Sodium-glucose cotransporter 2 inhibition and glycemic control in type 1 diabetes: results of an 8-week open-label proof-of-concept trial.


OBJECTIVE:Adjunctive-to-insulin therapy with sodium-glucose cotransporter 2 (SGLT2) inhibition may improve glycemic control in type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS:We evaluated the glycemic efficacy and safety of empagliflozin 25 mg daily in 40 patients treated for 8 weeks in a single-arm open-label proof-of-concept trial (NCT01392560). RESULTS:Mean A1C decreased from 8.0 ± 0.9% (64 ± 10 mmol/mol) to 7.6 ± 0.9% (60 ± 10 mmol/mol) (P < 0.0001), fasting glucose from 9.0 ± 4.3 to 7.0 ± 3.2 mmol/L (P = 0.008), symptomatic hypoglycemia (<3.0 mmol/L) from 0.12 to 0.04 events per patient per day (P = 0.0004), and daily insulin dose from 54.7 ± 20.4 to 45.8 ± 18.8 units/day (P < 0.0001). Mean urinary excretion of glucose increased from 19 ± 19 to 134 ± 61 g/day (P < 0.0001). Weight decreased from 72.6 ± 12.7 to 70.0 ± 12.3 kg (P < 0.0001), and waist circumference decreased from 82.9 ± 8.7 to 79.1 ± 8.0 cm (P < 0.0001). CONCLUSIONS:This proof-of-concept study strongly supports a randomized clinical trial of adjunctive-to-insulin empagliflozin in patients with T1D.


Diabetes Care


Diabetes care


Perkins BA,Cherney DZ,Partridge H,Soleymanlou N,Tschirhart H,Zinman B,Fagan NM,Kaspers S,Woerle HJ,Broedl UC,Johansen OE




Has Abstract


2014-05-01 00:00:00














  • Dairy consumption and the incidence of hyperglycemia and the metabolic syndrome: results from a french prospective study, Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR).

    abstract:OBJECTIVE:In the French Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR) cohort, cross-sectional analyses have shown that a higher consumption of dairy products and calcium are associated with a lower prevalence of the metabolic syndrome (MetS). We assess the influence of dairy products on...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Fumeron F,Lamri A,Abi Khalil C,Jaziri R,Porchay-Baldérelli I,Lantieri O,Vol S,Balkau B,Marre M,Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR) Study Group.

    更新日期:2011-04-01 00:00:00

  • Remissions of diabetes mellitus after weight reduction by jejunoileal bypass.

    abstract::Limited weight loss following jejunoileal bypass in 24 diabetic persons who were still distinctly overweight five to ten months after a mean weight decrease of 78 lbs. was accompanied by a return of normal fasting glucose and insulin levels, normal insulin responses, and a decrease in glucose intolerance. The glucose ...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Ahmad U,Danowski TS,Nolan S,Stephan T,Sunder JH,Bahl VK

    更新日期:1978-05-01 00:00:00

  • Impact of iron deficiency anemia on prevalence of gestational diabetes mellitus.

    abstract:OBJECTIVE:Increased Hb and ferritin have been associated with gestational diabetes mellitus (GDM). This study was performed to determine whether the prevalence of GDM is influenced by iron deficiency anemia. RESEARCH DESIGN AND METHODS:In a retrospective case-control study, 242 women with iron deficiency anemia (Hb<10...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Lao TT,Ho LF

    更新日期:2004-03-01 00:00:00

  • Self-monitoring of blood glucose in noninsulin-using type 2 diabetic patients: right answer, but wrong question: self-monitoring of blood glucose can be clinically valuable for noninsulin users.

    abstract::Given the importance of glycemic control in the development of diabetes complications, the plethora of tools now available to monitor the day-to-day trends in glycemia is remarkable. In this regard, self-monitoring of blood glucose (SMBG) has been considered a key component of patient management. Arguably, there remai...

    journal_title:Diabetes care

    pub_type: 评论,杂志文章


    authors: Polonsky WH,Fisher L

    更新日期:2013-01-01 00:00:00

  • Translating lifestyle intervention to practice in obese patients with type 2 diabetes: Improving Control with Activity and Nutrition (ICAN) study.

    abstract:OBJECTIVE:To assess the efficacy of a lifestyle intervention program that can be readily translated into clinical practice for obese patients with type 2 diabetes. RESEARCH DESIGN AND METHODS:The study consisted of a 12-month randomized controlled trial of 147 health plan members with type 2 diabetes and obesity (BMI ...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Wolf AM,Conaway MR,Crowther JQ,Hazen KY,L Nadler J,Oneida B,Bovbjerg VE,Improving Control with Activity and Nutrition (ICAN) Study.

    更新日期:2004-07-01 00:00:00

  • Excess BMI Accelerates Islet Autoimmunity in Older Children and Adolescents.

    abstract:OBJECTIVE:Sustained excess BMI increases the risk of type 1 diabetes (T1D) in autoantibody-positive relatives without diabetes of patients. We tested whether elevated BMI also accelerates the progression of islet autoimmunity before T1D diagnosis. RESEARCH DESIGN AND METHODS:We studied 706 single autoantibody-positive...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Ferrara-Cook C,Geyer SM,Evans-Molina C,Libman IM,Becker DJ,Gitelman SE,Redondo MJ,Type 1 Diabetes TrialNet Study Group.

    更新日期:2020-03-01 00:00:00

  • Impact of specific glucose-control strategies on microvascular and macrovascular outcomes in 58,000 adults with type 2 diabetes.

    abstract:OBJECTIVE:Comparative effectiveness research methods are used to compare the effect of four distinct glucose-control strategies on subsequent myocardial infarction and nephropathy in type 2 diabetes. RESEARCH DESIGN AND METHODS:A total of 58,000 adults with type 2 diabetes and A1C <7% (53 mmol/mol) while taking two or...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Neugebauer R,Fireman B,Roy JA,O'Connor PJ

    更新日期:2013-11-01 00:00:00

  • Prediction of the relative blood glucose response of mixed meals using the white bread glycemic index.

    abstract::Unexpected plasma glucose responses to different mixed meals fed to normal and diabetic volunteers have recently been reported. We have therefore examined in normal volunteers the effect of mixing carbohydrate foods of different glycemic indices (GIs) without the addition of fat and protein. The observed GI of the mix...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Wolever TM,Nuttall FQ,Lee R,Wong GS,Josse RG,Csima A,Jenkins DJ

    更新日期:1985-09-01 00:00:00

  • Replacement of Red and Processed Meat With Other Food Sources of Protein and the Risk of Type 2 Diabetes in European Populations: The EPIC-InterAct Study.

    abstract:OBJECTIVE:There is sparse evidence for the association of suitable food substitutions for red and processed meat on the risk of type 2 diabetes. We modeled the association between replacing red and processed meat with other protein sources and the risk of type 2 diabetes and estimated its population impact. RESEARCH D...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Ibsen DB,Steur M,Imamura F,Overvad K,Schulze MB,Bendinelli B,Guevara M,Agudo A,Amiano P,Aune D,Barricarte A,Ericson U,Fagherazzi G,Franks PW,Freisling H,Quiros JR,Grioni S,Heath AK,Huybrechts I,Katze V,Laouali N,

    更新日期:2020-11-01 00:00:00

  • Effects of BAYm 1099, new alpha-glucosidase inhibitor, on acute metabolic responses and metabolic control in NIDDM over 1 mo.

    abstract::To examine the clinical role of BAYm 1099, 15 diet-treated non-insulin-dependent diabetic (NIDDM) subjects were randomized to start drug (50 mg 3 times/day) or placebo after a 4-wk run-in period in a double-blind crossover study. Treatment periods (4 wk) were separated by a 2-wk washout period. During the last week of...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Samad AH,Ty Willing TS,Alberti KG,Taylor R

    更新日期:1988-04-01 00:00:00

  • Unrecognized diabetes among hospitalized patients.

    abstract:OBJECTIVE:To evaluate the hospital care rendered to hyperglycemic individuals who did not have a diagnosis of diabetes before admission. RESEARCH DESIGN AND METHODS:A total of 1,034 consecutively hospitalized adult patients at a 750-bed inner-city teaching hospital were evaluated. Patients with one or more plasma gluc...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Levetan CS,Passaro M,Jablonski K,Kass M,Ratner RE

    更新日期:1998-02-01 00:00:00

  • Utility of casual postprandial glucose levels in type 2 diabetes management.

    abstract:OBJECTIVE:Because readily available glycemic indicators are needed to guide clinical decision-making for intensification of diabetes therapy, our goals were to define the relationship between casual postprandial plasma glucose (cPPG) levels and HbA(1c) in patients with type 2 diabetes and to determine the predictive ch...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: El-Kebbi IM,Ziemer DC,Cook CB,Gallina DL,Barnes CS,Phillips LS

    更新日期:2004-02-01 00:00:00

  • Alcohol consumption and the incidence of type 2 diabetes: a 20-year follow-up of the Finnish twin cohort study.

    abstract:OBJECTIVE:The aim of this study was to investigate alcohol consumption in relation to the incidence of type 2 diabetes. RESEARCH DESIGN AND METHODS:The study population consisted of 22778 twins of the Finnish Twin Cohort. This cohort was compiled in 1975 and includes all same-sexed twins born in Finland before 1958. I...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Carlsson S,Hammar N,Grill V,Kaprio J

    更新日期:2003-10-01 00:00:00

  • High concentrations of AGE-LDL and oxidized LDL in circulating immune complexes are associated with progression of retinopathy in type 1 diabetes.

    abstract:OBJECTIVE:To determine whether immunocomplexes (ICs) containing advanced glycation end product (AGE)-LDL (AGE-LDL) and oxidized LDL (oxLDL) contribute to the development of retinopathy over a 16-year period in subjects with type 1 diabetes. RESEARCH DESIGN AND METHODS:Levels of AGE-LDL and oxLDL in ICs were measured i...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验


    authors: Lopes-Virella MF,Baker NL,Hunt KJ,Lyons TJ,Jenkins AJ,Virella G,DCCT\/EDIC Study Group.

    更新日期:2012-06-01 00:00:00

  • Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma with Pre-diabetic phenotypes: meta-analysis of 57 studies on nondiabetic individuals.

    abstract:OBJECTIVE:The provariant of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor (PPAR)gamma has been identified as a risk allele for type 2 diabetes. The purpose of the present study was to reveal a significant association with pre-diabetic phenotypes in nondiabetic individuals based on a systematic...

    journal_title:Diabetes care

    pub_type: 杂志文章,meta分析


    authors: Tönjes A,Scholz M,Loeffler M,Stumvoll M

    更新日期:2006-11-01 00:00:00

  • Dietary pectin and glycemic control in diabetes.

    abstract::Seventeen diabetic subjects requiring insulin and who exhibited glycemic stability over a 9-12-mo control period received 5 g of pectin with each meal and at bedtime for 3 mo. Hemoglobin A1c (HbA1c) and glycosylated serum protein were measured in each patient on multiple occasions to assess glycemic control. No clear-...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Gardner DF,Schwartz L,Krista M,Merimee TJ

    更新日期:1984-03-01 00:00:00

  • Clinical correlates of plantar pressure among diabetic veterans.

    abstract:OBJECTIVE:To assess the relationship between diabetes characteristics, medical history, foot deformity, sensory neuropathy, and plantar foot pressure. RESEARCH DESIGN AND METHODS:There were 517 subjects from a cohort of diabetic veterans enrolled in a prospective study of risk factors for foot complications who contri...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Ahroni JH,Boyko EJ,Forsberg RC

    更新日期:1999-06-01 00:00:00

  • Carotid atherosclerosis and serum lipoprotein(a) concentrations in patients with NIDDM.

    abstract:OBJECTIVE:To investigate the association of carotid atherosclerosis and serum lipoprotein(a) [Lp(a)] concentrations in subjects with NIDDM. RESEARCH DESIGN AND METHODS:We measured carotid intima-media thickness (IMT) and Lp(a) concentrations in 117 NIDDM subjects. Subjects were divided into tertiles according to IMT v...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Yamamoto M,Egusa G,Yamakido M

    更新日期:1997-05-01 00:00:00

  • Binding of biosynthetic human insulin to erythrocytes of normal and insulin-dependent diabetic subjects: comparison with pork and human pancreatic insulin.

    abstract::Biosynthetic human insulin (BHI) was compared with highly purified human pancreatic and pork insulin with regard to its ability to bind to erythrocytes of normal and insulin-dependent diabetic subjects (type I diabetes). The binding affinity or capacity of erythrocyte from both normal and diabetic subjects were compar...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Bachmann W,Sieger C,Lacher F,Lotz N

    更新日期:1981-03-01 00:00:00

  • Beneficial effect of low-glycemic index diet in overweight NIDDM subjects.

    abstract:OBJECTIVE:To determine whether low-glycemic index (GI) diets have clinical utility in overweight patients with non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS:Six patients with NIDDM were studied on both high- and low-GI diets of 6-wk duration with metabolic diets with a randomized crossov...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Wolever TM,Jenkins DJ,Vuksan V,Jenkins AL,Wong GS,Josse RG

    更新日期:1992-04-01 00:00:00

  • Heterogeneous Contribution of Insulin Sensitivity and Secretion Defects to Gestational Diabetes Mellitus.

    abstract:OBJECTIVE:To characterize physiologic subtypes of gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS:Insulin sensitivity and secretion were estimated in 809 women at 24-30 weeks' gestation, using oral glucose tolerance test-based indices. In women with GDM (8.3%), defects in insulin sensitivity or secret...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Powe CE,Allard C,Battista MC,Doyon M,Bouchard L,Ecker JL,Perron P,Florez JC,Thadhani R,Hivert MF

    更新日期:2016-06-01 00:00:00

  • Clustering of cardiovascular risk factors associated with the insulin resistance syndrome: assessment by principal component analysis in young hyperandrogenic women.

    abstract:OBJECTIVE:Hyperinsulinemia is often associated with several metabolic abnormalities and increased blood pressure, which are risk factors for cardiovascular disease. It has been hypothesized that insulin resistance may underlie all these features. However, recent data suggest that some links between insulin resistance a...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Zanolin ME,Tosi F,Zoppini G,Castello R,Spiazzi G,Dorizzi R,Muggeo M,Moghetti P

    更新日期:2006-02-01 00:00:00

  • Influence of hepatic steatosis (fatty liver) on severity and composition of dyslipidemia in type 2 diabetes.

    abstract:OBJECTIVE:The objective of this study was to examine the associations between the severity of hepatic steatosis and dyslipidemia in type 2 diabetes, including circulating apolipoprotein B100 (apoB) concentrations and lipoprotein particle size and numbers. RESEARCH DESIGN AND METHODS:Computed tomography imaging was use...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Toledo FG,Sniderman AD,Kelley DE

    更新日期:2006-08-01 00:00:00

  • Pioglitazone treatment improves nitrosative stress in type 2 diabetes.

    abstract:OBJECTIVE:The purpose of this study was to determine the effect of 24 weeks of treatment with 45 mg/day pioglitazone on peripheral skin blood flow (SkBF) and skin nitric oxide (NO) production in vivo in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS:This was a randomized, parallel, cross-over, double-blind...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验


    authors: Vinik AI,Ullal J,Parson HK,Barlow PM,Casellini CM

    更新日期:2006-04-01 00:00:00

  • Insulin, pancreatic polypeptide, and glucagon antibodies in insulin-dependent diabetes mellitus.

    abstract::To assess the possible value of the use of high-purity pork insulin (HPPI) in the United States, the serum insulin (I), pancreatic polypeptide (PP), glucagon (G), and somatostatin (SRIF) antibody binding characteristics have been determined in 90 conventional insulin-treated diabetic subjects and related to their degr...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Asplin CM,Hollander P,Pecoraro RE,Brodsky J,Palmer JP

    更新日期:1981-05-01 00:00:00

  • Differences in the prevalence of diabetes and impaired glucose tolerance according to maternal or paternal history of diabetes.

    abstract:OBJECTIVE:To determine whether diabetes risk is influenced by which parent (a parental history of diabetes is a well-documented risk factor for NIDDM) is reported to have diabetes. RESEARCH DESIGN AND METHODS:We compared the prevalence of NIDDM and IGT for 4914 subjects according to their parental history of diabetes ...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Mitchell BD,Valdez R,Hazuda HP,Haffner SM,Monterrosa A,Stern MP

    更新日期:1993-09-01 00:00:00

  • Serum xylosyltransferase activity in diabetic patients as a possible marker of reduced proteoglycan biosynthesis.

    abstract:OBJECTIVE:Proteoglycan metabolism is altered in diabetic patients. The xylosyltransferases (XTs) are the initial and rate-limiting enzymes in the biosynthesis of the glycosaminoglycan chains in proteoglycans. Here, we analyzed whether the changed proteoglycan metabolism leads to altered serum XT levels in diabetic pati...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Götting C,Kuhn J,Kleesiek K

    更新日期:2008-10-01 00:00:00

  • Absence of Islet Autoantibodies and Modestly Raised Glucose Values at Diabetes Diagnosis Should Lead to Testing for MODY: Lessons From a 5-Year Pediatric Swedish National Cohort Study.

    abstract:OBJECTIVE:Identifying maturity-onset diabetes of the young (MODY) in pediatric populations close to diabetes diagnosis is difficult. Misdiagnosis and unnecessary insulin treatment are common. We aimed to identify the discriminatory clinical features at diabetes diagnosis of patients with glucokinase (GCK), hepatocyte n...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Carlsson A,Shepherd M,Ellard S,Weedon M,Lernmark Å,Forsander G,Colclough K,Brahimi Q,Valtonen-Andre C,Ivarsson SA,Elding Larsson H,Samuelsson U,Örtqvist E,Groop L,Ludvigsson J,Marcus C,Hattersley AT

    更新日期:2020-01-01 00:00:00

  • Impact of Type 2 Diabetes and Postmenopausal Hormone Therapy on Incidence of Cognitive Impairment in Older Women.

    abstract:OBJECTIVE:In older women, higher levels of estrogen may exacerbate the increased risk for cognitive impairment conveyed by diabetes. We examined whether the effect of postmenopausal hormone therapy (HT) on cognitive impairment incidence differs depending on type 2 diabetes. RESEARCH DESIGN AND METHODS:The Women's Heal...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验


    authors: Espeland MA,Brinton RD,Hugenschmidt C,Manson JE,Craft S,Yaffe K,Weitlauf J,Vaughan L,Johnson KC,Padula CB,Jackson RD,Resnick SM,WHIMS Study Group.

    更新日期:2015-12-01 00:00:00

  • Prognostic value of dobutamine-atropine stress myocardial perfusion imaging in patients with diabetes.

    abstract:OBJECTIVE:Exercise tolerance in patients with diabetes is frequently impaired due to noncardiac disease such as claudication and polyneuropathy. This study assesses the prognostic value of dobutamine stress myocardial perfusion imaging in patients with diabetes. RESEARCH DESIGN AND METHODS:A total of 207 consecutive d...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章


    authors: Schinkel AF,Elhendy A,van Domburg RT,Bax JJ,Vourvouri EC,Sozzi FB,Valkema R,Roelandt JR,Poldermans D

    更新日期:2002-09-01 00:00:00