Quantitative importance of dietary constituents other than glucose as insulin secretagogues in type II diabetes.

Abstract:

:In seven type II (non-insulin-dependent) diabetic patients, given either 50 g glucose or a mixed meal potentially containing 61 g glucose as starch and sucrose, the postmeal plasma glucose area integrated over 4 h was less after the mixed meal. The insulin area was considerably greater (2.1-fold). The greater increase in insulin could be explained largely, but not entirely, by the protein and fructose in the mixed meal (85%) which, in addition to glucose, are known insulin secretagogues. The residual unexplained increase may be due to a synergistic interaction of these secretagogues, an unidentified insulin secretagogue, or by a reduced insulin removal rate. These possibilities remain to be explored.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Nuttall FQ,Gannon MC

doi

10.2337/diacare.11.1.72

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

72-6

issue

1

eissn

0149-5992

issn

1935-5548

journal_volume

11

pub_type

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