Abstract:
:Nocturnal hypoglycemia in insulin-treated diabetic persons is often difficult to recognize clinically. It has been suggested that a useful biochemical test to demonstrate this would be the increased excretion of cortisol in the urine during the overnight period. However, of six diabetic persons who had nocturnal hypoglycemia (less than or equal to 2.5 mmol/L), plasma cortisol profiles and overnight urinary cortisol-creatinine ratios were abnormal in only one. In four others the plasma cortisol levels and cortisol excretion indices were indistinguishable from either a normal control group or a group of five diabetic subjects who did not develop nocturnal hypoglycemia. The remaining patient had a raised urinary cortisol-creatinine ratio, but did not show increased plasma levels of cortisol, growth hormone, or glucagon during the hypoglycemic phase. These data do not support the usefulness of the urinary cortisol-creatinine index as a marker of nocturnal hypoglycemia in diabetes.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Scott RS,Scandrett MSdoi
10.2337/diacare.4.5.514subject
Has Abstractpub_date
1981-09-01 00:00:00pages
514-8issue
5eissn
0149-5992issn
1935-5548journal_volume
4pub_type
杂志文章相关文献
DIABETES CARE文献大全abstract:OBJECTIVE:Although the Diabetes Prevention Program (DPP) and the Finnish Diabetes Prevention Study (FDPS) demonstrated that weight loss from lifestyle change reduces type 2 diabetes incidence in patients with prediabetes, the translation into community settings has been difficult. The objective of this study is to repo...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc10-2115
更新日期:2011-07-01 00:00:00
abstract::A cross-sectional study on the prevalence of atherosclerotic vascular disease (ASVD) and its risk factors in non-insulin-dependent diabetic and nondiabetic subjects was carried out from 1982 to 1984 in East Finland (Kuopio) and West Finland (Turku), two areas known to differ markedly in prevalence of ASVD in the nondi...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.11.6.449
更新日期:1988-06-01 00:00:00
abstract:OBJECTIVE:In patients with clinical hemochromatosis, the frequency of diabetes ranges from 20 to 50%, and the heterozygosity for the C282Y mutation in the HFE gene might be associated with an increased risk for diabetes. There are also some reports that suggest that iron overload might cause diabetic nephropathy. RESE...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.24.7.1187
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVE:Some evidence suggests an inverse association between type 2 diabetes and androgens in men and a positive association between type 2 diabetes and androgens in women. The purpose of this community-based study was to evaluate sex differences in the association between endogenous total and bioavailable estrogen ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.23.7.912
更新日期:2000-07-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of parenteral insulin therapy on endogenous insulin secretion in the Diabetes Prevention Trial-Type 1 (DPT-1). RESEARCH DESIGN AND METHODS:In the parenteral insulin arm of DPT-1, subjects without diabetes at high risk of future type 1 diabetes randomized to active treatment received...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2337/dc14-1825
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:High plasma adiponectin is associated with reduced risk of type 2 diabetes, probably a consequence of its insulin-sensitizing properties. In vivo data in rodents suggest that the insulin-sensitization responsible for improvement of glycemia occurs in muscle and liver. Whereas associations of plasma adiponecti...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.26.12.3315
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVE:Epidemiological studies and randomized clinical trials have demonstrated in various populations that resting heart rate (RHR) was an independent predictor of cardiovascular (CV) risk and all-cause mortality. However, few data specifically evaluated the relationship between RHR and long-term CV and renal compl...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc11-2468
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:The current study aimed to determine in the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications cohort whether or not abnormal levels of markers of inflammation and endothelial dysfunction measured in samples collected at DCCT baseline were able to predict ...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc12-2521
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:Whether ACE inhibition is useful for type 2 diabetic patients with micro- and macroalbuminuria remains unknown. The Non-Insulin-Dependent Diabetes, Hypertension, Microalbuminuria, Cardiovascular Events and Ramipril (DIABHYCAR) Study was set up to address this issue through a multicenter double-blind parallel ...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVE:Glycated hemoglobin (HbA1c) is positively associated with cardiovascular disease (CVD), although evidence is primarily observational. Mendelian randomization studies have only examined its relation with subtypes of CVD. We examined the relation of HbA1c with CVD and its subtypes in the UK Biobank using Mendel...
journal_title:Diabetes care
pub_type: 杂志文章,meta分析
doi:10.2337/dc18-0289
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:This study analyzed the lifetime health care expenditures and life years lost associated with diabetes in the U.S. RESEARCH DESIGN AND METHODS:Data from the National Health Interview Survey (NHIS), the Medical Expenditure Panel Survey from 1997 to 2000, and the NHIS Linked Mortality Public-use Files with a m...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc14-1453
更新日期:2015-03-01 00:00:00
abstract::Insulin resistance is the cornerstone for the development of non-insulin-dependent diabetes mellitus (NIDDM). Free fatty acids (FFAs) cause insulin resistance in muscle and liver and increase hepatic gluconeogenesis and lipoprotein production and perhaps decrease hepatic clearance of insulin. It is suggested that the ...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.14.12.1132
更新日期:1991-12-01 00:00:00
abstract:OBJECTIVE:Despite being a safe, effective therapy for lowering cardiovascular risk, only 20% of diabetic patients were using aspirin in the early 1990s. This study examines current physician practices and the use of aspirin therapy by individuals with diabetes. RESEARCH DESIGN AND METHODS:A random sample of diabetic p...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.25.6.965
更新日期:2002-06-01 00:00:00
abstract:OBJECTIVE:To relate deterioration in kidney function to some potential cardiovascular risk factors in type II diabetic patients. RESEARCH DESIGN AND METHODS:Twenty-four normoalbuminuric and 13 microalbuminuric patients completed a 3.4-yr prospective observational study. Glomerular filtration rate, urinary albumin excr...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.16.11.1427
更新日期:1993-11-01 00:00:00
abstract:OBJECTIVE:To examine the impact of Hurricane Katrina on the health of individuals with diabetes. RESEARCH DESIGN AND METHODS:This was an observational study in 1,795 adults with an A1C measurement 6 months before and 6-16 months after Hurricane Katrina in three health care systems: private (Tulane University Hospital ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-0670
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVE:To examine the effect of pioglitazone on myocardial insulin sensitivity and left ventricular (LV) function in patients with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS:Twelve subjects with T2D and 12 with normal glucose tolerance received a euglycemic insulin clamp. Myocardial glucose uptake (MGU) and...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc17-0078
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence and clinical associations of impaired awareness of hypoglycemia in a population-based sample of children and adolescents with type 1 diabetes. RESEARCH DESIGN AND METHODS:A validated questionnaire was administered to 656 patients with type 1 diabetes over a 6-month period to deter...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-0541
更新日期:2009-10-01 00:00:00
abstract::In June 2012, 13 thought leaders convened in a Diabetes Care Editors' Expert Forum to discuss the concept of personalized medicine in the wake of a recently published American Diabetes Association/European Association for the Study of Diabetes position statement calling for a patient-centered approach to hyperglycemia...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc13-0512
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:The study aim was to determine if multisystemic therapy (MST), an intensive home-based psychotherapy, could reduce hospital admissions for diabetic ketoacidosis (DKA) in youth with poorly controlled type 1 diabetes over 24 months. Potential cost savings from reductions in admissions were also evaluated. RESE...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc07-2094
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVE:Elevated heart rate has been predictive of cardiovascular disease and has been proposed as a global index of the autonomic nervous system influence on the heart. Hyperinsulinism has been shown to trigger sympathetic activity experimentally; however, the clinical and epidemiological data on the association of ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.23.5.624
更新日期:2000-05-01 00:00:00
abstract:OBJECTIVE:To estimate real-world off-label use of sodium-glucose cotransporter 2 (SGLT2) inhibitors in patients with type 1 diabetes, estimate rates of diabetic ketoacidosis (DKA), and compare them with DKA rates observed in sotagliflozin clinical trials. RESEARCH DESIGN AND METHODS:We identified initiators of SGLT2 i...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc19-1481
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:To assess the additional effect of sudden visceral fat reduction by omentectomy on metabolic syndrome, acute-phase reactants, and inflammatory mediators in patients with grade III obesity (G-III O) undergoing laparoscopic Roux-en-Y gastric bypass (LRYGB). RESEARCH DESIGN AND METHODS:Twenty-two patients were ...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc09-1833
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVE:Existing physical examination scoring systems for distal diabetic polyneuropathy (PNP) do not fulfill all of the following criteria: validity, manageability, predictive value, and hierarchy The aim of this study was to adapt the Neuropathy Disability Score (NDS) to diagnose PNP in diabetes so that it fulfills...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.23.6.750
更新日期:2000-06-01 00:00:00
abstract:OBJECTIVE:To compare fenofibric acid (FA) + statin to respective monotherapies on the prevalence of metabolic syndrome and its diagnostic components in patients with mixed dyslipidemia. RESEARCH DESIGN AND METHODS:Post hoc analysis of over 2,000 metabolic syndrome patients administered either FA + low- or moderate-dos...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc10-0357
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:To investigate whether the fall in soluble L-selectin (sL-selectin) level constitutes a marker for myocardial ischemia. RESEARCH DESIGN AND METHODS:The levels of soluble forms of adhesion molecules, i.e., intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), E-selectin (sE...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/diacare.22.12.2044
更新日期:1999-12-01 00:00:00
abstract:OBJECTIVE:To compare diabetes care and outcomes among Haitians, African Americans, and non-Hispanic whites. RESEARCH DESIGN AND METHODS:We analyzed data from 715 Haitian, 1,472 African American, and 466 non-Hispanic white adults with diabetes using χ² testing and multiple logistic regression. RESULTS:Haitians had a h...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc10-1387
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:Many non-European ethnic groups have an increased risk for diabetes; however, the published literature demonstrates considerable uncertainty about the rates of diabetes complications among minority populations. The objective of this study was to determine the risks of cardiovascular complications and of morta...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-2105
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:This multicenter open-label clinical trial compared the efficacy and safety of repaglinide/troglitazone combination therapy, repaglinide monotherapy, and troglitazone monotherapy in type 2 diabetes that had been inadequately controlled by sulfonylureas, acarbose, or metformin alone. RESEARCH DESIGN AND METHO...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.2337/diacare.23.7.979
更新日期:2000-07-01 00:00:00
abstract:OBJECTIVE:Emerging epidemiological evidence suggests that higher magnesium intake may reduce diabetes incidence. We aimed to examine the association between magnesium intake and risk of type 2 diabetes by conducting a meta-analysis of prospective cohort studies. RESEARCH DESIGN AND METHODS:We conducted a PubMed databa...
journal_title:Diabetes care
pub_type: 杂志文章,meta分析,评审
doi:10.2337/dc11-0518
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:Insulin resistance (IR) and the metabolic syndrome (MS) are associated with type 2 diabetes and adverse cardiovascular disease (CVD) risk factor profiles. Whether IR and MS predict CVD independently of diabetes and other CVD risk factors is not known. This study examines whether IR and/or presence of MS are i...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.26.3.861
更新日期:2003-03-01 00:00:00