Effect of chronic intermittent intravenous insulin therapy on antihypertensive medication requirements in IDDM subjects with hypertension and nephropathy.

Abstract:

OBJECTIVE:The prevalence of systemic hypertension is increased in patients with diabetes. In this prospective, randomized, crossover clinical trial, we assessed antihypertensive effects of chronic intermittent intravenous insulin therapy (CIIIT) on insulin-dependent diabetes mellitus (IDDM) subjects with hypertension and nephropathy by monitoring the amount of antihypertensive medication (AHM) required to maintain blood pressure (BP) < or = 140/90 mmHg. RESEARCH DESIGN AND METHODS:After a stabilization period, 26 hypertensive IDDM subjects were randomly assigned to a control or treatment phase for 3 months and then crossed over into the opposite phase for another 3 months. Addition of CIIIT during the treatment phase was the only procedural difference between the control and treatment phases. RESULTS:The AHM dosage requirements for maintenance of the baseline BP levels decreased significantly (46%; P < 0.0001) and linearly over time (P < 0.0058) during the treatment phase, while remaining essentially unchanged during the control phase. CONCLUSIONS:Our data suggest that CIIIT markedly improves BP control, as evidenced by the significantly reduced AHM dosage requirements in subjects with IDDM and hypertension, possibly through an improvement in vascular reactivity.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Aoki TT,Grecu EO,Prendergast JJ,Arcangeli MA,Meisenheimer R

doi

10.2337/diacare.18.9.1260

subject

Has Abstract

pub_date

1995-09-01 00:00:00

pages

1260-5

issue

9

eissn

0149-5992

issn

1935-5548

journal_volume

18

pub_type

临床试验,杂志文章,随机对照试验
  • Reduction in cardiovascular risk factors with intensive diabetes treatment in insulin-dependent diabetes mellitus.

    abstract::We measured plasma lipid and lipoprotein levels at baseline and at 6-mo intervals in 47 normolipidemic patients with classic insulin-dependent diabetes mellitus treated either with a conventional (n = 21) or intensive (n = 26) diabetes-treatment program. Patients were followed for a mean of 3 yr (range 1-4 yr). Intens...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.10.6.729

    authors: Rosenstock J,Strowig S,Cercone S,Raskin P

    更新日期:1987-11-01 00:00:00

  • Determinants for the effectiveness of lifestyle intervention in the Finnish Diabetes Prevention Study.

    abstract:OBJECTIVE:Intensive lifestyle intervention significantly reduced diabetes incidence among the participants in the Finnish Diabetes Prevention Study. We investigated whether and to what extent risk factors for type 2 diabetes and other baseline characteristics of the study participants modified the effectiveness of the ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc07-2162

    authors: Lindström J,Peltonen M,Eriksson JG,Aunola S,Hämäläinen H,Ilanne-Parikka P,Keinänen-Kiukaanniemi S,Uusitupa M,Tuomilehto J,Finnish Diabetes Prevention Study (DPS) Group.

    更新日期:2008-05-01 00:00:00

  • Effect of weight loss with lifestyle intervention on risk of diabetes.

    abstract:OBJECTIVE:Diabetes Prevention Program (DPP) participants randomized to the intensive lifestyle intervention (ILS) had significantly reduced risk of diabetes compared with placebo participants. We explored the contribution of changes in weight, diet, and physical activity on the risk of developing diabetes among ILS par...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc06-0560

    authors: Hamman RF,Wing RR,Edelstein SL,Lachin JM,Bray GA,Delahanty L,Hoskin M,Kriska AM,Mayer-Davis EJ,Pi-Sunyer X,Regensteiner J,Venditti B,Wylie-Rosett J

    更新日期:2006-09-01 00:00:00

  • Lifestyle Counseling and Long-term Clinical Outcomes in Patients With Diabetes.

    abstract:OBJECTIVE:To investigate the relationship between lifestyle counseling in primary care settings and clinical outcomes in patients with diabetes. RESEARCH DESIGN AND METHODS:We retrospectively studied hyperglycemic adults with diabetes treated at primary care practices between 2000 and 2014. We analyzed the relationshi...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc19-0629

    authors: Zhang H,Goldberg SI,Hosomura N,Shubina M,Simonson DC,Testa MA,Turchin A

    更新日期:2019-09-01 00:00:00

  • Effects of postmenopausal hormone replacement therapy on central abdominal fat, glycemic control, lipid metabolism, and vascular factors in type 2 diabetes: a prospective study.

    abstract:OBJECTIVE:To examine the effects of hormone replacement therapy (HRT) on lipid metabolism, glycemic control, total body and central abdominal fat, blood pressure (BP), and arterial pulse wave velocity (APWV) in overweight postmenopausal females with type 2 diabetes. RESEARCH DESIGN AND METHODS:This was a 12-month pros...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.22.9.1401

    authors: Samaras K,Hayward CS,Sullivan D,Kelly RP,Campbell LV

    更新日期:1999-09-01 00:00:00

  • Exogenous estrogen exposures and changes in diabetic retinopathy. The Wisconsin Epidemiologic Study of Diabetic Retinopathy.

    abstract:OBJECTIVE:To investigate whether the use of exogenous estrogen is associated with changes in the severity of diabetic retinopathy and the incidence of macular edema. RESEARCH DESIGN AND METHODS:The study design involved observation of two well-defined cohorts of women with diabetes. One group was diagnosed with diabet...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.22.12.1984

    authors: Klein BE,Klein R,Moss SE

    更新日期:1999-12-01 00:00:00

  • Cellular ions in NIDDM: relation of calcium to hyperglycemia and cardiac mass.

    abstract:OBJECTIVE:To investigate the role of hyperglycemia in mediating the clinical association of NIDDM with hypertension and left ventricular dysfunction and hypertrophy. RESEARCH DESIGN AND METHODS:Since hyperglycemia elevates cytosolic free calcium (Cai) both in myocardial and vascular smooth muscle cells, we utilized nu...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.19.12.1393

    authors: Barbagallo M,Gupta RK,Resnick LM

    更新日期:1996-12-01 00:00:00

  • Prevalence of diabetes and ethnic differences in cardiovascular risk factors. The 1992 Singapore National Health Survey.

    abstract:OBJECTIVE:The purpose of the 1992 Singapore National Health Survey was to determine the current distribution of major noncommunicable diseases and their risk factors, including the prevalence of diabetes and dyslipidemia, in Singapore. RESEARCH DESIGN AND METHODS:A combination of disproportionate stratified sampling a...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.22.2.241

    authors: Tan CE,Emmanuel SC,Tan BY,Jacob E

    更新日期:1999-02-01 00:00:00

  • Beta-cell dysfunction, insulin sensitivity, and glycosuria precede diabetes in hepatocyte nuclear factor-1alpha mutation carriers.

    abstract:OBJECTIVE:Patients with diabetes due to hepatocyte nuclear factor (HNF)-1alpha mutations have beta-cell deficiency, insulin sensitivity, altered proinsulin levels, and a low renal threshold for glucose. It is uncertain how many of these features precede the development of diabetes. The aim of our study was to test for ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.28.7.1751

    authors: Stride A,Ellard S,Clark P,Shakespeare L,Salzmann M,Shepherd M,Hattersley AT

    更新日期:2005-07-01 00:00:00

  • Association of NAD(P)H oxidase p22 phox gene variation with advanced carotid atherosclerosis in Japanese type 2 diabetes.

    abstract:OBJECTIVE:To evaluate the association between the C242T polymorphism of the p22 phox gene, an essential component of NAD(P)H oxidase in the vasculature, with intima-media thickness (IMT) of the carotid artery and risk factors for atherosclerosis in type 2 diabetic subjects. RESEARCH DESIGN AND METHODS:C242T polymorphi...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.26.2.458

    authors: Hayaishi-Okano R,Yamasaki Y,Kajimoto Y,Sakamoto K,Ohtoshi K,Katakami N,Kawamori D,Miyatsuka T,Hatazaki M,Hazama Y,Hori M

    更新日期:2003-02-01 00:00:00

  • Consumption of sugar-sweetened beverages among adults with type 2 diabetes.

    abstract:OBJECTIVE:To examine patterns of sugar-sweetened beverage (SSB) consumption among U.S. adults with type 2 diabetes in 2003-2006. RESEARCH DESIGN AND METHODS:We analyzed 24-h dietary recall data from the National Health and Nutrition Examination Survey 2003-2006 to estimate SSB consumption levels among 1,090 adults (ag...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc10-1687

    authors: Bleich SN,Wang YC

    更新日期:2011-03-01 00:00:00

  • Determinants of incident hyperglycemia 6 years after delivery in young rural Indian mothers: the Pune Maternal Nutrition Study (PMNS).

    abstract:OBJECTIVE:To study determinants of incident hyperglycemia in rural Indian mothers 6 years after delivery. RESEARCH DESIGN AND METHODS:The Pune Maternal Nutrition Study collected information in six villages near Pune on prepregnant characteristics and nutrition, physical activity, and glucose tolerance during pregnancy...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc07-0329

    authors: Kulkarni SR,Fall CH,Joshi NV,Lubree HG,Deshpande VU,Pasarkar RV,Bhat DS,Naik SS,Yajnik CS

    更新日期:2007-10-01 00:00:00

  • In patients with acute myocardial infarction, the impact of hyperglycemia as a risk factor for mortality is not homogeneous across age-groups.

    abstract:OBJECTIVE:To assess the impact of hyperglycemia in different age-groups of patients with acute myocardial infarction (AMI). RESEARCH DESIGN AND METHODS:A total of 2,027 patients with AMI were categorized into one of five age-groups: <50 years (n = 301), ≥50 and <60 (n = 477), ≥60 and <70 (n = 545), ≥70 and <80 (n = 49...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-1170

    authors: Nicolau JC,Serrano CV Jr,Giraldez RR,Baracioli LM,Moreira HG,Lima F,Franken M,Kalil R,Ramires JA,Giugliano RP

    更新日期:2012-01-01 00:00:00

  • Leptinemia is not a risk factor for ischemic heart disease in men. Prospective results from the Quebec Cardiovascular Study.

    abstract:OBJECTIVE:To investigate the possibility that leptin levels may be predictive of the risk of ischemic heart disease (IHD) through the relationship of leptin to body fat. RESEARCH DESIGN AND METHODS:The Quebec Cardiovascular Study cohort consisted of 2,103 French-Canadian men without IHD in 1985 who were followed until...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.21.5.782

    authors: Couillard C,Lamarche B,Mauriège P,Cantin B,Dagenais GR,Moorjani S,Lupien PJ,Després JP

    更新日期:1998-05-01 00:00:00

  • Impact of a natural disaster on diabetes: exacerbation of disparities and long-term consequences.

    abstract:OBJECTIVE:To examine the impact of Hurricane Katrina on the health of individuals with diabetes. RESEARCH DESIGN AND METHODS:This was an observational study in 1,795 adults with an A1C measurement 6 months before and 6-16 months after Hurricane Katrina in three health care systems: private (Tulane University Hospital ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-0670

    authors: Fonseca VA,Smith H,Kuhadiya N,Leger SM,Yau CL,Reynolds K,Shi L,McDuffie RH,Thethi T,John-Kalarickal J

    更新日期:2009-09-01 00:00:00

  • Incidence, prevalence, and mortality of diabetes in a large population. A report from the Skaraborg Diabetes Registry.

    abstract:OBJECTIVE:Our objective was to analyze the prevalence, incidence, and mortality of diabetes in a population of 280,539 inhabitants. RESEARCH DESIGN AND METHODS:The incidence, prevalence, and deaths from diabetes at all ages of a population have been prospectively followed in the county of Skaraborg, Sweden, since 1991...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.22.5.773

    authors: Berger B,Stenström G,Sundkvist G

    更新日期:1999-05-01 00:00:00

  • Management of the pregnant, insulin-dependent diabetic woman.

    abstract::An intensive care program was offered to all insulin-dependent, pregnant diabetic women who presented to The New York Hospital Obstetrical Clinic in their eighth week or less of gestation. The patients were hospitalized for 1 wk to normalize their blood glucose and to teach the technique of self-monitored glucose dete...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.3.1.63

    authors: Jovanovic L,Peterson CM

    更新日期:1980-01-01 00:00:00

  • Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT): urinary screening and baseline biochemical and cardiovascular assessments.

    abstract:OBJECTIVE:We assessed the association between early increases in albumin excretion and cardiovascular (CV) and renal markers in a large cohort of young people with type 1 diabetes. RESEARCH DESIGN AND METHODS:As part of preliminary screening for a multicenter, randomized controlled trial of statins/ACE inhibitors, we ...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2337/dc13-1634

    authors: Marcovecchio ML,Woodside J,Jones T,Daneman D,Neil A,Prevost T,Dalton RN,Deanfield J,Dunger DB,AdDIT Investigators.

    更新日期:2014-01-01 00:00:00

  • Contrasting the Genetic Background of Type 1 Diabetes and Celiac Disease Autoimmunity.

    abstract::Type 1 diabetes (T1D) and celiac disease (CeD) cluster in families and can occur in the same individual. Genetic loci have been associated with susceptibility to both diseases. Our aim was to explore the genetic differences between individuals developing both these diseases (double autoimmunity) versus those with only...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dcs15-2007

    authors: Gutierrez-Achury J,Romanos J,Bakker SF,Kumar V,de Haas EC,Trynka G,Ricaño-Ponce I,Steck A,Type 1 Diabetes Genetics Consortium.,Chen WM,Onengut-Gumuscu S,Simsek S,Diabeter.,Rewers M,Mulder CJ,Liu E,Rich SS,Wijmenga C

    更新日期:2015-10-01 00:00:00

  • Influence of insertion/deletion polymorphism in the ACE-I gene on the progression of diabetic glomerulopathy in type 1 diabetic patients with microalbuminuria.

    abstract:OBJECTIVE:To investigate the influence of the insertion/deletion polymorphism of the ACE gene on the progression of early diabetic glomerulopathy in patients with and without antihypertensive treatment (AHT). RESEARCH DESIGN AND METHODS:There were 30 microalbuminuric patients with >5 years of type 1 diabetes who had r...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/diacare.23.4.544

    authors: Rudberg S,Rasmussen LM,Bangstad HJ,Osterby R

    更新日期:2000-04-01 00:00:00

  • The effect of ruboxistaurin on nephropathy in type 2 diabetes.

    abstract:OBJECTIVE:Ruboxistaurin selectively inhibits protein kinase C-beta and ameliorates kidney disease in animal models of diabetes. The purpose of this study was to evaluate the effects of ruboxistaurin on diabetic nephropathy in humans. RESEARCH DESIGN AND METHODS:A randomized, double-blind, placebo-controlled, multicent...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.2337/diacare.28.11.2686

    authors: Tuttle KR,Bakris GL,Toto RD,McGill JB,Hu K,Anderson PW

    更新日期:2005-11-01 00:00:00

  • Detection of GAD65-reactive T-Cells in type 1 diabetes by immunoglobulin-free ELISPOT assays.

    abstract:OBJECTIVE:To investigate the prevalence of beta-cell autoantigen-reactive peripheral T-cells in type 1 diabetes, we developed an immunoglobulin-free enzyme-linked immunospot (ELISPOT) assay and assessed its usefulness for diagnosing this disease. RESEARCH DESIGN AND METHODS:Cellular immune responses to beta -cell auto...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.25.8.1390

    authors: Kotani R,Nagata M,Moriyama H,Nakayama M,Yamada K,Chowdhury SA,Chakrabarty S,Jin Z,Yasuda H,Yokono K

    更新日期:2002-08-01 00:00:00

  • Evaluation of the insulin resistance syndrome in 5- to 10-year-old overweight/obese African-American children.

    abstract:OBJECTIVE:To characterize the insulin sensitivity of overweight and obese 5- to 10-year-old (Tanner stage 1-3) African-American children screened for participation in a diabetes prevention study and to identify the association of insulin sensitivity with obesity, hyperlipidemia, and hypertension. RESEARCH DESIGN AND M...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.24.8.1359

    authors: Young-Hyman D,Schlundt DG,Herman L,De Luca F,Counts D

    更新日期:2001-08-01 00:00:00

  • The role of the National Diabetes Advisory Board in diabetes management.

    abstract::The history of the National Diabetes Advisory Board is reviewed, particularly from the perspective of the role of the board in advancing diabetes care. In addition, its potential future activities in the arena of translating research advances, for example, the results of the Diabetes Control and Complications Trial (D...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:

    authors: Genuth SM

    更新日期:1994-06-01 00:00:00

  • The antidiabetogenic effect of GLP-1 is maintained during a 7-day treatment period and improves diabetic dyslipoproteinemia in NIDDM patients.

    abstract:OBJECTIVE:To investigate the long-term antidiabetogenic effect of glucagon-like peptide 1 (GLP-1) and its influence on diabetic dyslipoproteinemia, patients with NIDDM were treated with GLP-1 subcutaneously for 1 week. RESEARCH DESIGN AND METHODS:Twelve patients participated in the study. The 1st week of the study, al...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.19.11.1200

    authors: Juntti-Berggren L,Pigon J,Karpe F,Hamsten A,Gutniak M,Vignati L,Efendic S

    更新日期:1996-11-01 00:00:00

  • Global Disability Burdens of Diabetes-Related Lower-Extremity Complications in 1990 and 2016.

    abstract:OBJECTIVE:No study has reported global disability burden estimates for individual diabetes-related lower-extremity complications (DRLECs). The Global Burden of Disease (GBD) study presents a robust opportunity to address this gap. RESEARCH DESIGN AND METHODS:GBD 2016 data, including prevalence and years lived with dis...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc19-1614

    authors: Zhang Y,Lazzarini PA,McPhail SM,van Netten JJ,Armstrong DG,Pacella RE

    更新日期:2020-05-01 00:00:00

  • Prior feeding alters the response to the 50-g glucose challenge test in pregnancy. The Staub-Traugott effect revisited.

    abstract:OBJECTIVE:To examine the effect of prior meal ingestion on the glucose, insulin, and C-peptide response to a 50-g glucose challenge test in the third trimester of pregnancy. RESEARCH DESIGN AND METHODS:Ten pregnant women with gestational diabetes mellitus and 12 nondiabetic pregnant control subjects matched for age an...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.16.12.1551

    authors: Lewis GF,McNally C,Blackman JD,Polonsky KS,Barron WM

    更新日期:1993-12-01 00:00:00

  • Effects of stress hyperglycemia on acute myocardial infarction: role of inflammatory immune process in functional cardiac outcome.

    abstract:OBJECTIVE:Stress hyperglycemia has been associated with increased mortality in patients with myocardial infarction (MI). We examined the association between plasma glucose levels, circulating inflammatory markers, T-cell activation, and functional cardiac outcome in patients with first MI. RESEARCH DESIGN AND METHODS:...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.26.11.3129

    authors: Marfella R,Siniscalchi M,Esposito K,Sellitto A,De Fanis U,Romano C,Portoghese M,Siciliano S,Nappo F,Sasso FC,Mininni N,Cacciapuoti F,Lucivero G,Giunta R,Verza M,Giugliano D

    更新日期:2003-11-01 00:00:00

  • Impact of iron deficiency anemia on prevalence of gestational diabetes mellitus.

    abstract:OBJECTIVE:Increased Hb and ferritin have been associated with gestational diabetes mellitus (GDM). This study was performed to determine whether the prevalence of GDM is influenced by iron deficiency anemia. RESEARCH DESIGN AND METHODS:In a retrospective case-control study, 242 women with iron deficiency anemia (Hb<10...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.27.3.650

    authors: Lao TT,Ho LF

    更新日期:2004-03-01 00:00:00

  • Immune Checkpoint Inhibitor-Associated Diabetes: A Single-Institution Experience.

    abstract:OBJECTIVE:To characterize immune checkpoint inhibitor-associated diabetes mellitus (ICI-DM) in a single-institution case series. RESEARCH DESIGN AND METHODS:Retrospective chart review of 18 patients with new-onset ICI-DM following anti-programmed cell death protein 1 (PD-1)/anti-programmed cell death protein ligand 1 ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc20-0609

    authors: Byun DJ,Braunstein R,Flynn J,Zheng J,Lefkowitz RA,Kanbour S,Girotra M

    更新日期:2020-12-01 00:00:00