Electron microscopy of insulin precipitates.

abstract：OBJECTIVE:To describe the impact of abdominal obesity and hepatic insulin resistance on phase-specific glycemic responses in older women. RESEARCH DESIGN AND METHODS:We studied 23 healthy older women (60-88 years old). Abdominal obesity was defined by an abdominal circumference > or =95 cm. Plasma glucose and insulin ...

journal_title：Diabetes care

authors： DiPietro L,Dziura J,Yeckel CW

更新日期：2010-01-01 00:00:00

abstract：:Due to the inherent pharmacokinetic properties of available insulins, normoglycemia is rarely, if ever, achieved in insulin-dependent diabetic patients without compromising their quality of life. Subcutaneous insulin absorption is influenced by many factors, among which the associated state of insulin (hexameric) in p...

journal_title：Diabetes care

authors： Brange J,Owens DR,Kang S,Vølund A

更新日期：1990-09-01 00:00:00

abstract：:Natriuretic peptides (NPs) play a key role in cardiovascular homeostasis, counteracting the deleterious effects of volume and pressure overload and activating antibrotic and antihypertrophic pathways in the heart. N-terminal B-type NP (NT-proBNP) also is a promising biomarker of global cardiovascular risk in the gener...

journal_title：Diabetes care

authors： Gruden G,Landi A,Bruno G

更新日期：2014-11-01 00:00:00

abstract：:Adjustment algorithms for conventional insulin therapy must be tested for safety and efficacy before clinical implementation. We did this by computer simulation. Accordingly, a computer simulator of human intermediary metabolism created 10 randomly chosen diabetic subjects for study. All were well defined with respect...

journal_title：Diabetes care

authors： Albisser AM,Sozzi S,Strack TR

更新日期：1990-04-01 00:00:00

abstract：OBJECTIVE:Studies comparing the incidence of blindness in persons with and without diabetes are scarce worldwide. In Germany, a decline in the incidence of blindness was found during the 1990s. The aim of this study was to analyze the recent time trend. RESEARCH DESIGN AND METHODS:Data were based on administrative fil...

journal_title：Diabetes care

authors： Claessen H,Kvitkina T,Narres M,Trautner C,Zöllner I,Bertram B,Icks A

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:To examine urinary levels of enterolactone and enterodiol, intestinal microbial metabolites of dietary lignans, in relation to type 2 diabetes (T2D) risk. RESEARCH DESIGN AND METHODS:Urinary concentrations of the lignan metabolites were assayed by liquid chromatography-mass spectrometry among 1,107 T2D and 1...

journal_title：Diabetes care

authors： Sun Q,Wedick NM,Pan A,Townsend MK,Cassidy A,Franke AA,Rimm EB,Hu FB,van Dam RM

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:Prediabetes and type 2 diabetes mellitus (T2DM) are believed to be common and associated with a worse metabolic profile in patients with nonalcoholic fatty liver disease (NAFLD). However, no previous study has systematically screened this population. RESEARCH DESIGN AND METHODS:We studied the prevalence and ...

journal_title：Diabetes care

authors： Ortiz-Lopez C,Lomonaco R,Orsak B,Finch J,Chang Z,Kochunov VG,Hardies J,Cusi K

更新日期：2012-04-01 00:00:00

abstract：:Seventeen pregnant diabetic women participated in a special outpatient program during which they learned to self-monitor blood glucose (BG) and to vary insulin dosage on the basis of the results. The Ames Eyetone reflectance meter and the Boehringer Reflomat were used for BG analysis. BG was self-monitored at least tw...

journal_title：Diabetes care

authors： Irsigler K,Bali-Taubald C

更新日期：1980-01-01 00:00:00

abstract：:Unexpected plasma glucose responses to different mixed meals fed to normal and diabetic volunteers have recently been reported. We have therefore examined in normal volunteers the effect of mixing carbohydrate foods of different glycemic indices (GIs) without the addition of fat and protein. The observed GI of the mix...

journal_title：Diabetes care

authors： Wolever TM,Nuttall FQ,Lee R,Wong GS,Josse RG,Csima A,Jenkins DJ

更新日期：1985-09-01 00:00:00

abstract：OBJECTIVE:Because a pseudonormal pattern of ventricular filling has never been considered in studies that reported a prevalence of left ventricular diastolic dysfunction (LVDD) between 20 and 40%, our aim was to more completely evaluate the prevalence of LVDD in subjects with diabetes. RESEARCH DESIGN AND METHODS:We s...

journal_title：Diabetes care

authors： Poirier P,Bogaty P,Garneau C,Marois L,Dumesnil JG

更新日期：2001-01-01 00:00:00

abstract：:The scientific literature demonstrates that fat replacers have a reasonable certainty of no harm. Whether they help produce desired health outcomes, i.e., decreased risk of coronary heart disease and certain types of cancer related to excess fat intake, weight reduction, changes in lipid profile, improved glycemic con...

journal_title：Diabetes care

authors： Warshaw H,Franz M,Powers MA,Wheeler M

更新日期：1996-11-01 00:00:00

abstract：OBJECTIVE:This study examined the prognostic significance of diabetes and microvascular complications in patients with heart failure with preserved ejection fraction (HFpEF). RESEARCH DESIGN AND METHODS:This analysis included 3,385 patients (mean age 69 ± 9.6 years; 49% male; 89% white) with HFpEF from the Treatment o...

journal_title：Diabetes care

authors： Sandesara PB,O'Neal WT,Kelli HM,Samman-Tahhan A,Hammadah M,Quyyumi AA,Sperling LS

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:In 2010, the American Diabetes Association (ADA) added hemoglobin A1c (A1C) to the guidelines for diagnosing type 2 diabetes. However, existing models for predicting diabetes risk were developed prior to the widespread adoption of A1C. Thus, it remains unknown how well existing diabetes risk prediction models...

journal_title：Diabetes care

authors： Lacy ME,Wellenius GA,Carnethon MR,Loucks EB,Carson AP,Luo X,Kiefe CI,Gjelsvik A,Gunderson EP,Eaton CB,Wu WC

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVE:To examine the prevalence and incidence of unrecognized myocardial infarction in a contemporary population with type 2 diabetes. RESEARCH DESIGN AND METHODS:We performed a retrospective analysis of the electrocardiograms (ECGs) recorded at baseline and after 2 years for the first 1,004 type 2 diabetic indivi...

journal_title：Diabetes care

authors： MacDonald MR,Petrie MC,Home PD,Komajda M,Jones NP,Beck-Nielsen H,Gomis R,Hanefeld M,Pocock SJ,Curtis PS,McMurray JJ

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:Peripheral neuropathy is the most frequent neurological complication in diabetic patients. The diagnosis is established by both clinical neurological examination and demonstration of reduced epidermal nerve fibers in skin biopsies (1). Whereas the decrease of free nerve endings has been extensively studied in...

journal_title：Diabetes care

authors： Reinisch CM,Traxler H,Piringer S,Tangl S,Nader A,Tschachler E

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVE:To quantify age-related variability of insulin needs during day and night closed-loop insulin delivery. RESEARCH DESIGN AND METHODS:We retrospectively analyzed data from hybrid closed-loop studies involving young children (1-6 years old, n = 20), children (7-12 years, n = 21), adolescents (13-17 years, n = 1...

journal_title：Diabetes care

authors： Dovc K,Boughton C,Tauschmann M,Thabit H,Bally L,Allen JM,Acerini CL,Arnolds S,de Beaufort C,Bergenstal RM,Campbell F,Criego A,Dunger DB,Elleri D,Evans ML,Fröhlich-Reiterer E,Hofer S,Kapellen T,Leelarathna L,Pieber T

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of normal aging on the protective responses against hypoglycemia, in view of the fact that type II diabetes is primarily a disease of aging, and its treatment is associated with risk of hypoglycemia with cognitive impairment. RESEARCH DESIGN AND METHODS:Plasma glucose was lowered st...

journal_title：Diabetes care

authors： Matyka K,Evans M,Lomas J,Cranston I,Macdonald I,Amiel SA

更新日期：1997-02-01 00:00:00

abstract：OBJECTIVE:To examine the safety and efficacy of dapagliflozin, a sodium-glucose cotransporter-2 inhibitor, added on to pioglitazone in type 2 diabetes inadequately controlled on pioglitazone. RESEARCH DESIGN AND METHODS:Treatment-naive patients or those receiving metformin, sulfonylurea, or thiazolidinedione entered a...

journal_title：Diabetes care

authors： Rosenstock J,Vico M,Wei L,Salsali A,List JF

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVE:The recommendations for dietary fats in patients with type 2 diabetes are based largely on the impact of fatty acids on fasting serum lipid and glucose concentrations. How fatty acids affect postprandial insulin, glucose, and triglyceride concentrations, however, remains unclear. The objective of this study w...

journal_title：Diabetes care

authors： Shah M,Adams-Huet B,Brinkley L,Grundy SM,Garg A

更新日期：2007-12-01 00:00:00

abstract：OBJECTIVE:We have investigated age-period-cohort effects and spatial and temporal trends for the incidence of type 1 diabetes among 0- to 14-year-old children in Norway. RESEARCH DESIGN AND METHODS:We included children with the diagnosis of type 1 diabetes in Norway during 1973-1982 and 1989-2003. We studied age, cale...

journal_title：Diabetes care

authors： Aamodt G,Stene LC,Njølstad PR,Søvik O,Joner G,Norwegian Childhood Diabetes Study Group.

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVE:Impaired muscular mitochondrial function is related to common insulin resistance in type 2 diabetes. Mitochondrial diseases frequently lead to diabetes, which is mostly attributed to defective beta-cell mitochondria and secretion. RESEARCH DESIGN AND METHODS:We assessed muscular mitochondrial function and li...

journal_title：Diabetes care

authors： Szendroedi J,Schmid AI,Meyerspeer M,Cervin C,Kacerovsky M,Smekal G,Gräser-Lang S,Groop L,Roden M

更新日期：2009-04-01 00:00:00

abstract：OBJECTIVE:We conducted a nested case-control investigation to examine whether elevated baseline concentrations of cystatin C predicted progression from normoglycemia to pre-diabetes over 6 years of follow-up from the Western New York Health Study. RESEARCH DESIGN AND METHODS:In 2002-2004, 1,455 participants from the W...

journal_title：Diabetes care

authors： Donahue RP,Stranges S,Rejman K,Rafalson LB,Dmochowski J,Trevisan M

更新日期：2007-07-01 00:00:00

abstract：OBJECTIVE:There is sparse evidence for the association of suitable food substitutions for red and processed meat on the risk of type 2 diabetes. We modeled the association between replacing red and processed meat with other protein sources and the risk of type 2 diabetes and estimated its population impact. RESEARCH D...

journal_title：Diabetes care

authors： Ibsen DB,Steur M,Imamura F,Overvad K,Schulze MB,Bendinelli B,Guevara M,Agudo A,Amiano P,Aune D,Barricarte A,Ericson U,Fagherazzi G,Franks PW,Freisling H,Quiros JR,Grioni S,Heath AK,Huybrechts I,Katze V,Laouali N,

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVE:A long-term health economic analysis was performed to establish the cost-effectiveness of real-time continuous glucose monitoring (RT-CGM) (Dexcom G6) versus self-monitoring of blood glucose (SMBG) alone in U.K.-based patients with type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS:The analysis used the IQVI...

journal_title：Diabetes care

authors： Roze S,Isitt J,Smith-Palmer J,Javanbakht M,Lynch P

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:To compare clinical outcomes obtained using treatment algorithms versus standard "usual care" to treat patients with type 2 diabetes in a community setting. RESEARCH DESIGN AND METHODS:An observational group comparison was implemented in three community-based clinics in San Antonio, Texas: 1). a community cl...

journal_title：Diabetes care

authors： Fanning EL,Selwyn BJ,Larme AC,DeFronzo RA

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVE:To compare peak pressures on the sole of the foot in non-insulin-dependent diabetic patients with isolated, unilateral amputations of the great toe and first metatarsal with the patients' contralateral, intact foot. RESEARCH DESIGN AND METHODS:Eleven patients with a unilateral great toe and partial first met...

journal_title：Diabetes care

authors： Lavery LA,Lavery DC,Quebedeax-Farnham TL

更新日期：1995-11-01 00:00:00

abstract：OBJECTIVE:To longitudinally characterize changes in insulin sensitivity in obese women during and after pregnancy. RESEARCH DESIGN AND METHODS:Six glucose-tolerant obese women underwent a 4-h euglycemic-hyperinsulinemic (500-600 pmol/l) clamping during the second (22.5 +/- 2 weeks [mean +/- SD]) and third trimester (3...

journal_title：Diabetes care

authors： Sivan E,Chen X,Homko CJ,Reece EA,Boden G

更新日期：1997-09-01 00:00:00

abstract：:Fifty-one children with insulin-dependent diabetes mellitus (IDDM) and 24 healthy sibling controls were compared on one of two temperament questionnaires completed by parents. Children with IDDM did not provide a characteristic temperament profile or show any problem areas. A regression analysis to predict diabetic co...

journal_title：Diabetes care

authors： Rovet JF,Ehrlich RM

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:Independent association of chronic kidney disease (CKD) and proliferative diabetic retinopathy (PDR) with cardiovascular disease (CVD) has not been established. In the Joslin 50-Year Medalist study, characterizing individuals with type 1 diabetes for 50 years or more, we examined the associations of CKD and P...

journal_title：Diabetes care

authors： Gordin D,Harjutsalo V,Tinsley L,Fickweiler W,Sun JK,Forsblom C,Amenta PS,Pober D,D'Eon S,Khatri M,Stillman IE,Groop PH,Keenan HA,King GL

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:We sought to determine whether levels of inflammatory markers and different cytokines are abnormal in nondiabetic offspring of type 2 diabetic subjects. RESEARCH DESIGN AND METHODS:Cytokine levels were measured in 19 healthy control subjects and 129 offspring of patients with type 2 diabetes (109 with normal...

journal_title：Diabetes care

authors： Ruotsalainen E,Salmenniemi U,Vauhkonen I,Pihlajamäki J,Punnonen K,Kainulainen S,Laakso M

更新日期：2006-12-01 00:00:00