Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin.

Abstract:

OBJECTIVE:Of patients who are prescribed metformin, 10-30% have evidence of reduced vitamin B12 absorption. B12-intrinsic factor complex uptake by ileal cell surface receptors is known to be a process dependent on calcium availability Metformin affects calcium-dependent membrane action. The objective of this study was to determine the magnitude and mechanism of the reduction in serum vitamin B12 after metformin administration. RESEARCH DESIGN AND METHODS:A comparative study design was employed using 2 groups (metformin and control). A total of 21 patients with type 2 diabetes received sulfonylurea therapy; 14 of these 21 patients were switched to metformin. Monthly serum total vitamin B12 measurements and holotranscobalamin (holoTCII) (B12-TCII) were performed. After 3 months of metformin therapy, oral calcium supplementation was administered. RESULTS:Serial serum vitamin B12 determinations revealed a similar decline in vitamin B12 and holoTCII. Oral calcium supplementation reversed the metformin-induced serum holoTCII depression. CONCLUSIONS:Patients receiving metformin have diminished B12 absorption and low serum total vitamin B12 and TCII-B12 levels because of a calcium-dependent ileal membrane antagonism, an effect reversed with supplemental calcium.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Bauman WA,Shaw S,Jayatilleke E,Spungen AM,Herbert V

doi

10.2337/diacare.23.9.1227

subject

Has Abstract

pub_date

2000-09-01 00:00:00

pages

1227-31

issue

9

eissn

0149-5992

issn

1935-5548

journal_volume

23

pub_type

临床试验,杂志文章
  • Effect of chronic intermittent intravenous insulin therapy on antihypertensive medication requirements in IDDM subjects with hypertension and nephropathy.

    abstract:OBJECTIVE:The prevalence of systemic hypertension is increased in patients with diabetes. In this prospective, randomized, crossover clinical trial, we assessed antihypertensive effects of chronic intermittent intravenous insulin therapy (CIIIT) on insulin-dependent diabetes mellitus (IDDM) subjects with hypertension a...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.18.9.1260

    authors: Aoki TT,Grecu EO,Prendergast JJ,Arcangeli MA,Meisenheimer R

    更新日期:1995-09-01 00:00:00

  • Inflammation markers and metabolic characteristics of subjects with 1-h plasma glucose levels.

    abstract:OBJECTIVE:To assess the association of 1-h plasma glucose (1hPG) and inflammation with normal glucose tolerance (NGT) and pre-diabetes. RESEARCH DESIGN AND METHODS:A cohort of 1,062 subjects was enrolled. After oral glucose load (oral glucose tolerance test), we compared subjects with NGT and pre-diabetes above and be...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-1342

    authors: Bardini G,Dicembrini I,Cresci B,Rotella CM

    更新日期:2010-02-01 00:00:00

  • Expression of matrix metalloproteinases, cytokines, and connexins in diabetic and nondiabetic human keratinocytes before and after transplantation into an ex vivo wound-healing model.

    abstract:OBJECTIVE:Wound healing is known to require a well-organized balance of numerous factors, e.g., cytokines, matrix metalloproteinases (MMPs), and their inhibitors, as well as direct cell-cell communication (connexins). Disruption of this balance may lead to the formation of chronic wounds such as diabetic foot ulcers. T...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc07-1304

    authors: Brandner JM,Zacheja S,Houdek P,Moll I,Lobmann R

    更新日期:2008-01-01 00:00:00

  • High incidence of childhood type 1 diabetes in Liguria, Italy, from 1989 to 1998.

    abstract:OBJECTIVE:Assessing updated incidence of type 1 diabetes in 0- to 14-year-old children in Liguria, a Northwest region of Italy. RESEARCH DESIGN AND METHODS:Incident cases were recorded prospectively from 1989 to 1998. Incidence rates (IRs) were standardized to the 1999 world population using the direct method. The ind...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.26.6.1786

    authors: Cotellessa M,Barbieri P,Mazzella M,Bonassi S,Minicucci L,Lorini R

    更新日期:2003-06-01 00:00:00

  • Heart rate variability in diabetes: relationship to age and duration of the disease.

    abstract::Heart rate variability (HRV) during deep breathing was studied with a neonatal heart monitor in 143 control subjects and 218 patients with diabetes (102 with IDDM and 116 with NIDDM). In the control group HRV decreased after age 20 by 4-5 beats per decade (from 29.7 +/- 5.8 beats at age 20-29 to 11.8 +/- 5.4 beats at ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.8.1.64

    authors: Masaoka S,Lev-Ran A,Hill LR,Vakil G,Hon EH

    更新日期:1985-01-01 00:00:00

  • Determinants of elevated urinary albumin in the 4,937 type 2 diabetic subjects recruited for the DIABHYCAR Study in Western Europe and North Africa.

    abstract:OBJECTIVE:Whether ACE inhibition is useful for type 2 diabetic patients with micro- and macroalbuminuria remains unknown. The Non-Insulin-Dependent Diabetes, Hypertension, Microalbuminuria, Cardiovascular Events and Ramipril (DIABHYCAR) Study was set up to address this issue through a multicenter double-blind parallel ...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors: Marre M,Lièvre M,Vasmant D,Gallois Y,Hadjadj S,Reglier JC,Chatellier G,Mann J,Viberti GC,Passa P

    更新日期:2000-04-01 00:00:00

  • Motor vehicle accidents and IDDM.

    abstract::A case-control study examining the 1-yr motor vehicle accident experiences of 158 insulin-dependent diabetes mellitus (IDDM) cases and 158 nondiabetic siblings was undertaken to evaluate the risk of motor vehicle accidents among drivers with IDDM. In multivariate analyses the overall accident risk of the cases and con...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.11.9.701

    authors: Songer TJ,LaPorte RE,Dorman JS,Orchard TJ,Cruickshanks KJ,Becker DJ,Drash AL

    更新日期:1988-10-01 00:00:00

  • Can new-onset diabetes after kidney transplant be prevented?

    abstract::Because the negative consequences of new-onset diabetes mellitus after transplantation (NODAT) diminish the significant gains of kidney transplantation, it is imperative to develop clinical interventions to reduce the incidence of NODAT. In this review, we discuss whether intensive lifestyle interventions that delay o...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/dc12-2067

    authors: Chakkera HA,Weil EJ,Pham PT,Pomeroy J,Knowler WC

    更新日期:2013-05-01 00:00:00

  • Beneficial effects of viscous dietary fiber from Konjac-mannan in subjects with the insulin resistance syndrome: results of a controlled metabolic trial.

    abstract:OBJECTIVE:Dietary fiber has recently received recognition for reducing the risk of developing diabetes and heart disease. The implication is that it may have therapeutic benefit in prediabetic metabolic conditions. To test this hypothesis, we investigated the effect of supplementing a high-carbohydrate diet with fiber ...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.2337/diacare.23.1.9

    authors: Vuksan V,Sievenpiper JL,Owen R,Swilley JA,Spadafora P,Jenkins DJ,Vidgen E,Brighenti F,Josse RG,Leiter LA,Xu Z,Novokmet R

    更新日期:2000-01-01 00:00:00

  • Glucose and insulin measurements from the oral glucose tolerance test and mortality prediction.

    abstract:OBJECTIVE:To verify what information from oral glucose tolerance tests (OGTTs) independently predicts mortality. RESEARCH DESIGN AND METHODS:A total of 1,401 initially nondiabetic participants from the Baltimore Longitudinal Study of Aging aged 17-95 years underwent one or more OGTTs (median 2, range 1-8), with insuli...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc07-2102

    authors: Metter EJ,Windham BG,Maggio M,Simonsick EM,Ling SM,Egan JM,Ferrucci L

    更新日期:2008-05-01 00:00:00

  • Metabolic control in adolescent girls: links to relationality and the female sense of self.

    abstract:OBJECTIVE:This study investigated whether intimacy and autonomy in mother-daughter interactions and relational aspects of the self are associated with metabolic control in adolescent girls with type 1 diabetes. RESEARCH DESIGN AND METHODS:This cross-sectional study included 88 girls with diabetes (mean age 14.9 +/- 2....

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.27.3.709

    authors: Maharaj S,Daneman D,Olmsted M,Rodin G

    更新日期:2004-03-01 00:00:00

  • Depression and diabetes: a large population-based study of sociodemographic, lifestyle, and clinical factors associated with depression in type 1 and type 2 diabetes.

    abstract:OBJECTIVE:The purpose of this study was to investigate factors associated with depression in type 1 and type 2 diabetes and test whether these differ from factors associated with depression in the nondiabetic population. RESEARCH DESIGN AND METHODS:In an unselected population study comprising 60,869 individuals, poten...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.28.8.1904

    authors: Engum A,Mykletun A,Midthjell K,Holen A,Dahl AA

    更新日期:2005-08-01 00:00:00

  • Cross-sectional analysis of renal function in black Americans with NIDDM.

    abstract::Our objective was to define glomerular filtration rate (GFR) and renal plasma flow (RPF) in Black Americans with non-insulin-dependent diabetes mellitus (NIDDM). This was a cross-sectional study of 71 Black NIDDM patients with diagnosed diabetes duration from 1 mo to 21 yr. Hyperglycemia was regulated and stabilized b...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.13.11.1186

    authors: Lebovitz HE,Palmisano J

    更新日期:1990-11-01 00:00:00

  • Incidences, treatments, outcomes, and sex effect on survival in patients with end-stage renal disease by diabetes status in Australia and New Zealand (1991 2005).

    abstract:OBJECTIVE:We aimed to update the epidemiology of type 1 and type 2 diabetic patients among the incident end-stage renal disease (ESRD) population in Australia and New Zealand (ANZ) and to determine whether outcome is worse for diabetic women, as described in the general population. RESEARCH DESIGNS AND METHODS:All res...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc07-0895

    authors: Villar E,Chang SH,McDonald SP

    更新日期:2007-12-01 00:00:00

  • Role of adiposity and lifestyle in the relationship between family history of diabetes and 20-year incidence of type 2 diabetes in U.S. women.

    abstract:OBJECTIVE:To evaluate to what extent the association between family history of diabetes and risk of type 2 diabetes can be explained by excess adiposity and lifestyle risk factors. RESEARCH DESIGN AND METHODS:We analyzed data from 73,227 women who participated in the Nurses' Health Study cohort. A family history of di...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-1586

    authors: van 't Riet E,Dekker JM,Sun Q,Nijpels G,Hu FB,van Dam RM

    更新日期:2010-04-01 00:00:00

  • Hypocalcemia, hypomagnesemia, and transient hypoparathyroidism during therapy with potassium phosphate in diabetic ketoacidosis.

    abstract::The effects of intravenous administration of potassium phosphate in the treatment of diabetic ketoacidosis were studied in nine children, ages 9 9/12 to 17 10/12 yr. During phosphate infusion (20--40 meq/L of fluid), all children maintained normal serum concentrations of phosphorus. Transient hypocalcemia occurred in ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.2.3.265

    authors: Zipf WB,Bacon GE,Spencer ML,Kelch RP,Hopwood NJ,Hawker CD

    更新日期:1979-05-01 00:00:00

  • Acute effects of insulin in the control of VLDL production in humans. Implications for the insulin-resistant state.

    abstract::The role of hyperinsulinemia in the pathogenesis of triglyceride (TG) and VLDL over-production in insulin-resistant states remains controversial. While studies in humans and animals have generally suggested that chronic hyperinsulinemia facilitates VLDL production, particularly in the presence of an abundant supply of...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/diacare.19.4.390

    authors: Lewis GF,Steiner G

    更新日期:1996-04-01 00:00:00

  • Diabetes in a Large Dementia Cohort: Clinical Characteristics and Treatment From the Swedish Dementia Registry.

    abstract:OBJECTIVE:We aimed to investigate the differences in clinical characteristics and pharmacological treatment associated with the presence of diabetes in a large cohort of patients with dementia. RESEARCH DESIGN AND METHODS:A cross-sectional registry-based study was conducted using data from the Swedish Dementia Registr...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc16-2516

    authors: Secnik J,Cermakova P,Fereshtehnejad SM,Dannberg P,Johnell K,Fastbom J,Winblad B,Eriksdotter M,Religa D

    更新日期:2017-09-01 00:00:00

  • Skin autofluorescence as a noninvasive marker of vascular damage in patients with type 2 diabetes.

    abstract:OBJECTIVE:Advanced glycation end products (AGEs) are thought to have a role in the pathogenesis of diabetes complications. We recently reported the association between skin autofluorescence, as a measure of tissue AGE accumulation, and diabetic neuropathy in a selected diabetic population. In this study, we investigate...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc05-2173

    authors: Lutgers HL,Graaff R,Links TP,Ubink-Veltmaat LJ,Bilo HJ,Gans RO,Smit AJ

    更新日期:2006-12-01 00:00:00

  • Lipid, glycemic, and insulin responses to meals rich in saturated, cis-monounsaturated, and polyunsaturated (n-3 and n-6) fatty acids in subjects with type 2 diabetes.

    abstract:OBJECTIVE:The recommendations for dietary fats in patients with type 2 diabetes are based largely on the impact of fatty acids on fasting serum lipid and glucose concentrations. How fatty acids affect postprandial insulin, glucose, and triglyceride concentrations, however, remains unclear. The objective of this study w...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc07-1026

    authors: Shah M,Adams-Huet B,Brinkley L,Grundy SM,Garg A

    更新日期:2007-12-01 00:00:00

  • Electron microscopy of insulin precipitates.

    abstract::Morphologic characteristics of insulin precipitates were examined by both scanning and transmission electron microscopy. Insulin precipitate obtained after 1 wk of in vivo storage in an implanted dog reservoir was compared with insulin precipitate produced in vitro by isoelectric precipitation, acid-freeze-heat precip...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.5.1.25

    authors: Schade DS,Eaton RP,DeLongo J,Saland LC,Ladman AJ,Carlson GA

    更新日期:1982-01-01 00:00:00

  • Predictors of glycemic control in insulin-using adults with type 2 diabetes.

    abstract:OBJECTIVE:To determine the characteristics that influence glycemic control among insulin-using adults with type 2 diabetes. RESEARCH DESIGN AND METHODS:We studied all 1,333 eligible members of a large not-for-profit health maintenance organization who responded to a 1997 survey. We tested associations among demographi...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.23.3.273

    authors: Nichols GA,Hillier TA,Javor K,Brown JB

    更新日期:2000-03-01 00:00:00

  • Clinical predictors of disease progression and medication initiation in untreated patients with type 2 diabetes and A1C less than 7%.

    abstract:OBJECTIVE:Many patients with early diabetes remain untreated. Our objectives were to identify clinical predictors of 1) worsening glycemic control and 2) medical treatment initiation in response to worsening glycemic control among patients with type 2 diabetes. RESEARCH DESIGN AND METHODS:We identified 5,804 type 2 di...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc07-1934

    authors: Pani LN,Nathan DM,Grant RW

    更新日期:2008-03-01 00:00:00

  • Diabetes care in health maintenance organizations.

    abstract::An increasing amount of health care today is directed to the amelioration of chronic diseases for which there are no cures. Technological advances and the aging of the population have increased the costs of that care. In an attempt to control costs and increase the efficiency of health care, it is being increasingly d...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/diacare.15.1.s44

    authors: Geffner DL

    更新日期:1992-03-01 00:00:00

  • Declining Rates of Hospitalization for Selected Cardiovascular Disease Conditions Among Adults Aged ≥35 Years With Diagnosed Diabetes, U.S., 1998-2014.

    abstract:OBJECTIVE:Reductions in heart attack and stroke hospitalizations are well documented in the U.S. population with diabetes. We extended trend analyses to other cardiovascular disease (CVD) conditions, including stroke by type, and used four additional years of data. RESEARCH DESIGN AND METHODS:Using 1998-2014 National ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc17-1259

    authors: Burrows NR,Li Y,Gregg EW,Geiss LS

    更新日期:2018-02-01 00:00:00

  • Ser1369Ala variant in sulfonylurea receptor gene ABCC8 is associated with antidiabetic efficacy of gliclazide in Chinese type 2 diabetic patients.

    abstract:OBJECTIVE:The purpose of this study was to investigate whether genetic variants could influence the antidiabetic efficacy of gliclazide in type 2 diabetic patients. RESEARCH DESIGN AND METHODS:A total of 1,268 type 2 diabetic patients whose diabetes was diagnosed within the past 5 years and who had no recent hypoglyce...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/dc07-2248

    authors: Feng Y,Mao G,Ren X,Xing H,Tang G,Li Q,Li X,Sun L,Yang J,Ma W,Wang X,Xu X

    更新日期:2008-10-01 00:00:00

  • Cardiovascular and Other Outcomes Postintervention With Insulin Glargine and Omega-3 Fatty Acids (ORIGINALE).

    abstract:OBJECTIVE:The Outcome Reduction With Initial Glargine Intervention (ORIGIN) trial reported neutral effects of insulin glargine on cardiovascular outcomes and cancers and reduced incident diabetes in high-cardiovascular risk adults with dysglycemia after 6.2 years of active treatment. Omega-3 fatty acids had neutral eff...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc15-1676

    authors: ORIGIN Trial Investigators.

    更新日期:2016-05-01 00:00:00

  • Detection of Diabetes Status and Type in Youth Using Electronic Health Records: The SEARCH for Diabetes in Youth Study.

    abstract:OBJECTIVE:Diabetes surveillance often requires manual medical chart reviews to confirm status and type. This project aimed to create an electronic health record (EHR)-based procedure for improving surveillance efficiency through automation of case identification. RESEARCH DESIGN AND METHODS:Youth (<20 years old) with ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc20-0063

    authors: Wells BJ,Lenoir KM,Wagenknecht LE,Mayer-Davis EJ,Lawrence JM,Dabelea D,Pihoker C,Saydah S,Casanova R,Turley C,Liese AD,Standiford D,Kahn MG,Hamman R,Divers J

    更新日期:2020-10-01 00:00:00

  • Well-being and treatment satisfaction in older people with diabetes.

    abstract:OBJECTIVE:To measure well-being and treatment satisfaction and their correlates in older people with diabetes. RESEARCH DESIGN AND METHODS:A postal survey was conducted of 1,000 diabetic patients aged > or = 60 years, representing 56% of the resident older diabetic population in an inner-city health district with a la...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.21.6.930

    authors: Petterson T,Lee P,Hollis S,Young B,Newton P,Dornan T

    更新日期:1998-06-01 00:00:00

  • Pharmacological treatment of the pathogenetic defects in type 2 diabetes: the randomized multicenter South Danish Diabetes Study.

    abstract:OBJECTIVE:To determine the effect of treatment with insulin aspart compared with NPH insulin, together with metformin/placebo and rosiglitazone/placebo. The hypothesis was that combined correction of major pathogenetic defects in type 2 diabetes would result in optimal glycemic control. RESEARCH DESIGN AND METHODS:Thi...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2337/dc10-0531

    authors: Gram J,Henriksen JE,Grodum E,Juhl H,Hansen TB,Christiansen C,Yderstræde K,Gjessing H,Hansen HM,Vestergaard V,Hangaard J,Beck-Nielsen H

    更新日期:2011-01-01 00:00:00