Association of NAD(P)H oxidase p22 phox gene variation with advanced carotid atherosclerosis in Japanese type 2 diabetes.

abstract：OBJECTIVE:Therapies with metformin, sulfonylureas, or insulin improve glycemic control in the short term but do not prevent progressive islet beta-cell failure or long-term deterioration in glycemia. Our goal was to evaluate, in patients recently diagnosed with type 2 diabetes (<3 years), the long-term efficacy of mono...

journal_title：Diabetes care

authors： Viberti G,Kahn SE,Greene DA,Herman WH,Zinman B,Holman RR,Haffner SM,Levy D,Lachin JM,Berry RA,Heise MA,Jones NP,Freed MI

更新日期：2002-10-01 00:00:00

abstract：OBJECTIVE:To determine the best autoantibody-based testing strategy for recruiting relatives for future intervention trials and to establish the role of islet cell antibodies (ICAs) within this strategy. RESEARCH DESIGN AND METHODS:ICAs, insulin autoantibodies (IAAs), GAD antibodies, and IA-2 antibodies were determine...

journal_title：Diabetes care

authors： Bingley PJ,Williams AJ,Gale EA

更新日期：1999-11-01 00:00:00

abstract：:Pregnancy induces complex changes in energy metabolism, manifested clinically by insulin resistance, low fasting blood glucose levels, and proneness to ketosis. It is quite unusual for pregnant women who do not have type I diabetes to progress from ketosis to frank ketoacidosis, although this phenomenon is common in l...

journal_title：Diabetes care

authors： Bedalov A,Balasubramanyam A

更新日期：1997-06-01 00:00:00

abstract：OBJECTIVE:To investigate why, in spite of a vast variety of treatment agents, the alleviation of pain in patients with diabetic neuropathy is difficult. Previous studies have not used a treatment algorithm based on anatomic site and neuropathophysiological source of the neuropathic pain. RESEARCH DESIGN AND METHODS:A ...

journal_title：Diabetes care

authors： Pfeifer MA,Ross DR,Schrage JP,Gelber DA,Schumer MP,Crain GM,Markwell SJ,Jung S

更新日期：1993-08-01 00:00:00

abstract：OBJECTIVE:Mild demyelination may contribute more to the pathophysiology of nerve fiber injury in diabetic sensorimotor polyneuropathy (DSP) than previously thought. We investigated the clinical and electrodiagnostic classifications of nerve injury in diabetic patients to detect evidence of conduction slowing in DSP. R...

journal_title：Diabetes care

authors： Dunnigan SK,Ebadi H,Breiner A,Katzberg HD,Lovblom LE,Perkins BA,Bril V

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVE:Epidemiological studies and randomized clinical trials have demonstrated in various populations that resting heart rate (RHR) was an independent predictor of cardiovascular (CV) risk and all-cause mortality. However, few data specifically evaluated the relationship between RHR and long-term CV and renal compl...

journal_title：Diabetes care

authors： Miot A,Ragot S,Hammi W,Saulnier PJ,Sosner P,Piguel X,Torremocha F,Marechaud R,Hadjadj S

更新日期：2012-10-01 00:00:00

abstract：:This study examined the effect of age on the posthepatic delivery of oral glucose (PHDG) during steady-state conditions. We used an intravenous-oral modification of the euglycemic insulin-clamp technique to assess PHDG in six men aged 24-39 yr (young) and eight men aged 65-83 yr (old). Each subject underwent two studi...

journal_title：Diabetes care

authors： Tonino RP,Minaker KL,Rowe JW

更新日期：1989-06-01 00:00:00

abstract：OBJECTIVE:To assess the effects of empagliflozin, a selective sodium-glucose cotransporter 2 (SGLT2) inhibitor, on broad biological systems through proteomics. RESEARCH DESIGN AND METHODS:Aptamer-based proteomics was used to quantify 3,713 proteins in 144 paired plasma samples obtained from 72 participants across the ...

journal_title：Diabetes care

authors： Ferrannini E,Murthy AC,Lee YH,Muscelli E,Weiss S,Ostroff RM,Sattar N,Williams SA,Ganz P

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:Several methods have been proposed to evaluate insulin sensitivity from the data obtained from the oral glucose tolerance test (OGTT). However, the validity of these indices has not been rigorously evaluated by comparing them with the direct measurement of insulin sensitivity obtained with the euglycemic insu...

journal_title：Diabetes care

authors： Matsuda M,DeFronzo RA

更新日期：1999-09-01 00:00:00

abstract：OBJECTIVE:We prospectively investigated in hypertensive patients with type 2 diabetes if bedtime treatment with ≥1 hypertension medications exerts better blood pressure control and cardiovascular risk reduction than conventional therapy, in which all medications are ingested in the morning. RESEARCH DESIGN AND METHODS...

journal_title：Diabetes care

authors： Hermida RC,Ayala DE,Mojón A,Fernández JR

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:To assess the success and baseline predictors of maintaining glycemic control for up to 5 years of therapy using basal insulin glargine or standard glycemic care in people with dysglycemia treated with zero or one oral glucose-lowering agents. RESEARCH DESIGN AND METHODS:Data from 12,537 participants in the ...

journal_title：Diabetes care

authors： ORIGIN Trial Investigators.

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVE:To compare albumin-to-creatinine ratio (ACR) and albumin concentration (ALB) for detection of microalbuminuria using precise data on CIs for sensitivity and specificity and to determine sex- and age-specific discriminator values for ACR. RESEARCH DESIGN AND METHODS:All consecutive patients investigated for t...

journal_title：Diabetes care

authors： Bakker AJ

更新日期：1999-02-01 00:00:00

abstract：:Use of pure porcine insulin versus partially purified insulin of bovine/porcine origin might be expected to have certain clinical benefits, e.g., a lower incidence of skin reactions, a lower insulin dosage, better diabetes regulation, and greater preservation of endogenous insulin secretion. To test this hypothesis, w...

journal_title：Diabetes care

authors： Asplin C,Raghu P,Clemons P,Lyen K,Tatpati O,McKnight B,Baker L,Guthrie R,Sperling M,Palmer J

更新日期：1987-05-01 00:00:00

abstract：OBJECTIVE:To study the association between microalbuminuria and development of preeclampsia and preterm delivery in pregnant women with type 1 diabetes. RESEARCH DESIGN AND METHODS:This was a population-based prospective study in 846 normoalbuminuric or microalbuminuric women with type 1 diabetes without antihypertens...

journal_title：Diabetes care

authors： Jensen DM,Damm P,Ovesen P,Mølsted-Pedersen L,Beck-Nielsen H,Westergaard JG,Moeller M,Mathiesen ER

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:Microalbuminuria can reflect the progress of microvascular complications and may be predictive of macrovascular disease in type 2 diabetes. The effect of intensive glycemic control on microalbuminuria in patients in the U.S. who have had type 2 diabetes for several years has not previously been evaluated. RE...

journal_title：Diabetes care

authors： Levin SR,Coburn JW,Abraira C,Henderson WG,Colwell JA,Emanuele NV,Nuttall FQ,Sawin CT,Comstock JP,Silbert CK

更新日期：2000-10-01 00:00:00

abstract：OBJECTIVE:To assess the long-term cost-effectiveness of aspirin use among adults aged >or=40 years with newly diagnosed type 2 diabetes. RESEARCH DESIGN AND METHODS:We used a validated cost-effectiveness model of type 2 diabetes to assess the lifetime health and cost consequences of use or nonuse of aspirin. The model...

journal_title：Diabetes care

authors： Li R,Zhang P,Barker LE,Hoerger TJ

更新日期：2010-06-01 00:00:00

abstract：:The consensus algorithm for the medical management of type 2 diabetes was published in August 2006 with the expectation that it would be updated, based on the availability of new interventions and new evidence to establish their clinical role. The authors continue to endorse the principles used to develop the algorith...

journal_title：Diabetes care

authors： Nathan DM,Buse JB,Davidson MB,Ferrannini E,Holman RR,Sherwin R,Zinman B,American Diabetes Association.,European Association for Study of Diabetes.

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:The structural basis of normoalbuminuric renal insufficiency in patients with type 2 diabetes remains to be elucidated. We compared renal biopsy findings in patients with type 2 diabetes and estimated glomerular filtration rate (eGFR) and measured GFR of <60 mL/min/1.73 m2, associated with either normo-, micr...

journal_title：Diabetes care

authors： Ekinci EI,Jerums G,Skene A,Crammer P,Power D,Cheong KY,Panagiotopoulos S,McNeil K,Baker ST,Fioretto P,Macisaac RJ

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVE:Consumption of soy protein has recently been shown to improve the blood lipid levels in nondiabetic subjects. The purpose of this study was to evaluate if a dietary supplement of soy protein, isoflavones, and cotyledon fiber (Abalon) affects cardiovascular risk markers, blood glucose, and insulin levels in ty...

journal_title：Diabetes care

authors： Hermansen K,Søndergaard M,Høie L,Carstensen M,Brock B

更新日期：2001-02-01 00:00:00

abstract：OBJECTIVE:To determine whether the association between depressive symptoms and glycemic control is mediated by blood glucose monitoring (BGM). RESEARCH DESIGN AND METHODS:A total of 276 adolescents with type 1 diabetes (mean age +/- SD, 15.6 +/- 1.4 years) completed a measure of depressive symptoms. Sociodemographic a...

journal_title：Diabetes care

authors： McGrady ME,Laffel L,Drotar D,Repaske D,Hood KK

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVE:To examine the evolution of the dysregulated glucagon responses to mixed-meal tolerance tests (MMTTs) in youth with recent-onset type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS:MMTTs were performed in 25 youth (9-18 years of age) with 1.5-12 months disease duration (year 1); 22 subjects were restudied 1 y...

journal_title：Diabetes care

authors： Sherr J,Tsalikian E,Fox L,Buckingham B,Weinzimer S,Tamborlane WV,White NH,Arbelaez AM,Kollman C,Ruedy KJ,Cheng P,Beck RW,Diabetes Research in Children Network.

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:To compare the glucose variability associated with insulin glargine and NPH/Lente insulin used as the basal insulin component of a multiple daily injection (MDI) regimen in pediatric patients with type 1 diabetes. RESEARCH DESIGN AND METHODS:Continuous glucose monitoring data were collected from a subset of ...

journal_title：Diabetes care

authors： White NH,Chase HP,Arslanian S,Tamborlane WV,4030 Study Group.

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:To investigate whether the use of exogenous estrogen is associated with changes in the severity of diabetic retinopathy and the incidence of macular edema. RESEARCH DESIGN AND METHODS:The study design involved observation of two well-defined cohorts of women with diabetes. One group was diagnosed with diabet...

journal_title：Diabetes care

authors： Klein BE,Klein R,Moss SE

更新日期：1999-12-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to compare different outcome measures in the audit of management of diabetic foot ulcers RESEARCH DESIGN AND METHODS:Data collected prospectively in a consecutive cohort of patients referred to a specialist multidisciplinary foot care clinic between 1 January 2000 and 31 Decembe...

journal_title：Diabetes care

authors： Jeffcoate WJ,Chipchase SY,Ince P,Game FL

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVE:To compare diabetes care and outcomes among Haitians, African Americans, and non-Hispanic whites. RESEARCH DESIGN AND METHODS:We analyzed data from 715 Haitian, 1,472 African American, and 466 non-Hispanic white adults with diabetes using χ² testing and multiple logistic regression. RESULTS:Haitians had a h...

journal_title：Diabetes care

authors： Vimalananda VG,Rosenzweig JL,Cabral HJ,David MM,Lasser KE

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:Recent studies suggest that air pollution plays a role in type 2 diabetes (T2D) incidence and mortality. The underlying physiological mechanisms have yet to be established. We hypothesized that air pollution adversely affects insulin sensitivity and secretion and serum lipid levels. RESEARCH DESIGN AND METHO...

journal_title：Diabetes care

authors： Chen Z,Salam MT,Toledo-Corral C,Watanabe RM,Xiang AH,Buchanan TA,Habre R,Bastain TM,Lurmann F,Wilson JP,Trigo E,Gilliland FD

更新日期：2016-04-01 00:00:00

abstract：:Since little is known regarding the appropriate time for preprandial insulin administration, we compared the effects of 30-min subcutaneous insulin infusions started 60 min, 30 min, and immediately before meal ingestion on postprandial plasma glucose and insulin profiles in eight subjects with insulin-dependent diabet...

journal_title：Diabetes care

authors： Dimitriadis GD,Gerich JE

更新日期：1983-07-01 00:00:00

abstract：OBJECTIVE:Many studies have shown that diabetes increases the risk of cardiovascular disease (CVD) in women to a greater extent than in men. One explanation could be that diabetes has more adverse effects on CVD risk factors in women than in men. We compared diabetes-associated differences in CVD risk factors in men an...

journal_title：Diabetes care

authors： Howard BV,Cowan LD,Go O,Welty TK,Robbins DC,Lee ET

更新日期：1998-08-01 00:00:00

abstract：OBJECTIVE:This study was designed to examine metabolic and hormonal effects of long-term exercise in healthy subjects and insulin-dependent (type I) diabetic patients. RESEARCH DESIGN AND METHODS:Two studies were performed. First, 16 healthy males (32 +/- 3 yr) were studied during a semitriathlon competition (2 km swi...

journal_title：Diabetes care

authors： Koivisto VA,Sane T,Fyhrquist F,Pelkonen R

更新日期：1992-11-01 00:00:00

abstract：:Two-thirds of all deaths in developed countries are caused by the major noncommunicable diseases, e.g., cardiovascular disease, cancer, and non-insulin-dependent diabetes mellitus (NIDDM). There is increasing evidence that these diseases are a consequence of life-style change, and they have a number of risk factors in...

journal_title：Diabetes care

authors： Zimmet PZ

更新日期：1988-03-01 00:00:00