Effect of aldose reductase inhibitor (tolrestat) on urinary albumin excretion rate and glomerular filtration rate in IDDM subjects with nephropathy.

Abstract:

OBJECTIVE:To explore the possible link between diabetic nephropathy and the enhanced activity of the polyol pathway, known to occur in IDDM subjects. RESEARCH DESIGN AND METHODS:We studied the effects of the aldose reductase inhibitor tolrestat (200 mg/day) on urinary albumin excretion rate and glomerular filtration rate in 20 IDDM patients with diabetic nephropathy. RESULTS:Six months of placebo treatment produced no significant changes in glomerular filtration rate, urinary albumin excretion rate, and renal plasma flow. Consequently, filtration fraction remained unchanged. During tolrestat treatment, glomerular filtration rate decreased from the basal value of 156 +/- 14 ml.min-1.1.73 m2 to 142 +/- 13.7 ml.min-1.1.73 m2 (P < 0.001) at 2 mo; 128 +/- 12.4 ml.min-1.1.73 m2 (P < 0.001) at 4 mo; and 123.7 +/- 13.0 ml.min-1.1.73 m2 at 6 mo. A significant decrease of urinary albumin excretion rate was observed during the trial (basal values 219 +/- 32.5 vs. 196.9 +/- 28.5 micrograms/min at 2 mo [P < 0.05]; 171.6 +/- 25.5 micrograms/min at 4 mo [P < 0.001]; and 58.6 +/- 19.3 micrograms/min at 6 mo [P < 0.001]). No significant change in renal plasma flow was seen during tolrestat treatment. Filtration fraction significantly decreased in the tolrestat group from the basal value of 0.23 +/- 0.02 to 0.21 +/- 0.01 at 2 mo (P < 0.005); 0.18 +/- 0.02 at 4 mo (P < 0.001); and 0.17 +/- 0.02 at 6 mo (P < 0.001). CONCLUSIONS:The polyol pathway is implicated in hemodynamic changes associated with early diabetic nephropathy, and aldose reductase treatment can positively influence these parameters.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Passariello N,Sepe J,Marrazzo G,De Cicco A,Peluso A,Pisano MC,Sgambato S,Tesauro P,D'Onofrio F

doi

10.2337/diacare.16.5.789

subject

Has Abstract

pub_date

1993-05-01 00:00:00

pages

789-95

issue

5

eissn

0149-5992

issn

1935-5548

journal_volume

16

pub_type

临床试验,杂志文章
  • Lactation Duration and Long-term Risk for Incident Type 2 Diabetes in Women With a History of Gestational Diabetes Mellitus.

    abstract:OBJECTIVE:We examined the association of lactation duration with incident type 2 diabetes among women with a history of gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS:We monitored 4,372 women with a history of GDM participating in the Nurses' Health Study II for incident type 2 diabetes over 25 years...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc19-2237

    authors: Ley SH,Chavarro JE,Li M,Bao W,Hinkle SN,Wander PL,Rich-Edwards J,Olsen S,Vaag A,Damm P,Grunnet LG,Mills JL,Hu FB,Zhang C

    更新日期:2020-04-01 00:00:00

  • Efficacy of feedback from quarterly laboratory comparison in maintaining quality of a hospital capillary blood glucose monitoring program.

    abstract:OBJECTIVE:A 1-year randomized prospective study was conducted to investigate the efficacy of feedback from split-sample testing as part of a capillary blood glucose quality assurance program. RESEARCH DESIGN AND METHODS:A total of 124 nurses were randomized to either group A (quarterly comparisons with feedback) or gr...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.19.2.168

    authors: Jones HE,Cleave B,Zinman B,Szalai JP,Nichol HL,Hoffman BR

    更新日期:1996-02-01 00:00:00

  • The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic adults.

    abstract:OBJECTIVE:We sought to compare the effects of combined calcium and vitamin D supplementation versus placebo on blood glucose and markers of inflammation in nondiabetic adults aged > or =65 years. RESEARCH DESIGN AND METHODS:A total of 314 Caucasian adults without diabetes received either 500 mg calcium citrate and 700...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc06-1994

    authors: Pittas AG,Harris SS,Stark PC,Dawson-Hughes B

    更新日期:2007-04-01 00:00:00

  • Oxygen Therapy in Myocardial Infarction Patients With or Without Diabetes: A Predefined Subgroup Analysis From the DETO2X-AMI Trial.

    abstract:OBJECTIVE:To determine the effects of oxygen therapy in myocardial infarction (MI) patients with and without diabetes. RESEARCH DESIGN AND METHODS:In the Determination of the Role of Oxygen in Suspected Acute Myocardial Infarction (DETO2X-AMI) trial, 6,629 normoxemic patients with suspected MI were randomized to oxyge...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc19-0590

    authors: Nyström T,James SK,Lindahl B,Östlund O,Erlinge D,Herlitz J,Omerovic E,Mellbin L,Alfredsson J,Fröbert O,Jernberg T,Hofmann R,DETO2X-SWEDEHEART Investigators.

    更新日期:2019-11-01 00:00:00

  • The independent contributions of diabetic neuropathy and vasculopathy in foot ulceration. How great are the risks?

    abstract:OBJECTIVE:To describe the relative contributions of neurological and vascular abnormalities to the overall risk of diabetic foot ulceration. RESEARCH DESIGN AND METHODS:A case-control study of diabetic veterans from the Seattle Veterans Affairs Medical Center was conducted using data collected from 46 patients with di...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.18.2.216

    authors: McNeely MJ,Boyko EJ,Ahroni JH,Stensel VL,Reiber GE,Smith DG,Pecoraro RF

    更新日期:1995-02-01 00:00:00

  • Development of questionnaire to examine relationship of physical activity and diabetes in Pima Indians.

    abstract::There was a need to design a questionnaire that could accurately assess the activity patterns of Native Americans to evaluate the relationship between physical activity and diabetes. Such a questionnaire was developed and implemented into the data collection scheme of the prospective Pima Indian Study of Arizona. The ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.13.4.401

    authors: Kriska AM,Knowler WC,LaPorte RE,Drash AL,Wing RR,Blair SN,Bennett PH,Kuller LH

    更新日期:1990-04-01 00:00:00

  • Insomnia with objective short sleep duration is associated with type 2 diabetes: A population-based study.

    abstract:OBJECTIVE:We examined the joint effects of insomnia and objective short sleep duration, the combination of which is associated with higher morbidity, on diabetes risk. RESEARCH DESIGN AND METHODS:A total of 1,741 men and women randomly selected from Central Pennsylvania were studied in the sleep laboratory. Insomnia w...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-0284

    authors: Vgontzas AN,Liao D,Pejovic S,Calhoun S,Karataraki M,Bixler EO

    更新日期:2009-11-01 00:00:00

  • Dietary phylloquinone and menaquinones intakes and risk of type 2 diabetes.

    abstract:OBJECTIVE:To investigate whether dietary phylloquinone and menaquinones intakes are related to risk of type 2 diabetes. RESEARCH DESIGN AND METHODS:We used data from a prospective cohort study in 38,094 Dutch men and women, aged 20-70 years. Dietary phylloquinone and menaquinones intakes were assessed using a validate...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-2302

    authors: Beulens JW,van der A DL,Grobbee DE,Sluijs I,Spijkerman AM,van der Schouw YT

    更新日期:2010-08-01 00:00:00

  • Fish oil and glycemic control in diabetes. A meta-analysis.

    abstract:OBJECTIVE:Hypertriglyceridemia is associated with cardiovascular disease in diabetes. Fibrates effectively lower, but do not always normalize, serum triglyceride levels. Fish oil supplements may then be added to lower serum triglyceride levels. Doubt remains whether the net effect of fish oil intake on glycemic control...

    journal_title:Diabetes care

    pub_type: 杂志文章,meta分析

    doi:10.2337/diacare.21.4.494

    authors: Friedberg CE,Janssen MJ,Heine RJ,Grobbee DE

    更新日期:1998-04-01 00:00:00

  • Evaluation of the effect of performance monitoring and feedback on care process, utilization, and outcome.

    abstract:OBJECTIVE:We evaluated a program of performance measurement and monitoring by assessing care process, utilization of services, and outcomes. RESEARCH DESIGN AND METHODS:Information on 63,264 diabetic individuals who were continuously enrolled as members of Kaiser Permanente Southern California from 1 January 1994 to 3...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.23.2.192

    authors: Petitti DB,Contreras R,Ziel FH,Dudl J,Domurat ES,Hyatt JA

    更新日期:2000-02-01 00:00:00

  • Collaborative care management of major depression among low-income, predominantly Hispanic subjects with diabetes: a randomized controlled trial.

    abstract:OBJECTIVE:To determine whether evidence-based socioculturally adapted collaborative depression care improves receipt of depression care and depression and diabetes outcomes in low-income Hispanic subjects. RESEARCH DESIGN AND METHODS:This was a randomized controlled trial of 387 diabetic patients (96.5% Hispanic) with...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc09-1711

    authors: Ell K,Katon W,Xie B,Lee PJ,Kapetanovic S,Guterman J,Chou CP

    更新日期:2010-04-01 00:00:00

  • Personality and family profiles of chronic insulin-dependent diabetic patients using portable insulin infusion pump therapy: a preliminary investigation.

    abstract::Thirty patients were studied before and after introduction of portable insulin infusion pump therapy to determine the psychological and family impact of this new technological intervention. No negative psychological impact or dysfunction appeared to be associated with introduction of the pump. On the contrary, the pos...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.7.2.137

    authors: Shapiro J,Wigg D,Charles MA,Perley M

    更新日期:1984-03-01 00:00:00

  • Asymptomatic bacteriuria and hemoglobin A1.

    abstract::We measured hemoglobin A1 (HbA1) and performed clean-catch urine cultures in 752 patients (411 men and 341 women) with non-insulin-dependent diabetes mellitus (NIDDM) attending an outpatient diabetes clinic. Prevalence of bacteriuria was significantly greater in diabetic women than in controls (9.1 vs. 5.0%, P less th...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.9.5.518

    authors: Schmitt JK,Fawcett CJ,Gullickson G

    更新日期:1986-09-01 00:00:00

  • Inflammation and progressive nephropathy in type 1 diabetes in the diabetes control and complications trial.

    abstract:OBJECTIVE:Progressive nephropathy represents a substantial source of morbidity and mortality in type 1 diabetes. Increasing albuminuria is a strong predictor of progressive renal dysfunction and heightened cardiovascular risk. Early albuminuria probably reflects vascular endothelial dysfunction, which may be mediated i...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc08-0277

    authors: Lin J,Glynn RJ,Rifai N,Manson JE,Ridker PM,Nathan DM,Schaumberg DA

    更新日期:2008-12-01 00:00:00

  • Joint contractures in patients with juvenile diabetes and their siblings.

    abstract::Six hundred fifteen children (310 with diabetes, 106 nondiabetic siblings, and 199 nonsibling controls) were examined for the presence of joint contractures. Forty children had contractures: 8.4 per cent of those with diabetes and 4.6 per cent of those without diabetes. Contractures were present, however, in 9.4 per c...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.1.6.360

    authors: Traisman HS,Traisman ES,Marr TJ,Wise J

    更新日期:1978-11-01 00:00:00

  • Risk factors for foot infections in individuals with diabetes.

    abstract:OBJECTIVE:To prospectively determine risk factors for foot infection in a cohort of people with diabetes. RESEARCH DESIGN AND METHODS:We evaluated then followed 1,666 consecutive diabetic patients enrolled in a managed care-based outpatient clinic in a 2-year longitudinal outcomes study. At enrollment, patients underw...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/dc05-2425

    authors: Lavery LA,Armstrong DG,Wunderlich RP,Mohler MJ,Wendel CS,Lipsky BA

    更新日期:2006-06-01 00:00:00

  • Rapid A1c availability improves clinical decision-making in an urban primary care clinic.

    abstract:OBJECTIVE:Failure to meet goals for glycemic control in primary care settings may be due in part to lack of information critical to guide intensification of therapy. Our objective is to determine whether rapid-turnaround A1c availability would improve intensification of diabetes therapy and reduce A1c levels in patient...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/diacare.26.4.1158

    authors: Miller CD,Barnes CS,Phillips LS,Ziemer DC,Gallina DL,Cook CB,Maryman SD,El-Kebbi IM

    更新日期:2003-04-01 00:00:00

  • Ambient Air Pollutants Have Adverse Effects on Insulin and Glucose Homeostasis in Mexican Americans.

    abstract:OBJECTIVE:Recent studies suggest that air pollution plays a role in type 2 diabetes (T2D) incidence and mortality. The underlying physiological mechanisms have yet to be established. We hypothesized that air pollution adversely affects insulin sensitivity and secretion and serum lipid levels. RESEARCH DESIGN AND METHO...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc15-1795

    authors: Chen Z,Salam MT,Toledo-Corral C,Watanabe RM,Xiang AH,Buchanan TA,Habre R,Bastain TM,Lurmann F,Wilson JP,Trigo E,Gilliland FD

    更新日期:2016-04-01 00:00:00

  • Relative Pancreas Volume Is Reduced in First-Degree Relatives of Patients With Type 1 Diabetes.

    abstract:OBJECTIVE:Pancreas size is reduced in patients at type 1 diabetes onset and in autoantibody (AAB)-positive donors without diabetes. We sought to determine whether pancreas volume (PV) imaging could improve understanding of the loss of pancreas size in first-degree relatives (FDRs) of patients with type 1 diabetes. We a...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc18-1512

    authors: Campbell-Thompson ML,Filipp SL,Grajo JR,Nambam B,Beegle R,Middlebrooks EH,Gurka MJ,Atkinson MA,Schatz DA,Haller MJ

    更新日期:2019-02-01 00:00:00

  • Incidence of diabetes in American Indians of three geographic areas: the Strong Heart Study.

    abstract:OBJECTIVE:To estimate incidence rates of diabetes and associated risk factors among participants of the Strong Heart Study. RESEARCH DESIGN AND METHODS:Of the 4,549 Strong Heart Study participants examined at baseline, 3,638 returned for a similar examination after an average of 4 years. The 1985 World Health Organiza...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/diacare.25.1.49

    authors: Lee ET,Welty TK,Cowan LD,Wang W,Rhoades DA,Devereux R,Go O,Fabsitz R,Howard BV

    更新日期:2002-01-01 00:00:00

  • Home Use of Day-and-Night Hybrid Closed-Loop Insulin Delivery in Suboptimally Controlled Adolescents With Type 1 Diabetes: A 3-Week, Free-Living, Randomized Crossover Trial.

    abstract:OBJECTIVE:This study evaluated the feasibility, safety, and efficacy of day-and-night hybrid closed-loop insulin delivery in adolescents with type 1 diabetes under free-living conditions. RESEARCH DESIGN AND METHODS:In an open-label randomized crossover study, 12 suboptimally controlled adolescents on insulin pump the...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc16-1094

    authors: Tauschmann M,Allen JM,Wilinska ME,Thabit H,Acerini CL,Dunger DB,Hovorka R

    更新日期:2016-11-01 00:00:00

  • Effect of age on systemic delivery of oral glucose in men.

    abstract::This study examined the effect of age on the posthepatic delivery of oral glucose (PHDG) during steady-state conditions. We used an intravenous-oral modification of the euglycemic insulin-clamp technique to assess PHDG in six men aged 24-39 yr (young) and eight men aged 65-83 yr (old). Each subject underwent two studi...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.12.6.394

    authors: Tonino RP,Minaker KL,Rowe JW

    更新日期:1989-06-01 00:00:00

  • The antidiabetogenic effect of GLP-1 is maintained during a 7-day treatment period and improves diabetic dyslipoproteinemia in NIDDM patients.

    abstract:OBJECTIVE:To investigate the long-term antidiabetogenic effect of glucagon-like peptide 1 (GLP-1) and its influence on diabetic dyslipoproteinemia, patients with NIDDM were treated with GLP-1 subcutaneously for 1 week. RESEARCH DESIGN AND METHODS:Twelve patients participated in the study. The 1st week of the study, al...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.19.11.1200

    authors: Juntti-Berggren L,Pigon J,Karpe F,Hamsten A,Gutniak M,Vignati L,Efendic S

    更新日期:1996-11-01 00:00:00

  • Implementation of treatment protocols in the Diabetes Control and Complications Trial.

    abstract:OBJECTIVE:To describe the methods used to implement intensive and conventional therapies in the Diabetes Control and Complications Trial (DCCT) and the metabolic results that occurred with the different treatment regimens. RESEARCH DESIGN AND METHODS:The DCCT was a controlled clinical trial that demonstrated the benef...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.2337/diacare.18.3.361

    authors:

    更新日期:1995-03-01 00:00:00

  • Alcohol and the NIDDM patient.

    abstract::Historically, alcohol use by the diabetic patient has been controversial. Recent studies in the general population have shown an improvement in mortality with moderate alcohol intake (one to three drinks per day). This improved mortality is greatest in those individuals who have a higher risk of ischemic heart disease...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/diacare.19.5.509

    authors: Bell DS

    更新日期:1996-05-01 00:00:00

  • Delayed vascular reactivity to ischemia in diabetic microangiopathy.

    abstract::To investigate vascular responses in insulin-dependent diabetic patients both with and without retinopathy, we have assessed vasodilation by forearm transcutaneous pO2 measurement after 10 min of ischemia produced by a sphygmomanometer cuff. Diabetic patients with proliferative retinopathy had a delayed vasodilatory r...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.7.1.47

    authors: Haitas B,Barnes A,Shogry ME,Weindling M,Rolfe P,Turner RC

    更新日期:1984-01-01 00:00:00

  • The Use of Glyburide Compared With Other Sulfonylureas and the Risk of Cancer in Patients With Type 2 Diabetes.

    abstract:OBJECTIVE:To determine whether the use of glyburide is associated with an increased risk of cancer compared with the use of other second-generation sulfonylureas among patients with type 2 diabetes. RESEARCH DESIGN AND METHODS:The U.K. Clinical Practice Research Datalink was used to conduct a cohort study among 52,600...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc15-1358

    authors: Tuccori M,Wu JW,Yin H,Majdan A,Azoulay L

    更新日期:2015-11-01 00:00:00

  • Controlled trial of a multifaceted intervention for improving quality of care for rural patients with type 2 diabetes.

    abstract:OBJECTIVE:Despite good evidence and clinical practice guidelines, studies document that treatment of type 2 diabetes is less than optimal. Lack of resources or limited access may put patients in rural communities at particular risk for suboptimal care. RESEARCH DESIGN AND METHODS:We conducted a prospective, before/aft...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.26.11.3061

    authors: Majumdar SR,Guirguis LM,Toth EL,Lewanczuk RZ,Lee TK,Johnson JA

    更新日期:2003-11-01 00:00:00

  • Reciprocal association of plasma IGF-1 and interleukin-6 levels with cardiometabolic risk factors in nondiabetic subjects.

    abstract:OBJECTIVE:To examine the relationship between plasma IGF-1 and interleukin-6 (IL-6) levels in Caucasian nondiabetic subjects and evaluate the association of IGF-1 and IL-6 with the cardiometabolic risk factors characterizing metabolic syndrome (MetS). RESEARCH DESIGN AND METHODS:The study group consisted of 186 Caucas...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc08-0553

    authors: Succurro E,Andreozzi F,Sciacqua A,Hribal ML,Perticone F,Sesti G

    更新日期:2008-09-01 00:00:00

  • Efficacy and safety of switching from the DPP-4 inhibitor sitagliptin to the human GLP-1 analog liraglutide after 52 weeks in metformin-treated patients with type 2 diabetes: a randomized, open-label trial.

    abstract:OBJECTIVE:To assess the efficacy and safety of switching from sitagliptin to liraglutide in metformin-treated adults with type 2 diabetes. RESEARCH DESIGN AND METHODS:In an open-label trial, participants randomized to receive either liraglutide (1.2 or 1.8 mg/day) or sitagliptin (100 mg/day), each added to metformin, ...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc11-2113

    authors: Pratley RE,Nauck MA,Bailey T,Montanya E,Filetti S,Garber AJ,Thomsen AB,Furber S,Davies M,1860-LIRA-DPP-4 Study Group.

    更新日期:2012-10-01 00:00:00