Role of hemochromatosis C282Y and H63D mutations in HFE gene in development of type 2 diabetes and diabetic nephropathy.

abstract：OBJECTIVE:Individuals with impaired glucose tolerance (IGT) are at high risk for developing type 2 diabetes mellitus (T2DM). We examined which characteristics at baseline predicted the development of T2DM versus maintenance of IGT or conversion to normal glucose tolerance. RESEARCH DESIGN AND METHODS:We studied 228 su...

journal_title：Diabetes care

authors： Defronzo RA,Tripathy D,Schwenke DC,Banerji M,Bray GA,Buchanan TA,Clement SC,Henry RR,Kitabchi AE,Mudaliar S,Ratner RE,Stentz FB,Musi N,Reaven PD,Gastaldelli A,ACT NOW Study.

更新日期：2013-11-01 00:00:00

abstract：:A cross-sectional study on the prevalence of atherosclerotic vascular disease (ASVD) and its risk factors in non-insulin-dependent diabetic and nondiabetic subjects was carried out from 1982 to 1984 in East Finland (Kuopio) and West Finland (Turku), two areas known to differ markedly in prevalence of ASVD in the nondi...

journal_title：Diabetes care

authors： Laakso M,Rönnemaa T,Pyörälä K,Kallio V,Puukka P,Penttilä I

更新日期：1988-06-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to evaluate the associations of BMI versus metabolic syndrome with cardiovascular diseases (CVDs) in elderly Chinese individuals. RESEARCH DESIGN AND METHODS:We conducted a population-based cross-sectional study in an urban sample of 2,334 elderly subjects (943 men and 1,391 wom...

journal_title：Diabetes care

authors： He Y,Jiang B,Wang J,Feng K,Chang Q,Zhu S,Fan L,Li X,Hu FB

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVE:Despite good evidence and clinical practice guidelines, studies document that treatment of type 2 diabetes is less than optimal. Lack of resources or limited access may put patients in rural communities at particular risk for suboptimal care. RESEARCH DESIGN AND METHODS:We conducted a prospective, before/aft...

journal_title：Diabetes care

authors： Majumdar SR,Guirguis LM,Toth EL,Lewanczuk RZ,Lee TK,Johnson JA

更新日期：2003-11-01 00:00:00

abstract：OBJECTIVE:A 1-year randomized prospective study was conducted to investigate the efficacy of feedback from split-sample testing as part of a capillary blood glucose quality assurance program. RESEARCH DESIGN AND METHODS:A total of 124 nurses were randomized to either group A (quarterly comparisons with feedback) or gr...

journal_title：Diabetes care

authors： Jones HE,Cleave B,Zinman B,Szalai JP,Nichol HL,Hoffman BR

更新日期：1996-02-01 00:00:00

abstract：OBJECTIVE:To investigate whether peripheral neuropathy (PN), as part of the microangiopathic complex, affects bone mineral density (BMD) of the peripheral or the axial skeleton in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS:Three study groups were examined. Group 1 comprised 21 males with type 1 diabete...

journal_title：Diabetes care

authors： Rix M,Andreassen H,Eskildsen P

更新日期：1999-05-01 00:00:00

abstract：OBJECTIVE:To compare the diagnostic accuracy and time expenditure of screening models based on glycated hemoglobin (HbA(1c)) level and psychometric measures for mood disorder (MD) among children with type 1 diabetes. RESEARCH DESIGN AND METHODS:With semistructured clinical interviews (Schedule for Affective Disorders ...

journal_title：Diabetes care

authors： Butwicka A,Fendler W,Zalepa A,Szadkowska A,Mianowska B,Gmitrowicz A,Młynarski W

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:To provide information about possible subclinical damage of the cochlear outer hair cells (OHCs) by means of transiently evoked otoacoustic emissions (TEOAEs) and distortion-product otoacoustic emissions (DPOAEs) in subjects with IDDM. RESEARCH DESIGN AND METHODS:TEOAEs and DPOAEs were recorded in 47 IDDM pa...

journal_title：Diabetes care

authors： Di Nardo W,Ghirlanda G,Paludetti G,Cercone S,Saponara C,Del Ninno M,Di Girolamo S,Magnani P,Di Leo MA

更新日期：1998-08-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to determine whether objectively measured physical activity and dietary macronutrient intake differentially predict body fat in adolescent girls with type 1 diabetes and control girls. RESEARCH DESIGN AND METHODS:This study comprised 23 girls (12-19 years) with type 1 diabetes a...

journal_title：Diabetes care

authors： Särnblad S,Ekelund U,Aman J

更新日期：2006-06-01 00:00:00

abstract：OBJECTIVE:The objective of this analysis was to evaluate the impact of several classes of oral antihyperglycemic therapy relative to sulfonylurea monotherapy on all-cause mortality among a cohort of patients with diabetes from the Veterans Health Administration (VHA). RESEARCH DESIGN AND METHODS:A retrospective cohort...

journal_title：Diabetes care

authors： Kahler KH,Rajan M,Rhoads GG,Safford MM,Demissie K,Lu SE,Pogach LM

更新日期：2007-07-01 00:00:00

abstract：OBJECTIVE:Pancreas size is reduced in patients at type 1 diabetes onset and in autoantibody (AAB)-positive donors without diabetes. We sought to determine whether pancreas volume (PV) imaging could improve understanding of the loss of pancreas size in first-degree relatives (FDRs) of patients with type 1 diabetes. We a...

journal_title：Diabetes care

authors： Campbell-Thompson ML,Filipp SL,Grajo JR,Nambam B,Beegle R,Middlebrooks EH,Gurka MJ,Atkinson MA,Schatz DA,Haller MJ

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVE:Focusing health interventions in places with suboptimal glycemic control can help direct resources to neighborhoods with poor diabetes-related outcomes, but finding these areas can be difficult. Our objective was to use indirect measures versus a gold standard, population-based A1C registry to identify areas ...

journal_title：Diabetes care

authors： Lee DC,Jiang Q,Tabaei BP,Elbel B,Koziatek CA,Konty KJ,Wu WY

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:We aimed to update the epidemiology of type 1 and type 2 diabetic patients among the incident end-stage renal disease (ESRD) population in Australia and New Zealand (ANZ) and to determine whether outcome is worse for diabetic women, as described in the general population. RESEARCH DESIGNS AND METHODS:All res...

journal_title：Diabetes care

authors： Villar E,Chang SH,McDonald SP

更新日期：2007-12-01 00:00:00

abstract：OBJECTIVE:To determine whether there is a familial abnormality in erythrocyte Na/Li countertransport (CT) kinetics in the approximate one-third of type 1 diabetic patients that succumb to a familial predisposition to nephropathy. RESEARCH DESIGN AND METHODS:Erythrocyte Na/Li CT kinetics were measured in nondiabetic fi...

journal_title：Diabetes care

authors： Mead PA,Wilkinson R,Thomas TH

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVE:Several national and international scoring systems are used to diagnose diabetic polyneuropathy (PNP). The variety in these scores and the lack of data on validity and predictive value has led to a comparison and validation of the scores with clinical standards for PNP to determine the most powerful measureme...

journal_title：Diabetes care

authors： Meijer JW,Smit AJ,Lefrandt JD,van der Hoeven JH,Hoogenberg K,Links TP

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVE:To determine contributions of trunk and extremity adiposity to cardiometabolic risk factors (blood pressure, fasting blood glucose, HDL cholesterol, and triglycerides) among white and African American adults. RESEARCH DESIGN AND METHODS:The sample consisted of 1,129 white women, 779 African American women, 1...

journal_title：Diabetes care

authors： Hu G,Bouchard C,Bray GA,Greenway FL,Johnson WD,Newton RL Jr,Ravussin E,Ryan DH,Katzmarzyk PT

更新日期：2011-06-01 00:00:00

abstract：:A survey conducted at a Veterans Administration Hospital to evaluate patient capability for self-management found that over 35 per cent of the patients interviewed lacked any formal training. Seventeen patients had been placed on insulin without formal instruction. Almost one half the patients who claimed to have atte...

journal_title：Diabetes care

authors： Miller LV,Goldstein J,Nicolaisen G

更新日期：1978-09-01 00:00:00

abstract：OBJECTIVE:Dyslipidemia contributes to the progression of microvascular disease in diabetes. However, different lipid variables may be important at different stages of nephropathy. This study examines the pattern of dyslipidemia associated with the progression of nephropathy in patients with type 1 diabetes. RESEARCH D...

journal_title：Diabetes care

authors： Thomas MC,Rosengård-Bärlund M,Mills V,Rönnback M,Thomas S,Forsblom C,Cooper ME,Taskinen MR,Viberti G,Groop PH

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVE:To know the nutritional pattern of people with diabetes in Spain and that pattern's relationship with targets of metabolic control. RESEARCH DESIGN AND METHODS:The Diabetes Nutrition and Complications Trial (DNCT) is a prospective multicenter study designed to determine the nutritional behavior of diabetic p...

journal_title：Diabetes care

authors：

更新日期：1997-07-01 00:00:00

abstract：OBJECTIVE:To compare blood glucose control and incidence of nocturnal hypoglycemia in adolescents with type 1 diabetes on multiple injection regimens managed with either an insulin analog combination or NPH insulin plus regular human insulin. RESEARCH DESIGN AND METHODS:In a randomized cross-over study, 28 adolescents...

journal_title：Diabetes care

authors： Murphy NP,Keane SM,Ong KK,Ford-Adams M,Edge JA,Acerini CL,Dunger DB

更新日期：2003-03-01 00:00:00

abstract：OBJECTIVE:To explore the possible link between diabetic nephropathy and the enhanced activity of the polyol pathway, known to occur in IDDM subjects. RESEARCH DESIGN AND METHODS:We studied the effects of the aldose reductase inhibitor tolrestat (200 mg/day) on urinary albumin excretion rate and glomerular filtration r...

journal_title：Diabetes care

authors： Passariello N,Sepe J,Marrazzo G,De Cicco A,Peluso A,Pisano MC,Sgambato S,Tesauro P,D'Onofrio F

更新日期：1993-05-01 00:00:00

abstract：:Coronary heart disease is the leading cause of death among patients with non-insulin-dependent diabetes mellitus (NIDDM). NIDDM patients have a high frequency of dyslipidemia, which along with obesity, hypertension, and hyperglycemia may contribute significantly to accelerated coronary atherosclerosis. Because risk fa...

journal_title：Diabetes care

authors： Garg A,Grundy SM

更新日期：1990-02-01 00:00:00

abstract：:In seven type II (non-insulin-dependent) diabetic patients, given either 50 g glucose or a mixed meal potentially containing 61 g glucose as starch and sucrose, the postmeal plasma glucose area integrated over 4 h was less after the mixed meal. The insulin area was considerably greater (2.1-fold). The greater increase...

journal_title：Diabetes care

authors： Nuttall FQ,Gannon MC

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:We have investigated age-period-cohort effects and spatial and temporal trends for the incidence of type 1 diabetes among 0- to 14-year-old children in Norway. RESEARCH DESIGN AND METHODS:We included children with the diagnosis of type 1 diabetes in Norway during 1973-1982 and 1989-2003. We studied age, cale...

journal_title：Diabetes care

authors： Aamodt G,Stene LC,Njølstad PR,Søvik O,Joner G,Norwegian Childhood Diabetes Study Group.

更新日期：2007-04-01 00:00:00

abstract：:Glycosylated serum protein (GSP) and glycosylated hemoglobin (GHb) were measured in 263 insulin-dependent and 41 non-insulin-dependent diabetic subjects. Both indices provided useful information in type II diabetes, but were extremely poor in judging control in type I diabetes. In both groups, there was poor correlati...

journal_title：Diabetes care

authors： Mehl TD,Wenzel SE,Russell B,Gardner D,Merimee TJ

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVE:To examine the acute glucose-lowering effects of aerobic exercise in children and adolescents with type 1 diabetes. RESEARCH DESIGN AND METHODS:Fifty children and adolescents with type 1 diabetes (ages 10 to <18 years) were studied during exercise. The 75-min exercise session consisted of four 15-min periods...

journal_title：Diabetes care

authors： Tansey MJ,Tsalikian E,Beck RW,Mauras N,Buckingham BA,Weinzimer SA,Janz KF,Kollman C,Xing D,Ruedy KJ,Steffes MW,Borland TM,Singh RJ,Tamborlane WV,Diabetes Research in Children Network (DirecNet) Study Group.

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:Alterations of pancreatic β-cell cholesterol content may contribute to β-cell dysfunction. Two important determinants of intracellular cholesterol content are the ATP-binding cassette (ABC) transporters A1 (ABCA1) and -G1 (ABCG1). Whether genetic variation in ABCA1 and ABCG1 predicts risk of type 2 diabetes i...

journal_title：Diabetes care

authors： Schou J,Tybjærg-Hansen A,Møller HJ,Nordestgaard BG,Frikke-Schmidt R

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:In 2010, the American Heart Association defined seven metrics (smoking, BMI, physical activity, diet, total cholesterol, blood pressure, and fasting plasma glucose) for ideal cardiovascular health (ICH). Subsequent studies have shown that the prevalence of achieving these metrics is very low in the general po...

journal_title：Diabetes care

authors： Alman AC,Maahs DM,Rewers MJ,Snell-Bergeon JK

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:Emerging evidence suggests that peripheral neuropathy begins in the early stages of diabetes pathogenesis. Our objective was to describe the prevalence of peripheral neuropathy and nerve dysfunction according to glucose tolerance and metabolic syndrome status and examine how these conditions are associated wi...

journal_title：Diabetes care

authors： Lee CC,Perkins BA,Kayaniyil S,Harris SB,Retnakaran R,Gerstein HC,Zinman B,Hanley AJ

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVE:A key milestone in progress towards providing an efficacious and safe closed-loop artificial pancreas system for outpatient use is the development of fully automated, portable devices with fault detection capabilities to ensure patient safety. The ability to remotely monitor the operation of the closed-loop s...

journal_title：Diabetes care

authors： O'Grady MJ,Retterath AJ,Keenan DB,Kurtz N,Cantwell M,Spital G,Kremliovsky MN,Roy A,Davis EA,Jones TW,Ly TT

更新日期：2012-11-01 00:00:00