Effect of type 1 diabetes on carotid structure and function in adolescents and young adults: the SEARCH CVD study.

Abstract:

OBJECTIVE:Type 1 diabetes mellitus causes increased carotid intima-media thickness (IMT) in adults. We evaluated IMT in young subjects with type 1 diabetes. RESEARCH DESIGN AND METHODS:Participants with type 1 diabetes (N = 402) were matched to controls (N = 206) by age, sex, and race or ethnicity. Anthropometric and laboratory values, blood pressure, and IMT were measured. ANCOVA was used to assess differences controlling for demographic risk factors, cardiovascular risk factors, and HbA1c. RESULTS:Subjects were 18.9 ± 3.3 years old (50% male, 82.7% non-Hispanic white). Youth with type 1 diabetes had thicker bulb IMT, which remained significantly different after adjustment for demographics and cardiovascular risk factors. Age, sex, adiposity, and systolic blood pressure were consistent significant determinants of IMT. Adjustment for HbA1c eliminated the difference, suggesting the difference was attributable to poor glycemic control. CONCLUSIONS:Carotid IMT may be increased in youth with type 1 diabetes at high risk for cardiovascular disease. Better control of diabetes may be essential in preventing progression of atherosclerosis.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Urbina EM,Dabelea D,D'Agostino RB Jr,Shah AS,Dolan LM,Hamman RF,Daniels SR,Marcovina S,Wadwa RP

doi

10.2337/dc12-2024

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

2597-9

issue

9

eissn

0149-5992

issn

1935-5548

pii

dc12-2024

journal_volume

36

pub_type

杂志文章
  • Glycemic control and prevention of retinopathy in Japanese NIDDM patients. A 10-year follow-up study.

    abstract:OBJECTIVE:To examine glycemic control for the prevention of retinopathy in early diagnosed Japanese NIDDM patients. RESEARCH DESIGN AND METHODS:There were 137 patients with NIDDM but without retinopathy who first visited our facility from 1983-1985. Their age at diagnosis ranged from 30-65 years, with a disease durati...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.20.4.621

    authors: Nakagami T,Kawahara R,Hori S,Omori Y

    更新日期:1997-04-01 00:00:00

  • Regional, geographic, and racial/ethnic variation in glycemic control in a national sample of veterans with diabetes.

    abstract:OBJECTIVE:We performed a retrospective analysis of a national cohort of veterans with diabetes to better understand regional, geographic, and racial/ethnic variation in diabetes control as measured by HbA(1c). RESEARCH DESIGN AND METHODS:A retrospective cohort study was conducted in a national cohort of 690,968 vetera...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc10-1504

    authors: Egede LE,Gebregziabher M,Hunt KJ,Axon RN,Echols C,Gilbert GE,Mauldin PD

    更新日期:2011-04-01 00:00:00

  • Urinary estriols: are they of value in normoglycemic diabetic pregnancy?

    abstract::The purpose of the study was to assess the value of 24-h urinary estriols in the management of diabetic pregnancies. Twenty-seven pregnant diabetic patients (White's class B through R) received insulin dosages twice daily as a combination of NPH and regular insulin. Laboratory and home monitored blood glucose was main...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.5.3.316

    authors: Fern PE,Grunert GM,Lewis SB

    更新日期:1982-05-01 00:00:00

  • Effect of a peroxisome proliferator-activated receptor-gamma agonist on myocardial blood flow in type 2 diabetes.

    abstract:OBJECTIVE:The relationship between coronary endothelial function and insulin resistance remains speculative. We sought to determine whether pioglitazone, an insulin-sensitizing peroxisome proliferator-activated receptor (PPAR)-gamma agonist, improves cardiac endothelial function in individuals with type 2 diabetes. RE...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.28.5.1145

    authors: McMahon GT,Plutzky J,Daher E,Bhattacharyya T,Grunberger G,DiCarli MF

    更新日期:2005-05-01 00:00:00

  • Fetal hemoglobin in diabetic patients.

    abstract:OBJECTIVE:To determine the occurrence of elevated fetal hemoglobin (HbF) among the diabetic population and determine the clinical situation of importance. RESEARCH DESIGN AND METHODS:A cross-sectional study was conducted. HbA1c and HbF were measured with high-performance liquid chromatography in 1,104 consecutive diab...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/diacare.17.8.828

    authors: Koskinen LK,Lahtela JT,Koivula TA

    更新日期:1994-08-01 00:00:00

  • Effect of temperament on metabolic control in children with diabetes mellitus.

    abstract::Fifty-one children with insulin-dependent diabetes mellitus (IDDM) and 24 healthy sibling controls were compared on one of two temperament questionnaires completed by parents. Children with IDDM did not provide a characteristic temperament profile or show any problem areas. A regression analysis to predict diabetic co...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.11.1.77

    authors: Rovet JF,Ehrlich RM

    更新日期:1988-01-01 00:00:00

  • Spanish diabetes self-management with and without automated telephone reinforcement: two randomized trials.

    abstract:OBJECTIVE:To determine 1) whether participants in the Spanish Diabetes Self-Management Program (SDSMP), when compared at 6 months to randomized control subjects, would demonstrate improvements in health status, health behaviors, and self-efficacy; and 2) whether SDSMP participants receiving monthly automated telephone ...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc07-1313

    authors: Lorig K,Ritter PL,Villa F,Piette JD

    更新日期:2008-03-01 00:00:00

  • Diabetic Neuropathy Is a Substantial Burden in People With Type 1 Diabetes and Is Strongly Associated With Socioeconomic Disadvantage: A Population-Representative Study From Scotland.

    abstract:OBJECTIVE:To assess the contemporaneous prevalence of diabetic peripheral neuropathy (DPN) in people with type 1 diabetes (T1D) in Scotland and study its cross-sectional association with risk factors and other diabetic complications. RESEARCH DESIGN AND METHODS:We analyzed data from a large representative sample of ad...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc19-1582

    authors: Jeyam A,McGurnaghan SJ,Blackbourn LAK,McKnight JM,Green F,Collier A,McKeigue PM,Colhoun HM,SDRNT1BIO Investigators.

    更新日期:2020-04-01 00:00:00

  • Intra-individual variability of the metabolic effect of inhaled insulin together with an absorption enhancer.

    abstract:OBJECTIVE:To study the metabolic effect and the variability of the effect elicited by inhalation of 87.2 U insulin powder combined with an absorption enhancer. The metabolic effect was compared with that of 10.2 U regular insulin injected subcutaneously and of 5.5 U regular insulin given intravenously RESEARCH DESIGN ...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.23.9.1343

    authors: Heinemann L,Klappoth W,Rave K,Hompesch B,Linkeschowa R,Heise T

    更新日期:2000-09-01 00:00:00

  • Pioglitazone treatment improves nitrosative stress in type 2 diabetes.

    abstract:OBJECTIVE:The purpose of this study was to determine the effect of 24 weeks of treatment with 45 mg/day pioglitazone on peripheral skin blood flow (SkBF) and skin nitric oxide (NO) production in vivo in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS:This was a randomized, parallel, cross-over, double-blind...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/diacare.29.04.06.dc05-0517

    authors: Vinik AI,Ullal J,Parson HK,Barlow PM,Casellini CM

    更新日期:2006-04-01 00:00:00

  • Diabetes nutrition and complications trial (DNCT): food intake and targets of diabetes treatment in a sample of Spanish people with diabetes. Diabetes and Nutrition Study Group of the Spanish Diabetes Association (GSEDNu).

    abstract:OBJECTIVE:To know the nutritional pattern of people with diabetes in Spain and that pattern's relationship with targets of metabolic control. RESEARCH DESIGN AND METHODS:The Diabetes Nutrition and Complications Trial (DNCT) is a prospective multicenter study designed to determine the nutritional behavior of diabetic p...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/diacare.20.7.1078

    authors:

    更新日期:1997-07-01 00:00:00

  • Prediction of the relative blood glucose response of mixed meals using the white bread glycemic index.

    abstract::Unexpected plasma glucose responses to different mixed meals fed to normal and diabetic volunteers have recently been reported. We have therefore examined in normal volunteers the effect of mixing carbohydrate foods of different glycemic indices (GIs) without the addition of fat and protein. The observed GI of the mix...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.8.5.418

    authors: Wolever TM,Nuttall FQ,Lee R,Wong GS,Josse RG,Csima A,Jenkins DJ

    更新日期:1985-09-01 00:00:00

  • Surveillance in Florida of continuous subcutaneous insulin infusion use in cohort.

    abstract::Because of concerns about safety and expense associated with continuous subcutaneous insulin infusion (CSII), all people who had used CSII as of July 1982 were identified. Annual follow-up has resulted in data for up to 61 mo. Of the 92 nonpregnant registrees, 31 were less than 20 yr old, 36 were 20-29, and 25 were 30...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.9.6.591

    authors: Deeb LC,Williams PE

    更新日期:1986-11-01 00:00:00

  • Impact of early neonatal breast-feeding on psychomotor and neuropsychological development in children of diabetic mothers.

    abstract:OBJECTIVE:In general, breast-feeding positively influences development of psychomotor function and cognition in children. Offspring of diabetic mothers (ODM) have delayed psychomotor and cognitive development. Recently, we observed a dose-dependent negative effect of early neonatal ingestion of breast milk from diabeti...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.28.3.573

    authors: Plagemann A,Harder T,Kohlhoff R,Fahrenkrog S,Rodekamp E,Franke K,Dudenhausen JW

    更新日期:2005-03-01 00:00:00

  • Role of liver in pathophysiology of NIDDM.

    abstract::Glucose homeostasis is physiologically maintained by the balance between glucose production by the liver and glucose utilization by the peripheral tissues. Insulin controls hepatic glucose production and promotes glucose utilization by the skeletal muscle. In non-insulin-dependent diabetes mellitus (NIDDM), postabsorp...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/diacare.15.3.430

    authors: Consoli A

    更新日期:1992-03-01 00:00:00

  • Obstructive sleep apnea and diabetic nephropathy: a cohort study.

    abstract:OBJECTIVE:Diabetic nephropathy (DN) is a leading cause of end-stage renal disease (ESRD). Obstructive sleep apnea (OSA) is common in type 2 diabetes and increases oxidative stress. Hence, OSA could promote the development and progression of DN. RESEARCH DESIGN AND METHODS:This was a cohort study in adults with type 2 ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc13-0450

    authors: Tahrani AA,Ali A,Raymond NT,Begum S,Dubb K,Altaf QA,Piya MK,Barnett AH,Stevens MJ

    更新日期:2013-11-01 00:00:00

  • Reciprocal association of plasma IGF-1 and interleukin-6 levels with cardiometabolic risk factors in nondiabetic subjects.

    abstract:OBJECTIVE:To examine the relationship between plasma IGF-1 and interleukin-6 (IL-6) levels in Caucasian nondiabetic subjects and evaluate the association of IGF-1 and IL-6 with the cardiometabolic risk factors characterizing metabolic syndrome (MetS). RESEARCH DESIGN AND METHODS:The study group consisted of 186 Caucas...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc08-0553

    authors: Succurro E,Andreozzi F,Sciacqua A,Hribal ML,Perticone F,Sesti G

    更新日期:2008-09-01 00:00:00

  • Guidelines for premeal insulin dose reduction for postprandial exercise of different intensities and durations in type 1 diabetic subjects treated intensively with a basal-bolus insulin regimen (ultralente-lispro).

    abstract:OBJECTIVE:To evaluate and validate appropriate premeal insulin dose reductions for postprandial exercises of different intensities and durations to minimize the risk of exercise-induced hypoglycemia in type 1 diabetic subjects. RESEARCH DESIGN AND METHODS:Eight male type 1 diabetic patients on a basal-bolus insulin re...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.24.4.625

    authors: Rabasa-Lhoret R,Bourque J,Ducros F,Chiasson JL

    更新日期:2001-04-01 00:00:00

  • Glycosylated hemoglobin in relation to rapid fluctuations in blood glucose in children with insulin-dependent diabetes: a comparison of methods with and without prior dialysis.

    abstract::To evaluate the importance of dialysis in the determination of glycosylated hemoglobin (HbA1), we studied blood glucose and HbA1 in 38 insulin-dependent diabetic children during a morning fast and again 6 h postprandially. We used two methods to determine glycosylated hemoglobin: (1) the conventional macrocolumn metho...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.4.5.551

    authors: Ditzel J,Kjaergaard JJ,Kawahara R,Ostergaard GZ,Mourits-Andersen T

    更新日期:1981-09-01 00:00:00

  • Assessing the outcome of the management of diabetic foot ulcers using ulcer-related and person-related measures.

    abstract:OBJECTIVE:The purpose of this study was to compare different outcome measures in the audit of management of diabetic foot ulcers RESEARCH DESIGN AND METHODS:Data collected prospectively in a consecutive cohort of patients referred to a specialist multidisciplinary foot care clinic between 1 January 2000 and 31 Decembe...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc06-0306

    authors: Jeffcoate WJ,Chipchase SY,Ince P,Game FL

    更新日期:2006-08-01 00:00:00

  • Elevation of IgA levels in the non-insulin-dependent (type II) diabetic patient.

    abstract::Serum immunoglobulin (G, A, M) levels were performed on 66 patients with non-insulin-dependent (type II) diabetes mellitus (NIDDM). When compared with 30 age-matched normal controls and 32 hospitalized controls there was no significant difference between the mean IgG and IgM levels. The IgA levels were significantly h...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.4.6.636

    authors: Gill CW,Bush WS,Burleigh WM,Cooke-Gomes D

    更新日期:1981-11-01 00:00:00

  • Estimates of insulin sensitivity using glucose and C-Peptide from the hyperglycemia and adverse pregnancy outcome glucose tolerance test.

    abstract::OBJECTIVE To determine if glucose and C-peptide values obtained as part of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study could be used to estimate insulin sensitivity during late pregnancy. RESEARCH DESIGN AND METHODS A total of 78 women enrolled in the HAPO study were recruited for this ancillary study...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/dc09-1463

    authors: Radaelli T,Farrell KA,Huston-Presley L,Amini SB,Kirwan JP,McIntyre HD,Catalano PM

    更新日期:2010-03-01 00:00:00

  • Combined heart rate- and accelerometer-assessed physical activity energy expenditure and associations with glucose homeostasis markers in a population at high risk of developing diabetes: the ADDITION-PRO study.

    abstract:OBJECTIVE:Regular physical activity (PA) reduces the risk of developing type 2 diabetes, and different subtypes of dysglycemia have shown different associations with PA. To better understand the associations of PA and glucose homeostasis, we examined the association of objectively measured PA energy expenditure (PAEE) ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc12-2671

    authors: Hansen AL,Carstensen B,Helge JW,Johansen NB,Gram B,Christiansen JS,Brage S,Lauritzen T,Jørgensen ME,Aadahl M,Witte DR,ADDITION-Denmark Steering Committee.

    更新日期:2013-10-01 00:00:00

  • Combined effect of nonalcoholic fatty liver disease and impaired fasting glucose on the development of type 2 diabetes: a 4-year retrospective longitudinal study.

    abstract:OBJECTIVE:To evaluate whether there is a difference in the association between nonalcoholic fatty liver disease (NAFLD) and incident diabetes based on the presence of impaired fasting glucose. RESEARCH DESIGN AND METHODS:A total of 7,849 individuals (5,409 men and 2,440 women) without diabetes, who underwent comprehen...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc10-1991

    authors: Bae JC,Rhee EJ,Lee WY,Park SE,Park CY,Oh KW,Park SW,Kim SW

    更新日期:2011-03-01 00:00:00

  • Dyslipidemias among normoglycemic members of familial NIDDM pedigrees.

    abstract:OBJECTIVE:To examine the hypothesis that hyperinsulinemia among relatives of NIDDM probands will increase the prevalence of DLPs, we measured insulin levels and examined the frequency of DLPs among NIDDM pedigree members. RESEARCH DESIGN AND METHODS:We performed 2-h 75-g OGTTs and measured lipid and insulin levels of ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.15.10.1285

    authors: Schumacher MC,Maxwell TM,Wu LL,Hunt SC,Williams RR,Elbein SC

    更新日期:1992-10-01 00:00:00

  • Asian Americans: diabetes prevalence across U.S. and World Health Organization weight classifications.

    abstract:OBJECTIVE:To compare diabetes prevalence among Asian Americans by World Health Organization and U.S. BMI classifications. RESEARCH DESIGN AND METHODS:Data on Asian American adults (n = 7,414) from the National Health Interview Survey for 1997-2005 were analyzed. Diabetes prevalence was estimated across weight and ethn...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-0573

    authors: Oza-Frank R,Ali MK,Vaccarino V,Narayan KM

    更新日期:2009-09-01 00:00:00

  • IDDM incidence in a multiracial population. The Hawaii IDDM Registry, 1980-1990.

    abstract:OBJECTIVE:The Hawaii IDDM Registry was created to determine the incidence rate of IDDM among children aged < 15 years of Oahu between 1980 and 1990. Because of the multiracial population living in Hawaii, it is an ideal state in which to study the effect of migration on IDDM incidence. RESEARCH DESIGN AND METHODS:Data...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.20.6.983

    authors: Patrick SL,Kadohiro JK,Waxman SH,Curb JD,Orchard TJ,Dorman JS,Kuller LH,LaPorte RE

    更新日期:1997-06-01 00:00:00

  • Incidence of type 1 diabetes in Lithuanians aged 0-39 years varies by the urban-rural setting, and the time change differs for men and women during 1991-2000.

    abstract:OBJECTIVE:Type 1 diabetes has been associated with factors related to welfare and social class. During the past decade, Lithuania has experienced a transition period, leading to dramatic changes in the socioeconomic structure of the society. RESEARCH DESIGN AND METHODS:Incidence in the group aged 0-39 years by urban-r...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.26.3.671

    authors: Pundziute-Lyckå A,Urbonaite B,Ostrauskas R,Zalinkevicius R,Dahlquist GG

    更新日期:2003-03-01 00:00:00

  • Acute complications and drug misuse are important causes of death for children and young adults with type 1 diabetes: results from the Yorkshire Register of diabetes in children and young adults.

    abstract:OBJECTIVE:To examine mortality rates and causes of death among subjects diagnosed with type 1 diabetes aged

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc07-2029

    authors: Feltbower RG,Bodansky HJ,Patterson CC,Parslow RC,Stephenson CR,Reynolds C,McKinney PA

    更新日期:2008-05-01 00:00:00

  • Sugar content of selected pharmaceuticals.

    abstract::Medications may contain significant amounts of various sugars. Data provided by 67 manufacturers have been tabulated to provide specific qualitative and quantitative information on sugar content of selected drug products. Since diabetic individuals may tolerate various sugar forms differently, it is useful to know spe...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.6.3.231

    authors: Souney PF,Cyr DA,Chang JT,Kaul AF

    更新日期:1983-05-01 00:00:00