Abstract:
OBJECTIVE:To prospectively determine risk factors for foot infection in a cohort of people with diabetes. RESEARCH DESIGN AND METHODS:We evaluated then followed 1,666 consecutive diabetic patients enrolled in a managed care-based outpatient clinic in a 2-year longitudinal outcomes study. At enrollment, patients underwent a standardized general medical examination and detailed foot assessment and were educated about proper foot care. They were then rescreened at scheduled intervals and also seen promptly if they developed any foot problem. RESULTS:During the evaluation period, 151 (9.1%) patients developed 199 foot infections, all but one involving a wound or penetrating injury. Most patients had infections involving only the soft tissue, but 19.9% had bone culture-proven osteomyelitis. For those who developed a foot infection, compared with those who did not, the risk of hospitalization was 55.7 times greater (95% CI 30.3-102.2; P < 0.001) and the risk of amputation was 154.5 times greater (58.5-468.5; P < 0.001). Foot wounds preceded all but one infection. Significant (P < 0.05) independent risk factors for foot infection from a multivariate analysis included wounds that penetrated to bone (odds ratio 6.7), wounds with a duration >30 days (4.7), recurrent wounds (2.4), wounds with a traumatic etiology (2.4), and presence of peripheral vascular disease (1.9). CONCLUSIONS:Foot infections occur relatively frequently in individuals with diabetes, almost always follow trauma, and dramatically increase the risk of hospitalization and amputation. Efforts to prevent infections should be targeted at people with traumatic foot wounds, especially those that are chronic, deep, recurrent, or associated with peripheral vascular disease.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Lavery LA,Armstrong DG,Wunderlich RP,Mohler MJ,Wendel CS,Lipsky BAdoi
10.2337/dc05-2425subject
Has Abstractpub_date
2006-06-01 00:00:00pages
1288-93issue
6eissn
0149-5992issn
1935-5548pii
29/6/1288journal_volume
29pub_type
杂志文章,多中心研究相关文献
DIABETES CARE文献大全abstract:OBJECTIVE:Newer medications offer more options for glycemic control in type 2 diabetes. However, they come at considerable costs. We undertook a health economic analysis to better understand the value of adding two newer medications (exenatide and sitagliptin) as second-line therapy to glycemic control strategies for p...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-1488
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:Women with diabetes have a high incidence and complication rate of urinary tract infections (UTIs). Our aims were to compare current treatment strategies with respect to recurrence rates in women with diabetes with those without diabetes. RESEARCH DESIGN AND METHODS:We used a Dutch registration database cont...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/dc07-2188
更新日期:2008-07-01 00:00:00
abstract::A cross-sectional study on the prevalence of atherosclerotic vascular disease (ASVD) and its risk factors in non-insulin-dependent diabetic and nondiabetic subjects was carried out from 1982 to 1984 in East Finland (Kuopio) and West Finland (Turku), two areas known to differ markedly in prevalence of ASVD in the nondi...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.11.6.449
更新日期:1988-06-01 00:00:00
abstract:OBJECTIVE:The goal of this study was to determine whether the haptoglobin (Hp) genotype was predictive of restenosis and major adverse cardiac events (MACEs) after percutaneous transluminal coronary angioplasty (PTCA) in individuals with diabetes. RESEARCH DESIGN AND METHODS:A consecutive series of 935 diabetic patien...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.26.9.2628
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVE:The prevalence of the metabolic syndrome, a potent risk factor for cardiovascular diseases (CVDs), has not been adequately explored in older individuals. Moreover, two sets of criteria have been proposed for the definition of metabolic syndrome, one by the World Health Organization (WHO) and one by the Nation...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.28.4.882
更新日期:2005-04-01 00:00:00
abstract:OBJECTIVE:Several methods have been proposed to evaluate insulin sensitivity from the data obtained from the oral glucose tolerance test (OGTT). However, the validity of these indices has not been rigorously evaluated by comparing them with the direct measurement of insulin sensitivity obtained with the euglycemic insu...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.22.9.1462
更新日期:1999-09-01 00:00:00
abstract:OBJECTIVE:To examine whether cardiovascular autonomic neuropathy (CAN) is an independent risk factor of cardiovascular disease (CVD) events during DCCT/EDIC. RESEARCH DESIGN AND METHODS:Standardized cardiovascular autonomic reflex tests (R-R response to paced breathing, Valsalva maneuver, postural changes in blood pre...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc16-1397
更新日期:2017-01-01 00:00:00
abstract::Medications may contain significant amounts of various sugars. Data provided by 67 manufacturers have been tabulated to provide specific qualitative and quantitative information on sugar content of selected drug products. Since diabetic individuals may tolerate various sugar forms differently, it is useful to know spe...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.6.3.231
更新日期:1983-05-01 00:00:00
abstract:OBJECTIVE:Observational studies have yielded inconsistent findings regarding the association of hemoglobin A(1c) (HbA(1c)) with survival in diabetic patients on dialysis. The association between pretransplant glycemic control and short- and long-term posttransplant outcomes in kidney transplant recipients is not clear....
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc11-0906
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:To compare a simple meal plan emphasizing healthy food choices with a traditional exchange-based meal plan in reducing HbA(1c) levels in urban African Americans with type 2 diabetes. RESEARCH DESIGN AND METHODS:A total of 648 patients with type 2 diabetes were randomized to receive instruction in either a he...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.26.6.1719
更新日期:2003-06-01 00:00:00
abstract:OBJECTIVE:To compare the health service utilization and long-term outcomes of acute myocardial infarction (AMI) patients with and without diabetes in Ontario. RESEARCH DESIGN AND METHODS:We examined 25,697 patients from Ontario (6,052 and 19,645 patients with and without diabetes, respectively) who were hospitalized b...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.26.5.1427
更新日期:2003-05-01 00:00:00
abstract::Because the negative consequences of new-onset diabetes mellitus after transplantation (NODAT) diminish the significant gains of kidney transplantation, it is imperative to develop clinical interventions to reduce the incidence of NODAT. In this review, we discuss whether intensive lifestyle interventions that delay o...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/dc12-2067
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:To assess the level of serum lipoprotein(a) [Lp(a)] in nonobese and obese NIDDM subjects with android body distribution. RESEARCH DESIGN AND METHODS:Serum Lp(a) levels were measured in 30 long-standing NIDDM patients (duration of diabetes 12.5 +/- 3 years, mean +/- SD), with 15 of the patients being obese of...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.11.1693
更新日期:1997-11-01 00:00:00
abstract:OBJECTIVE:To date no clinical trials have evaluated the role of dietary patterns on the incidence of microvascular diabetes complications. We hypothesized that a nutritional intervention based on the Mediterranean diet (MedDiet) would have greater protective effect on diabetic retinopathy and nephropathy than a low-fat...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2337/dc15-1117
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVE:Hypoxia plays a major pathogenic role in diabetic nephropathy (DN). We have investigated in this study the effect of hypoxia-inducible factor 1 α subunit (HIF1A) genetic polymorphisms on the development of DN. RESEARCH DESIGN AND METHODS:In 1,165 American type 1 diabetic patients with and without DN selected...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-1125
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:To quantify the incremental survival benefit of the pancreas allograft in simultaneous pancreas-kidney (SPK) transplant recipients. RESEARCH DESIGN AND METHODS:Data from the national transplant database from 2000 to 2007 were analyzed. SPK recipients who had functioning allografts to 1-year post transplant (...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc08-1718
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:To conduct a systematic review of the published literature on the efficacy and safety of herbal therapies and vitamin/mineral supplements for glucose control in patients with diabetes. RESEARCH DESIGN AND METHODS:We conducted an electronic literature search of MEDLINE, OLDMEDLINE, Cochrane Library Database, ...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.26.4.1277
更新日期:2003-04-01 00:00:00
abstract:OBJECTIVE:To determine whether an educational intervention for medical house staff improves blood glucose (BG) in hospitalized patients. RESEARCH DESIGN AND METHODS:All 116 medicine residents at an academic medical center were assigned to online or classroom training on inpatient dysglycemia in fall 2008. Both groups ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc11-0517
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVE:To investigate the effects of fenofibrate and coenzyme Q(10) (CoQ) on diastolic function, ambulatory blood pressure (ABP), and heart rate (HR) in type 2 diabetic subjects with left ventricular diastolic dysfunction (LVDD). RESEARCH DESIGN AND METHODS:We randomized, double-blind, 74 subjects to fenofibrate 16...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc08-0118
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVE:This double-blind, placebo-controlled, randomized, multicenter, parallel-group study compared the efficacy, safety, and tolerability of Technosphere insulin with Technosphere powder as placebo in insulin-naive type 2 diabetic patients whose diabetes was suboptimally controlled with oral antidiabetic agents. ...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc08-0315
更新日期:2008-11-01 00:00:00
abstract::We describe affinity sensors for monitoring various metabolites in blood plasma by optical means. The principle of detection is similar to that used in radioimmunoassays and is based on the competitive binding of a particular metabolite and a fluorescein-labeled analogue with receptor sites specific for the metabolite...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.5.3.245
更新日期:1982-05-01 00:00:00
abstract:OBJECTIVE:Predictors of insulin resistance have hitherto only been examined in cross-sectional studies without information on lifestyle factors. Few researchers have measured insulin sensitivity directly and compared different metabolic and lifestyle predictors in a large population. RESEARCH DESIGN AND METHODS:Our ai...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc07-0360
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVE:To determine whether food insecurity--the inability to reliably afford safe and nutritious food--is associated with poor glycemic control and whether this association is mediated by difficulty following a healthy diet, diabetes self-efficacy, or emotional distress related to diabetes. RESEARCH DESIGN AND MET...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc11-1627
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVE:To evaluate the accuracy of the UK Prospective Diabetes Study Outcomes Model (UKPDS-OM) in predicting clinical outcomes during the UKPDS posttrial monitoring (PTM) period. RESEARCH DESIGN AND METHODS:At trial end in 1997, the 4,031 surviving UKPDS patients, of the 5,102 originally enrolled in the study, retu...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-1120
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:To compare fenofibric acid (FA) + statin to respective monotherapies on the prevalence of metabolic syndrome and its diagnostic components in patients with mixed dyslipidemia. RESEARCH DESIGN AND METHODS:Post hoc analysis of over 2,000 metabolic syndrome patients administered either FA + low- or moderate-dos...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc10-0357
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:To test whether diabetic polyneuropathies (DPNs), retinopathy, or nephropathy is more prevalent in subjects with impaired glycemia (IG) (abnormality of impaired fasting glucose [IFG], impaired glucose tolerance [IGT], or impaired HbA(1c) [IA1C]) than in healthy subjects (non-IG). RESEARCH DESIGN AND METHODS:...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc11-1421
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVE:Type 1 diabetes is associated with a markedly increased risk of stroke, but only a few studies on the incidence of stroke in type 1 diabetes exist. Therefore, we assessed the incidence of stroke in patients with type 1 diabetes and studied the impact of diabetic nephropathy (DN) and severe diabetic retinopath...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/dc13-0669
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:Ruboxistaurin selectively inhibits protein kinase C-beta and ameliorates kidney disease in animal models of diabetes. The purpose of this study was to evaluate the effects of ruboxistaurin on diabetic nephropathy in humans. RESEARCH DESIGN AND METHODS:A randomized, double-blind, placebo-controlled, multicent...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.2337/diacare.28.11.2686
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the utility of a semipermeable polymeric membrane dressing for the treatment of chronic diabetic foot ulcers. RESEARCH DESIGN AND METHODS:Nineteen subjects with either insulin-dependent diabetes mellitus (IDDM) or non-insulin-dependent diabetes mellitus (NIDDM) and foot ulcers were randomly assig...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.17.4.322
更新日期:1994-04-01 00:00:00
abstract:OBJECTIVE:Little is known about the psychosocial challenges of adults living with type 1 diabetes or its impact on partner relationships. This qualitative study was undertaken to gain better understanding of these issues. RESEARCH DESIGN AND METHODS:Four focus groups were held, two with adult type 1 diabetic patients ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-1718
更新日期:2013-09-01 00:00:00