The antidiabetogenic effect of GLP-1 is maintained during a 7-day treatment period and improves diabetic dyslipoproteinemia in NIDDM patients.

Abstract:

OBJECTIVE:To investigate the long-term antidiabetogenic effect of glucagon-like peptide 1 (GLP-1) and its influence on diabetic dyslipoproteinemia, patients with NIDDM were treated with GLP-1 subcutaneously for 1 week. RESEARCH DESIGN AND METHODS:Twelve patients participated in the study. The 1st week of the study, all of them were on intensive insulin treatment and from day 8, four were randomized to a control group continuing with insulin, and eight to a treatment group where GLP-1 was given at meals together with regular insulin from day 8 to 12. On days 13 and 14, they were only given GLP-1 at meals. NPH insulin at bedtime was given throughout the study. RESULTS:In the GLP-1-treated patients, the doses of regular insulin, given to keep a satisfactory blood glucose control, were reduced compared with treatment with insulin only. GLP-1 virtually inhibited the early increase in blood glucose after the meals, whereas an increase of approximately 2 mmol was seen during an optimized insulin treatment. In agreement with the short half-life of the peptide, 2-h postprandial plasma insulin levels were significantly decreased both at day 12 and 14, suggesting that there was not enough GLP-1 left to stimulate endogenous insulin release and compensate for the decrease in the dose of exogenous insulin. Therefore, the effect of GLP-1 was lost before the next meal, resulting in increased preprandial blood glucose values at lunch and dinner. The concentration of VLDL triglycerides decreased already during the 1st week. This decrease persisted during the 2nd week when GLP-1 was included in the treatment. No changes were observed in the levels of LDL and HDL cholesterol. The LDL particle diameter increased from a mean of 22.3 to 22.6 nm (P < 0.01) in response to insulin treatment. A further increment to 22.9 nm (P < 0.05) was seen after GLP-1 treatment. The LDL particle size did not change in the control group. Lipoprotein lipase activity was decreased by 27% and hepatic lipase was reduced by 13% in the GLP-1-treated group. CONCLUSIONS:We confirm the antidiabetogenic effect of GLP-1 in NIDDM patients. This effect was maintained during 7 days, which implies that the patients did not develop tolerance during this treatment period. Intensive insulin treatment, leading to normotriglyceridemia, increased the mean LDL particle diameter, which is likely to lower the risk of future coronary heart disease in patients with NIDDM. Furthermore, an additive effect of GLP-1 is indicated. Hence, this study gives additional evidence that GLP-1 may be useful as an agent for treating NIDDM.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Juntti-Berggren L,Pigon J,Karpe F,Hamsten A,Gutniak M,Vignati L,Efendic S

doi

10.2337/diacare.19.11.1200

subject

Has Abstract

pub_date

1996-11-01 00:00:00

pages

1200-6

issue

11

eissn

0149-5992

issn

1935-5548

journal_volume

19

pub_type

临床试验,杂志文章,随机对照试验
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    abstract:OBJECTIVE:Little evidence exists regarding long-term diet quality and the risk of type 2 diabetes among Asian populations, who have undergone a nutrition transition and a diabetes epidemic. RESEARCH DESIGN AND METHODS:A total of 117,919 Chinese men and women, 40-74 years old, free of diabetes, cardiovascular disease, ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc17-1626

    authors: Yu D,Zheng W,Cai H,Xiang YB,Li H,Gao YT,Shu XO

    更新日期:2018-04-01 00:00:00

  • The role of the National Diabetes Advisory Board in diabetes management.

    abstract::The history of the National Diabetes Advisory Board is reviewed, particularly from the perspective of the role of the board in advancing diabetes care. In addition, its potential future activities in the arena of translating research advances, for example, the results of the Diabetes Control and Complications Trial (D...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:

    authors: Genuth SM

    更新日期:1994-06-01 00:00:00

  • Fetal hemoglobin in diabetic patients.

    abstract:OBJECTIVE:To determine the occurrence of elevated fetal hemoglobin (HbF) among the diabetic population and determine the clinical situation of importance. RESEARCH DESIGN AND METHODS:A cross-sectional study was conducted. HbA1c and HbF were measured with high-performance liquid chromatography in 1,104 consecutive diab...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/diacare.17.8.828

    authors: Koskinen LK,Lahtela JT,Koivula TA

    更新日期:1994-08-01 00:00:00

  • Increased 24-h energy expenditure in type 2 diabetes.

    abstract:OBJECTIVE:The aim of this study was to determine whether overweight and obese individuals with type 2 diabetes have higher basal and 24-h energy expenditure compared with healthy control subjects before and after adjustment for body composition, spontaneous physical activity (SPA), sex, and age. RESEARCH DESIGN AND ME...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.27.10.2416

    authors: Bitz C,Toubro S,Larsen TM,Harder H,Rennie KL,Jebb SA,Astrup A

    更新日期:2004-10-01 00:00:00

  • A highly successful and novel model for treatment of chronic painful diabetic peripheral neuropathy.

    abstract:OBJECTIVE:To investigate why, in spite of a vast variety of treatment agents, the alleviation of pain in patients with diabetic neuropathy is difficult. Previous studies have not used a treatment algorithm based on anatomic site and neuropathophysiological source of the neuropathic pain. RESEARCH DESIGN AND METHODS:A ...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/diacare.16.8.1103

    authors: Pfeifer MA,Ross DR,Schrage JP,Gelber DA,Schumer MP,Crain GM,Markwell SJ,Jung S

    更新日期:1993-08-01 00:00:00

  • Predictive Value of Fasting Glucose, Postload Glucose, and Hemoglobin A1c on Risk of Diabetes and Complications in Chinese Adults.

    abstract:OBJECTIVE:Uncertainty remains regarding the predictive value of various glycemic measures as they relate to the risk of diabetes and its complications. Using the cutoffs recommended by the American Diabetes Association's 2010 criteria, we determined the associations of fasting plasma glucose (FPG), 2-h postload glucose...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/dc18-1390

    authors: Lu J,He J,Li M,Tang X,Hu R,Shi L,Su Q,Peng K,Xu M,Xu Y,Chen Y,Yu X,Yan L,Wang T,Zhao Z,Qin G,Wan Q,Chen G,Dai M,Zhang D,Gao Z,Wang G,Shen F,Luo Z,Qin Y,Chen L,Huo Y,Li Q,Ye Z,Zhang Y,Du R,Che

    更新日期:2019-08-01 00:00:00

  • Metabolic Syndrome Components Are Associated With Symptomatic Polyneuropathy Independent of Glycemic Status.

    abstract:OBJECTIVE:Previous studies demonstrate that the metabolic syndrome is associated with distal symmetric polyneuropathy (DSP). We aimed to determine the magnitude of this effect and the precise components involved. RESEARCH DESIGN AND METHODS:We determined the symptomatic DSP prevalence in the Health, Aging, and Body Co...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc16-0081

    authors: Callaghan BC,Xia R,Banerjee M,de Rekeneire N,Harris TB,Newman AB,Satterfield S,Schwartz AV,Vinik AI,Feldman EL,Strotmeyer ES,Health ABC Study.

    更新日期:2016-05-01 00:00:00

  • 14. Management of Diabetes in Pregnancy: Standards of Medical Care in Diabetes-2019.

    abstract::The American Diabetes Association (ADA) "Standards of Medical Care in Diabetes" includes ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Co...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/dc19-S014

    authors: American Diabetes Association.

    更新日期:2019-01-01 00:00:00

  • Prevalence of Candida glabrata and its response to boric acid vaginal suppositories in comparison with oral fluconazole in patients with diabetes and vulvovaginal candidiasis.

    abstract:OBJECTIVE:A large proportion of vulvovaginal candidiasis (VVC) in diabetes is due to non-albicans Candida species such as C. glabrata and C. tropicalis. Observational studies indicate that diabetic patients with C. glabrata VVC respond poorly to azole drugs. We evaluated the response to oral fluconazole and boric acid ...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc06-1469

    authors: Ray D,Goswami R,Banerjee U,Dadhwal V,Goswami D,Mandal P,Sreenivas V,Kochupillai N

    更新日期:2007-02-01 00:00:00

  • Markers of insulin resistance are strong risk factors for retinopathy incidence in type 1 diabetes.

    abstract:OBJECTIVE:To determine the incidence of retinopathy and the relative importance of its risk factors in type 1 diabetes. RESEARCH DESIGN AND METHODS:This is a 7.3-year follow-up of 764 of 1,215 (63%) people with type 1 diabetes across Europe, aged 15-60 years at baseline with no retinopathy (the EURODIAB Prospective Co...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.24.2.284

    authors: Chaturvedi N,Sjoelie AK,Porta M,Aldington SJ,Fuller JH,Songini M,Kohner EM,EURODIAB Prospective Complications Study.

    更新日期:2001-02-01 00:00:00

  • Increased risk of childhood type 1 diabetes in children born after 1985.

    abstract:OBJECTIVE:The incidence rate of childhood type 1 diabetes is thought to be increasing; however, Danish studies have not confirmed this. Using a national diabetes register initiated in 1996 and two previous regional incidence studies, we studied the age-specific incidence of type 1 diabetes over 30 years. Here, we descr...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.25.12.2197

    authors: Svensson J,Carstensen B,Mølbak A,Christau B,Mortensen HB,Nerup J,Borch-Johnsen K

    更新日期:2002-12-01 00:00:00

  • Evaluation of patient's knowledge of diabetes self-care.

    abstract::A survey conducted at a Veterans Administration Hospital to evaluate patient capability for self-management found that over 35 per cent of the patients interviewed lacked any formal training. Seventeen patients had been placed on insulin without formal instruction. Almost one half the patients who claimed to have atte...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.1.5.275

    authors: Miller LV,Goldstein J,Nicolaisen G

    更新日期:1978-09-01 00:00:00

  • Influence of hepatic steatosis (fatty liver) on severity and composition of dyslipidemia in type 2 diabetes.

    abstract:OBJECTIVE:The objective of this study was to examine the associations between the severity of hepatic steatosis and dyslipidemia in type 2 diabetes, including circulating apolipoprotein B100 (apoB) concentrations and lipoprotein particle size and numbers. RESEARCH DESIGN AND METHODS:Computed tomography imaging was use...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc06-0455

    authors: Toledo FG,Sniderman AD,Kelley DE

    更新日期:2006-08-01 00:00:00

  • Is pancreatic diabetes (type 3c diabetes) underdiagnosed and misdiagnosed?

    abstract::Exocrine pancreatic insufficiency is frequently associated with diabetes, with high prevalence in both insulin-dependent or insulin-independent patients. Exocrine pancreatic failure has often been perceived as a complication of diabetes. In contrast, recent clinical observations lead to the notion that nonendocrine pa...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/dc08-s244

    authors: Hardt PD,Brendel MD,Kloer HU,Bretzel RG

    更新日期:2008-02-01 00:00:00

  • Random blood glucose measurement at antenatal booking to screen for overt diabetes in pregnancy: a retrospective study.

    abstract:OBJECTIVE:To assess random venous blood glucose (RBG) measurement at antenatal booking to detect "overt diabetes in pregnancy" (ODIP). RESEARCH DESIGN AND METHODS:A retrospective analysis of regional hospital obstetric data from 2004-2008 was performed. Universal RBG screening was included at booking. Oral glucose tol...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-0533

    authors: Church D,Halsall D,Meek C,Parker RA,Murphy HR,Simmons D

    更新日期:2011-10-01 00:00:00

  • Rising incidence of type 2 diabetes in children in the U.K.

    abstract:OBJECTIVE:To estimate the incidence of type 2 diabetes in children <17 years of age and to investigate the relationship of diabetes with increasing childhood obesity in the U.K. and the Republic of Ireland (ROI). RESEARCH DESIGN AND METHODS:Active monthly reporting of cases by consultant pediatricians occurred through...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc06-1813

    authors: Haines L,Wan KC,Lynn R,Barrett TG,Shield JP

    更新日期:2007-05-01 00:00:00

  • Improvement in sexual functioning in patients with type 2 diabetes and depression treated with bupropion.

    abstract:OBJECTIVE:Major depressive disorder (MDD) and type 2 diabetes have independent adverse effects on sexual functioning (SF). Bupropion (BU) reportedly has few sexual side effects, but its use in diabetes has not been studied. RESEARCH DESIGN AND METHODS:This article reports a planned secondary analysis of SF in 90 patie...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc10-1714

    authors: Sayuk GS,Gott BM,Nix BD,Lustman PJ

    更新日期:2011-02-01 00:00:00

  • Effect of ezetimibe on hepatic fat, inflammatory markers, and apolipoprotein B-100 kinetics in insulin-resistant obese subjects on a weight loss diet.

    abstract:OBJECTIVE:Nonalcoholic fatty liver disease is highly prevalent in obese and type 2 diabetic individuals and is strongly associated with dyslipidemia and inflammation. Weight loss and/or pharmacotherapy are commonly used to correct these abnormalities. RESEARCH DESIGN AND METHODS:We performed a 16-week intervention tri...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc09-1765

    authors: Chan DC,Watts GF,Gan SK,Ooi EM,Barrett PH

    更新日期:2010-05-01 00:00:00

  • Challenges to healthy eating for people with diabetes in a low-income, minority neighborhood.

    abstract:OBJECTIVE:This study used qualitative interviews with black and Latino participants with diabetes to further understanding about types of foods eaten, food preparation, sources of foods and meals, communication with providers, and effects of race and ethnicity on eating in this population. RESEARCH DESIGN AND METHODS:...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc12-1632

    authors: Breland JY,McAndrew LM,Gross RL,Leventhal H,Horowitz CR

    更新日期:2013-10-01 00:00:00

  • Association of Maternal Folate and Vitamin B12 in Early Pregnancy With Gestational Diabetes Mellitus: A Prospective Cohort Study.

    abstract:OBJECTIVE:To investigate the association of folate and vitamin B12 in early pregnancy with gestational diabetes mellitus (GDM) risk. RESEARCH DESIGN AND METHODS:The data of this study were from a subcohort within the Shanghai Preconception Cohort Study. We included pregnancies with red blood cell (RBC) folate and vita...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc20-1607

    authors: Chen X,Zhang Y,Chen H,Jiang Y,Wang Y,Wang D,Li M,Dou Y,Sun X,Huang G,Yan W

    更新日期:2021-01-01 00:00:00

  • Intact proinsulin and beta-cell function in lean and obese subjects with and without type 2 diabetes.

    abstract:OBJECTIVE:Type 2 diabetes is a heterogeneous disease in which both beta-cell dysfunction and insulin resistance are pathogenetic factors. Disproportionate hyperproinsulinemia (elevated proinsulin/insulin) is another abnormality in type 2 diabetes whose mechanism is unknown. Increased demand due to obesity and/or insuli...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.22.4.609

    authors: Røder ME,Dinesen B,Hartling SG,Houssa P,Vestergaard H,Sodoyez-Goffaux F,Binder C

    更新日期:1999-04-01 00:00:00

  • Frequency of severe hypoglycemia in patients with type I diabetes with impaired awareness of hypoglycemia.

    abstract:OBJECTIVE:To determine the frequency of hypoglycemia in patients with type I diabetes and impaired awareness of hypoglycemia by prospective assessment. RESEARCH DESIGN AND METHODS:A prospective study was undertaken for 12 months in 60 patients with type I diabetes: 29 had impaired awareness of hypoglycemia and 31 reta...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/diacare.17.7.697

    authors: Gold AE,MacLeod KM,Frier BM

    更新日期:1994-07-01 00:00:00

  • Detection of GAD65-reactive T-Cells in type 1 diabetes by immunoglobulin-free ELISPOT assays.

    abstract:OBJECTIVE:To investigate the prevalence of beta-cell autoantigen-reactive peripheral T-cells in type 1 diabetes, we developed an immunoglobulin-free enzyme-linked immunospot (ELISPOT) assay and assessed its usefulness for diagnosing this disease. RESEARCH DESIGN AND METHODS:Cellular immune responses to beta -cell auto...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.25.8.1390

    authors: Kotani R,Nagata M,Moriyama H,Nakayama M,Yamada K,Chowdhury SA,Chakrabarty S,Jin Z,Yasuda H,Yokono K

    更新日期:2002-08-01 00:00:00

  • On the association between diabetes and mental disorders in a community sample: results from the German National Health Interview and Examination Survey.

    abstract:OBJECTIVE:To determine the relationship between mental disorders and diabetes in a representative community sample. RESEARCH DESIGN AND METHODS:This was a cross-sectional study. Data on diabetes and HbA(1c) values were obtained by structured questionnaires and by laboratory assessments. Current psychiatric disorders w...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.26.6.1841

    authors: Kruse J,Schmitz N,Thefeld W,German National Health Interview and Examination Survey.

    更新日期:2003-06-01 00:00:00

  • Reciprocal association of plasma IGF-1 and interleukin-6 levels with cardiometabolic risk factors in nondiabetic subjects.

    abstract:OBJECTIVE:To examine the relationship between plasma IGF-1 and interleukin-6 (IL-6) levels in Caucasian nondiabetic subjects and evaluate the association of IGF-1 and IL-6 with the cardiometabolic risk factors characterizing metabolic syndrome (MetS). RESEARCH DESIGN AND METHODS:The study group consisted of 186 Caucas...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc08-0553

    authors: Succurro E,Andreozzi F,Sciacqua A,Hribal ML,Perticone F,Sesti G

    更新日期:2008-09-01 00:00:00

  • Impact of HbA1c, followed from onset of type 1 diabetes, on the development of severe retinopathy and nephropathy: the VISS Study (Vascular Diabetic Complications in Southeast Sweden).

    abstract:OBJECTIVE:HbA1c is strongly related to the development of diabetes complications, but it is still controversial which HbA1c level to strive for in the treatment of type 1 diabetes. The aim of the current study was to evaluate HbA1c, followed from diagnosis, as a predictor of severe microvascular complications and to fo...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc14-1203

    authors: Nordwall M,Abrahamsson M,Dhir M,Fredrikson M,Ludvigsson J,Arnqvist HJ

    更新日期:2015-02-01 00:00:00

  • Evaluation of nonfasting tests to screen for childhood and adolescent dysglycemia.

    abstract:OBJECTIVE:To assess performance of nonfasting tests to screen children for dysglycemia (prediabetes or diabetes). RESEARCH DESIGN AND METHODS:This was a cross-sectional study of 254 overweight or obese (BMI ≥85th percentile) children aged 10-17 years. Subjects came for two visits to a clinical research unit. For visit...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-0827

    authors: Lee JM,Gebremariam A,Wu EL,LaRose J,Gurney JG

    更新日期:2011-12-01 00:00:00

  • Inflammation markers and metabolic characteristics of subjects with 1-h plasma glucose levels.

    abstract:OBJECTIVE:To assess the association of 1-h plasma glucose (1hPG) and inflammation with normal glucose tolerance (NGT) and pre-diabetes. RESEARCH DESIGN AND METHODS:A cohort of 1,062 subjects was enrolled. After oral glucose load (oral glucose tolerance test), we compared subjects with NGT and pre-diabetes above and be...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-1342

    authors: Bardini G,Dicembrini I,Cresci B,Rotella CM

    更新日期:2010-02-01 00:00:00

  • Carotid atherosclerosis and serum lipoprotein(a) concentrations in patients with NIDDM.

    abstract:OBJECTIVE:To investigate the association of carotid atherosclerosis and serum lipoprotein(a) [Lp(a)] concentrations in subjects with NIDDM. RESEARCH DESIGN AND METHODS:We measured carotid intima-media thickness (IMT) and Lp(a) concentrations in 117 NIDDM subjects. Subjects were divided into tertiles according to IMT v...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.20.5.829

    authors: Yamamoto M,Egusa G,Yamakido M

    更新日期:1997-05-01 00:00:00

  • Predictors of glycemic control in insulin-using adults with type 2 diabetes.

    abstract:OBJECTIVE:To determine the characteristics that influence glycemic control among insulin-using adults with type 2 diabetes. RESEARCH DESIGN AND METHODS:We studied all 1,333 eligible members of a large not-for-profit health maintenance organization who responded to a 1997 survey. We tested associations among demographi...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.23.3.273

    authors: Nichols GA,Hillier TA,Javor K,Brown JB

    更新日期:2000-03-01 00:00:00