Glucocorticoid-induced ketoacidosis in gestational diabetes: sequela of the acute treatment of preterm labor. A case report.

Abstract:

:Pregnancy induces complex changes in energy metabolism, manifested clinically by insulin resistance, low fasting blood glucose levels, and proneness to ketosis. It is quite unusual for pregnant women who do not have type I diabetes to progress from ketosis to frank ketoacidosis, although this phenomenon is common in larger mammals. In the case described here, glucocorticoid administration in the setting of a prolonged fast triggered a metabolic cascade leading to ketoacidosis in a pregnant woman without type 1 diabetes. Other details of this illustrative case serve to synthesize several disparate observations regarding the pathogenesis of pregnancy ketoacidosis. Physicians should be aware of the potential for rapidly developing ketoacidosis with atypical biochemical and clinical features in pregnant women who are treated with high doses of glucocorticoids.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Bedalov A,Balasubramanyam A

doi

10.2337/diacare.20.6.922

subject

Has Abstract

pub_date

1997-06-01 00:00:00

pages

922-4

issue

6

eissn

0149-5992

issn

1935-5548

journal_volume

20

pub_type

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