Abstract:
OBJECTIVE:To investigate whether the use of exogenous estrogen is associated with changes in the severity of diabetic retinopathy and the incidence of macular edema. RESEARCH DESIGN AND METHODS:The study design involved observation of two well-defined cohorts of women with diabetes. One group was diagnosed with diabetes at < 30 years of age and used insulin (younger-onset group), and the other group was diagnosed at > or = 30 years of age with no criteria regarding therapy (older-onset group). Subjects received standard examinations, medical interviews, and retinal photography in 1980-1982. Specific questions about exogenous hormone exposure were added to the study questionnaire at the first follow-up examination 4 years after the baseline examination. Change in the severity of retinopathy 6 and 10 years after the 4-year follow-up examination were examined regarding the use of oral contraceptives at the first follow-up examination in the younger-onset group and at 6 years after the first follow-up examination regarding hormone replacement therapy in the older-onset group. RESULTS:Changes in the severity of retinopathy and incidence of macular edema were unrelated to either type of estrogen exposure in univariable and multivariable analyses. CONCLUSIONS:These data are compatible with the hypothesis that the medications used by our population do not affect the severity of diabetic retinopathy or macular edema.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Klein BE,Klein R,Moss SEdoi
10.2337/diacare.22.12.1984subject
Has Abstractpub_date
1999-12-01 00:00:00pages
1984-7issue
12eissn
0149-5992issn
1935-5548journal_volume
22pub_type
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