Importance of timing of preprandial subcutaneous insulin administration in the management of diabetes mellitus.

Abstract:

:Since little is known regarding the appropriate time for preprandial insulin administration, we compared the effects of 30-min subcutaneous insulin infusions started 60 min, 30 min, and immediately before meal ingestion on postprandial plasma glucose and insulin profiles in eight subjects with insulin-dependent diabetes mellitus. Of these three regimens, administration of insulin 60 min before meal ingestion provided plasma glucose and insulin profiles closest to normal and permitted less insulin to be used. Our results suggest that adjustments in the timing as well as in the amount of insulin administered preprandially may be used in the management of diabetes and that prolonging the interval between administration of insulin and meal ingestion may reduce insulin requirements and thus decrease the hyperinsulinemia usually associated with insulin therapy.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Dimitriadis GD,Gerich JE

doi

10.2337/diacare.6.4.374

subject

Has Abstract

pub_date

1983-07-01 00:00:00

pages

374-7

issue

4

eissn

0149-5992

issn

1935-5548

journal_volume

6

pub_type

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