The development and utility of a novel scale that quantifies the glycemic progression toward type 1 diabetes over 6 months.


OBJECTIVE:We developed a scale to serve as a potential end point for 6-month glycemic progression (PS6M) toward type 1 diabetes (T1D) in autoantibody-positive relatives of individuals with T1D. RESEARCH DESIGN AND METHODS:The PS6M was developed from Diabetes Prevention Trial-Type 1 (DPT-1) data and tested in the TrialNet Pathway to Prevention Study (PTP). It is the difference between 6-month glucose sum values (30-120 min oral glucose tolerance test values) and values predicted for nonprogressors. RESULTS:The PS6M predicted T1D in the PTP (P < 0.001). The area under the receiver operating chacteristic curve was greater (P < 0.001) for the PS6M than for the baseline-to-6-month difference. PS6M values were higher in those with two or more autoantibodies, 30-0 min C-peptide values <2.00 ng/mL, or DPT-1 Risk Scores >7.00 (P < 0.001 for all). CONCLUSIONS:The PS6M is an indicator of short-term glycemic progression to T1D that could be a useful tool for assessing preventive treatments and biomarkers.


Diabetes Care


Diabetes care


Sosenko JM,Skyler JS,Beam CA,Boulware D,Mahon JL,Krischer JP,Greenbaum CJ,Rafkin LE,Matheson D,Herold KC,Palmer JP,Type 1 Diabetes TrialNet and Diabetes Prevention Trial–Type 1 Study Groups.




Has Abstract


2015-05-01 00:00:00














  • Urinary estriols: are they of value in normoglycemic diabetic pregnancy?

    abstract::The purpose of the study was to assess the value of 24-h urinary estriols in the management of diabetic pregnancies. Twenty-seven pregnant diabetic patients (White's class B through R) received insulin dosages twice daily as a combination of NPH and regular insulin. Laboratory and home monitored blood glucose was main...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Fern PE,Grunert GM,Lewis SB

    更新日期:1982-05-01 00:00:00

  • Electron microscopy of insulin precipitates.

    abstract::Morphologic characteristics of insulin precipitates were examined by both scanning and transmission electron microscopy. Insulin precipitate obtained after 1 wk of in vivo storage in an implanted dog reservoir was compared with insulin precipitate produced in vitro by isoelectric precipitation, acid-freeze-heat precip...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Schade DS,Eaton RP,DeLongo J,Saland LC,Ladman AJ,Carlson GA

    更新日期:1982-01-01 00:00:00

  • Personalized management of hyperglycemia in type 2 diabetes: reflections from a Diabetes Care Editors' Expert Forum.

    abstract::In June 2012, 13 thought leaders convened in a Diabetes Care Editors' Expert Forum to discuss the concept of personalized medicine in the wake of a recently published American Diabetes Association/European Association for the Study of Diabetes position statement calling for a patient-centered approach to hyperglycemia...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Raz I,Riddle MC,Rosenstock J,Buse JB,Inzucchi SE,Home PD,Del Prato S,Ferrannini E,Chan JC,Leiter LA,Leroith D,Defronzo R,Cefalu WT

    更新日期:2013-06-01 00:00:00

  • Muscular endurance in long-term IDDM patients.

    abstract:OBJECTIVE:To determine the short-term muscular endurance and working capacity of leg muscles in long-term IDDM patients in relation to neuropathic complications, muscle strength, and metabolic control. RESEARCH DESIGN AND METHODS:The muscular endurance of extensors and flexors at the ankle and knee was assessed in 44 ...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Andersen H

    更新日期:1998-04-01 00:00:00

  • Diabetes in employer-sponsored health insurance.

    abstract:OBJECTIVE:To examine medical and mental health care expenditures for large numbers of individuals with diabetes enrolled in employment-sponsored insurance plans. RESEARCH DESIGN AND METHODS:Health insurance billing data for approximately 1.3 million individuals enrolled in health insurance plans sponsored by 862 large...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Peele PB,Lave JR,Songer TJ

    更新日期:2002-11-01 00:00:00

  • Bariatric/Metabolic Surgery to Treat Type 2 Diabetes in Patients With a BMI

    abstract:OBJECTIVE:Global usage of bariatric surgery has been dictated for the past quarter century by National Institutes of Health recommendations restricting these operations to individuals with a BMI ≥35 kg/m(2). Strong evidence now demonstrates that bariatric procedures markedly improve or cause remission of type 2 diabete...

    journal_title:Diabetes care

    pub_type: 杂志文章,meta分析


    authors: Cummings DE,Cohen RV

    更新日期:2016-06-01 00:00:00

  • Elevated ambulatory blood pressure in microalbuminuric IDDM patients is inversely associated with renal plasma flow. A compensatory mechanism?

    abstract:OBJECTIVE:To evaluate the relationship between renal function, ambulatory blood pressure (AMBP), and glycemic control in microalbuminuric IDDM patients compared with normoalbuminuric patients. RESEARCH DESIGN AND METHODS:Nineteen male patients (age 33 +/- 6 years) with slight microalbuminuria (UAE 20-70 micrograms/min...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Poulsen PL,Juhl B,Ebbehøj E,Klein F,Christiansen C,Mogensen CE

    更新日期:1997-03-01 00:00:00

  • Delayed gastric emptying and gastric autoimmunity in type 1 diabetes.

    abstract:OBJECTIVE:Delayed gastric emptying and/or gastrointestinal symptoms occur in 30-50% of diabetic patients. Known contributing factors are autonomic neuropathy and acute hyperglycemia, but the role of gastric autoimmunity has never been investigated, although 15-20% of type 1 diabetic patients exhibit parietal cell antib...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: De Block CE,De Leeuw IH,Pelckmans PA,Callens D,Máday E,Van Gaal LF

    更新日期:2002-05-01 00:00:00

  • N-Glycan Profile and Kidney Disease in Type 1 Diabetes.

    abstract:OBJECTIVE:Poorer glycemic control in type 1 diabetes may alter N-glycosylation patterns on circulating glycoproteins, and these alterations may be linked with diabetic kidney disease (DKD). We investigated associations between N-glycans and glycemic control and renal function in type 1 diabetes. RESEARCH DESIGN AND ME...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Bermingham ML,Colombo M,McGurnaghan SJ,Blackbourn LAK,Vučković F,Pučić Baković M,Trbojević-Akmačić I,Lauc G,Agakov F,Agakova AS,Hayward C,Klarić L,Palmer CNA,Petrie JR,Chalmers J,Collier A,Green F,Lindsay RS,Macrury S

    更新日期:2018-01-01 00:00:00

  • Treatment of recent-onset type 1 diabetic patients with DiaPep277: results of a double-blind, placebo-controlled, randomized phase 3 trial.

    abstract:OBJECTIVE:To evaluate safety and efficacy of DiaPep277 in preserving β-cell function in type 1 diabetic patients. RESEARCH DESIGN AND METHODS:DIA-AID 1 is a multinational, phase 3, balanced-randomized, double-blind, placebo-controlled, parallel-group clinical study. Newly diagnosed patients (N = 457, aged 16-45 years)...

    journal_title:Diabetes care

    pub_type: 杂志文章,收录出版


    authors: Raz I,Ziegler AG,Linn T,Schernthaner G,Bonnici F,Distiller LA,Giordano C,Giorgino F,de Vries L,Mauricio D,Procházka V,Wainstein J,Elias D,Avron A,Tamir M,Eren R,Peled D,Dagan S,Cohen IR,Pozzilli P,DIA-AID 1 Writin

    更新日期:2014-01-01 00:00:00

  • Lactation Duration and Long-term Risk for Incident Type 2 Diabetes in Women With a History of Gestational Diabetes Mellitus.

    abstract:OBJECTIVE:We examined the association of lactation duration with incident type 2 diabetes among women with a history of gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS:We monitored 4,372 women with a history of GDM participating in the Nurses' Health Study II for incident type 2 diabetes over 25 years...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Ley SH,Chavarro JE,Li M,Bao W,Hinkle SN,Wander PL,Rich-Edwards J,Olsen S,Vaag A,Damm P,Grunnet LG,Mills JL,Hu FB,Zhang C

    更新日期:2020-04-01 00:00:00

  • Non-insulin-dependent diabetes: 10-year outcome in relation to initial response to diet and subsequent sulfonylurea therapy.

    abstract::Thirty-eight non-insulin-dependent diabetic patients within 130% of desirable body weight were given a 100-g oral glucose tolerance test (OGTT) at diagnosis and after at least 1 mo of dietary treatment with energy and carbohydrate restriction. Thirteen "responders" showed an improvement in fasting blood glucose, gluco...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章


    authors: Sönksen PH,Lowy C,Perkins JR,Lim HS

    更新日期:1984-05-01 00:00:00

  • Skeletal muscle deoxygenation after the onset of moderate exercise suggests slowed microvascular blood flow kinetics in type 2 diabetes.

    abstract:OBJECTIVE:People with type 2 diabetes have impaired exercise responses even in the absence of cardiovascular complications. One key factor associated with the exercise intolerance is abnormally slowed oxygen uptake (VO2) kinetics during submaximal exercise. The mechanisms of this delayed adaptation during exercise are ...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Bauer TA,Reusch JE,Levi M,Regensteiner JG

    更新日期:2007-11-01 00:00:00

  • Accuracy and Longevity of an Implantable Continuous Glucose Sensor in the PRECISE Study: A 180-Day, Prospective, Multicenter, Pivotal Trial.

    abstract:OBJECTIVE:It is known that continuous glucose monitoring (CGM) systems can lower mean glucose compared with episodic self-monitoring of blood glucose. Implantable CGM systems may provide additional benefits. RESEARCH DESIGN AND METHODS:We studied the Eversense (Senseonics Inc.) implantable CGM sensor in 71 participant...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Kropff J,Choudhary P,Neupane S,Barnard K,Bain SC,Kapitza C,Forst T,Link M,Dehennis A,DeVries JH

    更新日期:2017-01-01 00:00:00

  • Hypocalcemia, hypomagnesemia, and transient hypoparathyroidism during therapy with potassium phosphate in diabetic ketoacidosis.

    abstract::The effects of intravenous administration of potassium phosphate in the treatment of diabetic ketoacidosis were studied in nine children, ages 9 9/12 to 17 10/12 yr. During phosphate infusion (20--40 meq/L of fluid), all children maintained normal serum concentrations of phosphorus. Transient hypocalcemia occurred in ...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Zipf WB,Bacon GE,Spencer ML,Kelch RP,Hopwood NJ,Hawker CD

    更新日期:1979-05-01 00:00:00

  • Intensity of resistance exercise determines adipokine and resting energy expenditure responses in overweight elderly individuals.

    abstract:OBJECTIVE:To evaluate the time course of leptin, adiponectin, and resting energy expenditure (REE) responses in overweight elderly males after acute resistance exercise protocols of various intensity configurations. RESEARCH DESIGN AND METHODS:Forty inactive men (65-82 years) were randomly assigned to one of four grou...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验


    authors: Fatouros IG,Chatzinikolaou A,Tournis S,Nikolaidis MG,Jamurtas AZ,Douroudos II,Papassotiriou I,Thomakos PM,Taxildaris K,Mastorakos G,Mitrakou A

    更新日期:2009-12-01 00:00:00

  • Diabetes, Associated Clinical Spectrum, Long-term Prognosis, and Genotype/Phenotype Correlations in 201 Adult Patients With Hepatocyte Nuclear Factor 1B (HNF1B) Molecular Defects.

    abstract:OBJECTIVE:Molecular defects of hepatocyte nuclear factor 1B (HNF1B) are associated with a multiorgan disease, including diabetes (maturity-onset diabetes of the young 5) and kidney abnormalities. The HNF1B syndrome is related to HNF1B mutations or to a 17q12 deletion spanning 15 genes, including HNF1B. Here, we describ...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究


    authors: Dubois-Laforgue D,Cornu E,Saint-Martin C,Coste J,Bellanné-Chantelot C,Timsit J,Monogenic Diabetes Study Group of the Société Francophone du Diabète.

    更新日期:2017-11-01 00:00:00

  • The use of medical hyperspectral technology to evaluate microcirculatory changes in diabetic foot ulcers and to predict clinical outcomes.

    abstract:OBJECTIVE:Foot ulceration is a serious complication of diabetes, and new techniques that can predict wound healing may prove very helpful. We tested the ability of medical hyperspectral technology (HT), a novel diagnostic scanning technique that can quantify tissue oxy- and deoxyhemoglobin to predict diabetic foot ulce...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Khaodhiar L,Dinh T,Schomacker KT,Panasyuk SV,Freeman JE,Lew R,Vo T,Panasyuk AA,Lima C,Giurini JM,Lyons TE,Veves A

    更新日期:2007-04-01 00:00:00

  • Association of intrauterine exposure to maternal diabetes and obesity with type 2 diabetes in youth: the SEARCH Case-Control Study.

    abstract:OBJECTIVE:Limited data exist on the association between in utero exposure to maternal diabetes and obesity and type 2 diabetes in diverse youth. These associations were explored in African-American, Hispanic, and non-Hispanic white youth participating in the SEARCH Case-Control Study. RESEARCH DESIGN AND METHODS:A tot...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究


    authors: Dabelea D,Mayer-Davis EJ,Lamichhane AP,D'Agostino RB Jr,Liese AD,Vehik KS,Narayan KM,Zeitler P,Hamman RF

    更新日期:2008-07-01 00:00:00

  • Combined use of fasting plasma glucose and HbA1c predicts the progression to diabetes in Chinese subjects.

    abstract:OBJECTIVE:We have previously suggested using the paired values of fasting plasma glucose (FPG) and HbA1c to identify potential diabetic subjects. In this article, we followed up on 208 nondiabetic subjects and examined their rates of progression to diabetes. We analyzed their likelihood of becoming diabetic according t...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Ko GT,Chan JC,Tsang LW,Cockram CS

    更新日期:2000-12-01 00:00:00

  • Cost-effectiveness of aspirin use among persons with newly diagnosed type 2 diabetes.

    abstract:OBJECTIVE:To assess the long-term cost-effectiveness of aspirin use among adults aged >or=40 years with newly diagnosed type 2 diabetes. RESEARCH DESIGN AND METHODS:We used a validated cost-effectiveness model of type 2 diabetes to assess the lifetime health and cost consequences of use or nonuse of aspirin. The model...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Li R,Zhang P,Barker LE,Hoerger TJ

    更新日期:2010-06-01 00:00:00

  • Consumption of sugar-sweetened beverages among adults with type 2 diabetes.

    abstract:OBJECTIVE:To examine patterns of sugar-sweetened beverage (SSB) consumption among U.S. adults with type 2 diabetes in 2003-2006. RESEARCH DESIGN AND METHODS:We analyzed 24-h dietary recall data from the National Health and Nutrition Examination Survey 2003-2006 to estimate SSB consumption levels among 1,090 adults (ag...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Bleich SN,Wang YC

    更新日期:2011-03-01 00:00:00

  • Role of liver in pathophysiology of NIDDM.

    abstract::Glucose homeostasis is physiologically maintained by the balance between glucose production by the liver and glucose utilization by the peripheral tissues. Insulin controls hepatic glucose production and promotes glucose utilization by the skeletal muscle. In non-insulin-dependent diabetes mellitus (NIDDM), postabsorp...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审


    authors: Consoli A

    更新日期:1992-03-01 00:00:00

  • Pioglitazone Improves Left Ventricular Diastolic Function in Subjects With Diabetes.

    abstract:OBJECTIVE:To examine the effect of pioglitazone on myocardial insulin sensitivity and left ventricular (LV) function in patients with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS:Twelve subjects with T2D and 12 with normal glucose tolerance received a euglycemic insulin clamp. Myocardial glucose uptake (MGU) and...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Clarke GD,Solis-Herrera C,Molina-Wilkins M,Martinez S,Merovci A,Cersosimo E,Chilton RJ,Iozzo P,Gastaldelli A,Abdul-Ghani M,DeFronzo RA

    更新日期:2017-11-01 00:00:00

  • Altered postprandial insulin requirement in IDDM patients with gastroparesis.

    abstract:OBJECTIVE:To evaluate the effect of gastric emptying on postprandial insulin requirement in insulin-dependent diabetes mellitus (IDDM) patients with and without gastroparesis. RESEARCH DESIGN AND METHODS:Postprandial insulin requirement and gastric emptying were simultaneously evaluated in five IDDM patients with gast...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章


    authors: Ishii M,Nakamura T,Kasai F,Onuma T,Baba T,Takebe K

    更新日期:1994-08-01 00:00:00

  • Progression of lower-extremity disability in older women with diabetes: the Women's Health and Aging Study.

    abstract:OBJECTIVE:Older patients with diabetes are more likely to have a higher prevalence of multiple risk factors for physical disability, as a result of diabetic complications. We evaluated the pace of decline in lower-extremity function and the risk for progression of disability in older women with diabetes. RESEARCH DESI...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Volpato S,Ferrucci L,Blaum C,Ostir G,Cappola A,Fried LP,Fellin R,Guralnik JM

    更新日期:2003-01-01 00:00:00

  • Blood glucose control by intermittent loop closure in the basal mode: computer simulation studies with a diabetic model.

    abstract::A semiclosed loop, bedside insulin infusion system using a simple basal infusion algorithm consisting of a linear transition between two insulin delivery rates as blood glucose (BG) increases has been developed. A theoretical study using computer simulation has now been undertaken to examine the effect of BG sampling ...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Furler SM,Kraegen EW,Smallwood RH,Chisholm DJ

    更新日期:1985-11-01 00:00:00

  • The impact of a decade of changing treatment on rates of severe hypoglycemia in a population-based cohort of children with type 1 diabetes.

    abstract:OBJECTIVE:To determine the impact of changes to treatment on the incidence of severe hypoglycemia and its risk factors in a large population-based cohort of children with type 1 diabetes. RESEARCH DESIGN AND METHODS:The cohort consisted of 1,335 children (age at entry 9.5 +/- 4.3 years [mean +/- SD], range 0-18), yiel...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Bulsara MK,Holman CD,Davis EA,Jones TW

    更新日期:2004-10-01 00:00:00

  • Effects of intravenous nicorandil before reperfusion for acute myocardial infarction in patients with stress hyperglycemia.

    abstract:OBJECTIVE:Stress hyperglycemia increases the risk of mortality and poor outcomes in patients with acute myocardial infarction (AMI). We aimed to assess effects of intravenous nicorandil administered before reperfusion on AMI patients with stress hyperglycemia. RESEARCH DESIGN AND METHODS:This study consisted of 158 co...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验


    authors: Ishii H,Ichimiya S,Kanashiro M,Amano T,Matsubara T,Murohara T

    更新日期:2006-02-01 00:00:00

  • Need for residential treatment for children with diabetes mellitus.

    abstract::Specialists in childhood diabetes in North America were queried about the need for residential facilities for their patients with recurrent hospitalizations and school deficits due to family coping problems. Of 132 respondents, 115 indicated a need for 5-12% of their patients, a total of 530, close to the estimate of ...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Rosenbloom AL

    更新日期:1982-09-01 00:00:00