Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin.

Abstract:

OBJECTIVE:Of patients who are prescribed metformin, 10-30% have evidence of reduced vitamin B12 absorption. B12-intrinsic factor complex uptake by ileal cell surface receptors is known to be a process dependent on calcium availability Metformin affects calcium-dependent membrane action. The objective of this study was to determine the magnitude and mechanism of the reduction in serum vitamin B12 after metformin administration. RESEARCH DESIGN AND METHODS:A comparative study design was employed using 2 groups (metformin and control). A total of 21 patients with type 2 diabetes received sulfonylurea therapy; 14 of these 21 patients were switched to metformin. Monthly serum total vitamin B12 measurements and holotranscobalamin (holoTCII) (B12-TCII) were performed. After 3 months of metformin therapy, oral calcium supplementation was administered. RESULTS:Serial serum vitamin B12 determinations revealed a similar decline in vitamin B12 and holoTCII. Oral calcium supplementation reversed the metformin-induced serum holoTCII depression. CONCLUSIONS:Patients receiving metformin have diminished B12 absorption and low serum total vitamin B12 and TCII-B12 levels because of a calcium-dependent ileal membrane antagonism, an effect reversed with supplemental calcium.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Bauman WA,Shaw S,Jayatilleke E,Spungen AM,Herbert V

doi

10.2337/diacare.23.9.1227

subject

Has Abstract

pub_date

2000-09-01 00:00:00

pages

1227-31

issue

9

eissn

0149-5992

issn

1935-5548

journal_volume

23

pub_type

临床试验,杂志文章
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    更新日期:2006-11-01 00:00:00

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    pub_type: 杂志文章

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    authors: Byun DJ,Braunstein R,Flynn J,Zheng J,Lefkowitz RA,Kanbour S,Girotra M

    更新日期:2020-12-01 00:00:00

  • Peroxisome proliferator-activated receptor γ polymorphism Pro12Ala Is associated with nephropathy in type 2 diabetes: evidence from meta-analysis of 18 studies.

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    journal_title:Diabetes care

    pub_type: 杂志文章,meta分析

    doi:10.2337/dc11-2142

    authors: Zhang H,Zhu S,Chen J,Tang Y,Hu H,Mohan V,Venkatesan R,Wang J,Chen H

    更新日期:2012-06-01 00:00:00

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    pub_type: 杂志文章

    doi:10.2337/diacare.8.1.64

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    更新日期:1985-01-01 00:00:00

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    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.23.7.912

    authors: Goodman-Gruen D,Barrett-Connor E

    更新日期:2000-07-01 00:00:00

  • Translating lifestyle intervention to practice in obese patients with type 2 diabetes: Improving Control with Activity and Nutrition (ICAN) study.

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    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.27.7.1570

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    更新日期:2004-07-01 00:00:00

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    journal_title:Diabetes care

    pub_type: 杂志文章

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    pub_type: 评论,杂志文章

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    authors: Avogaro A,Fadini GP,Del Prato S

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    pub_type: 杂志文章

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    更新日期:2007-07-01 00:00:00

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    更新日期:1993-12-01 00:00:00

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    pub_type: 临床试验,杂志文章,随机对照试验

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    pub_type: 杂志文章

    doi:10.2337/dc14-1931

    authors: Cho NH,Kim KM,Choi SH,Park KS,Jang HC,Kim SS,Sattar N,Lim S

    更新日期:2015-07-01 00:00:00

  • 14. Management of Diabetes in Pregnancy: Standards of Medical Care in Diabetes-2019.

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    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/dc19-S014

    authors: American Diabetes Association.

    更新日期:2019-01-01 00:00:00

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    journal_title:Diabetes care

    pub_type: 杂志文章

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    authors: Devore EE,Stampfer MJ,Breteler MM,Rosner B,Kang JH,Okereke O,Hu FB,Grodstein F

    更新日期:2009-04-01 00:00:00

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    abstract::Twenty-nine diabetic renal failure patients suffered a psychosocial crisis at the time when chronic dialysis or renal transplantation was required. These patients could be classified into groups as to the impact of the crisis in terms of participation in life-support therapy. Group 1 consisted of potentially lethal me...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.4.1.99

    authors: D'Elia JA,Piening S,Kaldany A,Malarick C,Unger K,Ice S,Anderson RB,Miller DG,Lundin AP

    更新日期:1981-01-01 00:00:00

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    pub_type: 杂志文章

    doi:10.2337/diacare.12.6.409

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    pub_type: 杂志文章,meta分析,评审

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  • Controversies for Glucose Control Targets in Type 2 Diabetes: Exposing the Common Ground.

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    journal_title:Diabetes care

    pub_type: 杂志文章,评审

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    更新日期:2019-09-01 00:00:00

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    pub_type: 杂志文章

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    pub_type: 杂志文章

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  • Development of paper-strip test for 3-hydroxybutyrate and its clinical application.

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    journal_title:Diabetes care

    pub_type: 杂志文章

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    pub_type: 杂志文章,随机对照试验

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