Abstract:
OBJECTIVE:We examined the effect of intrauterine diabetes exposure (IDE) on the incidence of diabetic end-stage renal disease (ESRD) in Pima Indians with type 2 diabetes. RESEARCH DESIGN AND METHODS:Individuals were followed from their first diabetic examination until December 2006, death, ESRD, or age of 45 years. RESULTS:Among the 1,850 diabetic participants, 102 had IDE. ESRD developed in 57, 5 of whom had IDE. Cumulative incidence of ESRD by age 45 was 19.3% in participants with IDE and 5.1% in those without; the age- and sex-adjusted incidence rate ratio was 4.12 (95% CI 1.54-11.02). After additional adjustment for age at diabetes onset, ESRD incidence was similar in the two groups (incidence rate ratio 1.38, 95% CI 0.45-4.24). CONCLUSIONS:IDE increases the age- and sex-adjusted incidence of ESRD fourfold in young adults with type 2 diabetes, mediated primarily by the earlier onset of type 2 diabetes in those with IDE.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Pavkov ME,Hanson RL,Knowler WC,Sievers ML,Bennett PH,Nelson RGdoi
10.2337/dc10-0811subject
Has Abstractpub_date
2010-11-01 00:00:00pages
2396-8issue
11eissn
0149-5992issn
1935-5548pii
dc10-0811journal_volume
33pub_type
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