Cost-effectiveness of aspirin use among persons with newly diagnosed type 2 diabetes.

Abstract:

OBJECTIVE:To assess the long-term cost-effectiveness of aspirin use among adults aged >or=40 years with newly diagnosed type 2 diabetes. RESEARCH DESIGN AND METHODS:We used a validated cost-effectiveness model of type 2 diabetes to assess the lifetime health and cost consequences of use or nonuse of aspirin. The model simulates the progression of diabetes and accompanying complications for a cohort of subjects with type 2 diabetes. The model predicts the outcomes of type 2 diabetes along five disease paths (nephropathy, neuropathy, retinopathy, coronary heart disease, and stroke) from the time of diagnosis until age 94 years or until death. RESULTS:Over a lifetime, aspirin users gained 0.31 life-years (LY) or 0.19 quality-adjusted LYs (QALYs) over nonaspirin users, at an incremental cost of $1,700; the incremental cost-effectiveness ratio (ICER) of aspirin use was $5,428 per LY gained or $8,801 per QALY gained. In probabilistic sensitivity analyses, the ICER was <$30,000 per QALY in all of 2,000 realizations in two scenarios. CONCLUSIONS:Regular use of aspirin among people with newly diagnosed diabetes is cost-effective.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Li R,Zhang P,Barker LE,Hoerger TJ

doi

10.2337/dc09-1888

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

1193-9

issue

6

eissn

0149-5992

issn

1935-5548

pii

dc09-1888

journal_volume

33

pub_type

杂志文章
  • Cardiovascular complications and mortality after diabetes diagnosis for South Asian and Chinese patients: a population-based cohort study.

    abstract:OBJECTIVE:Many non-European ethnic groups have an increased risk for diabetes; however, the published literature demonstrates considerable uncertainty about the rates of diabetes complications among minority populations. The objective of this study was to determine the risks of cardiovascular complications and of morta...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc12-2105

    authors: Shah BR,Victor JC,Chiu M,Tu JV,Anand SS,Austin PC,Manuel DG,Hux JE

    更新日期:2013-09-01 00:00:00

  • Comparison of a multiple daily insulin injection regimen (basal once-daily glargine plus mealtime lispro) and continuous subcutaneous insulin infusion (lispro) in type 1 diabetes: a randomized open parallel multicenter study.

    abstract:OBJECTIVE:Insulin pump therapy (continuous subcutaneous insulin infusion [CSII]) and multiple daily injections (MDIs) with insulin glargine as basal insulin and mealtime insulin lispro have not been prospectively compared in people naïve to either regimen in a multicenter study. We aimed to help close that deficiency. ...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2337/dc08-1874

    authors: Bolli GB,Kerr D,Thomas R,Torlone E,Sola-Gazagnes A,Vitacolonna E,Selam JL,Home PD

    更新日期:2009-07-01 00:00:00

  • Macroalbuminuria and renal pathology in First Nation youth with type 2 diabetes.

    abstract:OBJECTIVE:To determine the prevalence of macroalbuminuria and to describe the clinical and renal pathological changes associated with macroalbuminuria in a population of Canadian First Nation children and adolescents with type 2 diabetes. RESEARCH DESIGN AND METHODS:We conducted a retrospective chart review at a singl...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc08-1828

    authors: Sellers EA,Blydt-Hansen TD,Dean HJ,Gibson IW,Birk PE,Ogborn M

    更新日期:2009-05-01 00:00:00

  • Improvement of the plasma lipoprotein pattern after institution of insulin treatment in diabetes mellitus.

    abstract::Plasma lipids and lipoproteins were studied in 26 nonobese diabetic patients, either newly diagnosed or unsatisfactorily controlled by oral antidiabetic treatment. Measurements were performed before and 3-4 mo after the institution of insulin treatment. In a subgroup of seven patients, the activities of lipoprotein li...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.5.3.322

    authors: Agardh CD,Nilsson-Ehle P,Scherstén B

    更新日期:1982-05-01 00:00:00

  • Night Shift Work, Genetic Risk, and Type 2 Diabetes in the UK Biobank.

    abstract:OBJECTIVE:To examine the effects of past and current night shift work and genetic type 2 diabetes vulnerability on type 2 diabetes odds. RESEARCH DESIGN AND METHODS:In the UK Biobank, we examined associations of current (N = 272,214) and lifetime (N = 70,480) night shift work exposure with type 2 diabetes risk (6,770 ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc17-1933

    authors: Vetter C,Dashti HS,Lane JM,Anderson SG,Schernhammer ES,Rutter MK,Saxena R,Scheer FAJL

    更新日期:2018-04-01 00:00:00

  • Joint contractures in patients with juvenile diabetes and their siblings.

    abstract::Six hundred fifteen children (310 with diabetes, 106 nondiabetic siblings, and 199 nonsibling controls) were examined for the presence of joint contractures. Forty children had contractures: 8.4 per cent of those with diabetes and 4.6 per cent of those without diabetes. Contractures were present, however, in 9.4 per c...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.1.6.360

    authors: Traisman HS,Traisman ES,Marr TJ,Wise J

    更新日期:1978-11-01 00:00:00

  • Less nocturnal hypoglycemia and better post-dinner glucose control with bedtime insulin glargine compared with bedtime NPH insulin during insulin combination therapy in type 2 diabetes. HOE 901/3002 Study Group.

    abstract:OBJECTIVE:Available basal insulin formulations do not provide a constant and reliable 24-h insulin supply. We compared the efficacy and safety of glargine (a long-acting insulin analog) and NPH insulins in insulin-naive type 2 diabetic patients treated with oral antidiabetic agents. RESEARCH DESIGN AND METHODS:There w...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.2337/diacare.23.8.1130

    authors: Yki-Järvinen H,Dressler A,Ziemen M,HOE 901\/300s Study Group.

    更新日期:2000-08-01 00:00:00

  • Is type 2 diabetes a different disease in obese and nonobese patients?

    abstract:OBJECTIVE:The main purpose of this work was to study the possible differences in insulin secretion in a large group of type 2 diabetic patients in relation to diabetes duration, obesity, and the presence of secondary failure after treatment with oral hypoglycemic agents. RESEARCH DESIGN AND METHODS:There were 147 nono...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.21.10.1680

    authors: Prando R,Cheli V,Melga P,Giusti R,Ciuchi E,Odetti P

    更新日期:1998-10-01 00:00:00

  • Combination of insulin and metformin in the treatment of type 2 diabetes.

    abstract:OBJECTIVE:To investigate the metabolic effects of metformin, as compared with placebo, in type 2 diabetic patients intensively treated with insulin. RESEARCH DESIGN AND METHODS:Metformin improves glycemic control in poorly controlled type 2 diabetic patients. Its effect in type 2 diabetic patients who are intensively ...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.2337/diacare.25.12.2133

    authors: Wulffelé MG,Kooy A,Lehert P,Bets D,Ogterop JC,Borger van der Burg B,Donker AJ,Stehouwer CD

    更新日期:2002-12-01 00:00:00

  • The short-term impact of a continuing medical education program on providers' attitudes toward treating diabetes.

    abstract:OBJECTIVE:The objective of this study was to evaluate the short-term impact of a 7-h type 2 diabetes continuing medical education (CME) program. Outcomes included a measure of health care providers' diabetes knowledge and the Diabetes Attitude Scale (DAS), a validated measure of attitudes toward diabetes. RESEARCH DES...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.22.12.1929

    authors: Sharp LK,Lipsky MS

    更新日期:1999-12-01 00:00:00

  • Angiotensin I-converting enzyme gene polymorphism is associated with myocardial infarction, but not with retinopathy or nephropathy, in NIDDM.

    abstract:OBJECTIVE:To clarify the relationship between the angiotensin I-converting enzyme (ACE) gene polymorphism and diabetic micro- and macroangiopathy in patients with non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS:We examined 267 NIDDM patients with various stages of diabetic retinopathy, 61 ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.18.7.983

    authors: Fujisawa T,Ikegami H,Shen GQ,Yamato E,Takekawa K,Nakagawa Y,Hamada Y,Ueda H,Rakugi H,Higaki J

    更新日期:1995-07-01 00:00:00

  • Quality of care and outcomes in type 2 diabetic patients: a comparison between general practice and diabetes clinics.

    abstract:OBJECTIVE:The role of general practice and diabetes clinics in the management of diabetes is still a matter of debate. Methodological flaws in previous studies may have led to inaccurate conclusions when comparing the care provided in these different settings. We compared the care provided to type 2 diabetic patients a...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/diacare.27.2.398

    authors: De Berardis G,Pellegrini F,Franciosi M,Belfiglio M,Di Nardo B,Greenfield S,Kaplan SH,Rossi MC,Sacco M,Tognoni G,Valentini M,Nicolucci A,QuED Study.

    更新日期:2004-02-01 00:00:00

  • Characterization and significance of sulfonylurea receptors.

    abstract::This study describes and characterizes a putative sulfonylurea receptor. The radioligand used was [3H]glipizide (9 Ci/mmol). The beta-cell plasma membranes were derived from a transplantable rat insulinoma generated by subcutaneous injection of RINm5F cells and purified by ultracentrifugation on a 15-55% sucrose gradi...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.13.3.2

    authors: Siconolfi-Baez L,Banerji MA,Lebovitz HE

    更新日期:1990-08-01 00:00:00

  • Diabeloop DBLG1 Closed-Loop System Enables Patients With Type 1 Diabetes to Significantly Improve Their Glycemic Control in Real-Life Situations Without Serious Adverse Events: 6-Month Follow-up.

    abstract:OBJECTIVE:To analyze safety and efficacy of the Diabeloop Generation 1 (DBLG1) hybrid closed-loop artificial pancreas system in patients with type 1 diabetes in real-world conditions. RESEARCH DESIGN AND METHODS:After a 1-week run-in period with their usual pump, 25 patients were provided the commercial DBLG1 system. ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc20-1809

    authors: Amadou C,Franc S,Benhamou PY,Lablanche S,Huneker E,Charpentier G,Penfornis A,Diabeloop Consortium.

    更新日期:2021-01-11 00:00:00

  • A 16-week comparison of the novel insulin analog insulin glargine (HOE 901) and NPH human insulin used with insulin lispro in patients with type 1 diabetes.

    abstract:OBJECTIVE:To determine the safety and efficacy of the long-acting insulin analog, insulin glargine, as a component of basal bolus therapy in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS:Patients with type 1 diabetes receiving basal-bolus insulin treatment with NPH human insulin and insulin lispro were ra...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.2337/diacare.23.11.1666

    authors: Raskin P,Klaff L,Bergenstal R,Hallé JP,Donley D,Mecca T

    更新日期:2000-11-01 00:00:00

  • Cellular ions in NIDDM: relation of calcium to hyperglycemia and cardiac mass.

    abstract:OBJECTIVE:To investigate the role of hyperglycemia in mediating the clinical association of NIDDM with hypertension and left ventricular dysfunction and hypertrophy. RESEARCH DESIGN AND METHODS:Since hyperglycemia elevates cytosolic free calcium (Cai) both in myocardial and vascular smooth muscle cells, we utilized nu...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.19.12.1393

    authors: Barbagallo M,Gupta RK,Resnick LM

    更新日期:1996-12-01 00:00:00

  • Dietary intake of total, animal, and vegetable protein and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-NL study.

    abstract:OBJECTIVE:Dietary recommendations are focused mainly on relative dietary fat and carbohydrate content in relation to diabetes risk. Meanwhile, high-protein diets may contribute to disturbance of glucose metabolism, but evidence from prospective studies is scarce. We examined the association among dietary total, vegetab...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-1321

    authors: Sluijs I,Beulens JW,van der A DL,Spijkerman AM,Grobbee DE,van der Schouw YT

    更新日期:2010-01-01 00:00:00

  • Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes.

    abstract:OBJECTIVE:Abnormally elevated proinsulin secretion has been reported in type 2 and early type 1 diabetes when significant C-peptide is present. We questioned whether individuals with long-standing type 1 diabetes and low or absent C-peptide secretory capacity retained the ability to make proinsulin. RESEARCH DESIGN AN...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc17-2625

    authors: Sims EK,Bahnson HT,Nyalwidhe J,Haataja L,Davis AK,Speake C,DiMeglio LA,Blum J,Morris MA,Mirmira RG,Nadler J,Mastracci TL,Marcovina S,Qian WJ,Yi L,Swensen AC,Yip-Schneider M,Schmidt CM,Considine RV,Arvan P,Greenbau

    更新日期:2019-02-01 00:00:00

  • Determinants of fetal growth at different periods of pregnancies complicated by gestational diabetes mellitus or impaired glucose tolerance.

    abstract:OBJECTIVE:To determine maternal parameters with the strongest influence on fetal growth in different periods of pregnancies complicated by an abnormal glucose tolerance test (GTT). RESEARCH DESIGN AND METHODS:Retrospective study of 368 women with gestational diabetes mellitus (GDM; > or = 2 abnormal GTT values, n = 28...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.26.1.193

    authors: Schaefer-Graf UM,Kjos SL,Kilavuz O,Plagemann A,Brauer M,Dudenhausen JW,Vetter K

    更新日期:2003-01-01 00:00:00

  • Assessment of the psychological factors and responses in self-managed patients.

    abstract::In past studies on the psychological aspects of diabetes mellitus, symptoms of depression have been identified as the most common manifestation among diabetic patients. Other psychological manifestations have been anxiety, hypochondriasis, increased dependence and passivity, and poor self-image. Ten insulin-dependent ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.3.1.117

    authors: Dupuis A

    更新日期:1980-01-01 00:00:00

  • Reduction in cardiovascular risk factors with intensive diabetes treatment in insulin-dependent diabetes mellitus.

    abstract::We measured plasma lipid and lipoprotein levels at baseline and at 6-mo intervals in 47 normolipidemic patients with classic insulin-dependent diabetes mellitus treated either with a conventional (n = 21) or intensive (n = 26) diabetes-treatment program. Patients were followed for a mean of 3 yr (range 1-4 yr). Intens...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.10.6.729

    authors: Rosenstock J,Strowig S,Cercone S,Raskin P

    更新日期:1987-11-01 00:00:00

  • Effect of High-Deductible Insurance on High-Acuity Outcomes in Diabetes: A Natural Experiment for Translation in Diabetes (NEXT-D) Study.

    abstract:OBJECTIVE:High-deductible health plans (HDHPs) are now the predominant commercial health insurance benefit in the U.S. We sought to determine the effects of HDHPs on emergency department and hospital care, adverse outcomes, and total health care expenditures among patients with diabetes. RESEARCH DESIGN AND METHODS:We...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc17-1183

    authors: Wharam JF,Zhang F,Eggleston EM,Lu CY,Soumerai SB,Ross-Degnan D

    更新日期:2018-05-01 00:00:00

  • Improving the comparability of diabetes mortality statistics in the U.S. and Mexico.

    abstract:OBJECTIVE:The aim of this study was to increase the cross-state comparability of diabetes mortality statistics related in the U.S. and Mexico. RESEARCH DESIGN AND METHODS:We used multinomial logistic regression to estimate the effects of individual and community factors on a death for which diabetes was recorded as on...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc07-1370

    authors: Murray CJ,Dias RH,Kulkarni SC,Lozano R,Stevens GA,Ezzati M

    更新日期:2008-03-01 00:00:00

  • Markers of platelet activation are increased in adolescents with type 2 diabetes.

    abstract:OBJECTIVE:In adults with diabetes, in vivo platelet activation is a marker for atherosclerosis and cardiovascular disease (CVD). This pilot study investigated whether adolescents with diabetes had evidence of increased in vivo platelet activation. RESEARCH DESIGN AND METHODS:In vivo platelet activation was compared in...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc13-2718

    authors: Israels SJ,McNicol A,Dean HJ,Cognasse F,Sellers EA

    更新日期:2014-08-01 00:00:00

  • Blood pressure and cardiovascular disease risk in the Veterans Affairs Diabetes Trial.

    abstract:OBJECTIVE:Blood pressure ranges associated with cardiovascular disease (CVD) events in advanced type 2 diabetes are not clear. Our objective was to determine whether baseline and follow-up (On-Study) systolic blood pressure (SBP), diastolic blood pressure (DBP), and SBP combined with DBP predict CVD events in the Veter...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc10-1420

    authors: Anderson RJ,Bahn GD,Moritz TE,Kaufman D,Abraira C,Duckworth W,VADT Study Group.

    更新日期:2011-01-01 00:00:00

  • Diabetes, glycemic control, and new-onset heart failure in patients with stable coronary artery disease: data from the heart and soul study.

    abstract:OBJECTIVE:Diabetes is a predictor of both coronary artery disease (CAD) and heart failure. It is unknown to what extent the association between diabetes and heart failure is influenced by other risk factors for heart failure. RESEARCH DESIGN AND METHODS:We evaluated the association of diabetes and A1C with incident he...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc10-0286

    authors: van Melle JP,Bot M,de Jonge P,de Boer RA,van Veldhuisen DJ,Whooley MA

    更新日期:2010-09-01 00:00:00

  • Ginseng therapy in non-insulin-dependent diabetic patients.

    abstract:OBJECTIVE:To investigate the effect of ginseng on newly diagnosed non-insulin-dependent diabetes mellitus (NIDDM) patients. RESEARCH DESIGN AND METHODS:In this double-blind placebo-controlled study, 36 NIDDM patients were treated for 8 weeks with ginseng (100 or 200 mg) or placebo. Efficacy was evaluated with psychoph...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.2337/diacare.18.10.1373

    authors: Sotaniemi EA,Haapakoski E,Rautio A

    更新日期:1995-10-01 00:00:00

  • Hormone replacement therapy and its relationship to lipid and glucose metabolism in diabetic and nondiabetic postmenopausal women: results from the Third National Health and Nutrition Examination Survey (NHANES III).

    abstract:OBJECTIVE:Among postmenopausal women, those with diabetes experience more cardiovascular diseases than those without diabetes. We examine the relationship of hormone replacement therapy (HRT) with indicators of lipid and glucose metabolism using a national sample of diabetic and nondiabetic postmenopausal women. RESEA...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.25.10.1675

    authors: Crespo CJ,Smit E,Snelling A,Sempos CT,Andersen RE,NHANES III.

    更新日期:2002-10-01 00:00:00

  • Associations of Maternal Glycemia in the First Half of Pregnancy With Alterations in Cardiac Structure and Function in Childhood.

    abstract:OBJECTIVE:Gestational diabetes mellitus has been associated with offspring cardiac congenital malformations, ventricular hypertrophy, and diastolic dysfunction in large observational cohort studies and experimental animal models. We assessed the associations of maternal random glucose concentrations across the full ran...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc19-2580

    authors: Wahab RJ,Jaddoe VWV,Roest AAW,Toemen L,Gaillard R

    更新日期:2020-09-01 00:00:00

  • Predictors of Quality of Life and Other Patient-Reported Outcomes in the PANORAMA Multinational Study of People With Type 2 Diabetes.

    abstract:OBJECTIVE:PANORAMA, a nine-country cross-sectional type 2 diabetes study, investigated factors associated with quality of life (QoL), health status, and other patient-reported outcome measures (PROMs). RESEARCH DESIGN AND METHODS:Patients were randomly or consecutively selected from primary/secondary care. PROMs inclu...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/dc16-2655

    authors: Bradley C,Eschwège E,de Pablos-Velasco P,Parhofer KG,Simon D,Vandenberghe H,Gönder-Frederick L

    更新日期:2018-02-01 00:00:00