Abstract:
OBJECTIVE:Type 1 diabetes mellitus causes increased carotid intima-media thickness (IMT) in adults. We evaluated IMT in young subjects with type 1 diabetes. RESEARCH DESIGN AND METHODS:Participants with type 1 diabetes (N = 402) were matched to controls (N = 206) by age, sex, and race or ethnicity. Anthropometric and laboratory values, blood pressure, and IMT were measured. ANCOVA was used to assess differences controlling for demographic risk factors, cardiovascular risk factors, and HbA1c. RESULTS:Subjects were 18.9 ± 3.3 years old (50% male, 82.7% non-Hispanic white). Youth with type 1 diabetes had thicker bulb IMT, which remained significantly different after adjustment for demographics and cardiovascular risk factors. Age, sex, adiposity, and systolic blood pressure were consistent significant determinants of IMT. Adjustment for HbA1c eliminated the difference, suggesting the difference was attributable to poor glycemic control. CONCLUSIONS:Carotid IMT may be increased in youth with type 1 diabetes at high risk for cardiovascular disease. Better control of diabetes may be essential in preventing progression of atherosclerosis.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Urbina EM,Dabelea D,D'Agostino RB Jr,Shah AS,Dolan LM,Hamman RF,Daniels SR,Marcovina S,Wadwa RPdoi
10.2337/dc12-2024subject
Has Abstractpub_date
2013-09-01 00:00:00pages
2597-9issue
9eissn
0149-5992issn
1935-5548pii
dc12-2024journal_volume
36pub_type
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