Comparison of glycemic variability associated with insulin glargine and intermediate-acting insulin when used as the basal component of multiple daily injections for adolescents with type 1 diabetes.

Abstract:

OBJECTIVE:To compare the glucose variability associated with insulin glargine and NPH/Lente insulin used as the basal insulin component of a multiple daily injection (MDI) regimen in pediatric patients with type 1 diabetes. RESEARCH DESIGN AND METHODS:Continuous glucose monitoring data were collected from a subset of patients (n = 90) who agreed to use a continuous glucose monitoring system during an active-controlled, randomized, open-label study evaluating the safety and efficacy of insulin glargine and NPH/Lente insulin used with insulin lispro as part of an MDI regimen. RESULTS:Treatment with insulin glargine resulted in significant reductions in glucose variability as measured by the SD of glucose values (adjusted mean change from baseline to week 24: -13.4 mg/dl [-0.74 mmol/l]; P

journal_name

Diabetes Care

journal_title

Diabetes care

authors

White NH,Chase HP,Arslanian S,Tamborlane WV,4030 Study Group.

doi

10.2337/dc08-0800

subject

Has Abstract

pub_date

2009-03-01 00:00:00

pages

387-93

issue

3

eissn

0149-5992

issn

1935-5548

pii

dc08-0800

journal_volume

32

pub_type

杂志文章,随机对照试验
  • A health economic model to assess the long-term effects and cost-effectiveness of orlistat in obese type 2 diabetic patients.

    abstract:OBJECTIVES:Obesity is a common condition in type 2 diabetic patients. Treating obesity may enhance hypoglycemic treatment and contribute to the reduction of long-term microvascular and macrovascular complications. Orlistat reduces cardiovascular risk factors in obese type 2 diabetic patients. The objectives of this stu...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.25.2.303

    authors: Lamotte M,Annemans L,Lefever A,Nechelput M,Masure J

    更新日期:2002-02-01 00:00:00

  • Changes in triglyceride levels over time and risk of type 2 diabetes in young men.

    abstract:OBJECTIVE:The association between changes in triglyceride concentrations over time and diabetes is unknown. We assessed whether two triglyceride determinations obtained 5 years apart can predict incident type 2 diabetes. RESEARCH DESIGN AND METHODS:Triglyceride levels at baseline (time 1) and 5 years later (time 2), f...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc08-0825

    authors: Tirosh A,Shai I,Bitzur R,Kochba I,Tekes-Manova D,Israeli E,Shochat T,Rudich A

    更新日期:2008-10-01 00:00:00

  • Use of Sodium-Glucose Cotransporter 2 Inhibitors in Patients With Type 1 Diabetes and Rates of Diabetic Ketoacidosis.

    abstract:OBJECTIVE:To estimate real-world off-label use of sodium-glucose cotransporter 2 (SGLT2) inhibitors in patients with type 1 diabetes, estimate rates of diabetic ketoacidosis (DKA), and compare them with DKA rates observed in sotagliflozin clinical trials. RESEARCH DESIGN AND METHODS:We identified initiators of SGLT2 i...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc19-1481

    authors: Hampp C,Swain RS,Horgan C,Dee E,Qiang Y,Dutcher SK,Petrone A,Chen Tilney R,Maro JC,Panozzo CA

    更新日期:2020-01-01 00:00:00

  • Impact of HbA1c, followed from onset of type 1 diabetes, on the development of severe retinopathy and nephropathy: the VISS Study (Vascular Diabetic Complications in Southeast Sweden).

    abstract:OBJECTIVE:HbA1c is strongly related to the development of diabetes complications, but it is still controversial which HbA1c level to strive for in the treatment of type 1 diabetes. The aim of the current study was to evaluate HbA1c, followed from diagnosis, as a predictor of severe microvascular complications and to fo...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc14-1203

    authors: Nordwall M,Abrahamsson M,Dhir M,Fredrikson M,Ludvigsson J,Arnqvist HJ

    更新日期:2015-02-01 00:00:00

  • Genetics and the prediction of complications in type 1 diabetes.

    abstract:OBJECTIVE:Epidemiological evidence suggests that genetic factors can affect the course of type 1 diabetes complications produced by long-lasting hyperglycemia. In this review, the current strategies applicable to identifying these genetic factors are examined, as are recent findings on the genetics of diabetic nephropa...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:

    authors: Marre M

    更新日期:1999-03-01 00:00:00

  • Hypogonadotropic Hypogonadism in Men With Diabesity.

    abstract::One-third of men with obesity or type 2 diabetes have subnormal free testosterone concentrations. The lower free testosterone concentrations are observed in obese men at all ages, including adolescents at completion of puberty. The gonadotropin concentrations in these males are inappropriately normal; thus, these pati...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/dc17-2510

    authors: Dhindsa S,Ghanim H,Batra M,Dandona P

    更新日期:2018-07-01 00:00:00

  • Family functioning and metabolic control of school-aged children with IDDM.

    abstract::The relationship of two aspects of family life to metabolic control were examined as part of a longitudinal study of school-aged children with newly diagnosed insulin-dependent diabetes mellitus (IDDM). Glycosylated hemoglobin level was the primary index of metabolic control; weight-adjusted insulin dosage served as a...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.12.6.409

    authors: Kovacs M,Kass RE,Schnell TM,Goldston D,Marsh J

    更新日期:1989-06-01 00:00:00

  • Intra-individual variability of the metabolic effect of inhaled insulin together with an absorption enhancer.

    abstract:OBJECTIVE:To study the metabolic effect and the variability of the effect elicited by inhalation of 87.2 U insulin powder combined with an absorption enhancer. The metabolic effect was compared with that of 10.2 U regular insulin injected subcutaneously and of 5.5 U regular insulin given intravenously RESEARCH DESIGN ...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.23.9.1343

    authors: Heinemann L,Klappoth W,Rave K,Hompesch B,Linkeschowa R,Heise T

    更新日期:2000-09-01 00:00:00

  • Higher levels of urinary albumin excretion within the normal range predict faster decline in glomerular filtration rate in diabetic patients.

    abstract::OBJECTIVE To assess the relationship between albuminuria, including elevation within the normal range, and decline in glomerular filtration rate (GFR) in diabetic patients. RESEARCH DESIGN AND METHODS A total of 5,449 Japanese diabetic patients were categorized according to sex and urinary albumin-to-creatinine ratio ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc08-2151

    authors: Babazono T,Nyumura I,Toya K,Hayashi T,Ohta M,Suzuki K,Kiuchi Y,Iwamoto Y

    更新日期:2009-08-01 00:00:00

  • Altered postprandial insulin requirement in IDDM patients with gastroparesis.

    abstract:OBJECTIVE:To evaluate the effect of gastric emptying on postprandial insulin requirement in insulin-dependent diabetes mellitus (IDDM) patients with and without gastroparesis. RESEARCH DESIGN AND METHODS:Postprandial insulin requirement and gastric emptying were simultaneously evaluated in five IDDM patients with gast...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/diacare.17.8.901

    authors: Ishii M,Nakamura T,Kasai F,Onuma T,Baba T,Takebe K

    更新日期:1994-08-01 00:00:00

  • Combination insulin-sulfonylurea therapy.

    abstract::Combination sulfonylurea-insulin therapy for patients with diabetes mellitus has been evaluated by numerous investigators with various experimental designs. Much of the data are conflicting, and clear conclusions do not seem justified. Insulin-sulfonylurea therapy is probably not clinically useful in most patients wit...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/diacare.13.6.667

    authors: Lebovitz HE,Pasmantier R

    更新日期:1990-06-01 00:00:00

  • Metabolic consequences of hepatic steatosis in overweight and obese adolescents.

    abstract:OBJECTIVE:To test the hypothesis that hepatic steatosis is associated with risk factors for type 2 diabetes in overweight and obese youth, mediated by cardiorespiratory fitness. RESEARCH DESIGN AND METHODS:This was a cross-sectional study comparing insulin sensitivity between 30 overweight and obese adolescents with h...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-1754

    authors: Wicklow BA,Wittmeier KD,MacIntosh AC,Sellers EA,Ryner L,Serrai H,Dean HJ,McGavock JM

    更新日期:2012-04-01 00:00:00

  • Total plasma antioxidant capacity predicts thrombosis-prone status in NIDDM patients.

    abstract:OBJECTIVE:To explore the hypothesis that a relationship exists between free radical activity and abnormalities in hemostasis in NIDDM. RESEARCH DESIGN AND METHODS:The use of the total radical-trapping antioxidant parameter (TRAP) has very recently been proposed to explore the antioxidant property of a plasma and their...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.20.10.1589

    authors: Ceriello A,Bortolotti N,Pirisi M,Crescentini A,Tonutti L,Motz E,Russo A,Giacomello R,Stel G,Taboga C

    更新日期:1997-10-01 00:00:00

  • Cost and Cost-effectiveness of Large-scale Screening for Type 1 Diabetes in Colorado.

    abstract:OBJECTIVE:To assess the costs and project the potential lifetime cost-effectiveness of the ongoing Autoimmunity Screening for Kids (ASK) program, a large-scale, presymptomatic type 1 diabetes screening program for children and adolescents in the metropolitan Denver region. RESEARCH DESIGN AND METHODS:We report the res...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc19-2003

    authors: McQueen RB,Geno Rasmussen C,Waugh K,Frohnert BI,Steck AK,Yu L,Baxter J,Rewers M

    更新日期:2020-07-01 00:00:00

  • Evaluation of postural stability in elderly with diabetic neuropathy.

    abstract:OBJECTIVE:The objective of this study was to compare clinical and biomechanical characteristics of balance in diabetic polyneuropathic elderly patients and normal age-matched subjects. RESEARCH DESIGN AND METHODS:Fifteen elderly with distal neuropathy (DNP) and 15 healthy age-matched subjects were evaluated with the b...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.23.8.1187

    authors: Corriveau H,Prince F,Hébert R,Raîche M,Tessier D,Maheux P,Ardilouze JL

    更新日期:2000-08-01 00:00:00

  • Adverse effects of diabetes on multiple cardiovascular disease risk factors in women. The Strong Heart Study.

    abstract:OBJECTIVE:Many studies have shown that diabetes increases the risk of cardiovascular disease (CVD) in women to a greater extent than in men. One explanation could be that diabetes has more adverse effects on CVD risk factors in women than in men. We compared diabetes-associated differences in CVD risk factors in men an...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/diacare.21.8.1258

    authors: Howard BV,Cowan LD,Go O,Welty TK,Robbins DC,Lee ET

    更新日期:1998-08-01 00:00:00

  • Prevalence and predictors of breast and cervical cancer screening among Spanish women with diabetes.

    abstract::OBJECTIVE To examine the use of mammography and Papanicolaou (Pap) smear among women with diabetes and to identify predictors of adherence to these tests. RESEARCH DESIGN AND METHODS We analyzed data of a nationally representative sample of Spanish women. Diabetes status was self-reported. Screenings were assessed ask...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-0479

    authors: Jiménez-Garcia R,Hernandez-Barrera V,Carrasco-Garrido P,Gil A

    更新日期:2009-08-01 00:00:00

  • The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic adults.

    abstract:OBJECTIVE:We sought to compare the effects of combined calcium and vitamin D supplementation versus placebo on blood glucose and markers of inflammation in nondiabetic adults aged > or =65 years. RESEARCH DESIGN AND METHODS:A total of 314 Caucasian adults without diabetes received either 500 mg calcium citrate and 700...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc06-1994

    authors: Pittas AG,Harris SS,Stark PC,Dawson-Hughes B

    更新日期:2007-04-01 00:00:00

  • Treatment of recent-onset type 1 diabetic patients with DiaPep277: results of a double-blind, placebo-controlled, randomized phase 3 trial.

    abstract:OBJECTIVE:To evaluate safety and efficacy of DiaPep277 in preserving β-cell function in type 1 diabetic patients. RESEARCH DESIGN AND METHODS:DIA-AID 1 is a multinational, phase 3, balanced-randomized, double-blind, placebo-controlled, parallel-group clinical study. Newly diagnosed patients (N = 457, aged 16-45 years)...

    journal_title:Diabetes care

    pub_type: 杂志文章,收录出版

    doi:10.2337/dc13-1391

    authors: Raz I,Ziegler AG,Linn T,Schernthaner G,Bonnici F,Distiller LA,Giordano C,Giorgino F,de Vries L,Mauricio D,Procházka V,Wainstein J,Elias D,Avron A,Tamir M,Eren R,Peled D,Dagan S,Cohen IR,Pozzilli P,DIA-AID 1 Writin

    更新日期:2014-01-01 00:00:00

  • Total sialic acid and associated elements of the metabolic syndrome in women with and without previous gestational diabetes.

    abstract:OBJECTIVE:Inflammatory markers predict type 2 diabetes and relate to the metabolic syndrome. Gestational diabetes mellitus (GDM) predicts type 2 diabetes and may be part of this syndrome. To examine the association of inflammatory markers with GDM, we investigated total sialic acid (TSA) in women with and without previ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.25.8.1331

    authors: Sriharan M,Reichelt AJ,Opperman ML,Duncan BB,Mengue SS,Crook MA,Schmidt MI

    更新日期:2002-08-01 00:00:00

  • Circulating 25-hydroxyvitamin D concentrations are correlated with cardiometabolic risk among American black and white adolescents living in a year-round sunny climate.

    abstract:OBJECTIVE:Low vitamin D status is common among healthy black and white adolescents residing at southern U.S. latitudes with a year-round sunny climate. Thus we aimed to study the relationships between circulating 25-hydroxyvitamin D [25(OH)D] and cardiometabolic risk factors in this population. RESEARCH DESIGN AND MET...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-1944

    authors: Parikh S,Guo DH,Pollock NK,Petty K,Bhagatwala J,Gutin B,Houk C,Zhu H,Dong Y

    更新日期:2012-05-01 00:00:00

  • Etiological approach to characterization of diabetes type: the SEARCH for Diabetes in Youth Study.

    abstract:OBJECTIVE:To describe an etiologic approach to classification of diabetes types in youth based on the 1997 American Diabetes Association (ADA) framework, using data from the SEARCH for Diabetes in Youth Study. RESEARCH DESIGN AND METHODS:SEARCH conducted a comprehensive assessment of 2,291 subjects aged <20 years with...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc10-2324

    authors: Dabelea D,Pihoker C,Talton JW,D'Agostino RB Jr,Fujimoto W,Klingensmith GJ,Lawrence JM,Linder B,Marcovina SM,Mayer-Davis EJ,Imperatore G,Dolan LM,SEARCH for Diabetes in Youth Study.

    更新日期:2011-07-01 00:00:00

  • Absence of Islet Autoantibodies and Modestly Raised Glucose Values at Diabetes Diagnosis Should Lead to Testing for MODY: Lessons From a 5-Year Pediatric Swedish National Cohort Study.

    abstract:OBJECTIVE:Identifying maturity-onset diabetes of the young (MODY) in pediatric populations close to diabetes diagnosis is difficult. Misdiagnosis and unnecessary insulin treatment are common. We aimed to identify the discriminatory clinical features at diabetes diagnosis of patients with glucokinase (GCK), hepatocyte n...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc19-0747

    authors: Carlsson A,Shepherd M,Ellard S,Weedon M,Lernmark Å,Forsander G,Colclough K,Brahimi Q,Valtonen-Andre C,Ivarsson SA,Elding Larsson H,Samuelsson U,Örtqvist E,Groop L,Ludvigsson J,Marcus C,Hattersley AT

    更新日期:2020-01-01 00:00:00

  • Progression of lower-extremity disability in older women with diabetes: the Women's Health and Aging Study.

    abstract:OBJECTIVE:Older patients with diabetes are more likely to have a higher prevalence of multiple risk factors for physical disability, as a result of diabetic complications. We evaluated the pace of decline in lower-extremity function and the risk for progression of disability in older women with diabetes. RESEARCH DESI...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.26.1.70

    authors: Volpato S,Ferrucci L,Blaum C,Ostir G,Cappola A,Fried LP,Fellin R,Guralnik JM

    更新日期:2003-01-01 00:00:00

  • Glycated hemoglobin and risk of hypertension in the atherosclerosis risk in communities study.

    abstract:OBJECTIVE:Diabetes and hypertension often co-occur and share risk factors. Hypertension is known to predict diabetes. However, hyperglycemia also may be independently associated with future development of hypertension. We investigated glycated hemoglobin (HbA(1c)) as a predictor of incident hypertension. RESEARCH DESI...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-2248

    authors: Bower JK,Appel LJ,Matsushita K,Young JH,Alonso A,Brancati FL,Selvin E

    更新日期:2012-05-01 00:00:00

  • Effects of Light Therapy on Mood and Insulin Sensitivity in Patients With Type 2 Diabetes and Depression: Results From a Randomized Placebo-Controlled Trial.

    abstract:OBJECTIVE:Depression is common in patients with type 2 diabetes and adversely affects quality of life and diabetes outcomes. We assessed whether light therapy, an antidepressant, improves mood and insulin sensitivity in patients with depression and type 2 diabetes. RESEARCH DESIGN AND METHODS:This randomized, double-b...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc18-1732

    authors: Brouwer A,van Raalte DH,Nguyen HT,Rutters F,van de Ven PM,Elders PJM,Moll AC,Van Someren EJW,Snoek FJ,Beekman ATF,Bremmer MA

    更新日期:2019-04-01 00:00:00

  • Ser1369Ala variant in sulfonylurea receptor gene ABCC8 is associated with antidiabetic efficacy of gliclazide in Chinese type 2 diabetic patients.

    abstract:OBJECTIVE:The purpose of this study was to investigate whether genetic variants could influence the antidiabetic efficacy of gliclazide in type 2 diabetic patients. RESEARCH DESIGN AND METHODS:A total of 1,268 type 2 diabetic patients whose diabetes was diagnosed within the past 5 years and who had no recent hypoglyce...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/dc07-2248

    authors: Feng Y,Mao G,Ren X,Xing H,Tang G,Li Q,Li X,Sun L,Yang J,Ma W,Wang X,Xu X

    更新日期:2008-10-01 00:00:00

  • Aggressive blood pressure control increases coronary heart disease risk among diabetic patients.

    abstract:OBJECTIVE:Blood pressure control can reduce the risk of coronary heart disease (CHD) among diabetic patients; however, it is not known whether the lowest risk of CHD is among diabetic patients with the lowest blood pressure level. RESEARCH DESIGN AND METHODS:We performed a prospective cohort study (2000-2009) on diabe...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc13-0189

    authors: Zhao W,Katzmarzyk PT,Horswell R,Wang Y,Li W,Johnson J,Heymsfield SB,Cefalu WT,Ryan DH,Hu G

    更新日期:2013-10-01 00:00:00

  • Acceptability and satisfaction with a telecarer approach to the management of type 2 diabetes.

    abstract:OBJECTIVE:To examine patients' views of the acceptability of and satisfaction with telephone care center support provided to improve blood glucose control in type 2 diabetes. RESEARCH DESIGN AND METHODS:The Pro-Active Call-Center Treatment Support (PACCTS) Trial randomized patients from 47 general practices in a depri...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.28.2.283

    authors: Long AF,Gambling T,Young RJ,Taylor J,Mason JM,PACCTS Team.

    更新日期:2005-02-01 00:00:00

  • A model educational program for people with type 2 diabetes: a cooperative Latin American implementation study (PEDNID-LA).

    abstract:OBJECTIVE:To implement an educational program in 10 Latin American countries and to evaluate its effect on the clinical, biochemical, and therapeutic aspects as well as the economic cost of diabetes. RESEARCH DESIGN AND METHODS:Educators from each participating country were previously trained to implement the educatio...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.2337/diacare.24.6.1001

    authors: Gagliardino JJ,Etchegoyen G,PENDID-LA Research Group.

    更新日期:2001-06-01 00:00:00