Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin.


OBJECTIVE:Of patients who are prescribed metformin, 10-30% have evidence of reduced vitamin B12 absorption. B12-intrinsic factor complex uptake by ileal cell surface receptors is known to be a process dependent on calcium availability Metformin affects calcium-dependent membrane action. The objective of this study was to determine the magnitude and mechanism of the reduction in serum vitamin B12 after metformin administration. RESEARCH DESIGN AND METHODS:A comparative study design was employed using 2 groups (metformin and control). A total of 21 patients with type 2 diabetes received sulfonylurea therapy; 14 of these 21 patients were switched to metformin. Monthly serum total vitamin B12 measurements and holotranscobalamin (holoTCII) (B12-TCII) were performed. After 3 months of metformin therapy, oral calcium supplementation was administered. RESULTS:Serial serum vitamin B12 determinations revealed a similar decline in vitamin B12 and holoTCII. Oral calcium supplementation reversed the metformin-induced serum holoTCII depression. CONCLUSIONS:Patients receiving metformin have diminished B12 absorption and low serum total vitamin B12 and TCII-B12 levels because of a calcium-dependent ileal membrane antagonism, an effect reversed with supplemental calcium.


Diabetes Care


Diabetes care


Bauman WA,Shaw S,Jayatilleke E,Spungen AM,Herbert V




Has Abstract


2000-09-01 00:00:00












  • Association of Weight Loss Maintenance and Weight Regain on 4-Year Changes in CVD Risk Factors: the Action for Health in Diabetes (Look AHEAD) Clinical Trial.

    abstract:OBJECTIVE:Short-term weight loss improves cardiovascular disease (CVD) risk factors. We sought to determine the longer-term effects of maintaining weight loss or, conversely, regaining weight. RESEARCH DESIGN AND METHODS:We used data from Action for Health in Diabetes (Look AHEAD), a randomized trial of intensive life...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验


    authors: Wing RR,Espeland MA,Clark JM,Hazuda HP,Knowler WC,Pownall HJ,Unick J,Wadden T,Wagenknecht L,Action for Health in Diabetes (Look AHEAD) Study Group.

    更新日期:2016-08-01 00:00:00

  • Comparison of glargine insulin versus rosiglitazone addition in poorly controlled type 2 diabetic patients on metformin plus sulfonylurea.

    abstract:OBJECTIVE:We sought to examine the mechanisms by which the addition of glargine insulin or rosiglitazone improves glycemic control in type 2 diabetic subjects poorly controlled on maximally effective doses of metformin plus sulfonylurea. RESEARCH DESIGN AND METHODS:Subjects (aged 47 +/- 11 years, BMI 31 +/- 5 kg/m(2),...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章


    authors: Triplitt C,Glass L,Miyazaki Y,Wajcberg E,Gastaldelli A,De Filippis E,Cersosimo E,DeFronzo RA

    更新日期:2006-11-01 00:00:00

  • Glycemic control in early IDDM. The Wisconsin Diabetes Registry.

    abstract:OBJECTIVE:A cohort (n = 277) was followed from diabetes diagnosis to evaluate longitudinal glycemic control, urinary C-peptide levels, and certain features of diabetes self-management. RESEARCH DESIGN AND METHODS:Unselected cases with IDDM, who were less than 30 yr of age, were identified at diagnosis from a 28-county...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Allen C,Zaccaro DJ,Palta M,Klein R,Duck SC,D'Alessio DJ

    更新日期:1992-08-01 00:00:00

  • Immune Checkpoint Inhibitor-Associated Diabetes: A Single-Institution Experience.

    abstract:OBJECTIVE:To characterize immune checkpoint inhibitor-associated diabetes mellitus (ICI-DM) in a single-institution case series. RESEARCH DESIGN AND METHODS:Retrospective chart review of 18 patients with new-onset ICI-DM following anti-programmed cell death protein 1 (PD-1)/anti-programmed cell death protein ligand 1 ...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Byun DJ,Braunstein R,Flynn J,Zheng J,Lefkowitz RA,Kanbour S,Girotra M

    更新日期:2020-12-01 00:00:00

  • Peroxisome proliferator-activated receptor γ polymorphism Pro12Ala Is associated with nephropathy in type 2 diabetes: evidence from meta-analysis of 18 studies.

    abstract:OBJECTIVE:Insulin resistance plays a part in diabetic nephropathy (DN). The association between the peroxisome proliferator-activated receptor γ Pro to Ala alteration at codon 12 (Pro12Ala) polymorphism and the risk of insulin resistance has been confirmed. The association between the polymorphism and DN risk has also ...

    journal_title:Diabetes care

    pub_type: 杂志文章,meta分析


    authors: Zhang H,Zhu S,Chen J,Tang Y,Hu H,Mohan V,Venkatesan R,Wang J,Chen H

    更新日期:2012-06-01 00:00:00

  • Heart rate variability in diabetes: relationship to age and duration of the disease.

    abstract::Heart rate variability (HRV) during deep breathing was studied with a neonatal heart monitor in 143 control subjects and 218 patients with diabetes (102 with IDDM and 116 with NIDDM). In the control group HRV decreased after age 20 by 4-5 beats per decade (from 29.7 +/- 5.8 beats at age 20-29 to 11.8 +/- 5.4 beats at ...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Masaoka S,Lev-Ran A,Hill LR,Vakil G,Hon EH

    更新日期:1985-01-01 00:00:00

  • Sex differences in the association of endogenous sex hormone levels and glucose tolerance status in older men and women.

    abstract:OBJECTIVE:Some evidence suggests an inverse association between type 2 diabetes and androgens in men and a positive association between type 2 diabetes and androgens in women. The purpose of this community-based study was to evaluate sex differences in the association between endogenous total and bioavailable estrogen ...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Goodman-Gruen D,Barrett-Connor E

    更新日期:2000-07-01 00:00:00

  • Translating lifestyle intervention to practice in obese patients with type 2 diabetes: Improving Control with Activity and Nutrition (ICAN) study.

    abstract:OBJECTIVE:To assess the efficacy of a lifestyle intervention program that can be readily translated into clinical practice for obese patients with type 2 diabetes. RESEARCH DESIGN AND METHODS:The study consisted of a 12-month randomized controlled trial of 147 health plan members with type 2 diabetes and obesity (BMI ...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Wolf AM,Conaway MR,Crowther JQ,Hazen KY,L Nadler J,Oneida B,Bovbjerg VE,Improving Control with Activity and Nutrition (ICAN) Study.

    更新日期:2004-07-01 00:00:00

  • BMI and All-Cause Mortality in Normoglycemia, Impaired Fasting Glucose, Newly Diagnosed Diabetes, and Prevalent Diabetes: A Cohort Study.

    abstract:OBJECTIVE:This study examined associations between BMI and mortality in individuals with normoglycemia, impaired fasting glucose (IFG), newly diagnosed diabetes, and prevalent diabetes and identified BMI ranges associated with the lowest mortality in each group. RESEARCH DESIGN AND METHODS:A total of 12,815,006 adults...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Lee EY,Lee YH,Yi SW,Shin SA,Yi JJ

    更新日期:2017-08-01 00:00:00

  • Reinterpreting Cardiorenal Protection of Renal Sodium-Glucose Cotransporter 2 Inhibitors via Cellular Life History Programming.

    abstract::Cardiovascular outcome trials have provided evidence that sodium-glucose cotransporter 2 inhibitor (SGLT2i) treatment is associated with remarkably favorable cardiovascular outcomes. Here, we offer a novel hypothesis that may encompass many of these hypothetical mechanisms, i.e., the ability of SGLT2i to modify the tr...

    journal_title:Diabetes care

    pub_type: 评论,杂志文章


    authors: Avogaro A,Fadini GP,Del Prato S

    更新日期:2020-03-01 00:00:00

  • Elevated cystatin C concentration and progression to pre-diabetes: the Western New York study.

    abstract:OBJECTIVE:We conducted a nested case-control investigation to examine whether elevated baseline concentrations of cystatin C predicted progression from normoglycemia to pre-diabetes over 6 years of follow-up from the Western New York Health Study. RESEARCH DESIGN AND METHODS:In 2002-2004, 1,455 participants from the W...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Donahue RP,Stranges S,Rejman K,Rafalson LB,Dmochowski J,Trevisan M

    更新日期:2007-07-01 00:00:00

  • Effects on blood pressure, glucose, and lipid levels of a high-monounsaturated fat diet compared with a high-carbohydrate diet in NIDDM subjects.

    abstract:OBJECTIVE:To compare the influence on blood pressure, glucose, and lipid levels of a diet rich in monounsaturated fatty acids with an isocaloric, high-carbohydrate diet in 15 NIDDM subjects. RESEARCH DESIGN AND METHODS:A crossover design with diet interventions and wash-out periods of 3 wk was applied. The patients we...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Rasmussen OW,Thomsen C,Hansen KW,Vesterlund M,Winther E,Hermansen K

    更新日期:1993-12-01 00:00:00

  • Lowering of plasma glucose concentrations with bezafibrate in patients with moderately controlled NIDDM.

    abstract::The goal of this study was to investigate whether treatment with bezafibrate improves glucose tolerance in non-insulin-dependent diabetes mellitus (NIDDM). The study included 37 NIDDM patients with HbA1 concentrations greater than 8.5% and normal kidney and liver function who were being treated with diet alone or diet...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Jones IR,Swai A,Taylor R,Miller M,Laker MF,Alberti KG

    更新日期:1990-08-01 00:00:00

  • High Blood Pressure and Its Association With Incident Diabetes Over 10 Years in the Korean Genome and Epidemiology Study (KoGES).

    abstract:OBJECTIVE:No prospective, community-based cohort studies have investigated the association between blood pressure and diabetes in Asian ethnicity. We investigated this issue in a 10-year prospective, community-based study of Koreans. RESEARCH DESIGN AND METHODS:We studied whether high blood pressure was associated wit...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Cho NH,Kim KM,Choi SH,Park KS,Jang HC,Kim SS,Sattar N,Lim S

    更新日期:2015-07-01 00:00:00

  • 14. Management of Diabetes in Pregnancy: Standards of Medical Care in Diabetes-2019.

    abstract::The American Diabetes Association (ADA) "Standards of Medical Care in Diabetes" includes ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Co...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审


    authors: American Diabetes Association.

    更新日期:2019-01-01 00:00:00

  • Dietary fat intake and cognitive decline in women with type 2 diabetes.

    abstract:OBJECTIVE:Individuals with type 2 diabetes have high risk of late-life cognitive impairment, yet little is known about strategies to modify risk. Targeting insulin resistance and vascular complications-both associated with cognitive decline-may be a productive approach. We investigated whether dietary fat, which modula...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Devore EE,Stampfer MJ,Breteler MM,Rosner B,Kang JH,Okereke O,Hu FB,Grodstein F

    更新日期:2009-04-01 00:00:00

  • Psychosocial crisis in diabetic renal failure.

    abstract::Twenty-nine diabetic renal failure patients suffered a psychosocial crisis at the time when chronic dialysis or renal transplantation was required. These patients could be classified into groups as to the impact of the crisis in terms of participation in life-support therapy. Group 1 consisted of potentially lethal me...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: D'Elia JA,Piening S,Kaldany A,Malarick C,Unger K,Ice S,Anderson RB,Miller DG,Lundin AP

    更新日期:1981-01-01 00:00:00

  • Family functioning and metabolic control of school-aged children with IDDM.

    abstract::The relationship of two aspects of family life to metabolic control were examined as part of a longitudinal study of school-aged children with newly diagnosed insulin-dependent diabetes mellitus (IDDM). Glycosylated hemoglobin level was the primary index of metabolic control; weight-adjusted insulin dosage served as a...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Kovacs M,Kass RE,Schnell TM,Goldston D,Marsh J

    更新日期:1989-06-01 00:00:00

  • Magnesium intake and risk of type 2 diabetes: meta-analysis of prospective cohort studies.

    abstract:OBJECTIVE:Emerging epidemiological evidence suggests that higher magnesium intake may reduce diabetes incidence. We aimed to examine the association between magnesium intake and risk of type 2 diabetes by conducting a meta-analysis of prospective cohort studies. RESEARCH DESIGN AND METHODS:We conducted a PubMed databa...

    journal_title:Diabetes care

    pub_type: 杂志文章,meta分析,评审


    authors: Dong JY,Xun P,He K,Qin LQ

    更新日期:2011-09-01 00:00:00

  • Controversies for Glucose Control Targets in Type 2 Diabetes: Exposing the Common Ground.

    abstract::Glycated hemoglobin targets have been given in guidelines for the last three decades, mostly without change at around 6.5-7.0% (47-53 mmol/mol). Personalization of such targets has also long been advocated, but often with little and inappropriate guidance. More recently some have suggested higher targets might be indi...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审


    authors: Home P

    更新日期:2019-09-01 00:00:00

  • Incidence of type 1 diabetes in Lithuanians aged 0-39 years varies by the urban-rural setting, and the time change differs for men and women during 1991-2000.

    abstract:OBJECTIVE:Type 1 diabetes has been associated with factors related to welfare and social class. During the past decade, Lithuania has experienced a transition period, leading to dramatic changes in the socioeconomic structure of the society. RESEARCH DESIGN AND METHODS:Incidence in the group aged 0-39 years by urban-r...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Pundziute-Lyckå A,Urbonaite B,Ostrauskas R,Zalinkevicius R,Dahlquist GG

    更新日期:2003-03-01 00:00:00

  • Development of questionnaire to examine relationship of physical activity and diabetes in Pima Indians.

    abstract::There was a need to design a questionnaire that could accurately assess the activity patterns of Native Americans to evaluate the relationship between physical activity and diabetes. Such a questionnaire was developed and implemented into the data collection scheme of the prospective Pima Indian Study of Arizona. The ...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Kriska AM,Knowler WC,LaPorte RE,Drash AL,Wing RR,Blair SN,Bennett PH,Kuller LH

    更新日期:1990-04-01 00:00:00

  • Long-term Follow-up of Glycemic and Neurological Outcomes in an International Series of Patients With Sulfonylurea-Treated ABCC8 Permanent Neonatal Diabetes.

    abstract:OBJECTIVE:ABCC8 mutations cause neonatal diabetes mellitus that can be transient (TNDM) or, less commonly, permanent (PNDM); ∼90% of individuals can be treated with oral sulfonylureas instead of insulin. Previous studies suggested that people with ABCC8-PNDM require lower sulfonylurea doses and have milder neurological...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Bowman P,Mathews F,Barbetti F,Shepherd MH,Sanchez J,Piccini B,Beltrand J,Letourneau-Freiberg LR,Polak M,Greeley SAW,Rawlins E,Babiker T,Thomas NJ,De Franco E,Ellard S,Flanagan SE,Hattersley AT,Neonatal Diabetes Internat

    更新日期:2021-01-01 00:00:00

  • Development of paper-strip test for 3-hydroxybutyrate and its clinical application.

    abstract::A rapid paper-strip test for the semiquantitating 3-hydroxybutyrate (3-OHBA) has been developed. The color develops within 5 min after applying the serum to the paper strip, and the purple color was read either visually or by reflectance meter. This can detect 3-OHBA levels as low as 0.1 mmol/L up to 2.0 mmol/L. The m...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Harano Y,Suzuki M,Kojima H,Kashiwagi A,Hidaka H,Shigeta Y

    更新日期:1984-09-01 00:00:00

  • High incidence of childhood-onset IDDM in Kuwait. Kuwait Study Group of Diabetes in Childhood.

    abstract:OBJECTIVE:To determine the incidence of insulin-dependent diabetes mellitus (IDDM) in children aged 0-14 years in Kuwait, as part of the World Health Organization Multinational Collaborative Study (DIAMOND), and to determine if the incidence rates have increased. RESEARCH DESIGN AND METHODS:All cases of IDDM diagnosed...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Shaltout AA,Qabazard MA,Abdella NA,LaPorte RE,al Arouj M,Ben Nekhi A,Moussa MA,al Khawari MA

    更新日期:1995-07-01 00:00:00

  • Young Children Have Higher Variability of Insulin Requirements: Observations During Hybrid Closed-Loop Insulin Delivery.

    abstract:OBJECTIVE:To quantify age-related variability of insulin needs during day and night closed-loop insulin delivery. RESEARCH DESIGN AND METHODS:We retrospectively analyzed data from hybrid closed-loop studies involving young children (1-6 years old, n = 20), children (7-12 years, n = 21), adolescents (13-17 years, n = 1...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Dovc K,Boughton C,Tauschmann M,Thabit H,Bally L,Allen JM,Acerini CL,Arnolds S,de Beaufort C,Bergenstal RM,Campbell F,Criego A,Dunger DB,Elleri D,Evans ML,Fröhlich-Reiterer E,Hofer S,Kapellen T,Leelarathna L,Pieber T

    更新日期:2019-07-01 00:00:00

  • Heterogeneous Contribution of Insulin Sensitivity and Secretion Defects to Gestational Diabetes Mellitus.

    abstract:OBJECTIVE:To characterize physiologic subtypes of gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS:Insulin sensitivity and secretion were estimated in 809 women at 24-30 weeks' gestation, using oral glucose tolerance test-based indices. In women with GDM (8.3%), defects in insulin sensitivity or secret...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Powe CE,Allard C,Battista MC,Doyon M,Bouchard L,Ecker JL,Perron P,Florez JC,Thadhani R,Hivert MF

    更新日期:2016-06-01 00:00:00

  • C-Peptide Decline in Type 1 Diabetes Has Two Phases: An Initial Exponential Fall and a Subsequent Stable Phase.

    abstract:OBJECTIVE:The decline in C-peptide in the 5 years after diagnosis of type 1 diabetes has been well studied, but little is known about the longer-term trajectory. We aimed to examine the association between log-transformed C-peptide levels and the duration of diabetes up to 40 years after diagnosis. RESEARCH DESIGN AND...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Shields BM,McDonald TJ,Oram R,Hill A,Hudson M,Leete P,Pearson ER,Richardson SJ,Morgan NG,Hattersley AT,TIGI Consortium.

    更新日期:2018-07-01 00:00:00

  • Association of Blood Glucose Control and Lipids With Diabetic Retinopathy in the Veterans Affairs Diabetes Trial (VADT).

    abstract:OBJECTIVE:This study examined whether lipids modify the relationship between intensive glucose control (INT) and diabetic retinopathy (DR). RESEARCH DESIGN AND METHODS:The incidence and progression of DR were assessed in 858 of 1,791 participants with 7-field stereoscopic fundus photographs at baseline and 5 years lat...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验


    authors: Azad N,Bahn GD,Emanuele NV,Agrawal L,Ge L,Reda D,Klein R,Reaven PD,Hayward R,VADT Study Group.

    更新日期:2016-05-01 00:00:00

  • Costimulation modulation with abatacept in patients with recent-onset type 1 diabetes: follow-up 1 year after cessation of treatment.

    abstract::OBJECTIVE We previously reported that 2 years of costimulation modulation with abatacept slowed decline of β-cell function in recent-onset type 1 diabetes (T1D). Subsequently, abatacept was discontinued and subjects were followed to determine whether there was persistence of effect. RESEARCH DESIGN AND METHODS Of 112 ...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验


    authors: Orban T,Bundy B,Becker DJ,Dimeglio LA,Gitelman SE,Goland R,Gottlieb PA,Greenbaum CJ,Marks JB,Monzavi R,Moran A,Peakman M,Raskin P,Russell WE,Schatz D,Wherrett DK,Wilson DM,Krischer JP,Skyler JS,Type 1 Diabetes Trial

    更新日期:2014-04-01 00:00:00