Göteborg, Sweden, in 1968-69. The women were...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.15.11.1455
更新日期:1992-11-01 00:00:00
abstract::A semiclosed loop, bedside insulin infusion system using a simple basal infusion algorithm consisting of a linear transition between two insulin delivery rates as blood glucose (BG) increases has been developed. A theoretical study using computer simulation has now been undertaken to examine the effect of BG sampling ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.8.6.553
更新日期:1985-11-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that lower vital capacity is cross-sectionally associated with features of insulin resistance and is an independent predictor of incident type 2 diabetes. RESEARCH DESIGN AND METHODS:We conducted a prospective cohort study of vital capacity as a predictor of incident type 2 diabetes us...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.28.6.1472
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVE:Pancreas transplantation (PTX) normalizes glucose and improves microvascular complications, but its impact on macrovascular disease is still debated. RESEARCH DESIGN AND METHODS:Carotid intima-media thickness (IMT), shown to correlate with cardiovascular disease (CVD) risk and events, was determined prospect...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.27.7.1706
更新日期:2004-07-01 00:00:00
abstract::The goal of this research was to quantify the relationships between patient survival and a set of explanatory variables in a randomly selected sample of community-based patients with non-insulin-dependent diabetes mellitus (NIDDM). The sample included 343 patients with NIDDM initially entered into the study in 1981-19...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.11.7.538
更新日期:1988-07-01 00:00:00
abstract:OBJECTIVE:To determine the association between nonalcoholic fatty liver disease and the risk for development of diabetes. RESEARCH DESIGN AND METHODS:We conducted an observational cohort study in male workers > or = 40 years old in a Japanese company from 1997 to 2005. We excluded workers with alcohol intake > or = 20...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc07-0792
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVE:It is recommended that the psychological status of adolescents with diabetes be assessed periodically as part of ongoing care. The World Health Organization-Five Well-Being Index (WHO-5) is a short self-report instrument that appears suitable for this purpose. This study is the first to assess the reliability...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc07-0447
更新日期:2007-08-01 00:00:00
abstract:OBJECTIVE:The use of thiazolidinedione (TZD) derivatives is associated with fluid retention, especially when combined with insulin. Because TZDs improve the metabolic effect of insulin, they may also reverse the blunted vascular response to insulin. We hypothesize that improvement of the action of insulin on vascular t...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/diacare.29.03.06.dc05-01467
更新日期:2006-03-01 00:00:00
abstract::Stress is a potential contributor to chronic hyperglycemia in diabetes. Stress has long been shown to have major effects on metabolic activity. Energy mobilization is a primary result of the fight or flight response. Stress stimulates the release of various hormones, which can result in elevated blood glucose levels. ...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.15.10.1413
更新日期:1992-10-01 00:00:00