Can self-rated health scores be used for risk prediction in patients with type 2 diabetes?


OBJECTIVE:To investigate whether self-rated health profiles compiled using the EuroQol group's visual analog scale (EQ VAS) are independent predictors of vascular events and major complications in people with type 2 diabetes after controlling for standard clinical risk factors. RESEARCH DESIGN AND METHODS:The study is based on 7,348 individuals with a mean follow-up of 2.4 years after completing the EQ-5D questionnaire. We used Cox proportional hazards modeling to estimate hazard ratios associated with EQ VAS scores after controlling for baseline covariates: age, sex, smoking status, diabetes duration, A1C, systolic blood pressure, BMI, plasma lipids, and prior clinical history. RESULTS:A 10-point higher EQ VAS score was associated with a 6% (95% CI 1-11) lower risk of vascular events and a 22% (95% CI 15-28) lower risk of diabetes complications. CONCLUSIONS:Self-rated health profiles compiled using the EQ VAS provide valuable information on patient risk in addition to that determined from clinical risk factors alone.


Diabetes Care


Diabetes care


Hayes AJ,Clarke PM,Glasziou PG,Simes RJ,Drury PL,Keech AC




Has Abstract


2008-04-01 00:00:00














  • Dose response of inhaled dry-powder insulin and dose equivalence to subcutaneous insulin lispro.

    abstract:OBJECTIVE:To determine the pharmacokinetic (PK) and glucodynamic (GD) dose response of human insulin inhalation powder (HIIP) delivered via AIR particle technology and dose equivalence to subcutaneous (SC) insulin lispro. RESEARCH DESIGN AND METHODS:Twenty healthy, nonsmoking, male or female subjects (aged 29.6 +/- 6....

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验


    authors: Rave KM,Nosek L,de la Peña A,Seger M,Ernest CS 2nd,Heinemann L,Batycky RP,Muchmore DB

    更新日期:2005-10-01 00:00:00

  • Improvement of the plasma lipoprotein pattern after institution of insulin treatment in diabetes mellitus.

    abstract::Plasma lipids and lipoproteins were studied in 26 nonobese diabetic patients, either newly diagnosed or unsatisfactorily controlled by oral antidiabetic treatment. Measurements were performed before and 3-4 mo after the institution of insulin treatment. In a subgroup of seven patients, the activities of lipoprotein li...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Agardh CD,Nilsson-Ehle P,Scherstén B

    更新日期:1982-05-01 00:00:00

  • Predicting the development of diabetes in older adults: the derivation and validation of a prediction rule.

    abstract:OBJECTIVE:To create a simple prediction rule that could perform as well as the 2-h postchallenge plasma glucose (PCPG) test to predict those at risk for diabetes. We created a prediction rule in one sample and prospectively validated it for incident diabetes in a separate cohort. RESEARCH DESIGN AND METHODS:A cross-se...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Kanaya AM,Wassel Fyr CL,de Rekeneire N,Shorr RI,Schwartz AV,Goodpaster BH,Newman AB,Harris T,Barrett-Connor E

    更新日期:2005-02-01 00:00:00

  • Dietary fat intake predicts 1-year change in body fat in adolescent girls with type 1 diabetes.

    abstract:OBJECTIVE:The purpose of this study was to determine whether objectively measured physical activity and dietary macronutrient intake differentially predict body fat in adolescent girls with type 1 diabetes and control girls. RESEARCH DESIGN AND METHODS:This study comprised 23 girls (12-19 years) with type 1 diabetes a...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Särnblad S,Ekelund U,Aman J

    更新日期:2006-06-01 00:00:00

  • Monomeric insulins and their experimental and clinical implications.

    abstract::Due to the inherent pharmacokinetic properties of available insulins, normoglycemia is rarely, if ever, achieved in insulin-dependent diabetic patients without compromising their quality of life. Subcutaneous insulin absorption is influenced by many factors, among which the associated state of insulin (hexameric) in p...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审


    authors: Brange J,Owens DR,Kang S,Vølund A

    更新日期:1990-09-01 00:00:00

  • Head-to-head comparison of sirolimus- and paclitaxel-eluting stent in the same diabetic patient with multiple coronary artery lesions: a prospective, randomized, multicenter study.

    abstract:OBJECTIVE:It is still controversial whether sirolimus-eluting stent (SES) and paclitaxel-eluting stent (PES) are equally effective in patients with diabetes. In these patients, multiple individual variables may be responsible for neointimal hyperplasia, thus making difficult the comparison of the two drug-eluting stent...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Tomai F,Reimers B,De Luca L,Galassi AR,Gaspardone A,Ghini AS,Ferrero V,Favero L,Gioffrè G,Prati F,Tamburino C,Ribichini F

    更新日期:2008-01-01 00:00:00

  • Muscular endurance in long-term IDDM patients.

    abstract:OBJECTIVE:To determine the short-term muscular endurance and working capacity of leg muscles in long-term IDDM patients in relation to neuropathic complications, muscle strength, and metabolic control. RESEARCH DESIGN AND METHODS:The muscular endurance of extensors and flexors at the ankle and knee was assessed in 44 ...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Andersen H

    更新日期:1998-04-01 00:00:00

  • Hemodynamic effects of fenofibrate and coenzyme Q10 in type 2 diabetic subjects with left ventricular diastolic dysfunction.

    abstract:OBJECTIVE:To investigate the effects of fenofibrate and coenzyme Q(10) (CoQ) on diastolic function, ambulatory blood pressure (ABP), and heart rate (HR) in type 2 diabetic subjects with left ventricular diastolic dysfunction (LVDD). RESEARCH DESIGN AND METHODS:We randomized, double-blind, 74 subjects to fenofibrate 16...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验


    authors: Chew GT,Watts GF,Davis TM,Stuckey BG,Beilin LJ,Thompson PL,Burke V,Currie PJ

    更新日期:2008-08-01 00:00:00

  • Reductions in regimen distress are associated with improved management and glycemic control over time.

    abstract::OBJECTIVE Cross-sectional and longitudinal associations among regimen distress (RD), self-management, and glycemic control were undertaken to explore mechanisms of operation among these variables. RESEARCH DESIGN AND METHODS In a behavioral randomized control trial (RCT) to reduce RD, 392 adults with type 2 diabetes w...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Hessler D,Fisher L,Glasgow RE,Strycker LA,Dickinson LM,Arean PA,Masharani U

    更新日期:2014-01-01 00:00:00

  • Expression of matrix metalloproteinases, cytokines, and connexins in diabetic and nondiabetic human keratinocytes before and after transplantation into an ex vivo wound-healing model.

    abstract:OBJECTIVE:Wound healing is known to require a well-organized balance of numerous factors, e.g., cytokines, matrix metalloproteinases (MMPs), and their inhibitors, as well as direct cell-cell communication (connexins). Disruption of this balance may lead to the formation of chronic wounds such as diabetic foot ulcers. T...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Brandner JM,Zacheja S,Houdek P,Moll I,Lobmann R

    更新日期:2008-01-01 00:00:00

  • The use of medical hyperspectral technology to evaluate microcirculatory changes in diabetic foot ulcers and to predict clinical outcomes.

    abstract:OBJECTIVE:Foot ulceration is a serious complication of diabetes, and new techniques that can predict wound healing may prove very helpful. We tested the ability of medical hyperspectral technology (HT), a novel diagnostic scanning technique that can quantify tissue oxy- and deoxyhemoglobin to predict diabetic foot ulce...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Khaodhiar L,Dinh T,Schomacker KT,Panasyuk SV,Freeman JE,Lew R,Vo T,Panasyuk AA,Lima C,Giurini JM,Lyons TE,Veves A

    更新日期:2007-04-01 00:00:00

  • An Observational Study of the Equivalence of Age and Duration of Diabetes to Glycemic Control Relative to the Risk of Complications in the Combined Cohorts of the DCCT/EDIC Study.

    abstract:OBJECTIVE:This epidemiological analysis of the pooled Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) cohort describes the equivalence of a 1-percentage point increase in HbA1c (such as from 7% to 8%) and years of additional age or duration of type 1 diabete...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Bebu I,Braffett BH,Schade D,Sivitz W,Malone JI,Pop-Busui R,Lorenzi GM,Lee P,Trapani VR,Wallia A,Herman WH,Lachin JM,DCCT\/EDIC Research Group.

    更新日期:2020-10-01 00:00:00

  • Cardiovascular and Other Outcomes Postintervention With Insulin Glargine and Omega-3 Fatty Acids (ORIGINALE).

    abstract:OBJECTIVE:The Outcome Reduction With Initial Glargine Intervention (ORIGIN) trial reported neutral effects of insulin glargine on cardiovascular outcomes and cancers and reduced incident diabetes in high-cardiovascular risk adults with dysglycemia after 6.2 years of active treatment. Omega-3 fatty acids had neutral eff...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验


    authors: ORIGIN Trial Investigators.

    更新日期:2016-05-01 00:00:00

  • Prior feeding alters the response to the 50-g glucose challenge test in pregnancy. The Staub-Traugott effect revisited.

    abstract:OBJECTIVE:To examine the effect of prior meal ingestion on the glucose, insulin, and C-peptide response to a 50-g glucose challenge test in the third trimester of pregnancy. RESEARCH DESIGN AND METHODS:Ten pregnant women with gestational diabetes mellitus and 12 nondiabetic pregnant control subjects matched for age an...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lewis GF,McNally C,Blackman JD,Polonsky KS,Barron WM

    更新日期:1993-12-01 00:00:00

  • Low bone mineral density and its predictors in type 1 diabetic patients evaluated by the classic statistics and artificial neural network analysis.

    abstract:OBJECTIVE:To investigate factors associated with bone mineral density (BMD) in type 1 diabetes by classic statistic and artificial neural networks. RESEARCH DESIGN AND METHODS:A total of 175 eugonadal type 1 diabetic patients (age 32.8 ± 8.4 years) and 151 age- and BMI-matched control subjects (age 32.6 ± 4.5 years) w...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Eller-Vainicher C,Zhukouskaya VV,Tolkachev YV,Koritko SS,Cairoli E,Grossi E,Beck-Peccoz P,Chiodini I,Shepelkevich AP

    更新日期:2011-10-01 00:00:00

  • Early childhood gut microbiomes show strong geographic differences among subjects at high risk for type 1 diabetes.

    abstract:OBJECTIVE:Gut microbiome dysbiosis is associated with numerous diseases, including type 1 diabetes. This pilot study determines how geographical location affects the microbiome of infants at high risk for type 1 diabetes in a population of homogenous HLA class II genotypes. RESEARCH DESIGN AND METHODS:High-throughput ...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究


    authors: Kemppainen KM,Ardissone AN,Davis-Richardson AG,Fagen JR,Gano KA,León-Novelo LG,Vehik K,Casella G,Simell O,Ziegler AG,Rewers MJ,Lernmark Å,Hagopian W,She JX,Krischer JP,Akolkar B,Schatz DA,Atkinson MA,Triplett EW,TED

    更新日期:2015-02-01 00:00:00

  • Beneficial effects of a Dietary Approaches to Stop Hypertension eating plan on features of the metabolic syndrome.

    abstract:OBJECTIVE:To determine the effects of a Dietary Approaches to Stop Hypertension (DASH) eating plan on metabolic risks in patients with the metabolic syndrome. RESEARCH DESIGN AND METHODS:This was a randomized controlled outpatient trial conducted on 116 patients with the metabolic syndrome. Three diets were prescribed...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验


    authors: Azadbakht L,Mirmiran P,Esmaillzadeh A,Azizi T,Azizi F

    更新日期:2005-12-01 00:00:00

  • The SEE Study: Safety, Efficacy, and Equity of Implementing Autonomous Artificial Intelligence for Diagnosing Diabetic Retinopathy in Youth.

    abstract:OBJECTIVE:Diabetic retinopathy (DR) is a leading cause of vision loss worldwide. Screening for DR is recommended in children and adolescents, but adherence is poor. Recently, autonomous artificial intelligence (AI) systems have been developed for early detection of DR and have been included in the American Diabetes Ass...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Wolf RM,Liu TYA,Thomas C,Prichett L,Zimmer Galler I,Smith K,Abramoff MD,Channa R

    更新日期:2021-01-21 00:00:00

  • Insufficient control of blood pressure and incident diabetes.

    abstract:OBJECTIVE:Incidence of type 2 diabetes might be associated with preexisting hypertension. There is no information on whether incident diabetes is predicted by blood pressure control. We evaluated the hazard of diabetes in relation to blood pressure control in treated hypertensive patients. RESEARCH DESIGN AND METHODS:...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Izzo R,de Simone G,Chinali M,Iaccarino G,Trimarco V,Rozza F,Giudice R,Trimarco B,De Luca N

    更新日期:2009-05-01 00:00:00

  • Insulin resistance in the pathogenesis of NIDDM in Pima Indians.

    abstract::NIDDM in Pima Indians is characterized by obesity, abnormal insulin secretion, insulin resistance, and excess hepatic glucose output. Cross-sectional studies, and, as yet incomplete longitudinal studies of nondiabetic and diabetic Pima Indians suggest that the natural history of the disease begins with insulin resista...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审


    authors: Bogardus C

    更新日期:1993-01-01 00:00:00

  • Efficacy of metformin in the treatment of NIDDM. Meta-analysis.

    abstract:OBJECTIVE:The results differ concerning randomized controlled trials of the effects of metformin on blood glucose regulation and body weight. To get a systematic overview, a meta-analysis of the efficacy of metformin was performed by comparing metformin with placebo and sulfonylurea. RESEARCH DESIGN AND METHODS:All ra...

    journal_title:Diabetes care

    pub_type: 杂志文章,meta分析


    authors: Johansen K

    更新日期:1999-01-01 00:00:00

  • The Ipswich Touch Test: a simple and novel method to identify inpatients with diabetes at risk of foot ulceration.

    abstract:OBJECTIVE:To promote foot screening of inpatients with diabetes, we simplified sensory testing to lightly touching the tips of the first, third, and fifth toes (the Ipswich Touch Test [IpTT]). RESEARCH DESIGN AND METHODS:Respective performances of the IpTT and 10-g monofilament (MF) were compared with a vibration perc...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Rayman G,Vas PR,Baker N,Taylor CG Jr,Gooday C,Alder AI,Donohoe M

    更新日期:2011-07-01 00:00:00

  • Effect of a peroxisome proliferator-activated receptor-gamma agonist on myocardial blood flow in type 2 diabetes.

    abstract:OBJECTIVE:The relationship between coronary endothelial function and insulin resistance remains speculative. We sought to determine whether pioglitazone, an insulin-sensitizing peroxisome proliferator-activated receptor (PPAR)-gamma agonist, improves cardiac endothelial function in individuals with type 2 diabetes. RE...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: McMahon GT,Plutzky J,Daher E,Bhattacharyya T,Grunberger G,DiCarli MF

    更新日期:2005-05-01 00:00:00

  • A pregnancy and postpartum lifestyle intervention in women with gestational diabetes mellitus reduces diabetes risk factors: a feasibility randomized control trial.

    abstract:OBJECTIVE:To pilot, among women with gestational diabetes mellitus (GDM), the feasibility of a prenatal/postpartum intervention to modify diet and physical activity similar to the Diabetes Prevention Program. The intervention was delivered by telephone, and support for breastfeeding was addressed. RESEARCH DESIGN AND ...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验


    authors: Ferrara A,Hedderson MM,Albright CL,Ehrlich SF,Quesenberry CP Jr,Peng T,Feng J,Ching J,Crites Y

    更新日期:2011-07-01 00:00:00

  • Is pancreatic diabetes (type 3c diabetes) underdiagnosed and misdiagnosed?

    abstract::Exocrine pancreatic insufficiency is frequently associated with diabetes, with high prevalence in both insulin-dependent or insulin-independent patients. Exocrine pancreatic failure has often been perceived as a complication of diabetes. In contrast, recent clinical observations lead to the notion that nonendocrine pa...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审


    authors: Hardt PD,Brendel MD,Kloer HU,Bretzel RG

    更新日期:2008-02-01 00:00:00

  • Declining Rates of Hospitalization for Selected Cardiovascular Disease Conditions Among Adults Aged ≥35 Years With Diagnosed Diabetes, U.S., 1998-2014.

    abstract:OBJECTIVE:Reductions in heart attack and stroke hospitalizations are well documented in the U.S. population with diabetes. We extended trend analyses to other cardiovascular disease (CVD) conditions, including stroke by type, and used four additional years of data. RESEARCH DESIGN AND METHODS:Using 1998-2014 National ...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Burrows NR,Li Y,Gregg EW,Geiss LS

    更新日期:2018-02-01 00:00:00

  • Improvement of glycemic control in subjects with poorly controlled type 2 diabetes: comparison of two treatment algorithms using insulin glargine.

    abstract:OBJECTIVE:Large prospective studies have demonstrated that optimum glycemic control is not routinely achieved in clinical practice. Barriers to optimal insulin therapy include hypoglycemia, weight gain, and suboptimal initiation and dose titration. This study compared two treatment algorithms for insulin glargine initi...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Davies M,Storms F,Shutler S,Bianchi-Biscay M,Gomis R,ATLANTUS Study Group.

    更新日期:2005-06-01 00:00:00

  • Dietary intervention in patients with gestational diabetes mellitus: a systematic review and meta-analysis of randomized clinical trials on maternal and newborn outcomes.

    abstract:OBJECTIVE:Diet is the cornerstone treatment of patients with gestational diabetes mellitus (GDM), but its role in maternal and newborn outcomes has been scarcely studied. The purpose of this study was to analyze the efficacy of dietary interventions on maternal or newborn outcomes in patients with GDM. RESEARCH DESIGN...

    journal_title:Diabetes care

    pub_type: 杂志文章,meta分析,评审


    authors: Viana LV,Gross JL,Azevedo MJ

    更新日期:2014-12-01 00:00:00

  • A 16-week comparison of the novel insulin analog insulin glargine (HOE 901) and NPH human insulin used with insulin lispro in patients with type 1 diabetes.

    abstract:OBJECTIVE:To determine the safety and efficacy of the long-acting insulin analog, insulin glargine, as a component of basal bolus therapy in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS:Patients with type 1 diabetes receiving basal-bolus insulin treatment with NPH human insulin and insulin lispro were ra...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Raskin P,Klaff L,Bergenstal R,Hallé JP,Donley D,Mecca T

    更新日期:2000-11-01 00:00:00

  • Effect of weight loss with lifestyle intervention on risk of diabetes.

    abstract:OBJECTIVE:Diabetes Prevention Program (DPP) participants randomized to the intensive lifestyle intervention (ILS) had significantly reduced risk of diabetes compared with placebo participants. We explored the contribution of changes in weight, diet, and physical activity on the risk of developing diabetes among ILS par...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验


    authors: Hamman RF,Wing RR,Edelstein SL,Lachin JM,Bray GA,Delahanty L,Hoskin M,Kriska AM,Mayer-Davis EJ,Pi-Sunyer X,Regensteiner J,Venditti B,Wylie-Rosett J

    更新日期:2006-09-01 00:00:00