Abstract:
OBJECTIVE:To compare fenofibric acid (FA) + statin to respective monotherapies on the prevalence of metabolic syndrome and its diagnostic components in patients with mixed dyslipidemia. RESEARCH DESIGN AND METHODS:Post hoc analysis of over 2,000 metabolic syndrome patients administered either FA + low- or moderate-dose statin; FA alone; or low-, moderate-, or high-dose statin alone. RESULTS:FA + low- or moderate-dose statin combination therapy reduced the presence of metabolic syndrome (35.7 or 35.9%, respectively) more than low-, moderate-, or high-dose statin monotherapy (15.5, 16.6, or 13.8%, respectively), mostly due to improvements in triglycerides and HDL cholesterol levels. Mean glucose levels slightly decreased with FA monotherapy, slightly increased with statin monotherapy, and were essentially unchanged with FA + statin. FA with or without statin also reduced non-HDL cholesterol, apolipoprotein B, total cholesterol, VLDL cholesterol, and high-sensitivity C-reactive protein. CONCLUSIONS:FA + statin in patients with mixed dyslipidemia reduces the prevalence of metabolic syndrome.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Bays HE,Roth EM,McKenney JM,Kelly MT,Thakker KM,Setze CM,Obermeyer K,Sleep DJdoi
10.2337/dc10-0357subject
Has Abstractpub_date
2010-09-01 00:00:00pages
2113-6issue
9eissn
0149-5992issn
1935-5548pii
dc10-0357journal_volume
33pub_type
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